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Articles 31 - 60 of 97
Full-Text Articles in Physical Sciences and Mathematics
Multiple Recoding Mechanisms Produce Cyclooxygenase And Cyclooxygenase-Related Proteins From Frameshift-Containing Cox-3/Cox-1b Transcripts In Rat And Human, John Cameron Hunter
Multiple Recoding Mechanisms Produce Cyclooxygenase And Cyclooxygenase-Related Proteins From Frameshift-Containing Cox-3/Cox-1b Transcripts In Rat And Human, John Cameron Hunter
Theses and Dissertations
To increase diversity of enzymes and proteins, cells mix and match exonic and intronic regions retained in mature mRNAs by alternative splicing. An estimated 94% of all multi-exon genes express one or more alternatively spliced transcripts generating proteins with similar or modified functions. Cyclooxygenase is a signaling enzyme that catalyzes the rate-limiting step in the synthesis of diverse bioactive lipids termed prostaglandins. Prostaglandins are involved in myriad physiological and pathopysiological processes including vasoregulation, stomach mucosal maintenance, parturition, pain, fever, inflammation, neoplasia and angiogenesis and are inhibited by aspirin-like drugs known as NSAIDs. In 2002 an alternatively spliced, intron-1 retaining variant …
Flow Valve Diagnostics For Label-Free, Quantitative Biomarker Detection: Device Fabrication, Surface Modification, And Testing, Danielle Scarlet Mansfield
Flow Valve Diagnostics For Label-Free, Quantitative Biomarker Detection: Device Fabrication, Surface Modification, And Testing, Danielle Scarlet Mansfield
Theses and Dissertations
Diseases are often diagnosed by detection of disease-specific biomarkers in fluid samples. However, many state-of-the-art detection methods require a lab with complex machinery, trained operators, and/or lengthy analysis time. In contrast, point-of-care (POC) devices are brought to the patient's location, they are easy to use, and results are obtained almost immediately. Many current POC devices are too difficult to be used without a skilled assistant, and although many are able to detect analytes above a threshold value, they give little or no quantitative information. This work presents the development of polymer-based microfluidic devices capable of sensing and quantifying biomarkers in …
Synthesis And Biological Evaluation Of Various Derivatives Of A Broad-Spectrum Anticancer Nucleoside, Jadd R. Shelton
Synthesis And Biological Evaluation Of Various Derivatives Of A Broad-Spectrum Anticancer Nucleoside, Jadd R. Shelton
Theses and Dissertations
Recently the Peterson lab discovered a promising anticancer adenosine derivative-- 2´,3´-bis-O-tert-butyldimethylsilyl-5´-deoxy-5´-[N-(methylcarbamoyl)amino]-N6-(N-phenylcarbamoyl)adenosine. This compound showed selective toxicity against human colon cancer cells in vitro with LC50's = 6--10 µM. It was hypothesized that the lead compound exerted its cytotoxic effects by interacting with a protein kinase. A systematic Structure Activity Relationship (SAR) was undertaken in an attempt to increase the kinase-binding affinity of the lead compound. Many regions of the lead compound were examined: the N6-phenyl urea moiety, the 5´-N-methyl urea group, the 2´,3´-bis-O-TBS groups, the nucleobase, and the ribose sugar. Results of these studies produced some promising new derivatives. In …
Quantum Dynamics Using Lie Algebras, With Explorations In The Chaotic Behavior Of Oscillators, Ryan Thomas Sayer
Quantum Dynamics Using Lie Algebras, With Explorations In The Chaotic Behavior Of Oscillators, Ryan Thomas Sayer
Theses and Dissertations
We study the time evolution of driven quantum systems using analytic, algebraic, and numerical methods. First, we obtain analytic solutions for driven free and oscillator systems by shifting the coordinate and phase of the undriven wave function. We also factorize the quantum evolution operator using the generators of the Lie algebra comprising the Hamiltonian. We obtain coupled ODE's for the time evolution of the Lie algebra parameters. These parameters allow us to find physical properties of oscillator dynamics. In particular we find phase-space trajectories and transition probabilities. We then search for chaotic behavior in the Lie algebra parameters as a …
Self-Organizing Fluid Flow Patterns In Crystalline Rock: Theoretical Approach To The Hydrothermal Systems In The Middle Fork Of The Boise River, Scott A. Himes
Self-Organizing Fluid Flow Patterns In Crystalline Rock: Theoretical Approach To The Hydrothermal Systems In The Middle Fork Of The Boise River, Scott A. Himes
Theses and Dissertations
The thermal springs along the Middle Fork of the Boise River (MFBR) within the Atlanta lobe of the Idaho batholith discharge in discrete locations that appear to be part of self-organizing flow systems. Infiltrating water flows through Basin and Range fractures to depth where it is heated and ultimately discharged at the intersection of trans-Challis oriented faults along the MFBR. Isotopic compositions of the thermal waters have a linear trend with elevation suggesting that the recharge locations are near each thermal spring and the hydrothermal system is not one large interconnected system, but rather multiple individual hydrothermal systems. Water chemically …
Array-Based Characterization Of Military Jet Aircraft Noise, David William Krueger
Array-Based Characterization Of Military Jet Aircraft Noise, David William Krueger
Theses and Dissertations
Since the 1950s the jet aeroacoustics community has been involved in predicting and measuring the noise distribution in jets. In this work, cylindrical and planar Fourier near-field acoustical holography are used to investigate radiation from a full-scale, installed jet engine. Practical problems involving measurement aperture and the highly directional nature of the source are addressed. Insights from numerical simulations reveal usable reconstruction regions. A comparison of cylindrical and planar NAH for the respective measurement apertures shows cylindrical NAH outperforms planar NAH on reconstructions both towards and away from the source.
