Physical Sciences and Mathematics Commons^™

Synthesis, In Vitro, And In Vivo Evaluation Of Novel N-Phenylindazolyl Diarylureas As Potential Anti-Cancer Agents., Lucas N Solano, Grady L Nelson, Conor T Ronayne, Shirisha Jonnalagadda, Sravan K Jonnalagadda, Kaija Kottke, Robert Chitren, Joseph L Johnson, Manoj K Pandey, Subash C. Jonnalagadda, Venkatram R Mereddy

Faculty Scholarship for the College of Science & Mathematics

Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC50 values in the range of 0.4–50 μM in several cancer cell lines including murine metastatic breast cancer 4T1, murine glioblastoma GL261, human triple negative breast cancer MDA-MB-231, human pancreatic cancer MIAPaCa-2, and human colorectal cancer cell line WiDr. The ester group in the lead compound 8i was modified to incorporate amino-amides to increase solubility and stability while retaining biological activity. Further in vitro studies reveal that lead candidates inhibit tube length in HUVEC …

Sure 2020 Undergraduate Science Conference Booklet, Sure Network

Group Reports

The SURE 2020 Conference was the third series of Science Undergraduate Research Experience (SURE) Conferences, following earlier series in 2018 (with three conferences in Dublin, Athlone and Waterford) and in 2019 (with three conferences in Dublin, Sligo and Carlow). The 2020 online conference had a total of 24 oral presentations and 35 poster presentations, and was attended by over 450 students, academic staff, professional body and industry representatives.

The aims of the conference were to:

1. Provide current students with an opportunity to gain an understanding of the work which has been undertaken by recent graduates, and the career opportunities that …

Mobilizing Crop Biodiversity, Susan Mccouch, Zahra Katy Navabi, Michael Abberton, Noelle L. Anglin, Rosa Lia Barbieri, Michael Baum, Kirstin Bett, Helen Booker, Gerald L. Brown, Glenn J. Bryan, Luigi Cattivelli, David Charest, Kellye Eversole, Marcelo Freitas, Kioumars Ghamkhar, Dario Grattipaglia, Robert Henry, Maria Cleria Valadares Inglis, Tofazzal Islam, Zakaria Kehel, Paul J. Kersey, Graham J. King, Stephen Kresovich, Emily Marden, Sean Mayes, Marie Noelle Ndjiondjiop, Henry T. Nguyen, Samuel Rezende Paiva, Roberto Papa, Peter W.B. Phillips, Awais Rasheed

College of Agriculture and Life Sciences Faculty Publications

No abstract provided.

Elaia 2020/2021, Stephen Case

ELAIA

Volumes 3/4, 2020/2021

Modeling The Influence Of Public Risk Perceptions On The Adoption Of Green Stormwater Infrastructure: An Application Of Bayesian Belief Networks Versus Logistic Regressions On A Statewide Survey Of Households In Vermont, Qing Ren, Asim Zia, Donna M. Rizzo, Nancy Mathews

College of Engineering and Mathematical Sciences Faculty Publications

There is growing environmental psychology and behavior literature with mixed empirical evidence about the influence of public risk perceptions on the adoption of environmentally friendly “green behaviors”. Adoption of stormwater green infrastructure on residential properties, while costlier in the short term compared to conventional greywater infrastructure, plays an important role in the reduction of nutrient loading from non-point sources into freshwater rivers and lakes. In this study, we use Bayesian Belief Networks (BBNs) to analyze a 2015 survey dataset (sample size = 472 respondents) about the adoption of green infrastructure (GSI) in Vermont’s residential areas, most of which are located …

Mapping Disparities In Covid-19: Determining The Demographic, Economic, Educational, Housing, Quality Of Life, And Health Factors That Relate To Disparities In Covid-19 Infections And Deaths, Kate Stanley, Naima Shifa

Annual Student Research Poster Session

Background: Throughout the pandemic, minority groups, particularly African Americans and Hispanic/Latino Americans have experienced disproportionately high infection and death rates as compared to their white and Asian counterparts. Though this phenomenon could be attributed to high rates of pre-existing conditions in black and Hispanic communities, there are other underlying factors that cause such disparity. We set out to determine whether or not various demographic, economic, educational, health, housing, and quality of life indicators were correlated with higher rates of COVID-19 infection.

Methods: We used USAFacts COVID-19 data to select the 150 United States counties with the highest infection rates. We …

Santa Clara Magazine, Volume 61 Number 3, Fall 2020 [Print Issue V.61:2], Santa Clara University

Santa Clara Magazine

16 - THE GIFT Is sacrifice, given willingly and with love, what makes us human? Leslie Griffy.

