Physical Sciences and Mathematics Commons^™

Folic Acid-Targeted Polymeric Complex Imprinted With Doxorubicin And Quercetin For Controlled Drug Delivery In Cancer Therapy, Ceren Türkcan, Emi̇rhan İşeri̇

Turkish Journal of Chemistry

​Cancer therapy is often limited by the systemic toxicity and dose-dependent adverse effects of conventional chemotherapeutic agents such as doxorubicin (DOX). In this study, a folic acid-functionalized molecularly imprinted polymeric complex based on poly(HEMA) crosslinked with ethylene glycol dimethacrylate was synthesized for the controlled release of DOX in combination with quercetin (QUE), a flavonoid known for its antioxidant and chemosensitizing properties. The aim of this work was to develop and physicochemically characterize a preliminary targeted drug delivery platform at a material-design level. The polymeric complex was synthesized via free-radical polymerization following a DOX–QUE precomplex formation step. Structural characterization was performed …

A Poly-L-Lysine-Functionalized Electrochemical Immunosensor Enables Highly Sensitive Detection Of Tumor Necrosis Factor Receptor-Associated Protein 1, Berfi̇n Vural, Mustafa Kemal Sezgi̇ntürk

Turkish Journal of Chemistry

Tumor necrosis factor receptor-associated protein 1 (TRAP-1), a member of the mitochondrial heat shock protein family (HSP90), is essential for protein homeostasis, stress response, and cell cycle. TRAP-1 not only optimizes cellular energy production but also prevents cell death, thereby supporting the survival and proliferation of tumor cells. In addition to cancer, TRAP-1 has been associated with Parkinson’s disease, certain autoimmune disorders, and abnormalities in the kidney and urinary tract. In this study, a unique and useful indium tin oxide-polyethylene terephthalate (ITO–PET)-based electrochemical biosensor is described for detecting the biomarker TRAP-1. The ITO–PET electrode, selected as the working electrode, is …

Aptamer–Gold Nanoparticle-Based Lab-In-A-Tube Colorimetric Detection Of Malathion: Evaluation With Classical And Digital Readout Techniques, Emi̇ne Güler Çeli̇k

Turkish Journal of Chemistry

Colorimetric biosensing devices represent an important class of point-of-care (POC) diagnostics due to their ability to provide visible test outputs, their ease of integration with smartphone-based sensing, and their portability for field testing. In the context of agrifood safety, there is a growing need for portable, robust, and cost-effective detection devices. Pesticide residues can be present in a wide range of environmental and food samples, from water resources to fruits and vegetables, resulting in an increasing global demand for on-site testing. Colorimetric assays, when combined with smartphone-based sensing, can effectively address these needs. In this work, the aggregation-induced color change …

Sensitive Electrochemical Sensor For Simultaneous Determination Of Epinephrine And Norepinephrine By Sio2np@Mwcnt-Cooh Nanoparticle-Modified Spces​, Merve Yilmaz Çilçar, Meli̇ke Bi̇lgi̇ Kamaç, Ayşenur Yilmaz Kabaca, Şahi̇n Toparli, Faruk Terzi̇oğlu, Emi̇r Ateş

Turkish Journal of Chemistry

Epinephrine (EP) and norepinephrine (NEP), both neurotransmitters, are two important biomolecules that play critical roles in the body, from the central nervous system to metabolic processes. They are also important biomarkers for clinical diagnosis and monitoring. In this study, a novel, fast, practical, and high-performance electrochemical sensor based on a SiO2NP@MWCNT-COOH nanocomposite was developed for the simultaneous determination of EP and NEP. The nanocomposite was modified onto the surface of screen-printed electrodes (SPCEs) and its characterization was performed (SEM-EDX, XRD, FTIR, CV, DPV, and EIS). The individual and simultaneous determinations of EP and NEP were performed using square-wave voltammetry, yielding …