An Integrated Screening And Optimization Strategy, Nathaniel Jackson Rohbock
An Integrated Screening And Optimization Strategy, Nathaniel Jackson Rohbock
Theses and Dissertations
Within statistical methods, design of experiments (DOE) is well suited to make good inference from a minimal amount of data. Two types of designs within DOE are screening designs and optimization designs. Traditionally, these approaches have been necessarily separated by a gap between the objectives of each design and the methods available. Despite being so separated, in practice these designs are frequently connected by sequential experimentation. In fact, from the genesis of a project, the experimentor often knows that both designs will be necessary to accomplish his objectives. Due to advances in the understanding of experimental designs with complex aliasing …
Geologic Map Of The Deer Point Quadrangle, Garfield County, Utah, Nicholaus D. Driscoll
Geologic Map Of The Deer Point Quadrangle, Garfield County, Utah, Nicholaus D. Driscoll
Theses and Dissertations
A new geologic map of the Deer Point 7.5' quadrangle located in the southern region of Capitol Reef National Park in south-central Utah provides stratigraphic and structural detail not previously available. The Deer Point quadrangle was mapped at a scale of 1:24,000 and is the fourth geologic map completed at this scale in Capitol Reef National Park. Twelve Quaternary units and eighteen bedrock formations and members are exposed in the Deer Point quadrangle. Bedrock formations range in age from Triassic to Cretaceous. The details not available on previous geologic maps include: four alluvial terrace units, two lacustrine units, two mass …
A General Framework For Interactive Television News, Benjamin Bart Sellers
A General Framework For Interactive Television News, Benjamin Bart Sellers
Theses and Dissertations
We design a complete interactive television news system. We develop a news production system that allows for the creation of flexible, content-rich interactive news. This system embraces a general creation process to interactive news that is built on top of a newscast model that evolves from and conforms with the current production newscast model. It allows for content sharing and content reuse. We also create an interactive news viewing system that adapts well to a living room environment. It contains several interactive features designed to give the viewer control and allow them to watch the news when, where, and how …
Analog Feedback Control Of Broadband Fan Noise, Cole Victor Duke
Analog Feedback Control Of Broadband Fan Noise, Cole Victor Duke
Theses and Dissertations
Active noise control (ANC) has been implemented using analog filters to reduce broadband noise from a small axial cooling fan. Previous work successfully attenuated narrow-band, tonal portions of the noise using a digital controller. The practical performance limits of this system were reached and it was desirable to attenuate the noise further. Additional research, therefore, sought to attenuate broadband noise from the fan using a digital controller, but performance was limited by the group delay inherent in the digital signal processor (DSP). Current research attempts to further attenuate broadband noise and improve performance of the system by combining the tonal …
Mineral Chemistry Of Basalts Recovered From Hotspot Snake River Scientific Drilling Project, Idaho: Source And Crystallization Characteristics, Richard W. Bradshaw
Mineral Chemistry Of Basalts Recovered From Hotspot Snake River Scientific Drilling Project, Idaho: Source And Crystallization Characteristics, Richard W. Bradshaw
Theses and Dissertations
Mineral chemistry and petrography of basalts from the Kimama drill core recovered by Hotspot: Snake River Scientific Drilling Project, Idaho establish crystallization conditions of these lavas. Twenty-three basalt samples, from 20 individual lava flows were sampled from the upper 1000 m (of the 1912 m drilled) core drilled on the axis of the Snake River Plain, and represent approximately 3 m.y. of volcanism (rocks at the bottom of the hole are ~6 Ma). Rock from the upper 1000 m are typically fresh, while those lower in the core are more altered and are less likely to preserve fresh phenocrysts to …
Methods Of Music Classification And Transcription, Jonathan Peter Baker
Methods Of Music Classification And Transcription, Jonathan Peter Baker
Theses and Dissertations
We begin with an overview of some signal processing terms and topics relevant to music analysis including facts about human sound perception. We then discuss common objectives of music analysis and existing methods for accomplishing them. We conclude with an introduction to a new method of automatically transcribing a piece of music from a digital audio signal.
