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Full-Text Articles in Optics

M.O.D.U.S. Modular Optical Design Using Specular Film, Mario Gutierrez, Robert Thibodeau, Emma Show, Desiree Robinson, Lingyuan Meng, Sean Martin, Conner Beeson Aug 2026

M.O.D.U.S. Modular Optical Design Using Specular Film, Mario Gutierrez, Robert Thibodeau, Emma Show, Desiree Robinson, Lingyuan Meng, Sean Martin, Conner Beeson

Discovery Day - Daytona Beach

High-quality parabolic mirrors, which are vital components in reflecting telescopes, are typically bulky, costly, and highly fragile. This experiment explores the feasibility of using specular Class B Mylar as an unconventional, lightweight, and cost-effective alternative. This approach could enable new telescope designs by greatly reducing weight and manufacturing expenses, while also opening options for potential adaptability.   This approach involves using Mylar, a flexible, reflective style of plastic. The mylar is formed into a concave mirror by stretching a sheet over a chamber and depressurizing one side to force the sheet into the necessary curved shape. Multiple designs are being created …


Visualizing The Invisible: Simulating Electromagnetic Field In 3d Space With Matlab, Aashman Gupta, Eliane Dean, Riley Esperanca, Hailey Grabinski, Jacob Summerhays, Ameya Sute Aug 2026

Visualizing The Invisible: Simulating Electromagnetic Field In 3d Space With Matlab, Aashman Gupta, Eliane Dean, Riley Esperanca, Hailey Grabinski, Jacob Summerhays, Ameya Sute

Discovery Day - Daytona Beach

Electromagnetic field behaviours in free space are defined by Maxwell’s Equations, which couple the temporal and spatial variations of electric and magnetic fields through partial derivatives. These derivatives quantify the rate of change of each field’s vector component with respect to position and time in a 3D lattice, forming the basis for numerical field analysis. This research will develop a mathematical and computational framework using multivariable calculus to model, simulate, and visualize electromagnetic wave propagation in free space using MATLAB. Gradient, divergence, and curl operations are implemented to compute local field variations and energy transfer. The resulting data are used …


Single Fluorogens And Orientation-Localization Microscopy For Quantifying Chemical And Biomolecular Dynamics At The Nanoscale, Yiyang Chen, Yuanxin Qiu, Matthew D. Lew Aug 2026

Single Fluorogens And Orientation-Localization Microscopy For Quantifying Chemical And Biomolecular Dynamics At The Nanoscale, Yiyang Chen, Yuanxin Qiu, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Many chemical systems look uniform only because ensemble measurements average over their most interesting molecules. Electron-transfer rates vary across electrode surfaces; lipid membranes contain nanodomains with distinct packing and fluidity; peptide aggregates exhibit local polymorphism; and biomolecular condensates contain transient networks of interactions that are blurred in ensemble images. A central challenge in chemical imaging is not simply to see smaller structures, but to measure chemical variables such as polarity, redox potential, and molecular confinement at the single-molecule level. In this Account, we describe how fluorogens, molecules whose brightness, blinking, spectral shifts, orientation, rotational mobility, and motion are directly shaped …


Synthesis And Characterization Of Carbon Quantum Dots And Gold Nanoparticles For Norovirus Biosensing Applications In Water Systems, Breanne Evans Aug 2026

Synthesis And Characterization Of Carbon Quantum Dots And Gold Nanoparticles For Norovirus Biosensing Applications In Water Systems, Breanne Evans

Master's Theses

Rapid, reliable detection of viral pathogens remains a significant challenge across water-treatment and environmental monitoring systems, including drinking-water, wastewater, water reuse, and environmental surveillance applications. Waterborne viral contamination can pose substantial public-health risks, making early detection essential for protecting water quality and responding quickly to treatment failures or contamination events. Direct potable reuse (DPR) is one particularly demanding example because it requires continuous verification of treatment performance and the broader need for rapid virus monitoring extends across many water-treatment and environmental surveillance applications. Norovirus is a priority target because of its widespread occurrence in wastewater, environmental persistence, and exceptionally low …


Rapid-Prototyping Nanofabrication: Lcd-Based Projection Lithography And Physical Vapor Deposition, Sabeel Saleem Mohammmed Jun 2026

