Physical Sciences and Mathematics Commons^™

Applied Molecular Dynamics: From Targeting Viral Helicases, To Understanding The Interactions Of Cucurbituril Complexes In Ionic Solutions, Bryan Raubenolt

University of New Orleans Theses and Dissertations

Molecular Dynamics simulations are a highly useful tool in helping understand the fundamental interactions present in a variety of chemical systems. The work discussed here illustrates it’s use in determining the conformational dynamics of the Zika and SARS-Cov-2 helicase in a physiological environment, largely in an effort to discover inhibitors capable of rendering the protein inert. Additionally, we show how it can be used to understand paradoxical trends in the anion-induced precipitation of Cucurbituril cavitands.

Viral helicases are motor proteins tasked with unwinding the viral dsRNA, a crucial step in preparing the strand to be translatable by host cells. By …

Regional Integration: Physician Perceptions On Electronic Medical Record Use And Impact In South West Ontario, Sadiq Raji

Electronic Thesis and Dissertation Repository

Regional initiatives in the health care context in Canada are typically organized and administered along geographic boundaries or operational units. Regional integration of Electronic Medical Records (EMR) has been continuing across Canadian provinces in recent years, yet the use and impact of regionally integrated EMRs are not routinely assessed and questions remain about their impact on and use in physicians’ practices. Are stated goals of simplifying connections and sharing of electronic health information collected and managed by many health services providers being met? What are physicians’ perspectives on the use and impact of regionally integrated EMR? In this thesis, I …

Improving Hydrid Pet/Mri Cardiovascular Imaging With Improved Hardware Design And Attenuation Correction Coefficient, Adam Helmy Farag

Electronic Thesis and Dissertation Repository

According to the World Health Organization (WHO) report in 2019, cardiovascular diseases (CVD) cause 52% of all illness-related deaths globally and are considered to be the second most common cause of death in Canada. CVD is also estimated to cost the Canadian economy about $21.2 billion in direct and indirect costs. With these figures, it is vital to develop the most effective and accurate methods and tools to diagnose accurately CVD and their causes. One of the promising tools for accurate diagnostic and therapeutic of CVD is the integrated Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) PET/MRI technology, …

Development Of Computational Tools To Target Microrna, Luo Song

Dissertations & Theses (Open Access)

MicroRNAs (a.k.a, miRNAs) play an important role in disease development. However, few of their structures have been determined and structure-based computational methods remain challenging in accurately predicting their interactions with small molecules. To address this issue, my thesis is to develop integrated approaches to screening for novel inhibitors by targeting specific structure motifs in miRNAs. The project starts with implementing a tool to find potential miRNA targets with desired motifs. I combined both sequence information of miRNAs and known RNA structure data from Protein Data Bank (PDB) to predict the miRNA structure and identify the motif to target, then I …

Eelgrass (Zostera Marina) Population Decline In Morro Bay, Ca: A Meta-Analysis Of Herbicide Application In San Luis Obispo County And Morro Bay Watershed, Tyler King Sinnott

Master's Theses

The endemic eelgrass (Zostera marina) community of Morro Bay Estuary, located on the central coast of California, has experienced an estimated decline of 95% in occupied area (reduction of 344 acres to 20 acres) from 2008 to 2017 for reasons that are not yet definitively clear. One possible driver of degradation that has yet to be investigated is the role of herbicides from agricultural fields in the watershed that feeds into the estuary. Thus, the primary research goal of this project was to better understand temporal and spatial trends of herbicide use within the context of San Luis …

Narrowing The Wealth And Income Gap In Poland, China, And The United States, Cyndy Carboo, Zhiling Song, Jiawei Feng, Xudong Zhu

