Physical Sciences and Mathematics Commons^™

Nicotine In Tobacco Product Aerosols: 'It's Deja Vu All Over Again', Anna K. Duell, James F. Pankow, David H. Peyton

Chemistry Faculty Publications and Presentations

Introduction: The distribution of nicotine among its free-base (fb) and protonated forms in aerosolised nicotine affects inhalability. It has been manipulated in tobacco smoke and now in electronic cigarettes by the use of acids to de-freebase nicotine and form ‘nicotine salts’.

Methods: Measurements on electronic cigarette fluids (e-liquids) were carried out to determine (1) the fraction of nicotine in the free-base form (α fb) and (2) the levels of organic acid(s) and nicotine. Samples included JUUL ‘pods’, ‘look-a-like/knock-off’ pods and some bottled ‘nicotine salt’ and ‘non-salt’ e-liquids.

Results: α fb= 0.12 ±0.01 at 40°C (≈ 37°C) for 10 JUUL products, …

Ronald E. Mcnair Scholars Program Profiles And Abstracts 2020, Mcnair Scholars Program

McNair Symposium

This is the complete event program and provides presentation abstracts and biographies of McNair scholars and their mentors.

Combating Covid On College Campuses: The Impact Of Structural Changes On Viral Transmissions, Jared Knofczynski, Aria Killebrew Bruehl, Ben Warner, Ryne Shelton

altREU Projects

One of the most significant issues in the COVID-19 pandemic is the reopening of schools while minimizing the transmission of coronavirus. Opportunities for evaluating the effectiveness of policies that might be utilized at such institutions are limited, as the necessary empirical data has not been gathered yet. Agent-based modeling, where various entities within an environment are simulated as agents, offers an opportunity to examine the effectiveness of various policies in a way that drastically minimizes the health and economic risks involved. Agent-based modeling is common within biology, ecology and other fields; and has seen some use within the coronavirus literature. …

Hypergraph Analysis Of Structure Models, Cliff A. Joslyn, Teresa D. Schmidt, Martin Zwick

Systems Science Faculty Publications and Presentations

Theoretical discussion on the analysis of hypergraph networks; application of analysis methods to hypergraph networks derived by applying Reconstructability Analysis to health care data (the PhD dissertation work of Teresa Schmidt).

Addressing Parameter Uncertainty In Sd Models With Fit-To-History And Monte-Carlo Sensitivity Methods, Wayne Wakeland, Jack Homer

Systems Science Faculty Publications and Presentations

We present a practical guide, including a step-by-step flowchart, for establishing uncertainty intervals for key model outcomes in the face of uncertain parameters. The process starts with Powell optimization (e.g., using VensimTM) to find a set of uncertain parameters (the “optimum” parameter set or OPS) that minimize the model fitness error relative to available reference behavior data. The optimization process also helps in refinement of assumed parameter uncertainty ranges. Next, Markov Chain Monte Carlo (MCMC) or conventional Monte Carlo (MC) randomization is used to create a sample of parameter sets that fit the reference behavior data nearly as well as …

Inhibition Of Cancer Causing Genes Through The Delivery Of Omomyc In Anti-Myc Therapy: A Systematic Review, Angie Mcgraw

University Honors Theses

A systematic review of the available studies on the interference of OmoMyc with Myc's function in cancerous cells is presented. Myc is a transcription factor that regulates cellular processes such as apoptosis, proliferation, and differentiation. However, Myc is often overexpressed in a variety of cancers, resulting in abnormal growth of cancer cells. Although the inhibition of Myc has been highly desired, it remained a challenge due to its undruggable characteristics. Attempts to inhibit Myc have involved the usage of small-molecules, but these attempts have failed, causing adverse effects and incomplete inhibition of Myc. Despite promising preclinical studies of OmoMyc, it …

Water 4.0, Arthur Preston

OHSU-PSU School of Public Health Annual Conference

A review of local drinking water quality/technologies, and strategies to improve water quality using emerging next generation technology.

Statistical Analysis Of Social Network Change, Teresa D. Schmidt

Systems Science Friday Noon Seminar Series

We explore two statistical methods that infer social network structures and statistically test those structures for change over time: regression-based differential network analysis (R-DNA) and information theory-based differential network analysis (I-DNA). RDNA is adapted from bioinformatics and I-DNA employs reconstructability analysis. Both methods are used to analyze Medicaid claims data from one-year periods before and after the formation of the Health Share of Oregon Coordinated Care Organization (CCO). We hypothesized that Health Share’s CCO formation would be followed by several changes in the healthcare delivery network.

Application of R-DNA and I-DNA to claims data involves three steps: (a) the inference …

Synthesis Of Radioluminescent Caf2:Ln Core, Mesoporous Silica Shell Nanoparticles For Use In X-Ray Based Theranostics, Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun, Andrea M. Goforth

Chemistry Faculty Publications and Presentations

X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF₂ core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu …

Boron Trifluoride Etherate Promoted Microwave Assisted Synthesis Of Antimalarial Acridones, Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Jane X. Kelly

Chemistry Faculty Publications and Presentations

A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Several of the synthesized acridones exhibited potent antimalarial activities against CQ sensitive and multi-drug resistant (MDR) parasites.