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Articles 811 - 840 of 1810
Full-Text Articles in Gerontology
Age-Friendly Yarmouth Needs Assessment Report, Jan Mutchler, Ceara Somerville, Maryam Khaniyan, Molly Evans, Mai See Yang, Lindsey A. Baker, Hayley Gleason
Age-Friendly Yarmouth Needs Assessment Report, Jan Mutchler, Ceara Somerville, Maryam Khaniyan, Molly Evans, Mai See Yang, Lindsey A. Baker, Hayley Gleason
Center for Social and Demographic Research on Aging Publications
Communities throughout the nation are pursuing new strategies to promote health and quality of life among their residents. In 2014, the Town of Yarmouth joined the Age-Friendly Network through the World Health Organization and embarked on a five-year process to evaluate the community’s age-friendly features, plan for improvements, and implement change. The primary purpose of this report is to describe findings developed as part of the initial needs assessment phase of Yarmouth’s age-friendly initiative.
The Things They Carried: The Biological Residue Of Childhood Misfortune, Patricia M. Morton
The Things They Carried: The Biological Residue Of Childhood Misfortune, Patricia M. Morton
Open Access Dissertations
There is a well-established relationship between childhood misfortune and adult health, but how these early-life experiences “get under the skin” to later manifest as poor health is less clear. To elucidate this process, this dissertation investigates (1) how childhood conditions influence immune functioning and (2) whether these physiological consequences of early misfortune lead to poor health, indicated by ischemic heart disease (IHD) onset. Guided by cumulative inequality theory and biological embedding, this dissertation also examines adult health lifestyles and socioeconomic status (SES) as possible mechanisms linking childhood misfortune to inflammation and IHD in later life. Data come from six waves …
The Role Of Workplace Supervisor Support In Cargivers' Marital Relationships, Kenona H. Southwell
The Role Of Workplace Supervisor Support In Cargivers' Marital Relationships, Kenona H. Southwell
Open Access Dissertations
Family caregivers make important contributions to care recipients and the economy. However, providing care for ill or disabled family members can be challenging, particularly when the role of caregiver is accompanied by additional roles such as employee, spouse, and parent ( Hammer & Neal, 2008). There is some evidence that the demands of caregiving may negatively influence the quality of caregivers’ marriages (Bookwala, 2009). Much of caregiving research, however, is focused on the influence of caregiving and multiple caregiving roles on caregivers’ health (see Pinquart & Sörensen, 2011), but less attention has been paid to other aspects of caregivers’ lives …
Neural Activity Reveals Effects Of Aging On Inhibitory Processes During Word Retrieval, Ranjini Mohan
Neural Activity Reveals Effects Of Aging On Inhibitory Processes During Word Retrieval, Ranjini Mohan
Open Access Dissertations
Word retrieval difficulties are one of the most frustrating problems in older adults. Poorer access to phonological (speech sound) representation of the target word has been postulated as the underlying deficit, supported by findings of improvement in word retrieval after phonological priming. But the great variability in naming performance among older adults may reflect cognitive scaffolding or compensatory neurophysiological processes related to maintenance or decline of naming abilities. In order better understand aging effects in the underlying neurophysiological changes associated with phonological retrieval, the present study examined electrophysiological correlates of phonological priming and word retrieval in adults across the lifespan. …
Inégalités En Santé Chez Les Adultes Plus Vieux Dans Les Pays Développés: Réconcilier Théories Et Approches Politiques, Amélie Quesnel-Vallée, Andrea Willson, Sandra Reiter-Campeau
Inégalités En Santé Chez Les Adultes Plus Vieux Dans Les Pays Développés: Réconcilier Théories Et Approches Politiques, Amélie Quesnel-Vallée, Andrea Willson, Sandra Reiter-Campeau
Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail
Les politiques dont le but est de soutenir les personnes âgées creusent peut-être les inégalités. Des régimes de pensions de plus en plus privatisées et un manque de services de soutien subventionnés profitent de façon disproportionnée à ceux qui ont les moyens sociaux et économiques les plus forts à l’âge avancé. Les gens favorisés sont en meilleure santé que ceux qui sont désavantagés. Le Canada a l’occasion d’éviter un impact si biaisé des programmes pour les aînés, en puisant dans les approches créées par l’Organisation mondiale de la santé, des exemples internationaux et dans la théorie et la recherche sociologique. …
Research Brief: "Aging Well Among Women Veterans Compared With Non-Veterans In The Women’S Health Initiative", Institute For Veterans And Military Families At Syracuse University
Research Brief: "Aging Well Among Women Veterans Compared With Non-Veterans In The Women’S Health Initiative", Institute For Veterans And Military Families At Syracuse University
Institute for Veterans and Military Families
This study analyzes a veteran status' effects on aging among women 80 years and older. For policy and practice, this research clearly states that mental health and healthy behaviors are important for aging women, and that the VA should continue research on health needs of aging female veterans. Suggestions for future research include studies to better understand special health risks among older female veterans, how self-resiliency among female veterans affects their health as they age, and how educational attainment relates to older female veterans' health.
