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Articles 6001 - 6030 of 63107
Full-Text Articles in Social and Behavioral Sciences
Analysis Of American Think Tanks' Views On China-Us Chip Competition And Its Enlightenment, Bingcheng He, Guoli Yang
Analysis Of American Think Tanks' Views On China-Us Chip Competition And Its Enlightenment, Bingcheng He, Guoli Yang
Journal of Scientific Information Research
[Purpose/significance]This paper focuses on the viewpoints of leading American think tanks on chip competition with China, aiming to unravel the logic behind the formulation of U.S. chip policies towards China. It also seeks to explore innovative pathways for the development of China's chip industry and provide strategic recommendations beneficial to Sino-American chip competition. [Method/process]The study selects 20 representative research reports from 9 prominent think tanks and employs a literature analysis approach to dissect the viewpoints, motives, and potential influences found in these reports. [Result/conclusion]The results reveal that most American think tanks adopt a firm stance, perceiving the rise of China's …
2024 O'Callahan Society Newsletter, O'Callahan Society, College Of The Holy Cross
2024 O'Callahan Society Newsletter, O'Callahan Society, College Of The Holy Cross
O'Callahan Society Newsletters
This annual newsletter of the O'Callahan Society includes articles about the 2023 Annual Dinner. Admiral James G. Stavridis, United States Navy (Retired) was guest speaker. President of the College of the Holy Cross, Vincent D. Rougeau, made introductory remarks. VADM Peter Daly, US Navy (Ret) was 2024 Annual Meeting Speaker.
Fine-Grained Passenger Load Prediction Inside Metro Network Via Smart Card Data, Xiancai Tian, Chen Zhang, Baihua Zheng
Fine-Grained Passenger Load Prediction Inside Metro Network Via Smart Card Data, Xiancai Tian, Chen Zhang, Baihua Zheng
Research Collection School Of Computing and Information Systems
Metro system serves as the backbone for urban public transportation. Accurate passenger load prediction for the metro system plays a crucial role in metro service quality improvement, such as helping operators schedule train timetables and passengers plan their trips. However, existing works can only predict low-grained passenger flows of origin-destination (O-D) paths or inflows/outflows of each station but cannot predict passenger load distribution over the whole metro network. To this end, this paper proposes an end-to-end inference framework, PIPE, for passenger load prediction of every metro segment between two adjacent stations, by only utilizing smart card data. In particular, PIPE …
Decentralized Clinical Trials For Medications To Reduce The Risk Of Dementia: Consensus Report And Guidance, Leanne Howard, Carla Abdelnour, Erin Abner, Ricardo F. Allegri, Hiroko H. Dodge, Serge Gauthier, Camilla M. Hoyos, Gregory Jicha, Patrick G. Kehoe, Catherine J. Mummery, Adesola Ogunniyi, Nikolaos Scarmeas, Xiaoying Chen, Jodie R. Titiner, Christopher R. Weber, Ruth Peters
Decentralized Clinical Trials For Medications To Reduce The Risk Of Dementia: Consensus Report And Guidance, Leanne Howard, Carla Abdelnour, Erin Abner, Ricardo F. Allegri, Hiroko H. Dodge, Serge Gauthier, Camilla M. Hoyos, Gregory Jicha, Patrick G. Kehoe, Catherine J. Mummery, Adesola Ogunniyi, Nikolaos Scarmeas, Xiaoying Chen, Jodie R. Titiner, Christopher R. Weber, Ruth Peters
Neurology Faculty Publications
INTRODUCTION: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.
METHODS: A modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.