Acetylcholinesterase Immobilization On A Natural Thin Membrane For Stable Biocatalyst Design, Si̇nem Öztürk, Ceyhun Işik, Mustafa Teke

Turkish Journal of Chemistry

This study involved the immobilization of acetylcholinesterase (AChE) onto a natural thin membrane extracted from the inner epidermal layer of Allium cepa, with the aim of enhancing the enzyme’s stability, activity, and reusability for potential biotechnological applications. The membrane, composed of biocompatible polymers and naturally occurring functional groups, was used as a sustainable support in a combined strategy involving adsorption followed by glutaraldehyde-mediated cross-linking. Immobilization conditions were optimized by evaluating key factors such as enzyme concentration, membrane quantity, cross-linker dosage, and contact time to achieve maximal catalytic efficiency. Structural and morphological changes on the membrane surface were assessed via scanning …

Antifungal Activity Of Isolated Compounds From Centaurea Salicifolia Var. Salicifolia Against Candida Species, Including Multidrug-Resistant C. Auris, C. Inconspicua, And C. Dubliniensis, Seli̇n Tufan, Di̇lek Şatana, Nur Tan

Turkish Journal of Chemistry

Natural compounds obtained from plants have always held great potential for drug discovery and, as such, have drawn the attention of researchers as novel antifungal molecules that can be effective against fungal resistance. The antifungal activity of sesquiterpene lactones has been extensively investigated against various fungal strains, but there is limited data on their antifungal activity against Candida species. Sesquiterpene lactones are abundant in the Asteraceae family, and 90% of identified sesquiterpene lactones have been isolated from members of this family. Three extracts obtained from the aerial parts of Centaurea salicifolia var. salicifolia, which had not been investigated prior to …

Electrochemical Determination Of Terbutaline Using A Sno2 Nanoparticle-Modified Carbon Paste Electrode, Rauf Gulamov, Şenol Alpat, Si̇bel Kilinç Alpat

Turkish Journal of Chemistry

Terbutaline hemisulfate (THS), a selective beta-2 agonist, is preferred as a bronchodilator for the treatment of asthma and bronchitis, as well as a tocolytic agent to delay labor in acute situations during premature birth. The use of beta-2 agonists above a certain dose is considered doping in sports competitions. Therefore, it is important that they be determined with high sensitivity and selectivity within a short analysis time. In this study, a SnO2 nanoparticle-modified carbon paste electrode was developed for the determination of THS. Cyclic voltammetry and differential pulse voltammetry were employed as electrochemical methods. The operating conditions of the developed …

Chitosan Microparticle-Based Antibacterial Nasal Barrier Formulation And In Vivo Evaluations, Güli̇z Ak, Ayça Erek, Tuğba Karakayali, Şadi̇ye Çeti̇n, Şenay Şanlier

Turkish Journal of Chemistry

Microorganisms remain a major cause of infectious diseases, emphasizing the need for alternative and complementary antimicrobial strategies. In this context, plant-derived materials have attracted increasing attention for their antimicrobial and protective properties. Chitosan, a biocompatible and cationic biopolymer, has emerged as an effective carrier system for encapsulating such plant-derived components. In this study, chitosan microparticles were prepared through ionic gelation followed by spray drying and loaded with thyme oil and olive leaf extract. The resulting microparticles exhibited an average size of approximately 1.8 μm and a total phenolic content of 23 mg GAE/g. These microparticles were incorporated into a glycerin–starch …

Electronic Structure Discretization And Compression Using Diagonal Basis Sets, Casey Lee Dowdle

Dartmouth College Ph.D Dissertations

Numerically solving the electronic structure problem is a fundamentally difficult problem due to the exponential growth in the dimension of the Hilbert space as the system size increases. In order to solve problems at a chemically relevant accuracy, both the choice of basis set and numerical method are important factors that are intrinsically connected.