Socioeconomic Segregation And The Location Of Assisted Living Facilities In Wa State, Miranda M. Anderson
Socioeconomic Segregation And The Location Of Assisted Living Facilities In Wa State, Miranda M. Anderson
Symposium Of University Research and Creative Expression (SOURCE)
This research project looks at the relationships between segregation by socio-economic status, race & ethnicity, and the location of assisted living facilities in the state of Washington. We know that segregation affects a variety of living conditions and life chances and outcomes, such as employment, housing, and school success rates. We lack research, however, on the effects of segregation on the location of assisted living facilities. Are assisted living homes being located in heavily segregated neighborhoods? Assisted living homes are not subject to the standard regulations that a nursing home is, and often the residents of these homes are not …
The Future Of Aging In The Town Of Chatham: Chatham Council On Aging Needs Assessment Study, Jan E. Mutchler, Ceara Somerville, Maryam Khaniyan, Molly Evans
The Future Of Aging In The Town Of Chatham: Chatham Council On Aging Needs Assessment Study, Jan E. Mutchler, Ceara Somerville, Maryam Khaniyan, Molly Evans
Center for Social and Demographic Research on Aging Publications
This report describes efforts undertaken by the Town of Chatham Council on Aging (COA), in partnership with the Center for Social and Demographic Research on Aging within the Gerontology Institute at the University of Massachusetts Boston, to investigate the needs, interests, preferences, and opinions of Chatham’s older population. The focus of this report is on two cohorts of Chatham’s residents—those aged 50 to 59, and those individuals who are currently aged 60 and over. The content of this report is intended to inform the Town of Chatham, the Chatham Council on Aging, and organizations that provide services to older residents, …
Understanding The Communicative Processes Of Baby Boomer Women Adjusting To Retirement: Connecting Micro And Macro Discourses, Patricia E. Gettings
Understanding The Communicative Processes Of Baby Boomer Women Adjusting To Retirement: Connecting Micro And Macro Discourses, Patricia E. Gettings
Open Access Dissertations
Baby Boomers are changing the face of retirement in the United States. For example, retirement traditionally refers to the time when an individual who has worked full-time for the majority of her life chooses to entirely and permanently exit the workforce, but now includes a range of formations (e.g., bridge employment). Baby Boomer women are most affected by this “new” retirement because they have worked a broader range of jobs for longer periods of time than ever before. Transitioning to retirement implicates processes of adjusting beyond just a change in one’s employment status as retirees potentially confront instrumental (e.g., where …
Fear Conditioning And Extinction In Youth With Obsessive-Compulsive Disorder, Joseph F. Mcguire, Scott P. Orr, Monica S. Wu, Adam B. Lewin, Brent J. Small, Vicky Phares, Tanya K. Murphy, Sabine Wilhelm, Daniel S. Pine, Daniel Geller, Eric A. Storch
Fear Conditioning And Extinction In Youth With Obsessive-Compulsive Disorder, Joseph F. Mcguire, Scott P. Orr, Monica S. Wu, Adam B. Lewin, Brent J. Small, Vicky Phares, Tanya K. Murphy, Sabine Wilhelm, Daniel S. Pine, Daniel Geller, Eric A. Storch
Psychology Faculty Publications
BACKGROUND: Fear acquisition and extinction are central constructs in the cognitive-behavioral model of obsessive-compulsive disorder (OCD), which underlies exposure-based cognitive-behavioral therapy (CBT). Youth with OCD may have impairments in fear acquisition and extinction that carry treatment implications. We examined these processes using a differential conditioning procedure.
METHODS: Forty-one youth (19 OCD, 22 community comparisons) completed a battery of clinical interviews, rating scales, and a differential conditioning task that included habituation, acquisition, and extinction phases. Skin conductance response (SCR) served as the primary dependent measure.
