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Articles 1 - 30 of 47
Full-Text Articles in Gerontology
Increasing Nursing Aide Knowledge On Benefits Of Light For Sundowning Syndrome, Grace Hilfiker, Julie Masters
Increasing Nursing Aide Knowledge On Benefits Of Light For Sundowning Syndrome, Grace Hilfiker, Julie Masters
Honors Theses
In this study, the knowledge of nursing aides on the benefits of light for sundowning syndrome was investigated. While dementia and sundowning syndrome is discussed during nursing aide training in the state of Nebraska, there is no discourse focused on how light plays beneficial role in lessening the symptoms of sundowning syndrome for those who are afflicted with dementia. This study asked what the current knowledge base surrounding dementia and sundowning syndrome is of nursing aides in the state of Nebraska. The aim was to justify adding a focus on concrete methods to use when caring for patients with dementia …
What Factors Increase Risk Of Alzheimer's Disease And Related Dementia?, Elizabeth Vásquez, Kai Zhang
What Factors Increase Risk Of Alzheimer's Disease And Related Dementia?, Elizabeth Vásquez, Kai Zhang
Population Health Research Brief Series
Alzheimer’s disease is the most common form of dementia and ranks 7th in the leading causes of death in the United States (U.S.). This data slice uses nationwide data from 3,155 counties in the U.S. to identify the factors that best predict county-level rates of Alzheimer’s Disease and Related Dementias (ADRDs) in 2018. The results indicate that insufficient sleep, consuming less than one serving of fruits and vegetables per day, having no high school diploma, Black population percentage, and social vulnerability were among the leading factors predicting county-level ADRD prevalence.
Implementing An Alzheimer’S And Dementia Library Outreach Program: A Partnership Between The Nebraska Chapter Of The Alzheimer’S Association And Nebraska Libraries, Casey Wilkinson
Theses/Capstones/Creative Projects
This paper focuses on the establishment of an Alzheimer’s and dementia library outreach program in Nebraska, initiated by the Nebraska Chapter of the Alzheimer’s Association. The program aims to address the lack of community resources and support for individuals affected by dementia-related diseases in Nebraska. Extensive research, including interviews with successful library outreach programs globally, informed the program's foundation. A survey distributed to Nebraska libraries had a stellar response rate, with 57 libraries expressing interest in collaborating. An in-depth guide was created and distributed to the interested libraries, outlining program components such as educational programming, support groups, and a designated …
Building An Age & Dementia Friendly Barnstable: An Action Plan, Caitlin Coyle, Beth Rouleau, Shayna Gleason
Building An Age & Dementia Friendly Barnstable: An Action Plan, Caitlin Coyle, Beth Rouleau, Shayna Gleason
Center for Social and Demographic Research on Aging Publications
The Town of Barnstable has long-been aware of its aging population and, as a result, has initiated a number of planning processes to advance the livability of the community for all ages---this report documents the Age & Dementia Friendly planning process and associated ideas for action.
Aging In Middleton: A Community Needs Assessment, Sue Berger, Caitlin Coyle
Aging In Middleton: A Community Needs Assessment, Sue Berger, Caitlin Coyle
Center for Social and Demographic Research on Aging Publications
This report describes research undertaken by the Center for Social & Demographic Research on Aging within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Town of Middleton. The content of this report is meant to inform the Middleton Council on Aging (COA), and organizations that work with and on behalf of older residents of Middleton, for the purposes of planning and coordination of services. Through a process of community engagement and mixed method data collection, the goals of this project are twofold: 1) to inform the planning and design of the future senior center space …
The Impact Of Having Foreign Domestic Workers On Informal Caregivers Of Persons With Dementia: Findings From A Multi-Method Research In Singapore, Qi Yuan, Yunjue Zhang, Ellaisha Samari, Anitha Jeyagurunathan, Tee Hng Tan, Fiona Devi, Peizhi Wang, Harish Magadi, Richard Goveas, Li Ling Ng, Mythily Subramaniam
The Impact Of Having Foreign Domestic Workers On Informal Caregivers Of Persons With Dementia: Findings From A Multi-Method Research In Singapore, Qi Yuan, Yunjue Zhang, Ellaisha Samari, Anitha Jeyagurunathan, Tee Hng Tan, Fiona Devi, Peizhi Wang, Harish Magadi, Richard Goveas, Li Ling Ng, Mythily Subramaniam