Rapid-Prototyping Nanofabrication: Lcd-Based Projection Lithography And Physical Vapor Deposition, Sabeel Saleem Mohammmed

University Honors Theses

The semiconductor industry's continued growth, driven in large part by demand for artificial intelligence hardware, has highlighted the need for greater workforce development in regions adjacent to major fabrication centers like Oregon's Silicon Forest. This capstone project lays the groundwork for a small scale and student led semiconductor fabrication lab at Portland State University by demonstrating two of the core steps in chip manufacturing: photolithography and thin film deposition. Rather than relying on conventional fixed reticles, this work explores a unique, low cost approach to patterning that uses an ultraviolet-compatible liquid crystal display (LCD) as a programmable reticle, allowing arbitrary …


Matching Two Long Interferometric Pathlengths Using Low Temporal Coherence Light For Finding Hong–Ou–Mandel Dip, Keith A. Wyman, Noah S. Everett, Anil K. Patnaik Jun 2026

Matching Two Long Interferometric Pathlengths Using Low Temporal Coherence Light For Finding Hong–Ou–Mandel Dip, Keith A. Wyman, Noah S. Everett, Anil K. Patnaik

Faculty Publications

Hong–Ou–Mandel (HOM) dip from a biphoton source in a two-photon interferometer provides a myriad of quantum tools for quantum communication and sensing. But the stringent requirements for spatial coherence between the photon pair makes it prohibitively difficult to observe high-fidelity HOM dip in long-distance free-space implementations, e.g., for the photon pairs involved in quantum communication need to match the two path lengths within a few 10 s of micron because of the short coherence width of the two-photon wave-packet. While many techniques for the pathlength balancing of two interferometric arms have been studied and applied extensively, such balancing is further …


Winddensity-Mbir: Model-Based Iterative Reconstruction For Wind Tunnel 3d Density Estimation, Karl J. Weisenburger, Gregery T. Buzzard, Charles A. Bouman, Matthew R. Kemnetz Jun 2026

Winddensity-Mbir: Model-Based Iterative Reconstruction For Wind Tunnel 3d Density Estimation, Karl J. Weisenburger, Gregery T. Buzzard, Charles A. Bouman, Matthew R. Kemnetz

Faculty Publications

Experimentalists often use wind tunnels to study aerodynamic turbulence, but most wind tunnel imaging techniques are limited in their ability to take non-invasive three-dimensional (3D) density measurements of turbulence. Wavefront tomography is a technique that uses multiple wavefront measurements from various viewing angles to non-invasively measure the 3D density field of a turbulent medium. Existing methods make strong assumptions, such as a spline basis representation, to address the ill-conditioned nature of this problem. We formulate this problem as a Bayesian, sparse-view tomographic reconstruction problem and develop a model-based iterative reconstruction algorithm for measuring the volumetric 3D density field inside a …


Improving The Reliability And Performance Of A Supersonic Indraft Tube Wind Tunnel, Christian J. Kaml Jun 2026

Improving The Reliability And Performance Of A Supersonic Indraft Tube Wind Tunnel, Christian J. Kaml

Master's Theses

Access to supersonic testing is increasing in demand, and wind tunnels remain one of the safest and most cost-effective methods for gathering high-speed flow data. Despite being more economical than alternative options, supersonic wind tunnel facilities often require substantial investment to construct, operate, and maintain.

The novel indraft tube tunnel architecture was conceived as a high-speed flow testbed that incorporates features of both Ludwieg tubes and indraft wind tunnels to maintain costs low enough to be accessible even to small universities. This design was first developed and tested in 2018 at California Polytechnic State University, featuring a cost per test …


Polarimetric Terahertz Imaging For The Measurement Of Birefringence In Plastic, Rachel Cohen May 2026

Polarimetric Terahertz Imaging For The Measurement Of Birefringence In Plastic, Rachel Cohen

Theses

Birefringence offers a promising way to observe stress concentration in materials such as glass and plastic, and thereby to identify weaknesses. Polarimetric imaging can be used to measure the birefringence of material, so long as the material is transparent to the light being used for the imaging. In this research, 2D Terahertz imaging was investigated as a means of measuring the birefringence of plastics that are opaque to visible light but transparent to THz radiation, for the eventual purpose of analyzing the residual stress present. In order to do so, two separate terahertz cameras were characterized for potential use in …