RESULTS: During habituation, no difference between groups was observed. During acquisition, differential fear conditioning was observed …
Differential Health And Social Needs Of Older Adults Waitlisted For Public Housing Or Housing Choice Vouchers, Paula C. Carder, Gretchen Luhr, Jacklyn Nicole Kohon
Differential Health And Social Needs Of Older Adults Waitlisted For Public Housing Or Housing Choice Vouchers, Paula C. Carder, Gretchen Luhr, Jacklyn Nicole Kohon
Institute on Aging Publications
Affordable housing is an important form of income security for low-income older persons. This article describes characteristics of older persons waitlisted for either public housing or a housing choice voucher (HCV) (previously Section 8) in Portland, Oregon. 358 persons (32% response rate) completed a mailed survey with questions about demographics, health and housing status, food insecurity, and preference for housing with services. Findings indicate that many waitlisted older persons experienced homelessness or housing instability, poor health, high hospital use, and food insecurity. Public housing applicants were significantly more likely to report lower incomes, homelessness, and food insecurity than HCV applicants. …
Caring For Thai Older Persons With Long-Term Care Needs, John Knodel, Bussarawan Teerawichitchainan, Wiraporn Pothisiri
Caring For Thai Older Persons With Long-Term Care Needs, John Knodel, Bussarawan Teerawichitchainan, Wiraporn Pothisiri
Research Collection School of Social Sciences
Thailand is experiencing more acute population aging than most developing Asian countries. Its population aged 60 and older is anticipated to grow from 10% in 2000 to 38% by 2050. Meanwhile, the oldest-old population that is most likely to require long-term care (LTC) is estimated to increase tenfold during the first half of the 21st century. Family has remained a linchpin of support for Thai elders with LTC needs. Given population aging and other demographic trends such as smaller family size, migration of adult children, and lengthening survival at older ages, policy makers are concerned how such socio-demographic changes may …
Long-Term Care Needs In The Context Of Poverty And Population Aging: The Case Of Older Persons In Myanmar, Bussarawan Puk Teerawichitchainan, John Knodel
Long-Term Care Needs In The Context Of Poverty And Population Aging: The Case Of Older Persons In Myanmar, Bussarawan Puk Teerawichitchainan, John Knodel
Research Collection School of Social Sciences
Myanmar is one of the poorest and least healthy countries in Southeast Asia. Nevertheless, population aging is taking place. Myanmar's policy makers have only begun to pay attention to the implications of population aging for its economy and society, including the health system. There is virtually no official policy or program in place to provide long-term care (LTC) for older persons. Family has thus been the mainstay of financial and instrumental support for elderly with LTC needs. Myanmar's demographic transitions likely challenge the current form of family caregiving for frail older persons, especially in the coming decades. This study aims …
Value-Inspired Service Design In Elderly Home-Monitoring Systems, Na Liu, Sandeep Purao, Hwee-Pink Tan
Value-Inspired Service Design In Elderly Home-Monitoring Systems, Na Liu, Sandeep Purao, Hwee-Pink Tan
Research Collection School Of Computing and Information Systems
The provision of elderly home-monitoring systems to enhance aging-in-place requires the service to meet the needs of both the elderly and their caregivers. The design of such IT services requires interdisciplinary efforts to look beyond the technical requirements. Taking a value-inspired design perspective, the study argues that service design for promoting aging-in-place needs to reconcile the values of both the elderly and caregivers. Drawn from the framework of basic human values and the unique experience of the SHINESeniors project, the study extracts the core values for elderly and caregivers using a multi-method case analysis. We suggest that both system and …
Alzheimer's Biomarkers Are Correlated With Brain Connectivity In Older Adults Differentially During Resting And Task States, Yang Jiang, Haiqing Huang, Erin Abner, Lucas S. Broster, Gregory A. Jicha, Frederick A. Schmitt, Richard Kryscio, Anders H. Andersen, David Powell, Linda J. Van Eldik, Brian T. Gold, Peter T. Nelson, Charles D. Smith, Mingzhou Ding