In this thesis, we study the discretization and resulting compression of electronic Hamiltonians using diagonal basis sets. A diagonal basis set approximately diagonalizes the matrix and tensor representations of the one- and two-body potentials. This can reduce storage, simplify matrix-vector products, and lower the complexity of …

Palmnet: Confidence-Calibrated Edge-Cloud Ai For Field Diagnosis Of Date Palm Diseases, Muntadher Kareem, Raed Majeed

Karbala International Journal of Modern Science

Date palm (Phoenix dactylifera L.) is a cornerstone crop for Iraq and the wider MENA region, yet reliable in-field diagnosis of leaf disorders remains slow, labour-intensive, and constrained by a limited pool of agronomists. This paper presents PalmNet, a full-stack diagnostic system that classifies nine leaf conditions through a calibrated edge-cloud framework. The system is developed and evaluated on a public dataset of 3,089 field images spanning the nine classes, using a 70/15/15 stratified split. A ShuffleNetV2 student network, distilled from a ConvNeXt-Tiny teacher, is deployed on two complementary edge endpoints: a Raspberry Pi Zero 2 W field station …

Synchrotron X-Ray Diffraction Method For Continuous Strain Analysis Across Heterogenous Material Interface Layers, Sierra Damon

Discovery Day - Daytona Beach

Synchrotron X-ray diffraction method for continuous strain analysis across heterogenous material interface layers   The transfer of strain across a material interface is a relevant concept to quantify for numerous aerospace applications that involve coatings applied to substrates of different materials, particularly in the field of high temperature materials. X-ray diffraction (XRD) is a metrology technique capable of resolving strain within an arbitrary material by quantifying the shifts of Bragg peaks with respect to an unstrained sample and has seen increased use due to the capability of XRD to perform in-situ measurements on materials in extreme environments. Since different materials have …

Techniques, Skills, And Synthesis For “Cooking” In The Organic Laboratory, Emily C. Sylvester, Tim Evans

Open Education Materials

Lab manual for CHEM 211L, Organic Chemistry I Laboratory. Provides background and procedures for laboratory experiments, including fundamental techniques and several organic syntheses.

Creative Commons attribution.

The Use Of Chitosan-G-Poly (Acrylic Acid-Co-Acrylamide) In The Delivery Of Imatinib In The Small Intestine, Dawson Ohrt, Clint Everard

Nebraska Academy of Sciences: Programs and Proceedings

The use of hydrogels as drug delivery systems is the future of biotechnology, hydrogels can offer a new way of controlled delivery to specific areas of the body. Hydrogel also create new possibilities for treatments of gastrointestinal stromal tumors (GISTs). There are many different types of hydrogels that can be used in drug delivery. Hydrogels offer customizability in regard to the release of drugs in specific environments. The chemical properties of hydrogels allow for them to be manipulated for specific functions such as release at a specific pH . The hydrogel being used in the study is Chitosan-G-Poly (Acrylic Acid …

Isolation Of Lavender Compounds Via Steam Distillation, Emma Norris, Gwendolyn Flippin

Discovery Day - Daytona Beach

Steam distillation was used to extract (R)- Linalool, Linalyl acetate, and Camphor from lavender during the steam distillation experiment. The compounds were extracted via a steam distillation apparatus. A 250 mL two-neck round-bottom flask, a thermometer adapter, 25 mL a thermometer, a condenser, a distillation head, a vacuum adapter, lab jacks, and clamps made up the apparatus. Then the lavender was massed out and added to a beaker with 100 mL of water. Over time, the distillate is collected in a vial to be analyzed. (R)- Linalool is a nonaromatic alcohol containing two alkenes with the chemical formula C_10 H_18 …

Chemical Profiling Of Star Anise (Illicium Verum) Via Gc–Ms: Identifying Compounds With Pharmaceutical Potential, Legacy Wilson, Yegor Bushnev