School of Professional Studies

With the widespread of globalization, the wealth gap continues to widen globally. Due to the enormous differences in national conditions and political systems of various countries, this article selects China, the United States, and Poland as the research objects, and uses a specific time unit as the benchmark, and mainly focuses on the four directions of medical care, education, job opportunities, and pensions. A reader could understand the correlation between the wealth gap and multiple factors deeply in this article. This article analyzes the impact of income disparity on these three countries and proposes solutions to help narrow the gap …

The Impact Of Special Interest Groups On The Federal Dietary Guidelines: Consequences For American Health, Dory Mcmillan

School of Professional Studies

This research paper explores the impact of relationships between lobbyists and both the USDA and HSS, and the impact these relationships have on the Dietary Guidelines for Americans that the agencies work together to create. The paper focuses specifically on the information the guidelines present in regard to red meat consumption, and the impacts this may have on American health, and healthcare costs associated. It was hypothesized that a relationship would be found between special interest groups and the U.S. Department of Health and Human Services and/or the U.S. Department of Agriculture. Research found there was a relationship between special …

Healthy Food Portal Business Plan And Its Function Model, Alena Raupova

School of Professional Studies

Business planning is a tool of paramount importance in the process of company management, on the efficiency of which the future functioning of the enterprise depends. Formation of a business plan enables the team to productively and competently use existing funds and resources in their work and apply planning as a very effective management mechanism (Hamm, 2016).

The goal of this final project is to develop a business plan for a healthy nutrition portal for Bellyful LLC. Bellyful is based in Boston, USA, and the portal will be its first product. Our client is interested in researching the prospects of …

Worst Time Being Poor? The Hunger Problem In U.S. During Covid-19 Pandemic, Yuanhang Hu

School of Professional Studies

Food insecurity is deeply rooted in American society during and before the COVID-19 pandemic. Food Insecurity usually associates with economic indicators, such as unemployment rate, income level, etc. Currently, there are two main tools to fight the war of hunger. The first one is the government food assistance programs. And the second one is food pantries from the private sectors of the community. Both tools are facing numerous challenges due to COVID-19. The purpose of this article is to provide rational reasons to persuade the government to enhance the benefits of the Supplemental Nutrition Assistance Program (SNAP) and use administrative …

Rcap Solutions Breach Management - Case Study, Eugene Adu-Gyamfi, Gio Al Muarrawi, Kwame Ofori

School of Professional Studies

Companies get hacked every day, and our in-scope company for this case study, RCAP Solution, was not an exception. Security incidents have increased both in volume and range in recent years, and cyber-attacks have become more sophisticated than ever before. There are so many reasons that drive this fact; one is that our infrastructure was not protected efficiently, but also attackers have become more knowledgeable in initiating advanced attacks at a scale. Additionally, the entrance of emerging technologies such as blockchain, machine learning, and the internet of things, added additional complexity to the already complex scene. Cybercriminals are using various …

A Web-Based Ai Assistant Application Using Python And Javascript, Viet Le, Tej Bahadur, Jainee Shah, Roushan Ara

School of Professional Studies

Our research is mainly based on a chatbot which is powered by Artificial Intelligence. Nowadays, Artificial Intelligence assistants such as Apple’s Siri, Google’s Now and Amazon’s Alexa are currently fast-growing and widely integrated with many smart devices. These assistants are built with the primary purpose of being personal assistants for every individual user in certain contexts. In this research, we would highlight the development process of the chatbots, features, problems, case studies and limitations.

This research delivers the information, helps developers to build answer bots and integrate chatbots with business accounts. The aim is to assist users and allow transactions …

The Killingly Mascot Case Study, Jordan Lumpkins

School of Professional Studies

In the summer of 2019, in Killingly, Connecticut the local Board of Education voted to retire the "Redmen" mascot name it had used for nearly a century. This legislation was widely opposed and received extensive media coverage. Within a few months, the town experienced a massive political referendum where several local Board of Education members and Councilmen were replaced by single issue politicians promising to reinstate the "Redmen" name. Now holding a majority on the Board of Education, these Board members made Killingly the first school in U.S. history to reinstate a mascot after being deemed "derogatory."