Alzheimer's Biomarkers Are Correlated With Brain Connectivity In Older Adults Differentially During Resting And Task States, Yang Jiang, Haiqing Huang, Erin Abner, Lucas S. Broster, Gregory A. Jicha, Frederick A. Schmitt, Richard Kryscio, Anders H. Andersen, David Powell, Linda J. Van Eldik, Brian T. Gold, Peter T. Nelson, Charles D. Smith, Mingzhou Ding
Behavioral Science Faculty Publications
β-amyloid (Aβ) plaques and tau-related neurodegeneration are pathologic hallmarks of Alzheimer’s disease (AD). The utility of AD biomarkers, including those measured in cerebrospinal fluid (CSF), in predicting future AD risk and cognitive decline is still being refined. Here, we explored potential relationships between functional connectivity (FC) patterns within the default-mode network (DMN), age, CSF biomarkers (Aβ42 and pTau181), and cognitive status in older adults. Multiple measures of FC were explored, including a novel time series-based measure [total interdependence (TI)]. In our sample of 27 cognitively normal older adults, no significant associations were found between levels of Aβ …
The Case For Age-Friendly Communities, Margaret Neal, Alan Kenneth Delatorre
The Case For Age-Friendly Communities, Margaret Neal, Alan Kenneth Delatorre
Institute on Aging Publications
The report was funded by Grantmakers In Aging, an organization dedicated to promoting and strengthening grantmaking for an aging society. The movement toward age-friendly communities is growing, with the key impetus being population aging. Beyond what individuals themselves can do to age optimally, the movement to create communities that are age friendly focuses on how the economic, physical, and social environments can be improved to address not only the needs but also maximize the assets of an aging population, for the benefit of all.
Jockey Club Age-Friendly City Project : Action Plan : Islands, Asia-Pacific Institute Of Ageing Studies, Lingnan University
Jockey Club Age-Friendly City Project : Action Plan : Islands, Asia-Pacific Institute Of Ageing Studies, Lingnan University
Jockey Club Age-Friendly City Project - Reports
In response to the global ageing population, the World Health Organization (the “WHO”) devised the concept of “Global Age-friendly Cities” in 2005 to encourage cities all around the world to develop a healthy and comfortable living environment with age-friendly facilities and provide sufficient community support and health care services which benefit the older people, family and society. In order to proactively tackle the challenges of an ageing population and promote the concept of an age-friendly city, the Hong Kong Jockey Club Charities Trust launched the Jockey Club Age-friendly City Project (“Project”) in 2015 in partnership with four gerontology research institutes …
Jockey Club Age-Friendly City Project : Baseline Assessment Report : Islands, Asia-Pacific Institute Of Ageing Studies, Lingnan University
Jockey Club Age-Friendly City Project : Baseline Assessment Report : Islands, Asia-Pacific Institute Of Ageing Studies, Lingnan University
Jockey Club Age-Friendly City Project - Reports
The aim of this baseline assessment was to evaluate the current state of age-friendliness and make a list of recommendations for the future development of Islands District (the District) through adopting a bottom up and district-based approach. The baseline assessment provided opportunities for the elderly to voice their opinions and served as an appropriate strategy to meet their needs. Additionally, stakeholders from diverse groups can work together to build and maintain an age-friendly community.
Jockey Club Age-Friendly City Project : Baseline Assessment Report : Tsuen Wan, Asia-Pacific Institute Of Ageing Studies, Lingnan University
Jockey Club Age-Friendly City Project : Baseline Assessment Report : Tsuen Wan, Asia-Pacific Institute Of Ageing Studies, Lingnan University
Jockey Club Age-Friendly City Project - Reports
The aim of this baseline assessment was to evaluate the current state of age-friendliness and make a list of recommendations for the future development of Tsuen Wan District (the District) through adopting a bottom up and district-based approach. The baseline assessment provided opportunities for the elderly to voice their opinions and served as an appropriate strategy to meet their needs. Additionally, stakeholders from diverse groups can work together to build and maintain an age-friendly community.