Research Collection School of Social Sciences
Background: Informal caregivers of persons with dementia (PWDs) sometimes engage foreign domestic workers (FDWs) to support their caregiving journey. However, there has not been much research to establish if this is really beneficial. The current study aims to investigate whether engaging FDWs specifically for caregiving of PWDs truly moderates caregiver stress and to explore caregivers’ experiences of engaging FDWs. Methods: A multi-method study design with a quantitative and qualitative sub-study was adopted. For the quantitative sub-study, 282 informal caregivers of PWDs were recruited. Propensity score matching analysis was used. For the qualitative sub-study, 15 informal caregivers with FDWs were interviewed. …
Adult Day Services In Maine: Benefits, Challenges, And Opportunities, Elizabeth Gattine Jd, Eileen Griffin Jd, Kimberly I. Snow Mhsa, Ba
Adult Day Services In Maine: Benefits, Challenges, And Opportunities, Elizabeth Gattine Jd, Eileen Griffin Jd, Kimberly I. Snow Mhsa, Ba
Disability & Aging
In Maine and nationally, adult day services tend to be underfunded and underutilized compared to other types of long term services and supports (LTSS). In part, investment in adult day services is hampered by a lack of standardized data collection and limited research on issues of accessibility, cost-effectiveness, and the impact of adult day services on the broader health system. Lack of uniformity in state regulatory frameworks for licensing, program design, service delivery, and other administrative requirements further complicates cross-state comparisons. Considering these limitations, a key goal of this report is to provide a more detailed and comprehensive understanding of …
Most Home-Delivered Meal Recipients With Dementia Receive Support From Friends And Family, But More Social Activity Is Needed, Claire Pendergrast
Most Home-Delivered Meal Recipients With Dementia Receive Support From Friends And Family, But More Social Activity Is Needed, Claire Pendergrast
Population Health Research Brief Series
Home-delivered meal programs reduce hunger and food insecurity, promote socialization, and improve health and wellbeing for older adults. Regular social support from home-delivered meal drivers, alongside social support from friends and family, may be key to preventing isolation and improving health for older adults with dementia. This research brief shows that home-delivered meal recipients with dementia receive significant support from friends and family, but 83% would like more social activity. To better support older adults with dementia and family caregivers, aging services providers should expand virtual and dementia-friendly social engagement programming.
African-American Lay Pastoral Care Facilitators’ Perspectives On Dementia Caregiver Education And Training, Nik M. Lampe, Nidhi Desai, Tomeka Norton-Brown, Alexandra C. H. Nowakowski, Robert L. Glueckauf
African-American Lay Pastoral Care Facilitators’ Perspectives On Dementia Caregiver Education And Training, Nik M. Lampe, Nidhi Desai, Tomeka Norton-Brown, Alexandra C. H. Nowakowski, Robert L. Glueckauf
The Qualitative Report
The African-American Alzheimer’s Caregiver Training and Support Project 2 (ACTS 2) is a faith-integrated, skills-training and support program for distressed African American family caregivers of persons living with dementia across Florida. Caregivers participate in a 12-week, telephone-based, skills-building and support program led by faith community workers (i.e., lay pastoral care facilitators) who provide volunteer services to their denominations. In this case study, we examined facilitators’ perspectives and recommendations for supplementary audiovisual and written training materials to optimize group process and goal-setting skills. Utilizing a qualitative approach, we explored facilitators’ needs, experiences in using current training materials, and recommendations for supplementary …
Dementia Care Among Somali Elders, Emmanuel Asante Opoku
Dementia Care Among Somali Elders, Emmanuel Asante Opoku
All Graduate Theses, Dissertations, and Other Capstone Projects
Caring for persons with dementia is demanding and complicated since there is “no one-size-fits all formula for dementia care. The care needs to be modified to fit the various stages of the condition and each family's unique situation. Racial and ethnic differences place unique demand on all the forms of dementia care; in-home care (IHC), long-term care (LTC), adult day centers(ADC), short term care (STC) and hospice care (HC).