20 - NOT A MOMENT, BUT A MOVEMENT From protests in Benson in 1969 to a multi-decade movement called Unity, students of color have consistently pushed SCU to progress. Matt Morgan.

28 - ON BEING BETTER Discover the ways we can better support each other, particularly as white people seek to become allies to people of color. Lauren Loftus.

32 - THE SACRIFICIAL TWEET Social media missteps are costly, perhaps now more than ever. Just what are we willing to give up to …

Pattern Of Health Behavior And Its Association With Self-Rated Health: Evidence From The 2018 Behavioral Risk Factor Surveillance System In The United States, Linh Nguyen, Mamunur Rashid, M Mazharul Islam

Annual Student Research Poster Session

Physical inactivity, tobacco use, and alcohol consumption are linked with increased morbidity and mortality. To improve public health services, we need to keep policymakers updated with health-related issues. Yet, there are limited numbers of recent research on the combination of those lifestyle behaviors as the determinants of self-rated health (SRH) in the US. Therefore, this study (1) examines the pattern of physical activities, smoking, alcohol consumption, and SRH, and (2) investigates the association between the behaviors and SRH status among US citizens. We extracted data from the latest state-based survey of the 2018 Behavioral Risk Factor Surveillance System (BRFSS), which …

Genome-Wide Association Study In Accessions Of The Mini-Core Collection Of Mungbean (Vigna Radiata) From The World Vegetable Gene Bank (Taiwan), Alena Sokolkova, Marina Burlyaeva, Tatjana Valiannikova, Margarita Vishnyakova, Roland Schafleitner, Cheng Ruei Lee, Chau Ti Ting, Ramakrishnan Madhavan Nair, Sergey Nuzhdin, Maria Samsonova, Eric Von Wettberg

College of Agriculture and Life Sciences Faculty Publications

Background: Mungbean (Vigna radiata (L.) R. Wilczek, or green gram) is important tropical and sub-tropical legume and a rich source of dietary protein and micronutrients. In this study we employ GWAS to examine the genetic basis of variation in several important traits in mungbean, using the mini-core collection established by the World Vegetable Center, which includes 296 accessions that represent the major market classes. This collection has been grown in a common field plot in southern European part of Russia in 2018. Results: We used 5041 SNPs in 293 accessions that passed strict filtering for genetic diversity, linkage disequilibrium, population …

Imaging Data On Characterization Of Retinal Autofluorescent Lesions In A Mouse Model Of Juvenile Neuronal Ceroid Lipofuscinosis (Cln3 Disease), Qing Jun Wang, Kyung Sik Jung, Kabhilan Mohan, Mark E. Kleinman

Ophthalmology and Visual Science Faculty Publications

Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3 disease), a lethal pediatric neurodegenerative disease without cure, often presents with vision impairment and characteristic ophthalmoscopic features including focal areas of hyper-autofluorescence. In the associated research article “Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium” (Zhong et al., 2020) [1], we reported ophthalmoscopic observations of focal autofluorescent lesions or puncta in the Cln3^Δex7/8 mouse retina at as young as 8 month old. In this data article, we performed differential interference contrast and …

Gym Usage Behavior & Desired Digital Interventions: An Empirical Study, Meeralakshmi Radhakrishnan, Archan Misra, Rajesh Krishna Balan, Youngki Lee

Research Collection School Of Computing and Information Systems

Understanding individual’s exercise motives, participation patterns in a gym and reasons for dropout are essential for designing strategies to help gym-goers with long-term exercise adherence. In this work, we derive insights on various exercise-related behaviors of gymgoers, including evidence of a significant number of individuals exhibiting early dropout and also describing their attitudes towards digital technologies for sustained gym participation. By utilizing gym visitation data logs of 6513 individuals over a longitudinal period of 16 months in a campus gym, we show the retention and dropout rates of gym-goers. Our data indicates that 32% of the people quit their gym …

Instability Of Glucocorticoid Metabolites In Coyote Scats: Implications For Field Sampling, Erika T. Stevenson, Eric M. Gese, Lorin A. Neuman-Lee, Susannah S. French

USDA Wildlife Services: Staff Publications

Studying physiologic stress responses can assist in understanding the welfare of animals. One method of measuring the physiologic stress response is evaluating concentrations of glucocorticoid metabolites in feces. Previously, using an adrenocorticotropic hormone challenge, we found fecal glucocorticoid metabolite levels were a reliable indicator of physiologic stress response in coyotes (Canis latrans). We determine whether glucocorticoid metabolite concentrations remain stable when collecting feces over a 2-week period, a timeframe commonly used in scat surveys for wild canids. We collected feces from 6 captive coyotes maintained at the U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Predator …