Training For Research And Teaching In Geropsychology: Preparing The Next Generation Of Scholars And Educators, Brian D. Carpenter, Erin Sakai, Michele J. Karel, Victor A. Molinari
Training For Research And Teaching In Geropsychology: Preparing The Next Generation Of Scholars And Educators, Brian D. Carpenter, Erin Sakai, Michele J. Karel, Victor A. Molinari
Aging Studies Faculty Publications
For geropsychology to flourish in the years ahead, we need scientists to advance knowledge and teachers to draw new professionals into the field. In this project the authors surveyed 100 geropsychologists who completed a doctoral degree in clinical or counseling psychology about their experience with training for research and teaching. The majority were currently conducting some degree of research (38%) and some form of teaching (45%). The majority of ratings for components of research training were in the “very good to excellent” range, whereas elements of teacher training were rated in the “poor to good” range, though there was variability …
Factors Associated With Unmet Needs Among African-American Dementia Care Providers, P. J. Desin, Allison M. Caban-Holt, Erin L. Abner, Linda J. Van Eldik, Frederick A. Schmitt
Factors Associated With Unmet Needs Among African-American Dementia Care Providers, P. J. Desin, Allison M. Caban-Holt, Erin L. Abner, Linda J. Van Eldik, Frederick A. Schmitt
Sanders-Brown Center on Aging Faculty Publications
Racial and ethnic minorities currently comprise 20% of the U.S. population; in 2050, this figure is expected to rise to 42%. As a result, Alzheimer’s disease (AD), the 5th leading cause of death for people aged 65 and older, is likely to increase in these groups. Most dementia caregiving for these populations comes from family and friends, especially among families with lower socioeconomic status. A convenience sample of 30 African-American dementia caregivers was interviewed to determine unmet needs. Participants expressed a limited desire for formal services, such as support groups, legal advice, case management, and homemaker services. Instead, commonly expressed …
Incremental Validity Of Useful Field Of View Subtests For The Prediction Of Instrumental Activities Of Daily Living, Frederik Aust, Jerri D. Edwards
Incremental Validity Of Useful Field Of View Subtests For The Prediction Of Instrumental Activities Of Daily Living, Frederik Aust, Jerri D. Edwards
Aging Studies Faculty Publications
Introduction: The Useful Field of View Test (UFOV®) is a cognitive measure that predicts older adults’ ability to perform a range of everyday activities. However, little is known about the individual contribution of each subtest to these predictions, and the underlying constructs of UFOV performance remain a topic of debate.
Method: We investigated the incremental validity of UFOV subtests for the prediction of Instrumental Activities of Daily Living (IADL) performance in two independent datasets, the SKILL (n = 828) and ACTIVE (n = 2426) studies. We then explored the cognitive and visual abilities assessed by UFOV …
Bullying In Senior Living Facilities: A Qualitative Study, Felicia Jo Vandenest
Bullying In Senior Living Facilities: A Qualitative Study, Felicia Jo Vandenest
All Graduate Theses, Dissertations, and Other Capstone Projects
Resident-to resident bullying has attracted some attention in the popular press and is well-known to many who work with seniors in long-term care facilities. However, this is very little empirical literature that has address the topic of "senior bullying". The aim of the proposed qualitative study is to better understand the phenomenon of resident-to-resident bullying from the perspective of staff who work in long-term care facilities. Staff members (n=45) responded to a combination of open- and close-ended interview questions regarding their observations of senior-to-senior bullying. Results indicate that the majority of staff members (98%) have observed resident-to-resident bullying within senior …
Chronic Pancreatitis, Pain, And Anxiety In An Alcohol And High Fat Mouse Model, Tiffanie Clinkinbeard
Chronic Pancreatitis, Pain, And Anxiety In An Alcohol And High Fat Mouse Model, Tiffanie Clinkinbeard
Theses and Dissertations--Gerontology
Homeodynamic space (HDS) shrinks as vulnerability increases with aging and repeated damage to the cells. HDS is lost in alcoholic pancreatitis patients due to overconsumption of alcohol, smoking, and high fat diets. Etiologically relevant animal models for study of chronic pancreatitis (CP) are needed. In order to begin filling this gap a central purpose of this dissertation research was to examine relationships between the alcohol and high fat diet (AHF) and pancreatitis with attention to hypersensitivity and anxiety-like behaviors. The AHF diet induced pancreatitis described here etiologically mimics human risk factors of AHF consumption for advancement to alcoholic CP.