This paper aimed to study how Somali elders think and interact with dementia care services, from in-home care to hospice care. Some recommendations to study this issue is to do a …
A Rapid Review Of Internet Mediated Research Methods With People With Dementia: Practical, Technical And Ethical Considerations, Tharin Phenwan Dr, Judith Sixsmith Prof, Linda Mcswiggan Dr, Deans Buchanan Dr
A Rapid Review Of Internet Mediated Research Methods With People With Dementia: Practical, Technical And Ethical Considerations, Tharin Phenwan Dr, Judith Sixsmith Prof, Linda Mcswiggan Dr, Deans Buchanan Dr
The Qualitative Report
Doing research with People with Dementia (PwD) can be challenging given that disease symptoms of anxiety, forgetfulness, and fluctuating mental capacity can make recruitment and data collection difficult. Once COVID-19 made face-to-face data collection impractical, using internet-based methods became an alternative option to continue with research. However, data collection with PwD over the internet requires strategies to observe, support, and enable them to engage with research, especially with qualitative approaches. Nine articles were selected via a decade rapid scoping review (undertaken March-June 2020) to identify qualitative online methods used with PwD and associated challenges. Methods used were online interviews, clinical …
Life Satisfaction: Aging Female Informal Caregivers Of Persons With Dementia, Deborah Ann Monson
Life Satisfaction: Aging Female Informal Caregivers Of Persons With Dementia, Deborah Ann Monson
Dissertations
Purpose/Aims
The purpose of this study was to describe the relationship between aging female informal caregivers of persons with dementia (PWD) and care recipients’ PWD demographic factors, aging female informal caregivers of PWD social support factors, positive and negative feelings, a sense of flourishing, stress, and life satisfaction.
Background/Rationale
Older adults with dementia are living longer and the majority are receiving care by aging female informal caregivers. Dementia incrementally worsens over time impacting informal caregiver life satisfaction. Most studies have focused on negative aspects of informal caregiving. Therefore, this study investigated both positive and negative aspects of caregiving.
Conceptual Basis …
A Person-Centered Care Model’S Effectiveness For Older Adults With Dementia: A Systematic Review And Meta-Analysis, Karen Goeschel
A Person-Centered Care Model’S Effectiveness For Older Adults With Dementia: A Systematic Review And Meta-Analysis, Karen Goeschel
Honors Theses
I evaluated the effectiveness of person-centered care interventions for older adults with dementia. Quality of life and agitation levels were used as primary outcomes for the effectiveness of the intervention. Electronic databases were searched for studies which satisfied the inclusion principles and did not satisfy exclusion principles. Cluster-randomized trials and non-randomized control trials which compared person-centered care approaches to usual care were included. I performed two random-effects meta-analyses. Six studies with 1,384 patients were included. For older adults with dementia, person-centered care had no significant impact on quality-of-life improvement (SMD = -0.116, p = 0.206) or agitation reduction (SMD = …
Analyzing The Use Of A Montessori-Based Activity & Its Effect On Engagement & Affect In Persons With Dementia: A Replication Study, Emilee J. Andersen
Analyzing The Use Of A Montessori-Based Activity & Its Effect On Engagement & Affect In Persons With Dementia: A Replication Study, Emilee J. Andersen
All Graduate Theses, Dissertations, and Other Capstone Projects
Activities are an essential element in institutionalized settings for persons with dementia. Challenges are faced, however, when developing and implementing stimulating and meaningful activities for this population. Over the past two decades, Montessori-based activities (MBAs) have been investigated as a means for meeting the needs of persons with dementia residing in long-term care facilities. MBAs were developed to enhance the quality of life for individuals experiencing dementia through maximization of engaging and meaningful activities. The purpose of the current study was to expand on the empirical literature related to the use of MBAs for persons with dementia by replication of …
Loneliness, Sense Of Control, And Risk Of Dementia In Healthy Older Adults: A Moderated Mediation Analysis, Hwajin Yang, Germaine Tng, Wee Qin Ng, Sujin Yang
Loneliness, Sense Of Control, And Risk Of Dementia In Healthy Older Adults: A Moderated Mediation Analysis, Hwajin Yang, Germaine Tng, Wee Qin Ng, Sujin Yang
Research Collection School of Social Sciences
