The Hsp90-Myc-Cdk9 Network Drives Therapeutic Resistance In Mantle Cell Lymphoma,
2024
The Texas Medical Center Library
The Hsp90-Myc-Cdk9 Network Drives Therapeutic Resistance In Mantle Cell Lymphoma, Fangfang Yan, Vivian Jiang, Alexa Jordan, Yuxuan Che, Yang Liu, Qingsong Cai, Yu Xue, Yijing Li, Joseph Mcintosh, Zhihong Chen, Jovanny Vargas, Lei Nie, Yixin Yao, Heng-Huan Lee, Wei Wang, Johnnelson R Bigcal, Maria Badillo, Jitendra Meena, Christopher Flowers, Jia Zhou, Zhongming Zhao, Lukas M Simon, Michael Wang
Faculty, Staff and Student Publications
Brexucabtagene autoleucel CAR-T therapy is highly efficacious in overcoming resistance to Bruton's tyrosine kinase inhibitors (BTKi) in mantle cell lymphoma. However, many patients relapse post CAR-T therapy with dismal outcomes. To dissect the underlying mechanisms of sequential resistance to BTKi and CAR-T therapy, we performed single-cell RNA sequencing analysis for 66 samples from 25 patients treated with BTKi and/or CAR-T therapy and conducted in-depth bioinformatics™ analysis. Our analysis revealed that MYC activity progressively increased with sequential resistance. HSP90AB1 (Heat shock protein 90 alpha family class B member 1), a MYC target, was identified as early driver of CAR-T resistance. CDK9 …
Can The Impact Of Gravel Roads On Organic Layer Thickness Explain The Distribution Of Populus Tremuloides Along Road Networks In The Boreal Forest Of Eastern Canada?,
2024
Université du Quebec en Abitibi-Témiscamingue
Can The Impact Of Gravel Roads On Organic Layer Thickness Explain The Distribution Of Populus Tremuloides Along Road Networks In The Boreal Forest Of Eastern Canada?, Mathilde Marchais, Dominique Arseneault, Yves Bergeron
Aspen Bibliography
Roads are known to alter environmental conditions and the composition of road edge plant communities, particularly when exogenous materials are used as road surfacing. In this study, we evaluate the impact of gravel roads on the organic layer thickness (OLT) and aspen distribution in a boreal forest landscape of Eastern Canada. The OLT and aspen distribution were compared at different distances from the roads (0 m, 10 m, and >10 m) to determine whether a reduction in the OLT along the roads could explain the distribution of aspen along the road network, and in particular the role of the roads …
Oystershell Scale (Hemiptera: Diaspididae) Population Growth, Spread, And Phenology On Aspen In Arizona, Usa,
2024
Northern Arizona University
Oystershell Scale (Hemiptera: Diaspididae) Population Growth, Spread, And Phenology On Aspen In Arizona, Usa, Connor D. Crouch, Richard W. Hofstetter, Amanda M. Grady, Nylah N.S. Edwards, Kristen M. Waring
Aspen Bibliography
Oystershell scale (OSS; Lepidosaphes ulmi L.) is an invasive insect that threatens sustainability of aspen (Populus tremuloides Michx.) in the southwestern United States. OSS invasions have created challenges for land managers tasked with maintaining healthy aspen ecosystems for the ecological, economic, and aesthetic benefits they provide. Active management is required to suppress OSS populations and mitigate damage to aspen ecosystems, but before management strategies can be implemented, critical knowledge gaps about OSS biology and ecology must be filled. This study sought to fill these gaps by addressing 3 questions: (i) What is the short-term rate of aspen mortality in …
Educating Primary Care Providers On Use Of Pharmacogenetic Testing In Pain Management,
2024
Walden University
Educating Primary Care Providers On Use Of Pharmacogenetic Testing In Pain Management, Providence Sey
Walden Dissertations and Doctoral Studies
No abstract provided.