RESULTS: Overall, the recommendations support the delivery of decentralized trials in dementia prevention …
Design And Evaluation Of An Esa-Based Method Of Ensemble Subsetting For A Wofs (Warn On Forecast-Like System), Daniel J. Butler
Design And Evaluation Of An Esa-Based Method Of Ensemble Subsetting For A Wofs (Warn On Forecast-Like System), Daniel J. Butler
Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research
Forecasting severe thunderstorm environments in the southeastern United States can be challenging due to mesoscale heterogeneities such as shortwave troughs, pre-existing airmass boundaries, cold fronts aloft, low-level jets, dry air intrusions, and mesoscale lows. To combat these challenges, ensemble sensitivity analysis (ESA) may be applied to a Warn-on-Forecast (WOF)-like ensemble to improve forecasts of severe convection through ensemble weighting and subsetting. Ensemble-based weighting and subsetting uses ensemble members that most accurately represent the thunderstorm environment in areas of mesoscale heterogeneity. This study creates and evaluates the ensemble-based weighting and subsetting in four cases of severe thunderstorm occurrence. The open parameter …
Examining Dietary Disparities And Associated Factors Among Young Children Across Diverse Racial, Ethnic And Immigrant Households In Nebraska, Naveta Bhatti
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Early childhood is a crucial stage for developing eating behaviors which in turn plays a major role in determining health outcomes. Assessing children’s diet plays a crucial role in tackling the obesity epidemic. One of the ways to assess children’s dietary intake is by evaluating their dietary quality. Dietary quality refers to the overall healthfulness and nutritional value of an individual's diet, considering the combination of foods consumed over time. Research has consistently demonstrated that a high-quality diet is associated with a reduced risk of several health issues, such as all-cause mortality, cardiovascular disease incidence or mortality, cancer incidence or …
Private Management Of African Protected Areas Improves Wildlife And Tourism Outcomes But With Security Concerns In Conflict Regions, Sean Denny, Gabriel Englander, Patrick Hunnicutt
Private Management Of African Protected Areas Improves Wildlife And Tourism Outcomes But With Security Concerns In Conflict Regions, Sean Denny, Gabriel Englander, Patrick Hunnicutt
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Protected areas can conserve wildlife and benefit people when managed effectively. African governments increasingly delegate the management of protected areas to private, nongovernmental organizations, hoping that private organizations’ significant resources and technical capacities actualize protected areas’ potential. Does private sector management improve outcomes compared to a counterfactual of government management? We leverage the transfer of management authority from governments to African Parks (AP)—the largest private manager of protected areas in Africa—to show that private management significantly improves wildlife outcomes via reduced elephant poaching and increased bird abundances. Our results also suggest that AP’s management augments tourism, while the effect on …
Quantitative Evaluation Of Security Intelligence Policy Texts In China: Text Analysis Based On Pmc Model, Bin Zhang
Journal of Scientific Information Research
[Purpose/significance]Analyzing the laws, regulations and policies related to security intelligence in China can not only provide reference for decision-making, but also effectively enrich the connotation of China's overall national security concept. [Method/process]Using the LDA topic model, text mining was conducted on laws, regulations and policies related to security intelligence in China, and theme words were extracted from them. At the same time, based on the selection of policy indicators by existing scholars, scientifically select and design evaluation indicators for China's security intelligence laws, regulations, and policies. Referring to the overall national security concept, several representative policy contents were selected for …
The Colorado Wolf Reintroduction Portrayal In News Media, Megan K. Mcarthur, Monica V. Ogra
The Colorado Wolf Reintroduction Portrayal In News Media, Megan K. Mcarthur, Monica V. Ogra
Student Publications
The Colorado gray wolf (Canis lupus) reintroduction began in December 2023 in the hope of restoring this once native population to the area, and it has received mixed responses from the media. By answering the research question of 'How has the wolf reintroduction in Colorado been framed in news media?', this research poster looks at the portrayal of the reintroduction in news articles from six months before and after the first wolves were released. Media is an influential factor in people's opinions and it is important to be aware of the information being shared and any bias within them.
The Need For Localized, Socio-Economic Policy Measures For Controlling A Pandemic: An Empirical Study Of Covid-19 In India, Ashish Gupta, Prashant Das, Dongshin Kim
The Need For Localized, Socio-Economic Policy Measures For Controlling A Pandemic: An Empirical Study Of Covid-19 In India, Ashish Gupta, Prashant Das, Dongshin Kim
All Faculty Open Access Publications
The COVID-19 pandemic, a black swan event, created an unprecedented global health hazard and disrupted global economic activities. During the first wave of the COVID-19 pandemic, various governments announced lockdowns. India went under lockdown from 25 March 2020 for 21 days. These lockdowns disrupted the social fabric and economic activities. We examined the demographic and socio-economic determinants of COVID-19 infections and deaths across over 400 districts in India. Using statistical methods, we observed that the infection patterns demonstrate localized characteristics across districts. Areas with a larger male population and higher economic activity witnessed higher infection rates. Districts with more agricultural …
Mental Health In Price: A Report On Community Perspectives, Kristen Koci, Jessica Ulrich-Schad
Mental Health In Price: A Report On Community Perspectives, Kristen Koci, Jessica Ulrich-Schad
Publications
This report is from a research project conducted at the end 2022 that focuses on mental health in Price. Dr. Kristen Koci conducted interviews in Price to understand community members’ perspectives on and factors affecting mental health in the area. Community leaders from government and local organizations were interviewed along with general community residents, for a total of 27 interviews. The report that follows summarizes themes and perspectives gathered during these interviews.