Characterizing Stiffness Dynamics Of Normal And Malignant Breast Spheroids Using Brillouin Microscopy, Razanne Rafat Zaghloul, Karlin Hilai, Chenjun Shi, Jitao Zhang May 2026

Characterizing Stiffness Dynamics Of Normal And Malignant Breast Spheroids Using Brillouin Microscopy, Razanne Rafat Zaghloul, Karlin Hilai, Chenjun Shi, Jitao Zhang

Medical Student Research Symposium

Background: Breast cancer progression and metastasis are closely linked to alterations in the mechanical properties of tumor cells and their microenvironment. Softer, more deformable cells are often associated with higher metastatic potential. While atomic force microscopy (AFM) is the current gold standard for mechanical characterization, it is limited to surface measurements and can damage 3D cultures. It remains unclear how the mechanical properties evolve over time in normal versus malignant spheroids. This study utilizes Brillouin light-scattering microscopy, a non-contact and label-free optical technique, to assess stiffness changes in normal and malignant breast epithelial spheroids over time. Understanding these mechanical signatures …


Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante May 2026

Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante

Theses and Dissertations

This thesis presents the design and simulation of an 8-tube single-ring anti-resonant hollow-core fiber for sensing applications, with particular emphasis on methane gas detection at the fundamental absorption wavelength of 3.3 µm. Conventional solid-core silica optical fibers exhibit strong multi-phonon material absorption beyond 2.5 µm, rendering them fundamentally unsuitable for efficient light guidance and direct gas sensing at mid-infrared wavelengths. Anti-resonant hollow-core fibers overcome this limitation by guiding light predominantly through an air-filled hollow core via the anti-resonant reflecting optical waveguide mechanism, in which the thin silica glass walls of the cladding tubes act as Fabry-Pérot etalons that confine the …


Characterizing Atmospheric Turbulence With The Lunar Step Response Method, Patrick D. Carattini, Caleb J. Stilp, Katelyn M. Atkinson, Stephen C. Cain Mar 2026

Characterizing Atmospheric Turbulence With The Lunar Step Response Method, Patrick D. Carattini, Caleb J. Stilp, Katelyn M. Atkinson, Stephen C. Cain

Faculty Publications

Most methods that astronomers use to characterize the strength of atmospheric turbulence in and around their observatories use differential image motion monitors observing a star to provide the necessary data for the measurement. With the Moon becoming a greater national priority, the need to characterize atmospheric paths between observatories on Earth and the Moon is potentially going to grow in the future. To this end, the differential image motion monitor is not an ideal instrument for characterizing turbulence along paths between observatories and the Moon as the bright Moon makes it difficult to detect and locate stars in its vicinity. …


Dual-Function Plasmonic Structure For Logic Operations And Circular Polarization Detection, Marjan Bazian, Mark C. Harrison Mar 2026

Dual-Function Plasmonic Structure For Logic Operations And Circular Polarization Detection, Marjan Bazian, Mark C. Harrison

Engineering Faculty Articles and Research

Many integrated photonic devices have a high potential for dual applications, making them more versatile components in photonic integrated circuits. In this study, we show that a plasmonic XOR gate structure, originally designed to perform logic operations, can also be used as a circular polarization detector. This multi-purpose capability stems from the phase-encoded input mechanism that controls the output response of the structure. We adapted this mechanism to select the output based on the polarization state of light. The design of this structure, utilizing the subwavelength field confinement of plasmonic waveguides, enables the integration of logic and detection functions into …


Computational Modeling Of Enhanced Nonlinear Optical Response In Plasmonic Waveguide Devices With Epsilon-Near-Zero Films, Kevin T. Le, Mark C. Harrison Mar 2026

Computational Modeling Of Enhanced Nonlinear Optical Response In Plasmonic Waveguide Devices With Epsilon-Near-Zero Films, Kevin T. Le, Mark C. Harrison