Objectives: Despite the rising prevalence of dementia, little research has been conducted to identify modifiable psychological factors that alleviate the risk of dementia in older adults and the underlying mechanisms. Given that loneliness is, in part, concomitant with a weakened sense of control, we examined whether sense of control would mediate the relation between loneliness and dementia risk. Further, considering that working -memory capacity is a critical cognitive resource that serves as a buffer against age-related cognitive decline, we examined a second-order moderated mediational model whereby working-memory capacity moderates the relation between control beliefs and dementia risk in older adults. …
Caregiver Knowledge And Perceptions Of Dementia-Specific Nutritional Approaches, Danielle Freitag
Caregiver Knowledge And Perceptions Of Dementia-Specific Nutritional Approaches, Danielle Freitag
All Graduate Theses, Dissertations, and Other Capstone Projects
Dementia is a syndrome that affects millions worldwide. The syndrome can cause great distress not only for the diagnosed individual but also for the family and friends who provide care. It is known that many caregivers for people with dementia face difficulties in planning and preparing meals, feeding, and making nutritional decisions for their loved ones. Several diets have been shown to assist with dementia-related symptoms pre and post diagnosis. However, what is unknown is whether caregivers are aware of the benefits of these diets and what the barriers are to implementing them into their nutrition regime. This study surveyed …
Early Detection Of Mild Cognitive Impairment With In-Home Sensors To Monitor Behavior Patterns In Community-Dwelling Senior Citizens In Singapore: Cross-Sectional Feasibility Study, Iris Rawtaer, Rathi Mahendran, Ee Heok Kua, Hwee-Pink Tan, Hwee Xian Tan, Tih-Shih Lee, Tze Pin Ng
Early Detection Of Mild Cognitive Impairment With In-Home Sensors To Monitor Behavior Patterns In Community-Dwelling Senior Citizens In Singapore: Cross-Sectional Feasibility Study, Iris Rawtaer, Rathi Mahendran, Ee Heok Kua, Hwee-Pink Tan, Hwee Xian Tan, Tih-Shih Lee, Tze Pin Ng
Research Collection School Of Computing and Information Systems
Background: Dementia is a global epidemic and incurs substantial burden on the affected families and the health care system. A window of opportunity for intervention is the predementia stage known as mild cognitive impairment (MCI). Individuals often present to services late in the course of their disease and more needs to be done for early detection; sensor technology is a potential method for detection.Objective: The aim of this cross-sectional study was to establish the feasibility and acceptability of utilizing sensors in the homes of senior citizens to detect changes in behaviors unobtrusively.Methods: We recruited 59 community-dwelling seniors (aged >65 years …
Rural Caregivers: Identification Of Informational Needs Through Telemedicine Questions, Shoshana H. Bardach, Allison Gibson, Kelly Parsons, April Stauffer, Gregory A. Jicha
Rural Caregivers: Identification Of Informational Needs Through Telemedicine Questions, Shoshana H. Bardach, Allison Gibson, Kelly Parsons, April Stauffer, Gregory A. Jicha
Sanders-Brown Center on Aging Faculty Publications
OBJECTIVES: The prevalence of Alzheimer's disease and associated disorders is increasing. Rural residents in the United States have less access to memory care specialists and educational and community resources than in other areas of the country. Over a decade ago, we initiated an interdisciplinary rural caregiving telemedicine program to reach Kentucky residents in areas of the state where resources for supporting individuals with dementia are limited. Telemedicine programs involve a short informational presentation followed by a question and answer session; programs are offered 4 times a year. The purpose of this study was to explore questions asked over 1 year …
Barriers To Utilizing Resources For The Dementia Caregiver, Rebecca L. M. Shanafelt
Barriers To Utilizing Resources For The Dementia Caregiver, Rebecca L. M. Shanafelt
All Graduate Theses, Dissertations, and Other Capstone Projects
The family caregiver of a person with dementia (PwD) provides valuable care and experiences negative health outcomes as a result. These negative health outcomes can be mitigated utilizing resources, however utilization rates remain low. While there is some research on barriers to accessing resources there is very little focused on caregivers of PwD. This study through semi-structured interviews with caregivers of PwD takes a deep look into the experience of first signs, diagnosis, and utilization of resources to better understand what those barriers might be. This study found that because of the healthcare structure caregivers do not learn about resources …
Objective Sleep Quality As A Predictor Of Mild Cognitive Impairment In Seniors Living Alone, Brian Chen, Hwee-Pink Tan, Irus Rawtaer, Hwee Xian Tan
Objective Sleep Quality As A Predictor Of Mild Cognitive Impairment In Seniors Living Alone, Brian Chen, Hwee-Pink Tan, Irus Rawtaer, Hwee Xian Tan
Research Collection School Of Computing and Information Systems