It is the …

How Museum Utilize Social Media On Communication, Jiake Han

School of Professional Studies

With the development of Internet, social media became more and more popular among people. Many industries realize the importance of social media in business. Traditionally, museum concentrates more on personal visual experience, which is hard to be replaced by online media. However, museums now also put more concentrate on social media platform because it expands the way of engagement. Especially, for Coronavirus, many organizations including museums have to close. Therefore, museums have to depend more on social media platforms to communicate with audiences. This research aims at finding how different kind of social media help museum communicate and engage with …

Cvs Covid-19 Screening Website: Test Automation, Savya Rawat

School of Professional Studies

CVS Pharmacy is an American retail corporation, also known as, and originally named, the Consumer Value Store owned by CVS Health, it is headquartered in Woonsocket, Rhode Island. CVS Pharmacy is currently the largest pharmacy chain in the United States by number of locations over 9,600 and total prescription revenue. CVS sells prescription drugs and a wide assortment of general merchandise, including over-the-counter drugs.

Now, coming to the reason why I have selected CVS pharmacy’s website cvs.com as my case study topic is because of CVS’s response to the covid-19 pandemic’s no-cost testing strategy. Whole of the world is suffering …

The Practical Applications Of Video Games Beyond Entertainment, Jack Martin

School of Professional Studies

Much of the attention directed toward video games is focused on their role as entertainment. However, researchers have found that video games can have other, more practical uses for society. This thesis is designed to examine three specific examples of the practical applications of video games: video games in education, video games as accessible technology, and the social uses of video games. This project is based on pre-existing research conducted by professionals studying the aforementioned subtopics. Anecdotal stories from educators, people with disabilities, and developers are also discussed. The thesis explores specific examples of video games being used practically, and …

Transparency And Yielding Of Law Officers Reform (Taylor) Act Of 2020: Proposal For Police Reform, Marwa Alnaal, Matthew L. Anderson, Hannah Brier, Mollie Campbell, Rose Wine

School of Professional Studies

The Transparency and Yielding of Law Officers Reform Act of 2020 (TAYLOR) proposes an example bill for law enforcement reform. During the summer of 2020, the United States witnessed civilian demonstrations nationwide calling for a change to policing. Our proposal is hoping to heed that call, offering a foundation for change that police forces and localities across the United States can utilize to rebuild trust and accountability.

The goal of the TAYLOR Act is not to defund the police; but rather, TAYLOR rethinks the priorities of the police. There can be no denying that the relationship of trust and security …

Higher Education Responses To Crisis: A Case Study Of Clark University And The Pandemic Of 2020, Lisa Gillingham

School of Professional Studies

The COVID-19 pandemic has delivered an existential challenge to universities and other academic institutions at a time when they are already grappling with other weighty issues that may alter the fabric of higher education. COVID-19 has forced these institutions to consider and employ new ways of conducting its work with a sense urgency that is unprecedented in the recent history of the academy. The rate of learning around these models is rapid, and Higher Education is ripe for change.

Clark University has addressed the pandemic with a plan to protect and pivot using strategies that support the continuation of its …

Bivariate Markov Chain Model Of Irritable Bowel Syndrome (Ibs) Subtypes And Abdominal Pain, Ricardo Reyna Jr.

Theses and Dissertations

Researchers use stochastic models like continuous-time Markov chains (CTMC) to model progression of morbidities of public health impact, like HIV and Hepatitis C. Most of the research in that area is done for a single disease. In this research, we use a bivariate continuous-time Markov chain (CTMC) to model progression of co-morbidities. In particular, we use a bivariate CTMC to model the joint progression of Irritable Bowel Syndrome (IBS) and abdominal pain. Symptoms of IBS are known to change throughout the duration of the disorder. Hence, patients are normally asked to make a journal of the stool type, symptoms, and …

Towards Development Of A Remote Charting System For Connected Healthcare, Alex Bodurka

Masters Theses

Health Care Providers play a crucial role in a patients well-being. While their primary role is to treat the patient, it is also vital to ensure that they can spend adequate time with the patient to create a unique treatment plan and build a personal relationship with their patients to help them feel comfortable during their treatment. Health Care Providers are frequently required to manually record patient data to track their healthcare progress during their hospital stay. However, with hospitals continuously trying to optimize their workflows, this crucial one-on-one time with the patient is often not practical.