Engineering Faculty Articles and Research

Silicon photonics faces fundamental limitations in nonlinear applications due to weak Kerr nonlinearity, substantial two-photon absorption, and coupling challenges with subwavelength structures. This work investigates epsilon-near-zero (ENZ) materials integrated into plasmonic waveguide architectures for enhanced nonlinear photonic devices. ENZ materials exhibit nonlinear refractive indices several orders of magnitude higher than conventional materials near their zero-permittivity wavelength, enabling giant optical effects over deeply sub-wavelength interaction lengths. We present finite element method simulations of plasmonic ENZ waveguides, investigating layer thickness optimization for nonlinear enhancement while minimizing optical losses. Initial modal analysis confirms superior field confinement in hybrid plasmonic-ENZ structures compared to conventional …


Sensing Negative-Cone Rotational Diffusion Of Dipole-Like Emitters, Yuanxin Qiu, Kaizhi A. Nie, Matthew D. Lew Mar 2026

Sensing Negative-Cone Rotational Diffusion Of Dipole-Like Emitters, Yuanxin Qiu, Kaizhi A. Nie, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Fluorescence anisotropy and single-molecule orientation-localization microscopy (SMOLM) are powerful techniques that quantify the rotational diffusion of dipole-like emitters, which is important for sensing molecular interactions and chemical environments at the nanoscale. Numerous theoretical and experimental studies have thoroughly characterized single-molecule rotations even when those rotations are much faster than the detector integration time. Here, we extend the theory of measuring rotational diffusion to situations where a single dipole rotates uniformly everywhere outside of an isotropic cone of a certain size, termed a negative cone. This scenario corresponds to negative fluorescence anisotropy 𝑟 and has been observed in emitters exhibiting strong …


Proposed Methodology For Correcting Fourier-Transform Infrared Spectroscopy Field-Of-View Scene-Change Artifacts, Kody A. Wilson, Michael L. Dexter, Benjamin F. Akers, Anthony L. Franz Jan 2026

Proposed Methodology For Correcting Fourier-Transform Infrared Spectroscopy Field-Of-View Scene-Change Artifacts, Kody A. Wilson, Michael L. Dexter, Benjamin F. Akers, Anthony L. Franz

Faculty Publications

Fourier-transform spectrometers are widely used for spectral measurements. Changes in the field of view during measurement introduce oscillations into the measured spectra known as scene-change artifacts. Field-of-view changes also introduce uncertainty about which target the measured spectrum represents. Though scene-change artifacts are often present in dynamic data, their significance is disputed in the current literature. This work presents a theoretical framework and experimental validation for scene-change artifacts. Field-of-view changes introduce variable interferogram offsets, which standard processing techniques assume are constant. The error between the interferogram offset and its estimate is Fourier-transformed, yielding scene-change artifacts, often confused with noise, in the …


Design, Fabrication Modeling, And Optical Metrology Of Mwir Silicon Metalenses, Weiyu Chen Jan 2026

Design, Fabrication Modeling, And Optical Metrology Of Mwir Silicon Metalenses, Weiyu Chen

Graduate Studies Theses and Dissertations 2026

Mid-wave infrared (MWIR) optical systems require compact, broadband, manufacturable components whose performance can be predicted and measured reliably. Silicon metalenses are attractive because silicon combines high refractive index, MWIR transparency, and semiconductor-compatible fabrication. This dissertation develops a scale-bridging design–fabrication-modeling–metrology framework for MWIR silicon metalenses.

A shared full-aperture framework connects meta-atom libraries, physical layout generation, angular-spectrum propagation, point-spread-function calculation, and focal-plane energy metrics. Building on this foundation, the Dispersive Sweatt Model (DSM) incorporates meta-atom dispersion into conventional ray-tracing software, enabling broadband co-optimization of metasurfaces and refractive elements. A process-aware design framework then incorporates scanning electron microscopy (SEM)-measured height–radius relationships produced by …


Connecting The Existing Fiber Infrastructure To The Future With Antiresonant Hollow Core Fibers, Timothy Bate Jan 2026

Connecting The Existing Fiber Infrastructure To The Future With Antiresonant Hollow Core Fibers, Timothy Bate

Graduate Studies Theses and Dissertations 2026

Optical fiber systems based on solid-core silica waveguides underpin modern telecommunications, high-power laser delivery, precision sensing, and coherent optical systems. However, nonlinear effects, material absorption, and thermal limitations within silica increasingly constrain further scaling in both optical power and transmission performance. Antiresonant hollow-core fibers provide a promising alternative by guiding light predominantly in air, substantially reducing nonlinear interactions, latency, and optical damage while enabling transmission regimes inaccessible to conventional solid-core fibers. Despite rapid advances in antiresonant hollow-core fiber attenuation and power handling, one of the largest remaining barriers to widespread adoption is reliable integration with the existing solid-core fiber ecosystem. …