Pile Burning After Conifer Removal From Aspen Stands Affects Tree Mortality, Regeneration, And Understory Recovery,
2024
California Polytechnic State University Humboldt
Pile Burning After Conifer Removal From Aspen Stands Affects Tree Mortality, Regeneration, And Understory Recovery, John-Pascal Berrill, Christa M. Dagley, Yoon G. Kim, J. Morgan Varner
Aspen Bibliography
Quaking aspen (Populus tremuloides Michx.) stands throughout the western United States provide valuable ecosystem services but can be lost via succession from aspen to conifer. Forest managers are cutting conifers, but disposal of cut wood can be challenging in remote or sensitive areas. Piling and burning is being tested within aspen stands but ecosystem responses to this treatment are understudied. We assessed aspen tree mortality, tree regeneration, and understory vegetation after forest restoration thinning followed by pile burning in seven aspen-conifer stands around Lake Tahoe, California and Nevada, USA. Pile burning was conducted after cut wood had dried (1.5–7.5 …
Cold-Inducible Rna Binding Protein Impedes Breast Tumor Growth In The Pymt Murine Model For Breast Cancer,
2024
University of New Mexico School of Medicine
Cold-Inducible Rna Binding Protein Impedes Breast Tumor Growth In The Pymt Murine Model For Breast Cancer, Daniel A. Lujan, Joey L. Ochoa, Ellen J. Beswick, Tamara A. Howard, Helen J. Hathaway, Nora I. Perrone-Bizzozero, Rebecca S. Hartley
Markey Cancer Center Faculty Publications
RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by associating with regulatory sequences in the untranslated regions of mRNAs. Cold-inducible RBP (CIRP) is a stress-induced RBP that was recently shown to modulate inflammation in response to cellular stress, where it increases or decreases pro-tumorigenic (proinflammatory) cytokines in different contexts. CIRP expression is altered in several cancers, including breast cancer, but the effects of CIRP on inflammation in breast cancer is not known. Here, we investigate if CIRP alters growth and the inflammatory profile of breast tumors. Transgenic mice overexpressing CIRP in the mammary epithelium were crossed with the PyMT mouse …
Avian Symbionts Of Sulawesi: Identifying And Correlating Malaria Parasites And The Microbiome In Communities Of Endemic Avian Hosts,
2024
CUNY Graduate Center
Avian Symbionts Of Sulawesi: Identifying And Correlating Malaria Parasites And The Microbiome In Communities Of Endemic Avian Hosts, Rachael Joakim
Dissertations, Theses, and Capstone Projects
Since the evolution of complex organisms, there have been communities of symbionts inhabiting them. Thanks to the development of parallel sequencing techniques, DNA of entire microbial communities can be sequenced from a single sample. Some microbes can be parasitic in nature, such as Haemosporida, an order of eukaryotes causing malaria. While most symbionts form a more commensal host relationship in wild systems, host-symbiont dynamics can vary in pathogenicity based on biotic and abiotic factors. In vertebrates, microbial communities in the gut play a major role in host function, including immune responses to Haemosporida. Though this relationship is most commonly explored …
Methamphetamine-Induced Dna Double-Stranded Breaks: The Impact Of The Dopamine Transporter And Insights Into The Mechanisms Of Dna Damage In Mouse Neuro 2a Cells,
2024
CUNY Graduate Center
Methamphetamine-Induced Dna Double-Stranded Breaks: The Impact Of The Dopamine Transporter And Insights Into The Mechanisms Of Dna Damage In Mouse Neuro 2a Cells, Lizette Couto
Dissertations, Theses, and Capstone Projects
Methamphetamine (METH) abuse remains a global health concern, with emerging evidence highlighting its genotoxic potential. In the central nervous system METH enters dopaminergic cells primarily through the dopamine transporter (DAT), which controls the dynamics of dopamine (DA) neurotransmission by driving the reuptake of extracellular DA into the presynaptic neuronal cell. Additional effects of METH on the storage of DA in synaptic vesicles lead to the dysregulated cytosolic accumulation of DA. Previous studies have shown that after METH disrupts intracellular vesicular stores of DA, the excess DA in the cytosol is rapidly oxidized. This generates an abundance of reactive oxygen species …
Surveys Of Aphonopelma Hentzi In Missouri: Conservation Efforts Through Population, Genetics, And Habitat Studies,
2024
University of Missouri-St. Louis
Surveys Of Aphonopelma Hentzi In Missouri: Conservation Efforts Through Population, Genetics, And Habitat Studies, Anderson B. Spencer Mr., Becky Hansis-O'Niell
Undergraduate Research Symposium
Aphonopelma hentzi and other tarantula species are greatly understudied organisms. In the Missouri regions there is little knowledge on their mating patterns, gene diversity, or population sizes. The focal glades in this experiment display regional fragmentation, which could prevent tarantulas from traveling and mating between regions of their glades. Due to the lack of knowledge surrounding them, methods for determining gene diversity are harmful to the organism. Our recent work has shown that it is possible to extract genetic information from the molts of burrowing tarantulas. This will allow us to safely determine the lineages and interbreeding patterns of the …
