Pseudomonas aeruginosa is a Gram-negative bacterium commonly found throughout the environment. It is a significant cause of disease and mortality in immunodeficient patients such as those suffering from cystic fibrosis (CF). Due to the emerging antibiotic resistance of P. aeruginosa, it is becoming increasingly more challenging to treat an infection by traditional means. Further complicating treatment, P. aeruginosa secretes a protein known as Inhibitor of Vertebrate Lysozyme (PaIVY) that binds to and inhibits C-type lysozyme, thus preventing the degradation of the bacterium. A reactive chemical warhead was synthesized from a rhenium(I) tricarbonyl derivative inorder to bind to and irreversibly …

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Denver - 1991 Parking Garage May 2021

Denver - 1991 Parking Garage

United States Data - Colorado

No abstract provided.

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Denver - 1989 University & I-25 May 2021

Denver - 1989 University & I-25

United States Data - Colorado

Relevant Publications

Environmental Science & Technology Publication (1990)

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Tuscan - 1994 May 2021

Tuscan - 1994

United States Data - Arizona

Relevant Publications

Environmental Science & Technology Publication (1996)

Final Report

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Grand Junction - 2001 May 2021

Grand Junction - 2001

United States Data - Colorado

Relevant Publications

Final Report

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Collin / Denton - 2002 - 2003 May 2021

Collin / Denton - 2002 - 2003

United States Data - Texas

No abstract provided.

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Austin - 1998 May 2021

Austin - 1998

United States Data - Texas

Relevant Publications

1998 Final Report

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Seatac Intl. Airport - 2013 May 2021

Seatac Intl. Airport - 2013

United States Data - Washington

Relevant Publications

Environmental Science & Technology Publication (2016)

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Phoenix May 2021

Phoenix

United States Data - Arizona

Relevant Publications

Environmental Science & Technology Publication (2008)

Denver - 1991 6th & I-70 May 2021

Denver - 1991 6th & I-70

United States Data - Colorado

Relevant Publications

Environmental Science & Technology Publication (1993)

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Glenwood Springs - 2001 May 2021

Glenwood Springs - 2001

United States Data - Colorado

Relevant Publications

Final Report

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Ute Pass - 1989 May 2021

Ute Pass - 1989

United States Data - Colorado

Relevant Publications

Environmental Science & Technology Publication (1996)

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Omaha - 2002 / 2004 May 2021

Omaha - 2002 / 2004

United States Data - Nebraska

Relevant Publications

2004 Final Report

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Suzuki Coupling Catalyzed By (8-(Dimesitylboryl)Quinoline)Palladium(0) Species: A Theoretical Analysis, Haley S. Rust May 2021

Suzuki Coupling Catalyzed By (8-(Dimesitylboryl)Quinoline)Palladium(0) Species: A Theoretical Analysis, Haley S. Rust

Honors Thesis

The Suzuki reaction is a catalyzed cross-coupling reaction which is of upmost importance in the formation of carbon-carbon (C-C) bonds in modern organic synthesis. Recently a new catalyst including an 8-(dimesitylboryl)quinoline for the coupling of aryl halides with phenylboronic acids was synthetized. We synthesized ligand that includes a frustrated Lewis pair, (quinolin-8-yl)dimesitylborane (DMBQ), complexed it with group X metals (nickel (Ni), palladium (Pd), and platinum (Pt)), and studied the process of oxidative addition with carbon-fluorine (C-F) bonds and activation towards Suzuki coupling. Mayer bond analysis and electron localization function maps showed a bond between the boron center in the ligand …

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Initial Investigation Of Wildflower Honey Using Headspace Solid-Phase Microextraction Coupled With Gas Chromatography-Mass Spectrometry For Geographical Information, Tyra Countiss May 2021

Initial Investigation Of Wildflower Honey Using Headspace Solid-Phase Microextraction Coupled With Gas Chromatography-Mass Spectrometry For Geographical Information, Tyra Countiss

Honors Theses

Honey has been used as a food, sugar substitute, and flavor enhancer forever. The uses for honey are extremely varied from food to medicine. It is widely touted that you can address seasonal allergies, especially those following a move, by eating local honey. For this to be true the composition of the local honey, including trapped pollen, would allow allergy symptoms to be eliminated. In this project, the volatile and semi-volatile aroma compounds in wild flower honey from several different locations were analyzed. Headspace solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) was used to help develop the …

