Dendrimer Gel Nanoparticles With Dual-Targeting Of Upar And Ribonucleotide Reductase R2 Influence Necrosis, Apoptosis, And Cell Cycle Arrest In Triple-Negative Breast Cancer,
2025
Missouri University of Science and Technology
Dendrimer Gel Nanoparticles With Dual-Targeting Of Upar And Ribonucleotide Reductase R2 Influence Necrosis, Apoptosis, And Cell Cycle Arrest In Triple-Negative Breast Cancer, Hsin Yin Chuang, Yue-Wern Huang, Hu Yang
Biological Sciences Faculty Research & Creative Works
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited treatment options due to the absence of estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) receptors. We previously developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles (GDP-uPA/GTI) with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2) to achieve selective antitumor effects. In this study, we investigated the underlying mechanisms of GDP-uPA/GTI-induced tumor inhibition. In vivo, GDP-uPA/GTI significantly downregulated R2 expression and activated caspase 8 and caspase 3, indicating caspase-dependent apoptosis. Histological evaluation of major organs revealed no observable toxicity. …
Dna Extrusion Size Determines Pathway Choice During Cag Repeat Expansion,
2025
Thomas Jefferson University
Dna Extrusion Size Determines Pathway Choice During Cag Repeat Expansion, Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R. Monte Carloi Iii, Sarah Barndt, Anna Pluciennik
Department of Biochemistry and Molecular Biology Faculty Papers
DNA triplet repeat expansion causes several primarly neurological disorders like Huntington's disease, myotonic dystrophy type 1, and fragile-X related disorders. There is general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the DNA mismatch repair protein MutSβ leads to repeat expansion by a mutagenic process. By contrast, the FAN1 nuclease attenuates triplet repeat expansion, the molecular basis of which was explained by our recent finding that FAN1 nuclease cleaves and initiates removal of extrahelical extrusions. Here we show that extrusions containing two or more triplet repeats are subject to recognition and processing by either …
Synthesis Of Disulfide Triazole Phosphorus Fire Retardant Via Photochemical Conditions,
2025
University of Nevada, Las Vegas
Synthesis Of Disulfide Triazole Phosphorus Fire Retardant Via Photochemical Conditions, Jason Liu
Undergraduate Research Symposium Lightning Talks
The development of fire retardants is critical to enhancing fire safety and advancing fire science. The novel synthesis of a disulfide triazole phosphorus thiolacid fire retardant under photochemical conditions, along with relevant testing on plume generation performance, aims to answer our research goals.The proposed specific synthesis and conditions provide for a more efficient and environmentally greener route compared to conventional methods, utilizing photochemical click reactions. Furthermore, the addition of sulfur element to conventionally sole phosphorus-based FR reduces the chance of leaching by increasing the molecular weight of the compound and overcoming the obstacle of low molecular weight problems while also …
Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum,
2025
Thomas Jefferson University
Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang
Department of Biochemistry and Molecular Biology Faculty Papers
Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …
A Bioarchaeological Study Of The Individuals From The Városfalva Burial Mound In Transylvania, Romania (15th-19th Century),
2025
University of South Florida
A Bioarchaeological Study Of The Individuals From The Városfalva Burial Mound In Transylvania, Romania (15th-19th Century), Vanessa C. Reeves
USF Tampa Graduate Theses and Dissertations
This study explores the lives and deaths of the Szekler people recovered from a burial mound in the Transylvanian village of Városfalva. The Transylvanian plateau is located in present day Romania, and is protected on the east and the south by the Carpathian Mountains. The Szekler people arrived in this area around 1000 CE, and were a nomadic group originating in the Asian Steppes region who later intermarried with various migratory groups as they moved across the Eurasian plains. The Szeklers eventually banded together with the proto-Hungarian Magyar peoples and settled in the Carpathian Basin, the easternmost frontier of the …
Chronosort: Revealing Hidden Dynamics In Alphafold3 Structure Predictions,
2025
Brigham Young University - Provo
Chronosort: Revealing Hidden Dynamics In Alphafold3 Structure Predictions, Matthew J. Argyle, William P. Heaps, Corbyn Kubalek, Spencer Gardiner, Bradley C. Bundy, Dennis Della Corte
Faculty Publications
Protein function emerges from dynamic conformational changes, yet structure prediction methods provide only static snapshots. While AlphaFold3 (AF3) predicts protein structures, the potential for extracting dynamic information from its ensemble predictions has remained underexplored. Here, we demonstrate that AF3 structural ensembles contain substantial dynamic information that correlates remarkably well with molecular dynamics simulations (MD). We developed ChronoSort, a novel algorithm that organizes static structure predictions into temporally coherent trajectories by minimizing structural differences between neighboring frames. Through systematic analysis of four diverse protein targets, we show that root-mean-square fluctuations derived from AF3 ensembles can correlate strongly with those from MD …
Data-Driven Modeling Of Dynamics And Adaptation In Mapk Pathway,
2025
George Mason University
Data-Driven Modeling Of Dynamics And Adaptation In Mapk Pathway, Elisha Erzoah, Maria Emelianenko, Mariaelena Pierobon
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
[Kadel] A Multilevel Extension Of Boolean Networks Captures Topologically-Stable Hybrid Attractors,
2025
Northeastern University
[Kadel] A Multilevel Extension Of Boolean Networks Captures Topologically-Stable Hybrid Attractors, Kishore Hari
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Parameterizing Ion–Lipid Interactions From Local Clusters To Reproduce Experimental Bulk Properties Of Lipid Bilayers,
2025
University of South Florida
Parameterizing Ion–Lipid Interactions From Local Clusters To Reproduce Experimental Bulk Properties Of Lipid Bilayers, W. Matthew Saunders