Tools, Techniques And Teamwork: Transferring New Technologies For Wildlife Management, Conservation And Economic Development, John Eisemann, Gail Keirn

USDA Wildlife Services: Staff Publications

Did you ever wonder who invented radio telemetry? Or breakaway snares? What about the bird repellent methyl anthranilate or the livestock protection collar? These and many other tools used in wildlife damage management resulted from creative thinking by biologists, technicians, researchers and managers working to solve complex wildlife issues. Over the past 90 years, these “aha moments” within the U.S. Department of Agriculture’s Wildlife Services program have ranged from developing novel scare devices, traps and vaccines to exploiting an animal’s visual capabilities to stop unwanted behaviors. Once discovered, these unique ideas may lead to practical, feasible and cost-effective wildlife damage …

Dynamical Climatic Model For Time To Flowering In Vigna Radiata, Konstantin Kozlov, Alena Sokolkova, Cheng Ruei Lee, Chau Ti Ting, Roland Schafleitner, Eric Bishop-Von Wettberg, Sergey Nuzhdin, Maria Samsonova

College of Agriculture and Life Sciences Faculty Publications

Background: Phenology data collected recently for about 300 accessions of Vigna radiata (mungbean) is an invaluable resource for investigation of impacts of climatic factors on plant development. Results: We developed a new mathematical model that describes the dynamic control of time to flowering by daily values of maximal and minimal temperature, precipitation, day length and solar radiation. We obtained model parameters by adaptation to the available experimental data. The models were validated by cross-validation and used to demonstrate that the phenology of adaptive traits, like flowering time, is strongly predicted not only by local environmental factors but also by plant …

Modeling Alternative Collaborative Governance Network Designs: An Agent-Based Model Of Water Governance In The Lake Champlain Basin, Vermont, Patrick Bitterman, Christopher J. Koliba

College of Agriculture and Life Sciences Faculty Publications

Published by Oxford University Press on behalf of the Public Management Research Association. With the widespread use of collaborative governance mechanisms for mitigating water pollution, an opportunity exists to test alternative institutional designs based on collaborative governance theory using computer simulation models, particularly when there is a clear relationship between governance networks, observable resource allocation decisions, and measurable outcomes. This is especially the case for wicked problems like nonpoint source water pollution where there are compelling questions regarding how best to design policies, allocate funds, and build administrative capacity to meet water quality standards. We present an agent-based model (ABM) …

2020 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Beth Heldebrandt

Programs

The 2020-2021 academic year is truly extraordinary and higher education’s new, hopefully temporary, normal began on rather short notice in Spring 2020. While our environment has changed, we, as a shared community, are pleased that the important work of faculty continues and evolves as faculty broaden and redefine the boundaries of scholarship, creativity, and innovation in accelerating hybrid and remote environments. And, as new forms and strategies for scholarship and creativity emerge, the core principles of faculty life and student learning remain central to the mission of Eastern Illinois University.

For that reason, our faculty, department chairs, college deans, the …

Contrasting Cumulative Risk And Multiple Individual Risk Models Of The Relationship Between Adverse Childhood Experiences (Aces) And Adult Health Outcomes, Marianna Lanoue, Brandon George, Deborah L Helitzer, Scott W Keith

College of Population Health Faculty Papers

BACKGROUND: A very large body of research documents relationships between self-reported Adverse Childhood Experiences (srACEs) and adult health outcomes. Despite multiple assessment tools that use the same or similar questions, there is a great deal of inconsistency in the operationalization of self-reported childhood adversity for use as a predictor variable. Alternative conceptual models are rarely used and very limited evidence directly contrasts conceptual models to each other. Also, while a cumulative numeric 'ACE Score' is normative, there are differences in the way it is calculated and used in statistical models. We investigated differences in model fit and performance between the …

Single‐Molecule 3d Orientation Imaging Reveals Nanoscale Compositional Heterogeneity In Lipid Membranes, Jin Lu, Hesam Mazidi, Tianben Ding, Oumeng Zhang, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

In soft matter, thermal energy causes molecules to continuously translate and rotate, even in crowded environments, thereby impacting the spatial organization and function of most molecular assemblies, such as lipid membranes. Directly measuring the orientation and spatial organization of large collections (>3000 molecules μm⁻²) of single molecules with nanoscale resolution remains elusive. In this paper, we utilize SMOLM, single‐molecule orientation localization microscopy, to directly measure the orientation spectra (3D orientation plus “wobble”) of lipophilic probes transiently bound to lipid membranes, revealing that Nile red's (NR) orientation spectra are extremely sensitive to membrane chemical composition. SMOLM images resolve …