Discovery Day - Daytona Beach

Title: Chemical Profiling of Star Anise (Illicium verum) via GC–MS: Identifying Compounds with Pharmaceutical Potential   Abstract: Star anise (Illicium verum) has been used for both medicinal and culinary applications due to its diverse bioactive compounds. It is a primary natural source of shikimic acid (𝐶7𝐻10𝑂5), a key precursor in the synthesis of the antiviral drug oseltamivir (Tamiflu), used to treat influenza. Additionally, star anise has been used to treat respiratory and digestive conditions and is widely used for flavoring due to its licorice-like aroma, mainly from trans-anethole (𝐶10𝐻12𝑂) , its major component. Previous studies have also demonstrated mild central nervous …

Extracting Aromatic Compounds From Dehydrated Rose Buds, Lana Sheridan

Discovery Day - Daytona Beach

Eugenol (C10H12O2), methyl eugenol (C11H14O2), and 2-phenylethanol (C8H10O) are chemically aromatic, natural compounds commonly present in various botanical sources and essential oils. Structurally, eugenol is a methoxyphenol bearing an allyl side chain; its methyl ether derivative, methyl eugenol, shares a similar framework but features a methoxy group replacing the free phenolic hydroxyl group found in eugenol. 2-Phenylethanol is an aromatic alcohol comprised of a benzene ring linked to an ethanol moiety. The objective of this project was to isolate and characterize these compounds in dried rose buds using distillation followed by chromatographic and spectrometric analysis. For the experiment, a steam …

Steam Distillation Star Anise, Makayla Maso, Kiara Maso

Discovery Day - Daytona Beach

Star anise (Illicium verum) contains several volatile organic compounds responsible for its characteristic aroma, including trans-anethole, estragole, limonene, and linalool. These compounds differ in structure and chemical properties, which influence their behavior during isolation and analysis. Trans-anethole and estragole are classified as aromatic phenylpropene derivatives that contain benzene rings and ether functionalities. In contrast, limonene and linalool are non-aromatic terpenes, with linalool additionally possessing an alcohol functional group. These compounds are widely utilized as flavoring agents and fragrance components, while terpenes such as limonene and linalool are also commonly employed as solvents and in formulation chemistry due to their volatility …

Extraction Of Cedarwood Essential Oils Via Steam Distillation, Forrest Dohner

Discovery Day - Daytona Beach

Many natural materials, including pine and eucalyptus, produce distinct scents due to the presence of volatile organic compounds. In cedarwood, this aroma arises from a combination of aromatic molecules, which are organic compounds containing conjugated carbon ring systems that interact with olfactory receptors. Specifically, cedarwood contains three primary compounds responsible for its scent: cedrol, cedrene, and thujopene. The objective of this experiment was to extract these essential oils from cedarwood and identify their chemical composition. Steam distillation was used to isolate the volatile components by passing steam through the cedarwood, causing the essential oils to vaporize at temperatures below their …

Polymer Degradation And Their Environmental Impact, Addison Orr, Vanessa Gilbert

Discovery Day - Daytona Beach

Synthetic polymer material usage has increased significantly within the last several decades due to their durability, resistance to mechanical wear, low density, and inexpensiveness. Despite these advantages, most synthetic polymers are not biodegradable and instead undergo slow degradation processes. The processes are multifaceted, involving physical, chemical, and biological mechanisms influenced by material properties and environmental conditions, such as soil, light, temperature, and moisture levels. As a result, the polymers break into microplastics and contaminate air, water, and soil, posing risks to human health and surrounding ecosystems. Additionally, polymer degradation can release harmful substances that disrupt food chains and can lead …

Production And Analysis Of Lavender Essential Oil: Extraction, Composition, And Applications, Mary Zoeller