Readability And Suitability Of Local Disaster Preparedness Materials In Predominantly Hispanic Border Communities: A Case Study Of Cameron County, Texas, Katarzyna Sepielak, Dawid K. Wladyka
Readability And Suitability Of Local Disaster Preparedness Materials In Predominantly Hispanic Border Communities: A Case Study Of Cameron County, Texas, Katarzyna Sepielak, Dawid K. Wladyka
Sociology Faculty Publications
Community awareness is a key component of disaster resilience and numerous agencies developed a plethora of preparedness materials. Previous studies evaluated national-level resources and social media content indicating that these efforts are not effectively reaching vulnerable populations, as the information is provided at or above the secondary education level. However, the local-specific content has been mostly overlooked in the analyses, subsequently neglecting the needs of areas with specific demographics and hazards, like predominantly Hispanic border communities. Thus, this study turns to local preparedness and mitigation materials, rather than general internet searches or national level documents. We analyze information provided on …
Enhancing Water Sustainability In North Africa: Literature Review And Synthesis Of Current Knowledge Gaps In Sudan, Osman M. A. Adam, Aaron R. Mittelstet, Derek M. Heeren, Troy E. Gilmore
Enhancing Water Sustainability In North Africa: Literature Review And Synthesis Of Current Knowledge Gaps In Sudan, Osman M. A. Adam, Aaron R. Mittelstet, Derek M. Heeren, Troy E. Gilmore
Department of Agricultural and Biological Systems Engineering: Presentations and White Papers
This study delves into the critical role of groundwater in addressing global water challenges, with a focus on the Nubian Sandstone Aquifer System (NSAS) in North Africa. Groundwater constitutes a source of potable water, irrigation, and industrial use, especially in arid regions where surface water is limited. We analyzed the status of water quantity, withdrawals, recharge, and geological characteristics in the NSAS, specifically in Sudan, Egypt, Libya, and Chad. Though the NSAS is largely an untapped resource, we evaluated various scenarios to determine the quantity of cropland that can be sustainably irrigated. The NSAS is located in an arid region, …
Privacy-Preserving Arbitrary Geometric Range Query In Mobile Internet Of Vehicles, Yinbin Miao, Lin Song, Xinghua Li, Hongwei Li, Kim-Kwang Raymond Choo, Robert H. Deng
Privacy-Preserving Arbitrary Geometric Range Query In Mobile Internet Of Vehicles, Yinbin Miao, Lin Song, Xinghua Li, Hongwei Li, Kim-Kwang Raymond Choo, Robert H. Deng
Research Collection School Of Computing and Information Systems
The mobile Internet of Vehicles (IoVs) has great potential for intelligent transportation, and creates spatial data query demands to realize the value of data. Outsourcing spatial data to a cloud server eliminates the need for local computation and storage, but it leads to data security and privacy threats caused by untrusted third-parties. Existing privacy-preserving spatial range query solutions based on Homomorphic Encryption (HE) have been developed to increase security. However, in the single server model, the private key is held by the query user, which incurs high computation and communication burdens on query users due to multiple rounds of interactions. …
Testing For Spatial Correlation Under A Complete Bipartite Network, Badi H. Baltagi, Long Liu
Testing For Spatial Correlation Under A Complete Bipartite Network, Badi H. Baltagi, Long Liu
Center for Policy Research
This note shows that for a spatial regression with a weight matrix depicting a complete bipartite network, the Moran I test for zero spatial correlation is never rejected when the alternative is positive spatial correlation no matter how large the true value of the spatial correlation coefficient. In contrast, the null hypothesis of zero spatial correlation is always rejected (with probability one asymptotically) when the alternative is negative spatial correlation and the true value of the spatial correlation coefficient is near -1.