Singapore has the fastest ageing population in the Asia Pacific region, with an estimated 82,000 seniors living with dementia. These figures are projected to increase to more than 130,000 by 2030. The challenge is to identify more community dwelling seniors with Mild Cognitive Impairment (MCI), a prodromal state, as it provides an opportunity for evidence-based early intervention to delay the onset of dementia. In this paper, we explore the use of Internet of Things (IoT) systems in detecting MCI symptoms in seniors who are living alone, and accurately grouping them into MCI positive and negative subjects. We present feature extraction …
Toward An Understanding Of Behavioral And Sensory Experiences When Living With Dementia And Related Disorders: An Environmental Gerontology Perspective, Elizabeth K. Rhodus
Toward An Understanding Of Behavioral And Sensory Experiences When Living With Dementia And Related Disorders: An Environmental Gerontology Perspective, Elizabeth K. Rhodus
Theses and Dissertations--Gerontology
Behavioral and psychological symptoms of dementia create challenges for those living with neurodegenerative cognitive impairment and their care partners. Pharmacological approaches for treatment of challenging behaviors seen in dementia have limited success and serious side effects. Because of this, nonpharmacological approaches are being investigated with increasing frequency. Of particular interest are nonpharmacological approaches involving environmental stimulation to change behaviors. Success of such approaches relies on sensory processing systems, personal preferences, and environmental congruence. There is limited evidence describing behaviors of persons with cognitive impairment in relation to these components. Currently, there is no guiding model for implementation of environmental and …
Livable Sudbury: A Community Needs Assessment, Caitlin Coyle, Jan Mutchler, Sue Berger, Ceara Somerville
Livable Sudbury: A Community Needs Assessment, Caitlin Coyle, Jan Mutchler, Sue Berger, Ceara Somerville
Center for Social and Demographic Research on Aging Publications
The Livable Sudbury Initiative is based on a distinctive framework meant to ensure that Sudbury is and remains an all-age and dementia-friendly place in which to live, work, and play. Structured around livability principles embedded in the Age-Friendly Community framework, the Livable Sudbury Initiative is designed to intersect with and inform other ongoing efforts, including development of the Sudbury Master Plan and a 14-town collaborative effort of the Minuteman Advisory Group on Interlocal Coordination (MAGIC) to advance regional age-friendly planning. The Sudbury framework considers physical infrastructure as well as social and service environments as it seeks to strengthen livability for …
The Effects Of Elderspeak On The Mood Of Older Adults With Dementia: A Preliminary Report, Kenia Torres-Soto
The Effects Of Elderspeak On The Mood Of Older Adults With Dementia: A Preliminary Report, Kenia Torres-Soto
All Graduate Theses, Dissertations, and Other Capstone Projects
Barriers to effective and harmonious communication between caregivers and those affected with dementia are common and inevitable. An example of a common barrier is aphasia, which is a prevalent communication deficit associated with dementia. The social environment may further hinder harmonious communication through the use of well-intended, but ineffective speech patterns. Elderspeak (ES), which is infantilizing speech directed at older adults, is one such speech pattern that is commonly used in long-term care facilities (LTC) and is related to negative outcomes for older adults receiving it. Older adults with mild to moderate cognitive impairment who were residents at a LTC …
Informing Care: Mapping The Social Organization Of Families’ Information Work In An Aging In Place Climate, Nicole K. Dalmer
Informing Care: Mapping The Social Organization Of Families’ Information Work In An Aging In Place Climate, Nicole K. Dalmer
Electronic Thesis and Dissertation Repository
Within an institutional ethnography method of inquiry, this dissertation makes visible the information work that permeates the care work of families of people living with dementia who are also aging at home. An institutional ethnography privileges people’s everyday work and acknowledges that local contexts are influenced by translocal, ruling relations. To map out the social organization of family caregivers’ information work, this dissertation details four separate, yet interrelated studies. The first study comprises two sets of interviews: one with 13 family caregivers of older adults to understand their experiences of the information work they do and a second with five …
Wenham Connects: An Age And Dementia Friendly Needs Assessment, Caitlin Coyle
Wenham Connects: An Age And Dementia Friendly Needs Assessment, Caitlin Coyle
Center for Social and Demographic Research on Aging Publications