Integrated Multiparametric Radiomics And Informatics System For Characterizing Breast Tumor Characteristics With The Oncotypedx Gene Assay, Michael A. Jacobs, Christopher B. Umbricht, Vishwa S. Parekh, Riham H. El Khouli, Leslie Cope, Katarzyna J. Macura, Susan Harvey, Antonio C. Wolff

Radiology Faculty Publications

Optimal use of multiparametric magnetic resonance imaging (mpMRI) can identify key MRI parameters and provide unique tissue signatures defining phenotypes of breast cancer. We have developed and implemented a new machine-learning informatic system, termed Informatics Radiomics Integration System (IRIS) that integrates clinical variables, derived from imaging and electronic medical health records (EHR) with multiparametric radiomics (mpRad) for identifying potential risk of local or systemic recurrence in breast cancer patients. We tested the model in patients (n = 80) who had Estrogen Receptor positive disease and underwent OncotypeDX gene testing, radiomic analysis, and breast mpMRI. The IRIS method was trained …

Nanoscale Battery Cathode Materials Induce Dna Damage In Bacteria, Tian A. Qiu, Valeria Guidolin, Khoi Nguyen L. Hoang, Thomas Pho, Andrea Carra, Peter W. Villalta, Jiayi He, Xiaoxiao Yao, Robert J. Hamers, Silvia Balbo, Z Vivian Feng, Christy L. Haynes

Faculty Authored Articles

The increasing use of nanoscale lithium nickel manganese cobalt oxide (LixNiyMnzCo1−y−zO2, NMC) as a cathode material in lithium-ion batteries poses risk to the environment. Learning toxicity mechanisms on molecular levels is critical to promote proactive risk assessment of these complex nanomaterials and inform their sustainable development. We focused on DNA damage as a toxicity mechanism and profiled in depth chemical and biological changes linked to DNA damage in two environmentally relevant bacteria upon nano-NMC exposure. DNA damage occurred in both bacteria, characterized by double-strand breakage and increased levels of many putative chemical modifications on bacterial DNA bases related to direct …

Investigating The Significance Of Aerosols In Determining The Coronavirus Fatality Rate Among Three European Countries, Wenzhao Li, Rejoice Thomas, Hesham El-Askary, Thomas Piechota, Daniele Struppa, Khaled A. Abdel Ghaffar

Mathematics, Physics, and Computer Science Faculty Articles and Research

The coronavirus pandemic has not only gripped the scientific community in the search for a vaccine or a cure but also in attempts using statistics and association analysis—to identify environmental factors that increase its potency. A study by Ogen (Sci Total Environ 726:138605, 2020a) explored the possible correlation between coronavirus fatality and high nitrogen dioxide exposure in four European countries—France, Germany, Italy and Spain. Meanwhile, another study showed the importance of nitrogen dioxide along with population density in determining the coronavirus pandemic rate in England. In this follow-up study, Aerosol Optical Depth (AOD) was introduced in conjunction with other variables …

Use Of Advanced Statistical Techniques To Predict All-Cause Mortality In The Systolic Blood Pressure Intervention Trial, William Kostis, Javier Cabrera, Chun Pang Lin, John Kostis, Jennifer Wellings, Stavros Zinonos, Jeanne Dobrzynski, Daniel Blickstein

Department of Medicine Faculty Papers

Background: The Systolic Blood Pressure Intervention Trial (SPRINT) was conducted in patients with hypertension and additional risk for cardiovascular disease who were randomized to the intensive blood pressure group targeting systolic blood pressure (SBP) less than 120 mm Hg and to the standard group where the target was less than 140 mm Hg. Analyses were done in the matched group of participants with the same gender, same age (±2 years) and same SBP (±3 mm Hg) at three months of treatment regardless of initial randomization to intensive or standard group (shaded area in Figure 1). Methods and results: During 3.26 …

The Impact Of A Six‐Year Climate Anomaly On The “Spanish Flu” Pandemic And Wwi, Alexander F. More, Christopher P. Loveluck, Heather Clifford, Michael J. Handley, Andrei V. Kurbatov, Michael Mccormick, Paul A. Mayewski

Teaching, Learning & Research Documents

Research study on the links between climate change and the 1918 flu pandemic.

Editorial: Wild Plants As Source Of New Crops, Eric Von Wettberg, Thomas M. Davis, Petr Smýkal

College of Agriculture and Life Sciences Faculty Publications

No abstract provided.