Exploring Performance-Based Contracts: A Good Option To Address Long-Term Road Maintenance In California?, Maria Calahorra-Jimenez, Richard Poythress
Exploring Performance-Based Contracts: A Good Option To Address Long-Term Road Maintenance In California?, Maria Calahorra-Jimenez, Richard Poythress
Mineta Transportation Institute
Performance-based contracts (PBCs) used in road maintenance provide flexibility for considering new materials, design, and technology to achieve predetermined performance targets. Several states in the U.S. have already used these types of contracts in road maintenance, and their experience can inform the use of PBCs in California. The objectives of this research are twofold. First, identify the benefits and challenges of PBCs compared to traditional contracts. Second, explore the main aspects of PBCs implementation for road maintenance and relate them to California's context. To this end, deductive-inductive content analysis was conducted on 84 peer-reviewed articles published between 1998 and 2023. …
Mapping Of Pavement Conditions Using Smartphone/Tablet Lidar Case Study: Sensor Performance Comparison, Calvin Beavers, Chad Day, Austin Krietemeyer, Scott M. Peterson, Yushin Ahn, Xiaojun Li
Mapping Of Pavement Conditions Using Smartphone/Tablet Lidar Case Study: Sensor Performance Comparison, Calvin Beavers, Chad Day, Austin Krietemeyer, Scott M. Peterson, Yushin Ahn, Xiaojun Li
Mineta Transportation Institute
Poor road conditions affect millions of drivers, and assessing the condition of paved surfaces is a critical step towards repairing them. This project explores the feasibility of using the Apple iPad Pro LiDAR sensor as a cost-effective tool for assessing the damage and condition of paved surfaces. Our research aims to provide accurate and precise measurements using readily available consumer devices and compare the results to state-of-the-art equipment. This investigation involved visual inspection, identification, and classification of pavement distresses, followed by a comparison of the iPad and iPhone LiDAR data with a survey-grade terrestrial laser scanner. The project revealed several …
Experimental Investigation Of The Self-Healing Potential Of Bacteria For Sustainable Concrete Structures Phase 2, Andrea Calabrese, Pitiporn Asvapathanagul, Nisarg N. Patel, Nanubala Dhruvan, Austin Adams, Michael Hernandez, Douglas S. Lopez-Cruz
Experimental Investigation Of The Self-Healing Potential Of Bacteria For Sustainable Concrete Structures Phase 2, Andrea Calabrese, Pitiporn Asvapathanagul, Nisarg N. Patel, Nanubala Dhruvan, Austin Adams, Michael Hernandez, Douglas S. Lopez-Cruz
Mineta Transportation Institute
Concrete is a critical component of so much of the modern construction industry. This material, well known for its versatility, robustness, longevity, and strength, is well-suited for a wide range of structural applications. Nonetheless, the widespread occurrence of cracks in concrete structures, primarily attributed to its limited tensile strength, shrinkage, and overstain, imposes a considerable economic and environmental challenge when it comes to retrofitting these fissures. This study tackles this problem by harnessing bacteria tolerant to high alkaline conditions to enable Microbially Induced Calcium Carbonate Precipitation (MICP) for the self-repair of concrete. This is achieved through an external application method, …
Battery Management System Development For Electric Vehicles And Fast Charging Infrastructure Improvement, Yu Yang, Hen-Geul Yeh, Cesar Ortiz
Battery Management System Development For Electric Vehicles And Fast Charging Infrastructure Improvement, Yu Yang, Hen-Geul Yeh, Cesar Ortiz
Mineta Transportation Institute
The electric vehicle (EV) has become increasingly popular due to its being zero-emission. However, a significant challenge faced by EV drivers is the range anxiety associated with battery usage. Addressing this concern, this project develops a more efficient battery management system (BMS) for electric vehicles based on a real-time, state-of-charge (SOC) estimation. The proposed study delivers three modules: (1) a new equivalent circuit model (ECM) for lithium-ion batteries, (2) a new SOC estimator based on the moving horizon method, and (3) an on-board FPGA implementation of the classical Coulomb counting method for SOC estimation. The research team extends the traditional …
Spatio-Temporal Analysis Of The Roadside Transportation-Related Air Quality (Startraq 2022): Data-Driven Exposure Analysis By Transportation Modes, Jaymin Kwon, Yushin Ahn, Steve Chung
Spatio-Temporal Analysis Of The Roadside Transportation-Related Air Quality (Startraq 2022): Data-Driven Exposure Analysis By Transportation Modes, Jaymin Kwon, Yushin Ahn, Steve Chung
Mineta Transportation Institute
Particulate matter (PM) pollution poses significant health risks, influenced by various meteorological factors and seasonal variations. This study investigates the impact of temperature and other meteorological variables on PM10 and PM2.5 levels in Fresno County, known for high air pollution. Multiple linear regression (MLR) and generalized additive models (GAMs) assess the significance of these relationships. Analyzing data from Fresno County, we examine PM10 and PM2.5 levels across "hot" (June to August) and "cool" (September to May) seasons. Findings indicate PM10, both MLR and GAM models identify statistically significant variables, excluding temperature and wind direction in each season. However, during the …