Temporal Trends In West Antarctic Accumulation Rates: Evidence From Observed And Simulated Records, Landon Kelly Burgener
Temporal Trends In West Antarctic Accumulation Rates: Evidence From Observed And Simulated Records, Landon Kelly Burgener
Theses and Dissertations
Reconstructed snow accumulation rate observations from five new firn cores show a statistically significant negative trend in accumulation rates over the past four decades across the central West Antarctic ice sheet. A negative temporal trend in accumulation is unexpected in light of rising surface temperatures and simulations run by GCMs. Both the magnitude of the mean accumulation rates and the range of interannual variability observed in the new records compares favorably to older records, suggesting that the new accumulation rate records may serve as a regional proxy for recent temporal trends in West Antarctic accumulation rates. The observed negative trend …
A Maple Program For Computing Landau-Ginzburg A- And B-Models And An Exploration Of Mirror Symmetry, Evan D. Merrell
A Maple Program For Computing Landau-Ginzburg A- And B-Models And An Exploration Of Mirror Symmetry, Evan D. Merrell
Theses and Dissertations
Mirror symmetry has been a significant area of research for geometry and physics for over two decades. Berglund and Hubsch proposed that for a certain family of singularities W, the so called "transposed" singularity WT should be the mirror partner of W. cite{BH} The techniques for constructing the orbifold LG models to test this conjecture were developed by FJR in cite{FJR} with a cohomological field theory generalized from the study of r-spin curves. The duality of LG A- and B-models became more elaborate when Krawitz cite{Krawitz} generalized the Intriligator-Vafa orbifold B-model to include contributions from more than one sector.This thesis …
The Synthesis And Structural Characterization Of Metal Oxide Nanoparticles Having Catalytic Applications, Stacey Janel Smith
The Synthesis And Structural Characterization Of Metal Oxide Nanoparticles Having Catalytic Applications, Stacey Janel Smith
Theses and Dissertations
Nanotechnology is blossoming into one of the premiere technologies of this century, but the key to its progress lies in developing more efficient nanosynthesis methods. Variations in synthetic technique, however, can cause variations in size, structure, and surface characteristics, thereby altering the physical properties and functionality of the particles. Careful structural characterizations are thus essential for understanding the properties and appropriate applications for particles produced by new synthetic techniques.In this work, a new ‘solvent-deficient’ method is presented for the synthesis of an unprecedentedly wide range of metal oxide nanomaterials including at least one metal oxide from each group in Groups …
Detection Likelihood Maps For Wilderness Search And Rescue: Assisting Search By Utilizing Searcher Gps Track Logs, Michael Thomas Roscheck
Detection Likelihood Maps For Wilderness Search And Rescue: Assisting Search By Utilizing Searcher Gps Track Logs, Michael Thomas Roscheck
Theses and Dissertations
Every year there are numerous cases of individuals becoming lost in remote wilderness environments. Principles of search theory have become a foundation for developing more efficient and successful search and rescue methods. Measurements can be taken that describe how easily a search object is to detect. These estimates allow the calculation of the probability of detection—the probability that an object would have been detected if in the area. This value only provides information about the search area as a whole; it does not provide details about which portions were searched more thoroughly than others. Ground searchers often carry portable …
Total Character Groups, Chelsea Lorraine Kennedy
Total Character Groups, Chelsea Lorraine Kennedy
Theses and Dissertations
The total character of a finite group G is the sum of the irreducible characters of G. When the total character of a finite group can be written as a monic polynomial with integer coefficients in an irreducible character of G, we say that G is a total character group. In this thesis we examine the total character of the dicyclic group of order 4n, the non-abelian groups of order p^3, and the symmetric group on n elements for all n ≥ 1. The dicyclic group of order 4n is a total character group precisely when n is congruent to …
K-S-Rings, Emma Louise Turner
K-S-Rings, Emma Louise Turner
Theses and Dissertations
For a finite group G we study certain rings called k-S-rings, one for each non-negative integer k, where the 1-S-ring is the centralizer ring of G. These rings have the property that the (k+1)-S-ring determines the k-S-ring. We show that the 4-S-ring determines G when G is any group with finite classes. We show that the 3-S-ring determines G for any finite group G, thus giving an answer to a question of Brauer. We show the 2-characters defined by Frobenius and the extended 2-characters of Ken Johnson are characters of representations of the 2-S-ring of G. We find the character …