As a solution, …

Design And Synthesis Of Novel No-Drug Hybrid Compound And Green Catalytic Activity Evaluation Of Synthesized Silver Nanoparticles-Halloysite Nanocomposite, Majed Abdullah Bajaber

University of New Orleans Theses and Dissertations

Acetaminophen is a well-known analgesic that can manage pain and reduce fever. SCP-1 is a derivative of acetaminophen that showed significantly reduced hepatotoxicity and nephrotoxicity comparative to acetaminophen. Nitric oxides have been well known to play a key role in a wide variety of physiological and pathophysiological important processes. It was therefore of interest to synthesize a nitric oxide donor linked to SCP-1 that could have enhanced analgesic and antipyretic activity. A furoxan CAS 1609 as NO-donor was synthesized and linked to SCP-1 successfully. The furoxan CAS 1609 was initially synthesized from tetronic acid to give 1,2- dioxime in 86 …

Phantom Ocean, Real Impact: Natural Surf Sound Experiments Alter Foraging Activity And Habitat Use Across Taxa, Ryan N. Wardle

Master's Theses

A growing body of research focuses on how background sounds shape and alter critical elements of animals’ lives, such as foraging behavior, habitat use, and ecological interactions (Bradbury & Vehrencamp, 2011; Barber et al., 2010; Kight & Swaddle, 2011; Shannon et al., 2016). Much of this research has centered on the effects of anthropogenic noise (Dominoni et al., 2020; Francis & Barber, 2013; Ortega, 2012; Swaddle et al., 2015), but recent studies have also revealed that natural sound sources can influence animal behavior (Davidson et al., 2017; Le et al., 2019). Natural sounds, such as crashing surf, can create conditions …

Hyperpolarized Carbon-13 Magnetic Resonance Measurements Of Tissue Perfusion And Metabolism, Keith Michel

Dissertations & Theses (Open Access)

Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly polarized nuclear magnetic moment. This polarization is created in a polarizer separate from the imaging magnet, and decays continuously towards a non-detectable thermal equilibrium once the imaging agent is removed from the polarizer and administered by intravenous injection. Specialized imaging strategies are therefore needed to extract as much information as possible from the HP signal during its limited lifetime.

In …

Gardasil Vaccine Trends Within Nevada, California, And The U.S.: A Comparative Study, Karen S. Gutierrez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite decreasing incidence in cervical cancer in the U.S., there continues to be an increase in public health concern for cervical cancer worldwide. Recent studies report that individuals are disproportionately affected based on region, sex, and race. Additionally, the human papillomavirus (HPV) attributable cancers may be reduced between 70% and 90% through the universal use of HPV-vaccines. In order to expand current knowledge and implement intervention programs in Nevada, it is critical to examine the associations among the Gardasil vaccine, cervical cancer screening, and adverse events following immunization as well as to understand the different socio-demographic subgroups affected. To our …

Envrment: Investigating Experience In A Virtual User-Composed Environment, Matthew Key

Master's Theses

Virtual Reality is a technology that has long held society's interest, but has only recently began to reach a critical mass of everyday consumers. The idea of modern VR can be traced back decades, but because of the limitations of the technology (both hardware and software), we are only now exploring its potential. At present, VR can be used for tele-surgery, PTSD therapy, social training, professional meetings, conferences, and much more. It is no longer just an expensive gimmick to go on a momentary field trip; it is a tool, and as with the automobile, personal computer, and smartphone, it …