Recovering Ancient Dna Using The Polymerase Chain Reaction,
2024
University of Missouri, St. Louis
Recovering Ancient Dna Using The Polymerase Chain Reaction, Rose Jennings
Undergraduate Research Symposium
Investigations into aDNA offer a window into the past that modern DNA and paleontological studies alone cannot provide and help address the evolution and connections between hominids, domestication timelines, the analysis of populations over time, and general diversity. Progress in aDNA research has been inherently technology-driven, with modern molecular biology methods, such as the inventions of Polymerase Chain Reaction (PCR) and Next Generation Sequencing (NGS), substantially increasing the analysis possibilities of aDNA. My research this semester has taken me along two parallel paths of investigation: literary research into aDNA and practical exposure to the laboratory techniques used in its analysis. …
Association Between Regulatory T Cells And Ischemic Heart Disease: A Mendelian Randomization Study,
2024
The Texas Medical Center Library
Association Between Regulatory T Cells And Ischemic Heart Disease: A Mendelian Randomization Study, Yucheng Hou, Ke Si, Jingyue Yang, Tan Liu, Basel Abdelazeem, Nonthikorn Theerasuwipakorn, Jingwei Zhao, Zhenya Shen
Faculty, Staff and Student Publications
BACKGROUND: An imbalance of innate and acquired immune responses is significantly involved in the pathophysiology of coronary atherosclerosis and the occurrence of ischemic heart disease (IHD). Regulatory T cells (Tregs) play an essential regulatory role in atherosclerotic plaque formation and maintenance; therefore, dysfunction of Tregs triggers the formation of atherosclerotic plaques and accelerates their progression. However, due to the inherent limitations of observational research, clinical evidence is limited concerning the relationship between the variation in peripheral Tregs and the risk of IHD, and the cause-and-effect relationship between these factors is unclear. Mendelian randomization (MR) uses genetic variation as a proxy …
Exploring The Evolution Of Callose Synthase In Green Plants,
2024
Purdue University
Exploring The Evolution Of Callose Synthase In Green Plants, Giovanna Durante
The Journal of Purdue Undergraduate Research
No abstract provided.
Aspen Recovery In Northern Yellowstone: A Comment On Brice Et Al. (2021),
2024
Oregon State University
Aspen Recovery In Northern Yellowstone: A Comment On Brice Et Al. (2021), Luke E. Painter, Robert L. Beschta, William J. Ripple
Aspen Bibliography
Aspen sapling recruitment increased as browsing by elk decreased, following the 1995–96 reintroduction of wolves in Yellowstone National Park. We address claims by Brice et al. (2021) that previous studies exaggerated recent aspen recovery. We conclude that their results actually supported previous work showing a trophic cascade benefiting aspen.
Single-Cell Multiomics Decodes Regulatory Programs For Mouse Secondary Palate Development,
2024
The Texas Medical Center Library
Single-Cell Multiomics Decodes Regulatory Programs For Mouse Secondary Palate Development, Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M Simon, Junichi Iwata, Zhongming Zhao
Faculty, Staff and Student Publications
Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is among the most common congenital birth defects. Here, we perform single-cell multiome sequencing and profile chromatin accessibility and gene expression simultaneously within the same cells (n = 36,154) isolated from mouse secondary palate across embryonic days (E) 12.5, E13.5, E14.0, and E14.5. We construct five trajectories representing continuous differentiation of cranial neural crest-derived multipotent cells into distinct lineages. By linking open chromatin signals to gene expression changes, we characterize the underlying lineage-determining transcription factors. In silico perturbation analysis identifies transcription factors SHOX2 and MEOX2 as important regulators …
Genomic Features Of Homologous Recombination Deficiency In Breast Cancer: Impact On Testing And Immunotherapy,
2024
Tennessee State University
Genomic Features Of Homologous Recombination Deficiency In Breast Cancer: Impact On Testing And Immunotherapy, Umer Ali, Sunitha Vungarala, Venkataswarup Tiriveedhi
Biology Faculty Research
Genomic instability is one of the well-established hallmarks of cancer. The homologous recombination repair (HRR) pathway plays a critical role in correcting the double-stranded breaks (DSB) due to DNA damage in human cells. Traditionally, the BRCA1/2 genes in the HRR pathway have been tested for their association with breast cancer. However, defects in the HRR pathway (HRD, also termed ‘BRCAness’), which has up to 50 genes, have been shown to be involved in tumorigenesis and treatment susceptibility to poly-ADP ribose polymerase inhibitors (PARPis), platinum-based chemotherapy, and immune checkpoint inhibitors (ICIs). A reliable consensus on HRD scores is yet to be …