Discovery Day - Daytona Beach

Steam distillation was performed to extract essential oil from lavender and analyze its chemical composition. Lavender is known to contain several compounds such as linalool, terpinen-4-ol, and linalyl acetate, which contribute to its characteristic aroma and biological activity. The purpose of this experiment was to isolate these compounds without decomposition and identify them using gas chromatography–mass spectrometry (GC-MS). Approximately 14.851 g of lavender was heated with water to generate steam, which carried the volatile compounds into a condenser where the vapor was cooled and collected. The distillate was transferred to a separatory funnel to isolate the organic layer from the …

Steam Distillation Of Jasmine, Mikayla Hulvey, Meliah Martin

Discovery Day - Daytona Beach

This experiment aimed to isolate various components, including benzyl acetate, linalool, indole, and farnesene, from jasmine buds. The functional groups include an ester in benzyl acetate, an alcohol in linalool, an amine in indole, and alkenes in farnesene. Jasmine buds were combined with distilled water and steam distilled using a standard distillation apparatus. The distillate, containing hydrosol and trace amounts of essential oil, was then collected for extraction using methyl tert-butyl (MTBE) for a liquid-liquid extraction. The organic layer was then separated, washed using brine, dried over anhydrous sodium sulfate, and then transferred for later analysis. The essential oil obtained …

Moss Biomonitoring And Isotopic Signatures Reveal Aviation Fuel As Local Lead Source Near Oregon Airports, Oluwaseyi E. Aderinboye, Alyssa E. Shiel, Lauren Stalford, Christina J. Murphy, Dean B. Atkinson

Chemistry Faculty Publications and Presentations

Lead emissions from piston-engine aircraft using leaded aviation gasoline (avgas) remain a significant source of environmental contamination near regional airports, posing potential health risks to nearby communities. Passive biomonitoring using the epiphytic moss Orthotrichum lyellii was combined with lead isotope fingerprinting to quantify lead concentrations and distinguish between legacy leaded gasoline and current avgas emissions near Hillsboro and Troutdale airports in Oregon. Here we show that lead levels are elevated by up to 50 times the rural background near airports, with isotopic signatures confirming avgas as a dominant local source. These findings indicate that avgas use contributes substantially to environmental …

Chemistry & Fine Arts Collaboration Posters 2025 - 2026, Basil Masri Zada, Corey Beck

Exhibition Catalogs

Supervisors Dr. Basil Masri Zada and Dr. Corey Beck bring together students from Ohio University’s Chemistry and Digital Art + Technology programs in a collaborative effort to make scientific concepts more accessible. Each artist has been assigned to work with a group of chemistry students, and they are then prompted to create an art poster with only the name of the compound. Enclosed in this pamphlet is the hard work of both students from the digital art program and the chemistry program.

Participating artists include:  Addie Smith, Madelyn Bartolone, Jabin Tasmin, Sara Pirahmaiden, Parker McGowan, Sophie Hillis, Leena Blanton, Jack …

Adaptive Phishing Url Detection Using Hybrid Fuzzy C-Means Clustering And Xgboost, Muntadher Mohammed Kareem, Rawaa I. Farhan

Karbala International Journal of Modern Science

Phishing attacks continue to evolve in sophistication, rendering static detection methods increasingly ineffective. Existing URL-based approaches suffer from limited adaptability to emerging phishing patterns, mislabeled training data, and insufficient validation protocols. This paper proposes a hybrid phishing URL detection system that integrates Fuzzy C-Means (FCM) clustering with XGBoost classification, enhanced by a novel Micro Adaptive Feature Extractor (MAFE). The system employs a multi-stage pipeline: feature engineering generating 36 statistical and interaction features, MAFE producing 15 adaptive features through class-aware dynamic weighting, micro-pattern detection, and entropy analysis, and FCM with K=2 clusters providing soft membership features to XGBoost. A two-pass confidence-based …

Development Of Minimalist Trifunctional Building Blocks For Chemical Biology Probe Synthesis, Luke E. Bohrer

Electronic Theses and Dissertations

The completion of the Human Genome Project in 2003 generated expectations that genomic information would accelerate the discovery of new protein drug targets and FDA-approved therapies. However, many small-molecule drug candidates continue to fail in clinical trials, and much of the human proteome remains undercharacterized in terms of structure, function, and disease relevance. Chemical tools are therefore essential for defining protein function, mapping protein interactions, and identifying disease-associated molecular mechanisms. Among these tools, small-molecule chemical probes provide a powerful strategy for connecting biological activity with target identification, functional analysis, and the development of effective therapies.