Integrated Optical Probes For Confocal Scanning Imaging And Adjustable Coherent-Gated Dynamic Sensing, Yonglin Huang Jan 2026

Integrated Optical Probes For Confocal Scanning Imaging And Adjustable Coherent-Gated Dynamic Sensing, Yonglin Huang

Graduate Studies Theses and Dissertations 2026

Optics and photonics have been one of the most important sciences and technologies that impact modern human life in a big way. For example, fiber-optics for communications and artificial intelligence. Optical probes are critical components for optical imaging and optical sensing technologies that have been actively researched and developed in the past decades. Advanced fiber-optic sensor probes with smaller size, better performance, lower noise, higher photon efficiency, rapid sensing time, and lower cost are needed in many applications, such as nanoscale material science, chemistry, and biomedical fields, etc.  In this project, new fiber-optic sensor probe technologies and integrated micro-optic devices …


Volumetric Fluorescence Microscopy For High-Throughput And High-Sensitivity Imaging: From Single Molecules To Tissues, Le-Mei Wang Jan 2026

Volumetric Fluorescence Microscopy For High-Throughput And High-Sensitivity Imaging: From Single Molecules To Tissues, Le-Mei Wang

Graduate Studies Theses and Dissertations 2026

Fluorescence microscopy is an indispensable tool in the biological sciences, enabling researchers to investigate intricate subcellular structures, particularly for volumetric studies. However, conventional optical microscopy for volumetric imaging remains fundamentally constrained by imaging speed and throughput. To bypass traditional serial z-scanning, we introduce an axially scan-free method using a phase layer cake to modulate the system's point spread function. This approach projects volumetric information onto a 2D plane in a single shot, offering high flexibility in tuning axial depth alongside simultaneous multicolor imaging with high spatial resolution and sensitivity. This dissertation divides these technical advancements into cellular and tissue imaging …


Impact Of Ethanol On The Evolution Of One-Step Synthesized Gold Nanoplates And Nanostars And Their Effects On Raman Signal Enhancement, Ananda Fania, Nonni Soraya Sambudi, Kirana Yuniati Putri, Yuliati Herbani, Affi Nur Hidayah Dec 2025

Impact Of Ethanol On The Evolution Of One-Step Synthesized Gold Nanoplates And Nanostars And Their Effects On Raman Signal Enhancement, Ananda Fania, Nonni Soraya Sambudi, Kirana Yuniati Putri, Yuliati Herbani, Affi Nur Hidayah

Makara Journal of Science

Gold nanoplates and nanostars were synthesized from a gold metal salt solution (HAuCl4) using a one-step synthesis method of ultraviolet C (UVC) light irradiation. The gold salt solution was mixed with ethanol in 6 mL with the following ratios: (1.5:4.5, 3:3, and 4.5:1.5), and subsequently irradiated with UVC light. Changes in localized surface plasmon resonance (LSPR) shifts were observed in real time at 30-min intervals for 2 h. The synthesis process produces gold nanoplates. While gold nanostars were synthesized from a solution of gold salt combined with ethanol, ascorbic acid, and AgNO3, maintaining a consistent ratio …


Investigation Of Laser Based Flow Diagnostics With Metastable Argon, Sterling S. Gordon Dec 2025

Investigation Of Laser Based Flow Diagnostics With Metastable Argon, Sterling S. Gordon

Physics Theses & Dissertations

The overarching motivation of this work is the development of seedless, non-intrusive, laser-based diagnostics for supersonic airflow in wind tunnels. To advance this goal, this dissertation fo-cuses on three-photon excitation in a research-grade argon beam within a tabletop vacuum system, which offers a controlled environment for testing and refining the approach. The chosen excitation scheme drives argon atoms to the 3d[5/2]₃ state using a pulsed Ti:Sapphire laser system, enabling time-of-flight (ToF) measurements on atoms that subsequently undergo a multi-step decay to the metastable 4s[3/2]₂ state. Although full realization of this excitation scheme was hindered by technical …