Unknotting Tunnels Of Hyperbolic Tunnel Number N Manifolds, Stephan Daniel Burton
Unknotting Tunnels Of Hyperbolic Tunnel Number N Manifolds, Stephan Daniel Burton
Theses and Dissertations
Adams conjectured that unknotting tunnels of tunnel number 1 manifolds are always isotopic to a geodesic. We generalize this question to tunnel number n manifolds. We find that there exist complete hyperbolic structures and a choice of spine of a compression body with genus 1 negative boundary and genus n ≥ 3 outer boundary for which (n−2) edges of the spine self-intersect. We use this to show that there exist finite volume one-cusped hyperbolic manifolds with a system of n tunnels for which (n−1) of the tunnels are homotopic to geodesics arbitrarily close to self-intersecting. This gives evidence that the …
An Applied Investigation Of Gaussian Markov Random Fields, Jessica Lyn Olsen
An Applied Investigation Of Gaussian Markov Random Fields, Jessica Lyn Olsen
Theses and Dissertations
Recently, Bayesian methods have become the essence of modern statistics, specifically, the ability to incorporate hierarchical models. In particular, correlated data, such as the data found in spatial and temporal applications, have benefited greatly from the development and application of Bayesian statistics. One particular application of Bayesian modeling is Gaussian Markov Random Fields. These methods have proven to be very useful in providing a framework for correlated data. I will demonstrate the power of GMRFs by applying this method to two sets of data; a set of temporal data involving car accidents in the UK and a set of spatial …
Technique And Cue Selection For Graphical Presentation Of Generic Hyperdimensional Data, Lee Mont Howard
Technique And Cue Selection For Graphical Presentation Of Generic Hyperdimensional Data, Lee Mont Howard
Theses and Dissertations
The process of visualizing n-D data presents the user with four problems: finding a hyperdimensional graphics package capable of rendering n-D data, finding a suitable presentation technique supported by the package that allows insight to be gained, using the provided user interface to interact with the presentation technique to explore the information in the data, and finding a way to share the information gained with others. Many graphics packages have been written to solve the first problem. However, existing packages do not sufficiently solve the other three problems. A hyperdimensional graphics package that sufficiently solves all these problems simplifies the …
Xprime-Em: Eliciting Expert Prior Information For Motif Exploration Using The Expectation-Maximization Algorithm, Wei Zhou
Theses and Dissertations
Understanding the possible mechanisms of gene transcription regulation is a primary challenge for current molecular biologists. Identifying transcription factor binding sites (TFBSs), also called DNA motifs, is an important step in understanding these mechanisms. Furthermore, many human diseases are attributed to mutations in TFBSs, which makes identifying those DNA motifs significant for disease treatment. Uncertainty and variations in specific nucleotides of TFBSs present difficulties for DNA motif searching. In this project, we present an algorithm, XPRIME-EM (Eliciting EXpert PRior Information for Motif Exploration using the Expectation-Maximization Algorithm), which can discover known and de novo (unknown) DNA motifs simultaneously from a …
Analysis And Design Tools For Structured Feedback Systems, Anurag Rai
Analysis And Design Tools For Structured Feedback Systems, Anurag Rai
Theses and Dissertations
As we begin to analyze and construct extremely complex systems, a theory for understanding and designing the underlying architecture becomes very important. To move in the direction of a precise theory of architecture, this thesis will provide some concrete tools to analyze and design complex systems with a given network structure. The first main result of this thesis analyzes the vulnerability of a system and shows that a system's vulnerability depends on its network structure. We will consider destabilization attacks acting on a single link in a system's logical interconnection structure. The concept of a vulnerable link is characterized and …
Spread Option Pricing With Stochastic Interest Rate, Yi Luo
Spread Option Pricing With Stochastic Interest Rate, Yi Luo
Theses and Dissertations
In this dissertation, we investigate the spread option pricing problem with stochastic interest rate. First, we will review the basic concept and theories of stochastic calculus, give an introduction of spread options and provide some examples of spread options in different markets. We will also review the market efficiency theory, arbitrage and assumptions that are commonly used in mathematical finance. In Chapter 3, we will review existing spread pricing models and term-structure models such as Vasicek Mode, and the Heath-Jarrow-Morton framework. In Chapter 4, we will use the martingale approach to derive a partial differential equation for the price of …