2024 July, Morehead State University. Office Of Communications & Marketing.
2024 July, Morehead State University. Office Of Communications & Marketing.
Morehead State Press Release Archive, 1961 to the Present
Press releases for July of 2024.
Bridging The Nature-Cultural Heritage Gap: Evaluating Sustainable Entanglements Through Cemeteries In Urban Asia, David Ocon, Wei Ping Young
Bridging The Nature-Cultural Heritage Gap: Evaluating Sustainable Entanglements Through Cemeteries In Urban Asia, David Ocon, Wei Ping Young
Research Collection School of Social Sciences
The expanding footprint of urban Asian settlements and increasing living standards have put pressure on cemetery sites. Public health narratives and the sanctity associated with death matters in Asian urban landscapes have fed into the rhetoric of cemeteries as undesirable heritage spaces. Often lacking protection, many cemeteries have been exhumed, cleared, and relocated to allow room for new developments and infrastructure, risking the survival of this quiet element of the urban cultural patrimony. Within an Asian context, synergies between nature and cultural heritage preservation are not prevalent in major cities like Singapore, Hong Kong, Tokyo, Manila, Kuala Lumpur, and Bangkok. …
Insourcing The Smart City: Assembling An Ideo-Technical Ecosystem Of Talent, Skills, And Civic-Mindedness In Singapore, Orlando Woods, Tim Bunnell, Lily Kong
Insourcing The Smart City: Assembling An Ideo-Technical Ecosystem Of Talent, Skills, And Civic-Mindedness In Singapore, Orlando Woods, Tim Bunnell, Lily Kong
Research Collection College of Integrative Studies
This article examines an alternative model of smart city formation, one based on the principle of insourcing technical competencies and capabilities to those responsible for city governance. This model counters the logic of technological outsourcing upon which many assumptions and critiques of the smart city rest, and thus reveals ways in which a more generative discourse can be forged. Drawing on a series of in-depth interviews with senior stakeholders from public and private sector organizations, we develop a case study of Singapore’s Smart Nation initiative. Through coordinated efforts to reorganize the public sector’s technological functions, develop nation-wide skills upgrading programs, …
Impact Of Rainfall On Air Temperature, Humidity And Thermal Comfort In Tropical Urban Parks, Juan A. Acero, Philip Carl Kestel, Hieu T. Dang, Leslie K. Norford
Impact Of Rainfall On Air Temperature, Humidity And Thermal Comfort In Tropical Urban Parks, Juan A. Acero, Philip Carl Kestel, Hieu T. Dang, Leslie K. Norford
Research Collection College of Integrative Studies
Urban areas in hot and humid tropical regions are frequently exposed to uncomfortable thermal levels. A well-developed urban heat mitigation strategy is increasing vegetation infrastructure, even though the impact differs based on regional climate. In this study we have evaluated the impact of rainfall on air temperature, humidity and thermal comfort inside a large urban park in Singapore, based on measurement campaigns. A comparison between the park and an urban site is presented. Results show that rainfall significantly reduces air temperature and improves thermal comfort levels, not only right after the rain event but also in the after-event dry period. …