Nucleic Acid Delivery With Α-Tocopherol-Polyethyleneimine-Polyethylene Glycol Nanocarrier System., A K M Nawshad Hossian, Seetharama D Jois, Subash C. Jonnalagadda, George Mattheolabakis

Faculty Scholarship for the College of Science & Mathematics

Purpose: Nucleic acid-based therapies are a promising therapeutic tool. The major obstacle in their clinical translation is their efficient delivery to the desired tissue. We developed a novel nanosized delivery system composed of conjugates of α-tocopherol, polyethyleneimine, and polyethylene glycol (TPP) to deliver nucleic acids.

Methods: We synthesized a panel of TPP molecules using different molecular weights of PEG and PEI and analyzed with various analytical approaches. The optimized version of TPP (TPP

Results: Through a panel of synthesized molecules, TPP

Conclusion: These results indicate that we successfully synthesized the TPP

Personalized Medicine: The Use Of Biomarkers And Molecularly Targeted Therapies For Patient Care And Cancer Intervention, Wafa Asad, Emily Schmitt Lavin

Mako: NSU Undergraduate Student Journal

Personalized medicine and targeted therapy have been emerging fields of study for the remediation and inhibition of cancer. Personalized medicine in the treatment of cancer involves using genetic, immune, and proteomic profiling to provide therapeutic options as well as prognostic background for every patient and their tumor’s genetic mutations. Targeted therapies allow researchers and medical personnel alike to determine the appropriate treatment for a patient based on the molecular basis and mechanistic actions of a cancerous tumor. The overall significance of this study was to express how these treatments use biomarkers to pinpoint the location, and severity of the cancer, …

Design And Synthesis Of Core–Shell Microgels With One‐Step Clickable Crosslinked Cores And Ultralow Crosslinked Shells, Molla R. Islam, Chelsea Nguy, Sanika Pandit, L. Andrew Lyon

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The present study is conducted to explore the engineering of core–shell microgels such that the core can be rapidly labeled with a variety of fluorophores, while the shell retains the softness needed in specific biomedical applications. Azide containing crosslinked core particles based on a crosslinked poly(N‐isopropylacrylamide) particle, using a one‐pot, multistep polymerization is synthesized. A core–shell microgel is then synthesized by growing a crosslinker‐free poly(N‐isopropylacrylamide)‐co‐acrylic acid (ULC10AAc) shell through a two‐step seed and feed polymerization. A simple “click” reaction between the azide present on the core and dibenzocyclooctyne containing fluorophores to make dyed core–shell …

Mitochondrial Oxidative And Nitrosative Stress And Alzheimer Disease, D. Allan Butterfield, Debra Boyd-Kimball

Chemistry Faculty Publications

Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive impairment (MCI). A major source of free radicals that lead to oxidative and nitrosative damage is mitochondria. This review paper discusses oxidative and nitrosative stress and markers thereof in the brain, along with redox proteomics, which are techniques that have been pioneered in the Butterfield laboratory. Selected biological alterations in—and oxidative and nitrosative modifications of—mitochondria in AD and MCI and systems of relevance thereof also are presented. The review article concludes with a section …

Exploring The Eating Disorder Examination Questionnaire, Clinical Impairment Assessment, And Autism Quotient To Identify Eating Disorder Vulnerability: A Cluster Analysis, Natalia Stewart Rosenfield, Erik Linstead

Engineering Faculty Articles and Research

Eating disorders are very complicated and many factors play a role in their manifestation. Furthermore, due to the variability in diagnosis and symptoms, treatment for an eating disorder is unique to the individual. As a result, there are numerous assessment tools available, which range from brief survey questionnaires to in-depth interviews conducted by a professional. One of the many benefits to using machine learning is that it offers new insight into datasets that researchers may not previously have, particularly when compared to traditional statistical methods. The aim of this paper was to employ k-means clustering to explore the Eating Disorder …

Perspective Article: Actions To Reconfigure Food Systems, Ana Maria Loboguerrero, Philip Thornton, Jonathan Wadsworth, Bruce M. Campbell, Mario Herrero, Daniel Mason-D'Croz, Dhanush Dinesh, Sophia Huyer, Andy Jarvis, Alberto Millan, Eva Wollenberg, Stephen Zebiak

Rubenstein School of Environment and Natural Resources Faculty Publications

There is broad agreement that current food systems are not on a sustainable trajectory that will enable us to reach the Sustainable Development Goals by 2030, particularly in the face of anthropogenic climate change. Guided by a consideration of some food system reconfigurations in the past, we outline an agenda of work around four action areas: rerouting old systems into new trajectories; reducing risks; minimising the environmental footprint of food systems; and realigning the enablers of change needed to make new food systems function. Here we highlight food systems levers that, along with activities within these four action areas, may …