Persistence And Foliation Theory And Their Application To Geometric Singular Perturbation, Ji Li
Persistence And Foliation Theory And Their Application To Geometric Singular Perturbation, Ji Li
Theses and Dissertations
Persistence problem of compact invariant manifold under random perturbation is considered in this dissertation. Under uniformly small random perturbation and the condition of normal hyperbolicity, the original invariant manifold persists and becomes a random invariant manifold. The random counterpart has random local stable and unstable manifolds. They could be invariantly foliated thanks to the normal hyperbolicity. Those underlie an extension of the geometric singular perturbation theory to the random case which means the slow manifold persists and becomes a random manifold so that the local global structure near the slow manifold persists under singular perturbation. A normal form for a …
New Computational Techniques In Fjrw Theory With Applications To Landau Ginzburg Mirror Symmetry, Amanda Francis
New Computational Techniques In Fjrw Theory With Applications To Landau Ginzburg Mirror Symmetry, Amanda Francis
Theses and Dissertations
Mirror symmetry is a phenomenon from physics that has inspired a lot of interesting mathematics. In the Landau-Ginzburg setting, we have two constructions, the A and B models, which are created based on a choice of an affine singularity with a group of symmetries. Both models are vector spaces equipped with multiplication and a pairing (making them Frobenius algebras), and they are also Frobenius manifolds. We give a result relating stabilization of singularities in classical singularity to its counterpart in the Landau-Ginzburg setting. The A model comes from so-called FJRW theory and can be de fined up to a full …
Diagonal Entry Restrictions In Minimum Rank Matrices, And The Inverse Inertia And Eigenvalue Problems For Graphs, Curtis G. Nelson
Diagonal Entry Restrictions In Minimum Rank Matrices, And The Inverse Inertia And Eigenvalue Problems For Graphs, Curtis G. Nelson
Theses and Dissertations
Let F be a field, let G be an undirected graph on n vertices, and let SF(G) be the set of all F-valued symmetric n x n matrices whose nonzero off-diagonal entries occur in exactly the positions corresponding to the edges of G. Let MRF(G) be defined as the set of matrices in SF(G) whose rank achieves the minimum of the ranks of matrices in SF(G). We develop techniques involving Z-hat, a process termed nil forcing, and induced subgraphs, that can determine when diagonal entries corresponding to specific vertices of G must be zero or nonzero for all matrices in …
Estimation Of The Effects Of Parental Measures On Child Aggression Using Structural Equation Modeling, Jordan Daniel Pyper
Estimation Of The Effects Of Parental Measures On Child Aggression Using Structural Equation Modeling, Jordan Daniel Pyper
Theses and Dissertations
A child's parents are the primary source of knowledge and learned behaviors for developing children, and the benefits or repercussions of certain parental practices can be long lasting. Although parenting practices affect behavioral outcomes for children, families tend to be diverse in their circumstances and needs. Research attempting to ascertain cause and effect relationships between parental influences and child behavior can be difficult due to the complex nature of family dynamics and the intricacies of real life. Structural equation modeling (SEM) is an appropriate method for this research as it is able to account for the complicated nature of child-parent …
Active Noise Control Of A Centrifugal Fan Mounted In A Mock Laptop Enclosure, John J. Esplin
Active Noise Control Of A Centrifugal Fan Mounted In A Mock Laptop Enclosure, John J. Esplin
Theses and Dissertations
Noise from information technology (IT) equipment is a significant problem in today's modern society. Active Noise Control (ANC) has shown promise in reducing the effect of IT fan noise on users. Though ANC has been applied to axial fans (such as those found in desktop computers), it has not been applied to centrifugal fans, such as those found in laptop computers. This work applies an ANC method to a centrifugal fan mounted in a mock laptop enclosure. This method is applied in four steps. First, secondary sources are placed in the vicinity of the fan. Second, an accurate model of …
Weak Cayley Table Isomorphisms, Long Pham Bao Nguyen
Weak Cayley Table Isomorphisms, Long Pham Bao Nguyen
Theses and Dissertations
We investigate weak Cayley table isomorphisms, a generalization of group isomorphisms. Suppose G and H are groups. A bijective map phi : G to H is a weak Cayley table isomorphism if it satisfies two conditions:(1) If x is conjugate to y, then phi(x) is conjugate to phi(y); (2) For all x, y in G, phi(xy) is conjugate to phi(x)phi(y).If there exists a weak Cayley table isomorphism between two groups, then we say that the two groups have the same weak Cayley table.This dissertation has two main goals. First, we wish to find sufficient conditions under which two groups have …