The Road To Tailored Adjuvant Chemotherapy For All Four Non-Pancreatic Periampullary Cancers: An International Multimethod Cohort Study, Bas A Uijterwijk, Daniël H Lemmers, Michele Ghidini, Johanna W Wilmink, Alberto Zaniboni, Giuseppe Kito Fusai, Alessandro Zerbi, Bas Groot Koerkamp, Misha Luyer, Poya Ghorbani, Roberto Salvia, Steven White, Benedetto Ielpo, Brian K P Goh, Ugo Boggi, Geert Kazemier, Michael G House, Vasileios K Mavroeidis, Bergthor Björnsson, Michele Mazzola, Mario Serradilla, Dimitris Korkolis, Adnan Alseidi, Keith J Roberts, Zahir Soonawalla, Patrick Pessaux, William E Fisher, Sharnice Koek, Tara S Kent, Miljana Vladimirov, Louisa Bolm, Nigel Jamieson, Raffaele Dalla Valle, Jorg Kleeff, Alessandro Mazzotta, Miguel Angel Suarez Muñoz, Santiago Sánchez Cabús, Chad G Ball, Adam C Berger, Clarissa Ferarri, Marc G Besselink, Mohammed Abu Hilal, International Study Group On Non-Pancreatic Periampullary Cancer (Isgaca)
The Road To Tailored Adjuvant Chemotherapy For All Four Non-Pancreatic Periampullary Cancers: An International Multimethod Cohort Study, Bas A Uijterwijk, Daniël H Lemmers, Michele Ghidini, Johanna W Wilmink, Alberto Zaniboni, Giuseppe Kito Fusai, Alessandro Zerbi, Bas Groot Koerkamp, Misha Luyer, Poya Ghorbani, Roberto Salvia, Steven White, Benedetto Ielpo, Brian K P Goh, Ugo Boggi, Geert Kazemier, Michael G House, Vasileios K Mavroeidis, Bergthor Björnsson, Michele Mazzola, Mario Serradilla, Dimitris Korkolis, Adnan Alseidi, Keith J Roberts, Zahir Soonawalla, Patrick Pessaux, William E Fisher, Sharnice Koek, Tara S Kent, Miljana Vladimirov, Louisa Bolm, Nigel Jamieson, Raffaele Dalla Valle, Jorg Kleeff, Alessandro Mazzotta, Miguel Angel Suarez Muñoz, Santiago Sánchez Cabús, Chad G Ball, Adam C Berger, Clarissa Ferarri, Marc G Besselink, Mohammed Abu Hilal, International Study Group On Non-Pancreatic Periampullary Cancer (Isgaca)
Center for Medical Ethics and Health Policy Staff Publications
Background: Despite differences in tumour behaviour and characteristics between duodenal adenocarcinoma (DAC), the intestinal (AmpIT) and pancreatobiliary (AmpPB) subtype of ampullary adenocarcinoma and distal cholangiocarcinoma (dCCA), the effect of adjuvant chemotherapy (ACT) on these cancers, as well as the optimal ACT regimen, has not been comprehensively assessed. This study aims to assess the influence of tailored ACT on DAC, dCCA, AmpIT, and AmpPB.
Patients and methods: Patients after pancreatoduodenectomy for non-pancreatic periampullary adenocarcinoma were identified and collected from 36 tertiary centres between 2010 - 2021. Per non-pancreatic periampullary tumour type, the effect of adjuvant chemotherapy and the main relevant regimens …
Lethal Phenotypes In Mendelian Disorders, Pilar Cacheiro, Samantha Lawson, Ignatia B Van Den Veyver, Gabriel Marengo, David Zocche, Stephen A Murray, Michael Duyzend, Peter N Robinson, Damian Smedley
Lethal Phenotypes In Mendelian Disorders, Pilar Cacheiro, Samantha Lawson, Ignatia B Van Den Veyver, Gabriel Marengo, David Zocche, Stephen A Murray, Michael Duyzend, Peter N Robinson, Damian Smedley
Center for Medical Ethics and Health Policy Staff Publications
Purpose: Existing resources that characterize the essentiality status of genes are based on either proliferation assessment in human cell lines, viability evaluation in mouse knockouts, or constraint metrics derived from human population sequencing studies. Several repositories document phenotypic annotations for rare disorders; however, there is a lack of comprehensive reporting on lethal phenotypes.