Active Measurement Of A Micron-Order Gap Under High-Speed And High-Temperature Conditions, Andrew Becker Oct 2025

Active Measurement Of A Micron-Order Gap Under High-Speed And High-Temperature Conditions, Andrew Becker

Doctoral Dissertations and Master's Theses

The hypersonic regime poses numerous challenges that researchers face in the development of hypersonic flight vehicles. Due to their excellent thermomechanical properties, ultra-high-temperature ceramics (UHTCs) have risen as a promising solution to act as a protective barrier between the harsh environment and surface materials of these flight bodies. The mechanical operation of a portable hypersonic simulation device was developed in-house and tested at Argonne National Laboratories (ANL) to gather in-situ material response of prospective UHTC samples when exposed to a hypersonic regime. An edge detection-based algorithm was developed and used in LabVIEW to monitor the health and operation of the …


Plasmonic Nanoparticle Integration On Fiber Optic: Role Of Organic Linker And Functionalization Length In Refractive Index Sensing, Shela Ilmiyah, Mohamad Syahadi, Muflikhah Muflikhah, Yuwana Pradana, Zainul Arifin Iman Supardi, Iwan Darmadi, Lia Aprilia Sep 2025

Plasmonic Nanoparticle Integration On Fiber Optic: Role Of Organic Linker And Functionalization Length In Refractive Index Sensing, Shela Ilmiyah, Mohamad Syahadi, Muflikhah Muflikhah, Yuwana Pradana, Zainul Arifin Iman Supardi, Iwan Darmadi, Lia Aprilia

Makara Journal of Science

Nanoplasmonic fiber optic sensors leverage the optical fiber’s inherent compactness and surface sensitivity via evanescent-field interactions with the localized surface plasmon resonance of the metallic nanoparticles. One of the popular approaches is self-assembly owing to its relatively low cost. Despite its low cost, the self-assembly technique has low reproducibility and exhibits low sensitivity because of low nanoplasmonic coverage on the fiber optic surface. In this study, several fabrication techniques were explored to assess the refractive index sensitivity by comparing three common organosilanes, i.e., (3-Aminopropyl)triethoxysilane (APTES), (3-Aminopropyl)trimethoxysilane, and (3-Mercaptopropyl)trimethoxysilane. Comparative analyses assessed the anchoring efficiency of the three silanes, sensor reproducibility, …


Single-Molecule Orientation And Localization Microscopy, Sophie Brasselet, Matthew D. Lew Sep 2025

Single-Molecule Orientation And Localization Microscopy, Sophie Brasselet, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Single-molecule localization microscopy (SMLM) offers enhanced spatial resolution in optical microscopy, providing detailed insights into the spatial organization of proteins in cells at the nanoscale. Over the past decade, SMLM has progressively incorporated the capability to retrieve the orientations of single molecules using their polarized dipolar emission pattern. Here we explore recent advancements in single-molecule orientation and localization microscopy (SMOLM), which yields super-resolved images of molecular three-dimensional (3D) orientations, wobble and 3D positions. This advancement opens possibilities to explore the nanoscale organization and conformation of biological molecules as well as to monitor and design local 3D optical fields in nanophotonics. …


Low-Cost Cutaneous Protoporphyrin Ix (Ppix) Detection (Cpd) Device For Follow-Up Monitoring Of Patients After Photodynamic Therapy, Md Asaduzzaman Rasel Aug 2025

Low-Cost Cutaneous Protoporphyrin Ix (Ppix) Detection (Cpd) Device For Follow-Up Monitoring Of Patients After Photodynamic Therapy, Md Asaduzzaman Rasel

Graduate Masters Theses

Background: Photodynamic Therapy (PDT) utilizes specific wavelengths of light to activate photosensitizing chemical compounds, known as photosensitizers, which induce the generation of cytotoxic reactive oxygen species (ROS) for the targeted destruction of cancer cells. Among various photosensitizers for PDT, Protoporphyrin IX (PpIX) is widely employed in oncology and dermatology due to its natural in situ generation via the metabolic conversion of 5- aminolevulinic acid (ALA), a non-phototoxic prodrug. Systemic administration of ALA after 3-6 hr drug delay leads to peak PpIX accumulation in tissues, facilitating therapeutic and diagnostic applications. However, PpIX can persist in the skin for 24–48 hours post-treatment, …