In …
A Qualitative Pilot Study Of Aging Women’S Physical Activity Experiences In One University Fitness And Wellness Center, Alexis Hobbs
A Qualitative Pilot Study Of Aging Women’S Physical Activity Experiences In One University Fitness And Wellness Center, Alexis Hobbs
Online Theses and Dissertations
Physical inactivity is one of the driving risk factors for developing health problems such as obesity, diabetes, and cardiovascular diseases (World Health Organization, 2003). The prevalence of these diseases increases with the aging process, which renders participation in physical activity crucial among the aging population. There is strong evidence that physical activity reduces the risk of these health disparities and disabilities (Young & Dinan, 2005), however despite these well-documented benefits, aging women still remain sedentary. This study examined the phenomenon of women 55 years of age or older and their lived experiences of participating in physical activity within a university …
The Influence Of Time On Food Intake Patterns: Age, Period, Cohort Differences, Karina L. Christopher
The Influence Of Time On Food Intake Patterns: Age, Period, Cohort Differences, Karina L. Christopher
Theses and Dissertations--Gerontology
The impact of diet and exercise on overall health and chronic disease risk has been well examined. Multiple studies show that Americans eat more now than they did fifty years ago. What isn’t known is how much of an impact time has on food intake patterns of individuals in terms of different age groups, historic periods of structural influences, and birth cohorts.
In order to identify the impact of time on food intake this study examined time from multiple perspectives. The first aim of this study was to determine food intake patterns among age groups across five time periods using …
Comt And Oprm1 Genotype Associations With Daily Knee Pain Variability And Activity Induced Pain, Lynn M. Martire, Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, Martin J. Sliwinski
Comt And Oprm1 Genotype Associations With Daily Knee Pain Variability And Activity Induced Pain, Lynn M. Martire, Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, Martin J. Sliwinski
Aging Studies Faculty Publications
Background: Osteoarthritis (OA) of the knee is a common and increasingly prevalent condition that is one of the primary causes of chronic pain. Staying physically active protects against disability from knee OA but is also very challenging. A critical but unexamined question is whether patients at greatest risk for becoming less active are those with a genetic predisposition for greater sensitivity to daily pain.
Aims: We examined day-to-day variability in knee OA pain for patients with different variants of catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) single nucleotide polymorphisms (SNPs), and whether patients with a specific genotype experience more pain following …
Walking-Induced Fatigue Leads To Increased Risk In Older Adults, S. Morrison, S. R. Colberg, H. K. Parson, S. Neumann, R. Handel, E. J. Vinik, J. Paulson, A. I. Vinik
Walking-Induced Fatigue Leads To Increased Risk In Older Adults, S. Morrison, S. R. Colberg, H. K. Parson, S. Neumann, R. Handel, E. J. Vinik, J. Paulson, A. I. Vinik
Rehabilitation Sciences Faculty Publications
Background- For older adults, falls are a serious health problem, with more than 30% of people older than 65 suffering a fall at least once a year. One element often overlooked in the assessment of falls is whether a person's balance, walking ability, and overall falls risk is affected by performing activities of daily living such as walking.
Objective- This study assessed the immediate impact of incline walking at a moderate pace on falls risk, leg strength, reaction time, gait, and balance in 75 healthy adults from 30 to 79 years of age. Subjects were subdivided into 5 equal groups …
What's Their Expiration Date? Age Discrimination In The Workplace, Bianca L. Tomlin
What's Their Expiration Date? Age Discrimination In The Workplace, Bianca L. Tomlin
Masters Theses
Age discrimination, although illegal, continues to have a presence within organizations against older individuals. Previous research on age discrimination has determined that the social identity of those older workers discriminated against are affected. This project examines how older workers are being discriminated against, how age discrimination affects the dignity of an older worker, and how age discrimination affects the professional identity of older workers. This study focuses on eleven white-collar workers, age 45-65 who have experienced age discrimination in the workplace. Analysis revealed that older workers found themselves being fired from organizations, barred from entry into organizations, and denied training …
It Is All About (U)Biquitin: Role Of Altered Ubiquitin-Proteasome System And Uchl1 In Alzheimer Disease, Antonella Tramutola, Fabio Di Domenico, Eugenio Barone, Marzia Perluigi, D. Allan Butterfield
It Is All About (U)Biquitin: Role Of Altered Ubiquitin-Proteasome System And Uchl1 In Alzheimer Disease, Antonella Tramutola, Fabio Di Domenico, Eugenio Barone, Marzia Perluigi, D. Allan Butterfield
Chemistry Faculty Publications
Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to oxidative stress-induced damage and these irreversible modifications lead to the alteration of protein structure and function. In order to maintain cell homeostasis, these oxidized/damaged proteins have to be removed in order to prevent their toxic accumulation. It is generally accepted that the age-related accumulation of “aberrant” proteins results from both the increased occurrence of damage and the decreased efficiency …