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Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences

2020

Zayed University

Articles 1 - 8 of 8

Full-Text Articles in Physical Sciences and Mathematics

The Impact Of Herbal Infusion Consumption On Oxidative Stress And Cancer: The Good, The Bad, The Misunderstood, Wamidh H. Talib, Israa A. Al-Ataby, Asma Ismail Mahmod, Sajidah Jawarneh, Lina T. Al Kury, Intisar Hadi Al-Yasari Sep 2020

The Impact Of Herbal Infusion Consumption On Oxidative Stress And Cancer: The Good, The Bad, The Misunderstood, Wamidh H. Talib, Israa A. Al-Ataby, Asma Ismail Mahmod, Sajidah Jawarneh, Lina T. Al Kury, Intisar Hadi Al-Yasari

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The release of reactive oxygen species (ROS) and oxidative stress is associated with the development of many ailments, including cardiovascular diseases, diabetes and cancer. The causal link between oxidative stress and cancer is well established and antioxidants are suggested as a protective mechanism against cancer development. Recently, an increase in the consumption of antioxidant supplements was observed globally. The main sources of these antioxidants include fruits, vegetables, and beverage. Herbal infusions are highly popular beverages consumed daily for different reasons. Studies showed the potent antioxidant effects of plants used in the …

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Resveratrol And Tumor Microenvironment: Mechanistic Basis And Therapeutic Targets, Wamidh H. Talib, Ahmad Riyad Alsayed, Faten Farhan, Lina T. Al Kury Sep 2020

Resveratrol And Tumor Microenvironment: Mechanistic Basis And Therapeutic Targets, Wamidh H. Talib, Ahmad Riyad Alsayed, Faten Farhan, Lina T. Al Kury

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Resveratrol (3,40,5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tumor microenvironment. These players include blood and lymphatic vessels, infiltrating immune cells, stromal fibroblasts …

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Computational And Pharmacological Evaluation Of Carveol For Antidiabetic Potential, Muhammad Shabir Ahmed, Arif Ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah Jul 2020

Computational And Pharmacological Evaluation Of Carveol For Antidiabetic Potential, Muhammad Shabir Ahmed, Arif Ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah

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© Copyright © 2020 Ahmed, Khan, Kury and Shah. Background: Carveol is a natural drug product present in the essential oils of orange peel, dill, and caraway seeds. The seed oil of Carum Carvi has been reported to be antioxidant, anti-inflammatory, anti-hyperlipidemic, antidiabetic, and hepatoprotective. Methods: The antidiabetic potential of carveol was investigated by employing in-vitro, in-vivo, and in-silico approaches. Moreover, alpha-amylase inhibitory assay and an alloxan-induced diabetes model were used for in-vitro and in-vivo analysis, respectively. Results: Carveol showed its maximum energy values (≥ -7 Kcal/mol) against sodium-glucose co-transporter, aldose reductase, and sucrose-isomaltase intestinal, whereas it exhibited intermediate energy …

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Ginkgo Biloba Extract Protects Against Methotrexate-Induced Hepatotoxicity: A Computational And Pharmacological Approach, Lina Tariq Al Kury, Fazli Dayyan, Fawad Ali Shah, Zulkifal Malik, Atif Ali Khan Khalil, Abdullah Alattar, Reem Alshaman, Amjad Ali, Zahid Khan May 2020

Ginkgo Biloba Extract Protects Against Methotrexate-Induced Hepatotoxicity: A Computational And Pharmacological Approach, Lina Tariq Al Kury, Fazli Dayyan, Fawad Ali Shah, Zulkifal Malik, Atif Ali Khan Khalil, Abdullah Alattar, Reem Alshaman, Amjad Ali, Zahid Khan

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Ginkgo biloba extract possess several promising biological activities; currently, it is clinically employed in the management of several diseases. This research work aimed to extrapolate the antioxidant and anti-inflammatory effects of Ginkgo biloba (Gb) in methotrexate (MTX)-induced liver toxicity model. These effects were analyzed using different in vivo experimental approaches and by bioinformatics analysis. Male SD rats were grouped as follows: saline; MTX; Gb (pretreated for seven days with 60, 120, and 180 mg/kg daily dose before MTX treatment); silymarin (followed by MTX treatment); Gb 180 mg/kg daily only; and silymarin only. Histopathological results revealed that MTX induced marked hepatic …

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On Privacy-Aware Escience Workflows, Khalid Belhajjame, Noura Faci, Zakaria Maamar, Vanilson Burégio, Edvan Soares, Mahmoud Barhamgi May 2020