Wenham is a small residential community of approximately 5,000 residents located about 22 miles north of Boston. Public transit access to downtown Boston located in the neighboring town of Hamilton provides access to employment and recreational activities outside of the town’s boundaries. In addition, Wenham is home to abundant green space (e.g., wetland systems and Wenham Lake) that provide residents with opportunities to enjoy the natural beauty of the area. The Wenham Council on Aging (COA)is a municipal department designed to serve the needs of Wenham’s residents age 60 and older. It is responsible for advocating on behalf of Wenham’s …
Early Detection Of Mild Cognitive Impairment In Elderly Through Iot: Preliminary Findings, Hwee-Xian Tan, Hwee-Pink Tan
Early Detection Of Mild Cognitive Impairment In Elderly Through Iot: Preliminary Findings, Hwee-Xian Tan, Hwee-Pink Tan
Research Collection School Of Computing and Information Systems
Mild Cognitive Impairment (MCI) results in the gradual decline in a person’s cognitive abilities, and subsequently an increased risk of developing dementia. Although there is no cure for dementia, timely medical and clinical interventions can be administered to elderly who have been diagnosed with MCI, to decelerate the process of further cognitive decline and prolong the duration that they enjoy quality of life. In this paper, we present our preliminary findings of early detection of MCI in elderly who are living in the community, through the use of Internet of Things (IoT) devices for continuous, unobtrusive sensing. Multimodal sensors are …
An Exploration Of Dementia Friendly Communities From The Perspective Of Persons Living With Dementia, Catherine Hebert
An Exploration Of Dementia Friendly Communities From The Perspective Of Persons Living With Dementia, Catherine Hebert
Electronic Theses and Dissertations
The growing global prevalence of dementia coupled with a shift in public perception from a hopeless disease to the possibility of living well with dementia has led to the formation of dementia friendly communities (DFC). DFCs are a new phenomenon in the United States, with a gap in knowledge on input from people living with dementia (PLWD). This study investigated DFCs from the perspective of PLWD in Western North Carolina, with the following research questions:
- How are interactions and relationships experienced by persons living with dementia in the community?
- How is community engagement experienced by PLWD?
- To what extent and …
Transitional Care For Older Adults With Dementia: Variation Across Patients And Providers, Patricia Prusaczyk
Transitional Care For Older Adults With Dementia: Variation Across Patients And Providers, Patricia Prusaczyk
Arts & Sciences Electronic Theses and Dissertations
Older adults with dementia are particularly vulnerable to negative outcomes and adverse events when they transition between healthcare settings such as being discharged from the hospital. However, little is known about how healthcare providers help patients prepare for a care transition – known as transitional care – among older adults with dementia. Therefore, this study sought to understand the transitional care currently delivered by hospital healthcare providers to older adults with dementia, how it compared to that received by older adults without dementia, and how it varied across different patient and provider characteristics. Guided by key provider/informant interviews and theory, …
Personal Constructs In Dementia Caregiving: The Family Caregiving Experience Of People Living With Dementia In Saudi Arabia, Eradah O. Hamad
Personal Constructs In Dementia Caregiving: The Family Caregiving Experience Of People Living With Dementia In Saudi Arabia, Eradah O. Hamad
Electronic Thesis and Dissertation Repository
As observed globally, family (informal and in-home) caregiving of older adults with Alzheimer’s disease or other forms of dementia has become a critical issue in the Arab region, including Saudi Arabia. This doctoral research psychometrically and conceptually evaluates an Arabic version of the Montgomery Borgatta Caregiver Burden Scale for use as a measurement tool to assess family caregivers of older adults living at home with dementia in Saudi Arabia. Currently, there is no published literature that addresses family caregiving for individuals with dementia in Saudi Arabia. Through further examination of family caregiving narratives, this research maps the personal and social …
Csf Protein Changes Associated With Hippocampal Sclerosis Risk Gene Variants Highlight Impact Of Grn/Pgrn, David W. Fardo, Yuriko Katsumata, John S. K. Kauwe, Yuetiva Deming, Oscar Harari, Carlos Cruchaga, Alzheimer’S Disease Neuroimaging Initiative, Peter T. Nelson
Csf Protein Changes Associated With Hippocampal Sclerosis Risk Gene Variants Highlight Impact Of Grn/Pgrn, David W. Fardo, Yuriko Katsumata, John S. K. Kauwe, Yuetiva Deming, Oscar Harari, Carlos Cruchaga, Alzheimer’S Disease Neuroimaging Initiative, Peter T. Nelson
Sanders-Brown Center on Aging Faculty Publications
Objective—Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs).
Methods—Alzheimer’s Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454). For controls, non-HS-Aging SNPs in APOE (rs429358/rs7412) and MAPT (rs8070723) were also analyzed against Aβ1-42 and total tau CSF analytes.
Results—The GRN risk …