Methods: We queried Online Mendelian Inheritance in Man for terms related to lethality and classified all Mendelian genes according to the earliest age of death recorded for the associated disorders, from prenatal death to no reports of premature death. We characterized the genes across these lethality categories, …
Personal But Necessarily Predictive? Developing A Bioethics Research Agenda For Ai-Enabled Decision-Making Tools, Vasiliki Rahimzadeh
Personal But Necessarily Predictive? Developing A Bioethics Research Agenda For Ai-Enabled Decision-Making Tools, Vasiliki Rahimzadeh
Center for Medical Ethics and Health Policy Staff Publications
No abstract provided.
A Risk Is Not A Harm: Abortion Exceptions In State Laws, Trevor M Bibler, Alison Suen
A Risk Is Not A Harm: Abortion Exceptions In State Laws, Trevor M Bibler, Alison Suen
Center for Medical Ethics and Health Policy Staff Publications
This letter responds to the article "Beneath the Sword of Damocles: Moral Obligations of Physicians in a Post-Dobbs Landscape," by Anne Drapkin Lyerly, Ruth R. Faden, and Michelle M. Mello, in the May-June 2024 issue of the Hastings Center Report.
Post-Trial Responsibilities In Pragmatic Clinical Trials: Fulfilling The Promise Of Research To Drive Real-World Change, Stephanie R Morain, P Pearl O'Rourke, Joseph Ali, Vasiliki Rahimzadeh, Devon K Check, Hayden B Bosworth, Jeremy Sugarman
Post-Trial Responsibilities In Pragmatic Clinical Trials: Fulfilling The Promise Of Research To Drive Real-World Change, Stephanie R Morain, P Pearl O'Rourke, Joseph Ali, Vasiliki Rahimzadeh, Devon K Check, Hayden B Bosworth, Jeremy Sugarman
Center for Medical Ethics and Health Policy Staff Publications
While considerable scholarship has explored responsibilities owed to research participants at the conclusion of explanatory clinical trials, no guidance exists regarding responsibilities owed at the conclusion of a pragmatic clinical trial (PCT). Yet post-trial responsibilities in PCTs present distinct considerations from those emphasized in existing guidance and prior scholarship. Among these considerations include the responsibilities of the healthcare delivery systems in which PCTs are embedded, and decisions about implementation for interventions that demonstrate meaningful benefit following their integration into usual care settings-or deimplementation for those that fail to do so. In this article, we present an overview of prior scholarship …
Trans-Ancestral Genetic Risk Factors For Treatment-Related Type 2 Diabetes Mellitus In Survivors Of Childhood Cancer, Cindy Im, Achal Neupane, Jessica L Baedke, Brian Lenny, Angela Delaney, Stephanie B Dixon, Eric J Chow, Sogol Mostoufi-Moab, Tianzhong Yang, Melissa A Richard, M Monica Gramatges, Philip J Lupo, Noha Sharafeldin, Smita Bhatia, Gregory T Armstrong, Melissa M Hudson, Kirsten K Ness, Leslie L Robison, Yutaka Yasui, Carmen L Wilson, Yadav Sapkota
Trans-Ancestral Genetic Risk Factors For Treatment-Related Type 2 Diabetes Mellitus In Survivors Of Childhood Cancer, Cindy Im, Achal Neupane, Jessica L Baedke, Brian Lenny, Angela Delaney, Stephanie B Dixon, Eric J Chow, Sogol Mostoufi-Moab, Tianzhong Yang, Melissa A Richard, M Monica Gramatges, Philip J Lupo, Noha Sharafeldin, Smita Bhatia, Gregory T Armstrong, Melissa M Hudson, Kirsten K Ness, Leslie L Robison, Yutaka Yasui, Carmen L Wilson, Yadav Sapkota
Center for Medical Ethics and Health Policy Staff Publications
Purpose: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in survivors of childhood cancer, with marked racial/ethnic differences in burden. In this study, we investigated trans-ancestral genetic risks for treatment-related T2D.
Patients and methods: Leveraging whole-genome sequencing data from the St Jude Lifetime Cohort (N = 3,676, 304 clinically ascertained cases), we conducted ancestry-specific genome-wide association studies among survivors of African and European genetic ancestry (AFR and EUR, respectively) followed by trans-ancestry meta-analysis. Trans-/within-ancestry replication including data from the Childhood Cancer Survivor Study (N = 5,965) was required for prioritization. Three external general population T2D polygenic …