On Privacy-Aware Escience Workflows, Khalid Belhajjame, Noura Faci, Zakaria Maamar, Vanilson Burégio, Edvan Soares, Mahmoud Barhamgi

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© 2020, Springer-Verlag GmbH Austria, part of Springer Nature. Computing-intensive experiments in modern sciences have become increasingly data-driven illustrating perfectly the Big-Data era. These experiments are usually specified and enacted in the form of workflows that would need to manage (i.e., read, write, store, and retrieve) highly-sensitive data like persons’ medical records. We assume for this work that the operations that constitute a workflow are 1-to-1 operations, in the sense that for each input data record they produce a single data record. While there is an active research body on how to protect sensitive data by, for instance, anonymizing datasets, …

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Nf-Κb Inhibitors Attenuate Mcao Induced Neurodegeneration And Oxidative Stress—A Reprofiling Approach, Awais Ali, Fawad Ali Shah, Alam Zeb, Imran Malik, Arooj Mohsin Alvi, Lina Tariq Alkury, Sajid Rashid, Ishtiaq Hussain, Najeeb Ullah, Arif Ullah Khan, Phil Ok Koh, Shupeng Li Mar 2020

Nf-Κb Inhibitors Attenuate Mcao Induced Neurodegeneration And Oxidative Stress—A Reprofiling Approach, Awais Ali, Fawad Ali Shah, Alam Zeb, Imran Malik, Arooj Mohsin Alvi, Lina Tariq Alkury, Sajid Rashid, Ishtiaq Hussain, Najeeb Ullah, Arif Ullah Khan, Phil Ok Koh, Shupeng Li

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© Copyright © 2020 Ali, Shah, Zeb, Malik, Alvi, Alkury, Rashid, Hussain, Ullah, Ullah Khan, Koh and Li. Stroke is the leading cause of morbidity and mortality worldwide. About 87% of stroke cases are ischemic, which disrupt the physiological activity of the brain, thus leading to a series of complex pathophysiological events. Despite decades of research on neuroprotectants to probe for suitable therapies against ischemic stroke, no successful results have been obtained, and new alternative approaches are urgently required in order to combat this pathological torment. To address these problems, drug repositioning/reprofiling is explored extensively. Drug repurposing aims to identify …

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Computer Aided Autism Diagnosis Using Diffusion Tensor Imaging, Yaser A. Elnakieb, Mohamed T. Ali, Ahmed Soliman, Ali H. Mahmoud, Ahmed M. Shalaby, Norah Saleh Alghamdi, Mohammed Ghazal, Ashraf Khalil, Andrew Switala, Robert S. Keynton, Gregory Neal Barnes, Ayman El-Baz Jan 2020

Computer Aided Autism Diagnosis Using Diffusion Tensor Imaging, Yaser A. Elnakieb, Mohamed T. Ali, Ahmed Soliman, Ali H. Mahmoud, Ahmed M. Shalaby, Norah Saleh Alghamdi, Mohammed Ghazal, Ashraf Khalil, Andrew Switala, Robert S. Keynton, Gregory Neal Barnes, Ayman El-Baz

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© 2013 IEEE. Autism Spectrum Disorder (ASD), commonly known as autism, is a lifelong developmental disorder associated with a broad range of symptoms including difficulties in social interaction, communication skills, and restricted and repetitive behaviors. In autism spectrum disorder, numerous studies suggest abnormal development of neural networks that manifest itself as abnormalities of brain shape, functionality, and/ or connectivity. The aim of this work is to present our automated computer aided diagnostic (CAD) system for accurate identification of autism spectrum disorder based on the connectivity of the white matter (WM) tracts. To achieve this goal, two levels of analysis are …

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Ai Techniques For Covid-19, Adedoyin Ahmed Hussain, Ouns Bouachir, Fadi Al-Turjman, Moayad Aloqaily Jan 2020

Ai Techniques For Covid-19, Adedoyin Ahmed Hussain, Ouns Bouachir, Fadi Al-Turjman, Moayad Aloqaily

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© 2013 IEEE. Artificial Intelligence (AI) intent is to facilitate human limits. It is getting a standpoint on human administrations, filled by the growing availability of restorative clinical data and quick progression of insightful strategies. Motivated by the need to highlight the need for employing AI in battling the COVID-19 Crisis, this survey summarizes the current state of AI applications in clinical administrations while battling COVID-19. Furthermore, we highlight the application of Big Data while understanding this virus. We also overview various intelligence techniques and methods that can be applied to various types of medical information-based pandemic. We classify the …

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