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One-Pot Synthesis Of Disubstituted Primary Amines From Nitriles Via Grignard Addition And Metal-Alcohol Reduction, Joshua Peltan May 2021

One-Pot Synthesis Of Disubstituted Primary Amines From Nitriles Via Grignard Addition And Metal-Alcohol Reduction, Joshua Peltan

Honors Theses

The process of developing a working base case procedure for a novel one-pot-two-step synthesis of primary amines from Grignard reagents, nitriles, sodium metal or alkali metal loaded silica gel, and alcohol is described. Initial steps towards applying the process broadly are detailed. The process has the potential to be an affordable, convenient, safer, greener, and more accessible alternative to exiting methods of accomplishing the same transformation. The reaction scheme has been proven to provide yields and purity comparable to existing methods for certain pairs of substrates; however, its utility as a general-purpose method for transforming arbitrary pairs of Grignard reagent …

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Computational And Experimental Studies Of Functionalized Phenolic Tertiary Phosphine Oxides As Organocatalysts For The Redox-Neutral Mitsunobu Reaction, Sadie Brown May 2021

Computational And Experimental Studies Of Functionalized Phenolic Tertiary Phosphine Oxides As Organocatalysts For The Redox-Neutral Mitsunobu Reaction, Sadie Brown

Electronic Theses and Dissertations

The purpose of this thesis was the identification of a more efficient catalyst analog that could perform the redox-neutral Mitsunobu reaction, which was achieved via two synthetic pathways: elimination-addition and addition-rearrangement. Furthermore, a computational investigation was conducted on the conflicting interpretations of the catalytic cycle. Our research group replicated Houk et al. work, as well as expanded the computations to examine the influence different functional groups had on the ground state and transition state structures. Important ground state and transition state structures were determined, which provided a more energetically favorable pathway of the catalytic cycle. Experimental work demonstrated that both …

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El Paso / Juarez - 1993 May 2021

El Paso / Juarez - 1993

United States Data - Texas

Relevant Publications

Environmental Science & Technology Publication (1996)

1993 Final Report

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Quantification Of Persistent Organic Pollutants In Various Matrices Using Stir Bar Sorptive Extraction And Isotope Dilution Mass Spectrometry, Weier Hao May 2021

Quantification Of Persistent Organic Pollutants In Various Matrices Using Stir Bar Sorptive Extraction And Isotope Dilution Mass Spectrometry, Weier Hao

Electronic Theses and Dissertations

A method was developed to quantify persistent organic pollutants (POPs) in a wide range of matrices including wastewater, dietary supplements, and human whole blood using stir-bar sorptive extraction, GC-MS/MS, and isotope dilution mass spectrometry (IDMS). The method enabled accurate, precise, sensitive, and efficient quantification of POPs in these matrices. Compared with calibration curves, IDMS provided measurements with a higher level of accuracy and precision, especially at lower measured concentrations. The use of GC-MS/MS enabled a lower limit of quantification compared with GC-MS. A reverse-IDMS method was performed to further eliminate biases from the labelled concentrations of the commercially available standards. …

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Proton Pump Inhibitors Promote Apoptosis In Jurkat T Lymphocytes, Asher Utz May 2021

Proton Pump Inhibitors Promote Apoptosis In Jurkat T Lymphocytes, Asher Utz

Departmental Honors & Graduate Capstone Projects

Cancer cells are known to rely on the anaerobic energy pathway of glycolysis even under normoxic conditions, resulting in measurable intracellular acidification that may trigger cell death by apoptosis. In normal cells, the pH is restored by activation of voltage-gated proton pumps, preventing apoptosis. Proton pump inhibitors (PPIs), such as omeprazole, inhibit the action of these voltage-gated proton pumps. Research has shown that omeprazole is also capable of inducing caspase-dependent apoptosis in Jurkat T-lymphocytes, but this area of study remains largely unexplored. The goal of this research was to determine the temporal dynamics of caspase activity in Jurkat cells treated …

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