Implementation Of An Electronic Alert For Improving Adherence To Diabetic Foot Exam Screenings In Type 2 Diabetic Patients In Primary Care Clinics, Ruby Denson

Student Scholarly Projects

Practice Problem: Patients with type 2 diabetes mellitus (T2DM) are at an increased risk of complications including foot ulcerations (Harris-Hayes et al., 2020). Preventive care is essential for the early detection of foot ulcers but despite the advantages of preventive screening, a limited number of primary care providers perform annual foot exams (Williams et al., 2018).

PICOT: The clinical question that guided this project was, “In adult patients with T2DM receiving care in a primary care setting, will the implementation of an electronic clinical reminder alert (ECR) increase provider adherence to performing an annual diabetic foot exam and risk …

An Exploration Of The Numeracy Skills Required For Safe, Quality Nursing Practice, Anna Wendel

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to explore the numeracy skills required for safe, quality nursing practice. Using a descriptive mixed methods design, this study answered two research questions: 1) What numeracy skills do nurses perceive as important for providing safe, quality nursing care in the first three years of practice? 2) How do nurses incorporate numeracy skills into daily patient care during the first three years of practice? Early career nurses from a not-for-profit health care organization in the mid-Atlantic region of the United States (n=109) responded to an online survey tool developed by the student investigator that ranked …

Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru

Dissertations & Theses (Open Access)

Less that 10% of pancreatic cancer patients are eligible for curative resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for treatment options. The objective of this thesis is to advance radiosensitization of treatment-resistant densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.

Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation after intravenous administration, …

Smart Wearable Device For Reduction Of Parkinson’S Disease Hand-Tremor, Bruno Ribeiro, Leopoldo Medeiros, Rodrigo Aguiar, Juan Carlos

ICT

Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide (Health Unlocked, 2017). People diagnosed with Parkinson's Disease can experience tremors, muscular rigidity and slowness of movement. Tremor is the most common symptom and external agents like stress and anxiety can make it worse, which may cause complications to complete simple day-to-day tasks.

Therefore Bio Protech proposes the development of a smart wearable device for reduction of the hand-tremors based on medical evidence that by applying vibration to the wrist may result in a reduction of the involuntary tremor. The device imitates the shape of a wristwatch …

Comparison Of Longitudinal Changes In Resting State Functional Magnetic Resonance Imaging Between Alzheimer’S And Healthy Controls, Berk Can Yilmaz

Theses

Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that is widely used for analyzing brain function using different approaches and methods. This study involves rs-fMRI analysis of Blood Oxygenation Level Dependent (BOLD) signals acquired from Alzheimer’s disease (AD) Patients and Healthy Controls (HC). Each subject in the study had both functional and anatomical images with at least one rs-fMRI scan with their Anatomical (T1) scans. Previous rs-fMRI studies have demonstrated that AD shows differences in Amplitude of Low Frequency (<0.1 Hz) Fluctuations (ALFF), and Regional Homogeneity (ReHo) measures according to HCs.

The aim of the study is to investigate individual and group level differences using ReHo and mALFF related …

Modeling Anatomic Changes For Adaptive Radiotherapy In Locally Advanced Lung Cancer Patient Population, James Alexander Kavanaugh

LSU Doctoral Dissertations

Anatomic changes occurring mid-treatment for patients undergoing radiation therapy for locally advanced lung cancer can degrade the quality of the intended treatment plan. These changes include tumor regression, geometric misalignment, and lung density changes (atelectasis and pleural effusion), and are visible on the daily 3D cone beam CT (CBCT). To maintain the intended treatment quality, adaptive radiotherapy (ART) can be employed to modify the treatment plan to account for these anatomic changes. However, the evaluation on when to adapt is currently completed manually by the treating clinicians, resulting in a subjective and inconsistent application. To address these limitations, a series …