USF Tampa Graduate Theses and Dissertations
Phospholipids are the main component of cell membranes, providing a delimiting boundary for cells from their environments or from their organelles from the cytosol. Thiscompartmentalization allows cells to maintain quite different solutions within their cells and organelles, including different mixtures dissolved ions. Consequently, these membranes are constantly flanked by complex mixtures of salts at varied concentrations. To study membrane structure, one cannot neglect the contribution of the salts in the local solution. Ions perturb bilayer structure via specific interaction with the phospholipids, primarily with the headgroups. Experimental studies of these systems are somewhat at odds — scattering experiments with different …
Improving Coral Restoration Outcomes Through Novel Molecular Applications,
2025
University of South Florida
Improving Coral Restoration Outcomes Through Novel Molecular Applications, Matthew H. Gamache
USF Tampa Graduate Theses and Dissertations
Coral reef ecosystems are declining globally from numerous stressors, including localized pollution, disease, and marine heatwaves induced by climate change. To preserve these ecosystems, it is critical to identify corals that can withstand stressors—primarily future marine heatwaves—and prioritize them for coral restoration efforts until these stressors are mitigated. Coral responses to thermal stress can be influenced by several partners, including mutualistic microalgae and a vast prokaryotic community. Here, I use advanced molecular techniques to examine which partners (coral host, algal symbiont, and microbial communities) are associated with coral health, how they contribute to holobiont physiology, and their potential to increase …
Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions,
2025
University of South Carolina
Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions, Natalie E. Strom, Courtney J. Weber, Olja Simoska
Faculty Publications
With the rising prevalence of metabolic diseases, infections, and mental health disorders, there is a growing demand for noninvasive diagnostic tools that enable early detection and continuous health monitoring. In this context, exhaled breath biomarkers provide insight into physiological and pathological processes. Electrochemical breath sensors (EBSs) have emerged as a promising platform for rapid, real-time, and cost-effective disease tracking via the detection of volatile breath biomarkers, such as NH3, NO, and CO2. Recent advancements in electrode materials, biological recognition elements, and sensor architectures—spanning nanomaterials, enzymes, aptamers, and molecularly imprinted polymers—have enhanced the analytical performance of EBSs. …
Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions,
2025
University of South Carolina
Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions, Natalie E. Strom, Courtney J. Weber, Olja Simoska
Faculty Publications
With the rising prevalence of metabolic diseases, infections, and mental health disorders, there is a growing demand for noninvasive diagnostic tools that enable early detection and continuous health monitoring. In this context, exhaled breath biomarkers provide insight into physiological and pathological processes. Electrochemical breath sensors (EBSs) have emerged as a promising platform for rapid, real-time, and cost-effective disease tracking via the detection of volatile breath biomarkers, such as NH3, NO, and CO2. Recent advancements in electrode materials, biological recognition elements, and sensor architectures—spanning nanomaterials, enzymes, aptamers, and molecularly imprinted polymers—have enhanced the analytical performance of EBSs. …
Losing Focus In The Age Of Tik Tok: Clinical Evidence For Policy Action On Social Media Use,
2025
Dún Laoghaire Institute of Art, Design and Technology
Losing Focus In The Age Of Tik Tok: Clinical Evidence For Policy Action On Social Media Use, Megan Conefrey, Robert Griffin
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Tracking Livestock Heart Rate & Location Using Long-Range Radio Networks. An Immediate Solution For Farms Without Reliable Wi-Fi,
2025
Atlantic Technological University
Tracking Livestock Heart Rate & Location Using Long-Range Radio Networks. An Immediate Solution For Farms Without Reliable Wi-Fi, Dermott Harkin, Martin Bradley
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Voices Matter: Tackling Accentism In Ireland. A Study Addressing Accent-Based Discrimination Awareness In Education,
2025
University of Limerick
Voices Matter: Tackling Accentism In Ireland. A Study Addressing Accent-Based Discrimination Awareness In Education, Sadhbh Reddington, Victoria Graham, Holly Jordan, Mairead Moriarty
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Supporting Single Parents: How Loneliness And Self-Stigma Can Impact Single Parents And Their Quality Of Life,
2025
National College of Ireland
Supporting Single Parents: How Loneliness And Self-Stigma Can Impact Single Parents And Their Quality Of Life, Alana Powell, David Mothersill
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Income Inequality And Attitudes Towards Immigrants – How Increased Inequality Drives Division,
2025
University of Limerick
Income Inequality And Attitudes Towards Immigrants – How Increased Inequality Drives Division, Niamh Anderson, Vincent O'Sullivan
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Ireland Blossoms Through Multiculturalism - Designing For Community Connection,
2025
Dún Laoghaire Institute of Art, Design and Technology
Ireland Blossoms Through Multiculturalism - Designing For Community Connection, Julia Kuczera, Shirley Casey, Hilary Kenna
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Unheard And Underserved: Exploring Support For Male Victims Of Partner Abuse,
2025
Dundalk Institute of Technology
Unheard And Underserved: Exploring Support For Male Victims Of Partner Abuse, Michael Keenan, Colletta Dalikeni
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Assessing Demand And Simulating Feasibility For Commuter Rail In Lagging Regional Areas. Case Study: Sligo,
2025
Atlantic Technological University
Assessing Demand And Simulating Feasibility For Commuter Rail In Lagging Regional Areas. Case Study: Sligo, Holly Briere-Edney, Brian Mccann
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