Aspen And Spruce Densities Affect Tree Size, Future Stand Volume, And Aboveground Carbon Following Precommercial Thinning,
2024
University of Alberta
Aspen And Spruce Densities Affect Tree Size, Future Stand Volume, And Aboveground Carbon Following Precommercial Thinning, Philip G. Comeau, Mike Bokalo
Aspen Bibliography
Data collected over a 30-year period from an experiment replicated across 21 locations in western Canada are used to explore the effects of precommercial thinning of trembling aspen to a range of densities in combination with three initial white spruce densities on tree growth and stand dynamics. Increasing differentiation amongst the 15 treatments was observed with age after thinning for both spruce and aspen responses. Spruce height and diameter declined with increasing aspen density. At age 10 spruce diameter with no aspen was 1.5× that of spruce in unthinned while it was 2.6× that of spruce in unthinned at age …
Tracing The Maternal Line In Glacial-Interglacial Migrations Of Populus Tremuloides: Finding Trees For Future Sustainable Forests By Searching In The Past,
2024
Colorado State University
Tracing The Maternal Line In Glacial-Interglacial Migrations Of Populus Tremuloides: Finding Trees For Future Sustainable Forests By Searching In The Past, Luke R. Tembrock, Frida A. Zink, Guozhe Zhang, Andrea Schuhmann, Cuihua Gu, Zhiqiang Wu
Aspen Bibliography
Maintaining and planting sustainable forests is fundamental in perpetuating the essential functions of these ecosystems. A central aspect of managing forests for future resilience is the consideration of past migration and evolution of trees using genetic and genomic data to ensure that functionally appropriate diversity is conserved and utilized. In our study, we generated and compared genetic and genomic data from the plastome to better understand phylogeography and molecular evolution in the tree species Populus tremuloides (aspen). With these analyses, we found evidence of divergence and migration between northern and southern sites. Additionally, evidence of deep incomplete plastome sorting across …
Parental Environnement Influences Offspring Gene Expression In The Olympia Oyster, Ostrea Lurida.,
2024
Louisiana State University and Agricultural and Mechanical College
Parental Environnement Influences Offspring Gene Expression In The Olympia Oyster, Ostrea Lurida., Mark S. Yeats
LSU Master's Theses
The Olympia Oyster is the only native oyster species on the Pacific coast of North America. Seasonality in water temperatures across this threatened species’ broad and fragmented range has been linked to its development, reproductive timing, reproductive activity, growth, and survival rates. Recent evidence suggests parental environments can have carry-over effects on larval growth and respiration rates in response to temperature. In this study, we utilized transcriptomic methods to identify the underlying mechanisms of this cross-generation plasticity. Sequence libraries of adult ctenidia tissue and pooled larval replicates were extracted and spawned from hatchery raised oysters of the same parentage immediately …
Multivalent Epigraph Hemagglutinin Vaccine Protects Against
Influenza B Virus In Mice,
2024
University of Nebraska-Lincoln
Multivalent Epigraph Hemagglutinin Vaccine Protects Against Influenza B Virus In Mice, Erika M. Petro-Turnquist, Brigette Corder Kampfe, Amber Gadeken, Matthew J. Pekarek, Eric A. Weaver
Nebraska Center for Virology: Faculty Publications
Influenza B virus is a respiratory pathogen that contributes to seasonal epidemics, accounts for approximately 25% of global influenza infections, and can induce severe disease in young children. While vaccination is the most commonly used method of preventing influenza infections, current vaccines only induce strain-specific responses and have suboptimal efficacy when mismatched from circulating strains. Further, two influenza B virus lineages have been described, B/Yamagatalike and B/Victoria-like, and the limited cross-reactivity between the two lineages provides an additional barrier in developing a universal influenza B virus vaccine. Here, we report a novel multivalent vaccine using computationally designed Epigraph hemagglutinin proteins …
Fusionnw, A Potential Clinical Impact Assessment Of Kinases In Pan-Cancer Fusion Gene Network,
2024
The Texas Medical Center Library
Fusionnw, A Potential Clinical Impact Assessment Of Kinases In Pan-Cancer Fusion Gene Network, Chengyuan Yang, Himansu Kumar, Pora Kim
Faculty, Staff and Student Publications
Kinase fusion genes are the most active fusion gene group in human cancer fusion genes. To help choose the clinically significant kinase so that the cancer patients that have fusion genes can be better diagnosed, we need a metric to infer the assessment of kinases in pan-cancer fusion genes rather than relying on the sample frequency expressed fusion genes. Most of all, multiple studies assessed human kinases as the drug targets using multiple types of genomic and clinical information, but none used the kinase fusion genes in their study. The assessment studies of kinase without kinase fusion gene events can …