This dissertation describes the development …

65th Annual Rocky Mountain Conference On Magnetic Resonance

Rocky Mountain Conference on Magnetic Resonance

Conference program, abstracts, and information about the 65th annual meeting of the Rocky Mountain Conference on Magnetic Resonance. Held in the Snowbird Resort and Conference Center, Snowbird, Utah, August 2-6, 2026.

The Computed Microwave Spectrum Of The Protonated Fullerene C60H+, Laszlo Nemes, Jos Oomens, Vincent J. Esposito, Vincent Boudon, Alexander G. G. M. Tielens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The largest known molecule in the interstellar medium of galaxies, C₆₀, has been detected in its neutral and cationic form through its vibrational, UV-driven fluorescence emission spectrum and its electronic absorption spectrum, respectively. The detection of several polycyclic aromatic hydrocarbon molecules through their pure rotation spectrum in cold, dense, molecular cloud cores suggests that C₆₀ might be present in these environments as well. The low flux of UV pumping photons in molecular cloud cores and the absence of suitably bright background stars, make detection of C₆₀ and its cation through the commonly used methods impractical. As …

Real Bullets, Plastic Guns: Evaluating The Strength Of 3-D Printed Gun Parts, Maria Latenia Mayol

Student Theses

Privately made firearms (PMFs), often referred to as “ghost guns,” are firearms manufactured or assembled by individuals rather than federally licensed manufacturers. Although the terms are frequently used interchangeably, “ghost gun” more specifically describes an unserialized firearm, whereas PMFs include a broader range of firearms produced through nontraditional manufacturing methods. PMFs may be entirely 3-D printed, assembled from partially completed firearm kits, or constructed by integrating additively manufactured components with commercially manufactured firearm parts. The increasing accessibility of additive manufacturing and widespread dissemination of computer-aided design files have raised concerns about concealment, regulation, and forensic evasion, particularly when factory-manufactured components …

Assessing The Impact Dynamics Of Less Lethal Ammunition, Steven Bermejo

Student Theses

Less-lethal ammunition is widely used by law enforcement as an alternative to lethal force during crowd control, on-street confrontations, and other situations requiring force. Although these projectiles are intended to reduce risk of fatal injury, serious injuries and fatalities have been reported, highlighting the need to better understand the factors that influence their impact behavior. This study evaluated the impact dynamics of four types of 12-gauge less-lethal ammunition, including rubber buckshot, single rubber ball, double rubber ball, and Byrna kinetic projectile, using kinetic energy calculations derived from projectile mass and velocity measurements. In addition, Attenuated Total Reflectance Fourier Transform Infrared …

Single Fluorogens And Orientation-Localization Microscopy For Quantifying Chemical And Biomolecular Dynamics At The Nanoscale, Yiyang Chen, Yuanxin Qiu, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Many chemical systems look uniform only because ensemble measurements average over their most interesting molecules. Electron-transfer rates vary across electrode surfaces; lipid membranes contain nanodomains with distinct packing and fluidity; peptide aggregates exhibit local polymorphism; and biomolecular condensates contain transient networks of interactions that are blurred in ensemble images. A central challenge in chemical imaging is not simply to see smaller structures, but to measure chemical variables such as polarity, redox potential, and molecular confinement at the single-molecule level. In this Account, we describe how fluorogens, molecules whose brightness, blinking, spectral shifts, orientation, rotational mobility, and motion are directly shaped …