Design And Development Of A Standalone Digital Holographic Microscope Employing Phase-Driven Reconstruction And Classification For Biomedical Imaging And Optical Diagnostics, Charlotte Kyeremah Aug 2025

Design And Development Of A Standalone Digital Holographic Microscope Employing Phase-Driven Reconstruction And Classification For Biomedical Imaging And Optical Diagnostics, Charlotte Kyeremah

Graduate Doctoral Dissertations

Access to advanced biomedical imaging technologies remains a significant challenge in resource-limited settings, especially for early disease detection and monitoring of diseases such as malaria, HIV, and other blood-borne diseases. Although point-of-care (POC) devices have gained popularity in global health, many rely on antibody-based tests, lateral flow strips, or optical readouts that often lack quantitative capabilities, sensitivity to early infections, or versatility in different diagnostic targets. In addition, these systems are typically dependent on disposable reagents or manual interpretation, which limits their effectiveness in remote areas. Digital Holographic Microscopy (DHM) presents a promising alternative as a label-free imaging method capable …


Method For Target Detection In A High Noise Environment Through Frequency Analysis Using An Event-Based Vision Sensor, Will Johnston, Shannon Young, David Howe, Rachel Oliver, Zachary Theis, Brian Mcreynolds, Michael L. Dexter Aug 2025

Method For Target Detection In A High Noise Environment Through Frequency Analysis Using An Event-Based Vision Sensor, Will Johnston, Shannon Young, David Howe, Rachel Oliver, Zachary Theis, Brian Mcreynolds, Michael L. Dexter

Faculty Publications

Event-based vision sensors (EVSs), often referred to as neuromorphic cameras, operate by responding to changes in brightness on a pixel-by-pixel basis. In contrast, traditional framing cameras employ some fixed sampling interval where integrated intensity is read off the entire focal plane at once. Similar to traditional cameras, EVSs can suffer loss of sensitivity through scenes with high intensity and dynamic clutter, reducing the ability to see points of interest through traditional event processing means. This paper describes a method to reduce the negative impacts of these types of EVS clutter and enable more robust target detection through the use of …


Volumetric Imaging Of Cellular Dynamics Using Light-Sheet Microscopy: From Subcellular Structures To Whole Organisms, Md Nasful Huda Prince Aug 2025

Volumetric Imaging Of Cellular Dynamics Using Light-Sheet Microscopy: From Subcellular Structures To Whole Organisms, Md Nasful Huda Prince

Optical Science and Engineering ETDs

Advancing biomedical imaging requires platforms that combine high-resolution, speed, and stability across biological scales. This dissertation presents three innovations designed to address limitations of conventional light-sheet and oblique plane imaging. First, we introduce Reflected Inline Detection in Epi-Oblique Plane Microscopy (RIDE-OPM), a compact and drift-resistant system that eliminates a tertiary detection path while maintaining alignment flexibility, enabling robust long-term live imaging. Second, we present a high-speed Axially Swept Light-Sheet Microscopy (ASLM) platform for cleared tissues, using dual foci and synchronized sweeping to achieve isotropic sub-micron resolution at up to 40 frames-per-second, a fourfold improvement over standard ASLM. Integrated with a …


Enhanced Point Cloud Generation From A Novel 360° Underwater Lidar, Olagoke E. Daramola Aug 2025

Enhanced Point Cloud Generation From A Novel 360° Underwater Lidar, Olagoke E. Daramola

Dissertations

This dissertation presents novel algorithms to improve the mapping capabilities of a 360-degree underwater Pulsed Laser Line Scanner LiDAR (PLLS-360°). Due to its 360° field-of-view (FOV), the PLLS-360° is a compact full-waveform omnidirectional imager suitable for seafloor mapping, underwater asset inspection, object detection, ice-sheet mapping, and construction progress monitoring. The proposed methodology includes an improved waveform fitting technique for saturated waveform recovery, detection array response correction, radiometric corrections, and fusion of LiDAR and sonar bathymetric datasets. The first part of this dissertation assesses the LiDAR’s performance and describes how the data for this unique 360° FOV architecture is processed. The …