Veterinary Medicine Commons^™

Rabies Post-Exposure Healthcare-Seeking Behaviors And Perceptions: Results From A Knowledge, Attitudes, And Practices Survey, Uganda, 2013, Sarah C. Bonaparte, Laura Adams, Barnabas Bakamutumaho, Galileu Barbosa Costa, Julie M. Cleaton, Amy Gilbert, Modupe Osinubi, Emily G. Pieracci, Sergio Recuenco, Victor Tugumizemu, Joseph Wamala, Ryan M. Wallace

United States Department of Agriculture Wildlife Services: Staff Publications

Background Rabies is a viral disease of animals and people causing fatal encephalomyelitis if left untreated. Although effective pre- and post-exposure vaccines exist, they are not widely available in many endemic countries within Africa. Since many individuals in these countries remain at risk of infection, post-exposure healthcare-seeking behaviors are crucial in preventing infection and warrant examination.

Methodology A rabies knowledge, attitudes, and practices survey was conducted at 24 geographically diverse sites in Uganda during 2013 to capture information on knowledge concerning the disease, response to potential exposure events, and vaccination practices. Characteristics of the surveyed population and of the canine-bite …

Differing Alterations Of Odor Volatiles Among Pathogenic Stimuli, Patrick Millet, Talia Martin, Maryanne Opiekun, Gary K. Beauchamp, Bruce A. Kimball

United States Department of Agriculture Wildlife Services: Staff Publications

Alterations of the volatile metabolome (the collection of volatiles present in secretions and other emanations) that occur in response to inflammation can be detected by conspecifics and chemometric analyses. Using a model system where mouse urinary metabolites are altered by treatment with lipopolysaccharide (found in the outer cell membrane of gram-negative bacteria), we hypothesized that alteration of body odor volatiles will vary according to the pathogen responsible for inducing the inflammation. We tested this hypothesis by treating mice with different immunogens that engage different immune signaling pathways. Results suggest that alterations of body odor volatiles resulting from inflammation do contain …

Using Object-Based Image Analysis To Detect Laughing Gull Nests, Benjamin F. Martini, Douglas A. Miller

United States Department of Agriculture Wildlife Services: Staff Publications

Remote sensing has long been used to study wildlife; however, manual methods of detecting wildlife in aerial imagery are often time-consuming and prone to human error, and newer computer vision techniques have not yet been extensively applied to wildlife surveys. We used the object-based image analysis (OBIA) software eCognition to detect laughing gull (Leucophaeus atricilla) nests in Jamaica Bay as part of an ongoing monitoring effort at the John F. Kennedy International Airport. Our technique uses a combination of high resolution 4-band aerial imagery captured via manned aircraft with a multispectral UltraCam Falcon M2 camera, LiDAR point cloud data, and …

Impact Of The Histidine‐Containing Phosphocarrier Protein Hpr On Carbon Metabolism And Virulence In Staphylococcus Aureus, Linda Pätzold, Anne-Christine Brausch, Evelyn-Laura Bielefeld, Lisa Zimmer, Greg A. Somerville, Markus Bischoff, Rosmarie Gaupp

School of Veterinary and Biomedical Sciences: Faculty Publications

Carbon catabolite repression (CCR) is a common mechanism pathogenic bacteria use to link central metabolism with virulence factor synthesis. In gram‐positive bacteria, catabolite control protein A (CcpA) and the histidine‐containing phosphocarrier protein HPr (encoded by ptsH) are the predominant mediators of CCR. In addition to modulating CcpA activity, HPr is essential for glucose import via the phosphotransferase system. While the regulatory functions of CcpA in Staphylococcus aureus are largely known, little is known about the function of HPr in CCR and infectivity. To address this knowledge gap, ptsH mutants were created in S. aureus that either lack the open reading …

An Evaluation Of The Anti-Carcinogenic Response Of Major Isothiocyanates In Non-Metastatic And Metastatic Melanoma Cells, Melina Mitsiogianni, Sotiris Kyriakou, Ioannis Anestopoulos, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidi

School of Veterinary and Biomedical Sciences: Faculty Publications

Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocy- anates, a class of phytochemicals, present in cruciferous vegetables have been characterized by considerable anti-cancer activity in both in vitro and in vivo experimental models. In the current study, we investigated the anti-cancer response of five isothiocyanates in an in vitro model of melanoma consisting of non-metastatic (A375, B16F-10) and metastatic (VMM1, Hs294T) malignant melanoma as well as non-melanoma epidermoid carcinoma (A431) and non-tumorigenic melanocyte-neighboring keratinocyte (HaCaT) cells. Our aim …

Il-10 As A Th2 Cytokine: Differences Between Mice And Humans, Mahima T. Rasquinha, Meghna Sur, Ninaad Lasrado, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

The discovery of interleukin (IL)-10 more than 30 years ago marked the beginning of our understanding of how cytokines regulate immune responses, based on cross-regulation between T helper (Th)1 and Th2 cytokines. Although multiple cell types were shown to produce IL-10, its identity as a Th2 cytokine remained strong since it was rigidly associated with Th2 clones in mice, whereas both Th1 and Th2 clones could secrete IL-10 in humans. However, as new Th1/Th2 cell functionalities emerged, anti-inflammatory action of IL-10 gained more attention than its inhibitory effect on Th1 cells, which may occur as an indirect consequence of suppression …

Cortisol In Hair As A Measure Of Chronic Stress During Sow Gestation And The Pattern Of Cortisol In Blood During Parturition In Sows, Talia Everding

Electronic Theses and Dissertations

Cortisol is known as the stress hormone, as it influences many metabolic processes to maintain glucose homeostasis during stressful experiences, including physical and psychological stress. It can be detected in biological matrices such as blood and hair and is released rapidly during sudden stressors and continuously during longterm stress. Blood cortisol fluctuates rapidly in response to acute stressors like pain, exertion, and fear; in hair cortisol accumulates steadily over the period of hair growth and may be useful for detecting chronically elevated cortisol resulting from long-term stress. The objective of this research was to, 1) determine the influence of a …

Extending Animal Welfare Science To Include Wild Animals, Walter Veit, Heather Browning

Animal Sentience

Ng’s (2016) target article built on his earlier work advocating a science of welfare biology (Ng 1995). Although there were problems with the models proposed in Ng’s original paper regarding the balance of pleasure and suffering for wild animals, his call for a science of wild animal welfare was a sound one. This does not require a new discipline but just an extension of the existing frameworks and methods of animal welfare science to include wild animals.

Multi-Level Movement Response Of Invasive Wild Pigs (Sus Scrofa) To Removal, Guillaume Bastille-Rousseau, Peter E. Schlichting, David A. Keiter, Joshua B. Smith, John C. Kilgo, George Wittemyer, Kurt C. Vercauteren, James C. Beasley, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

BACKGROUND: Lethal removal of invasive species, such as wild pigs (Sus scrofa), is often the most efficient approach for reducing their negative impacts. Wild pigs are one of the most widespread and destructive invasive mammals in the USA. Lethal management techniques are a key approach for wild pigs and can alter wild pig spatial behavior, but it is unclear how wild pigs respond to the most common removal technique, trapping.We investigated the spatial behavior of wild pigs following intensive removal of conspecifics via trapping at three sites within the Savannah River Site, SC, USA. We evaluated changes in …

Evaluating The Effects Of Mountain Beaver (Aplodontia Rufa) Management On Conifer Stocking In Western Oregon, Jimmy D. Taylor, Vanessa M. Petro

United States Department of Agriculture Wildlife Services: Staff Publications

Mountain beaver (Aplodontia rufa) is the most primitive rodent species in North America and is endemic to the Pacific Northwest, USA. Within their range, mountain beaver cause more conflict with conifer forest regeneration than any other vertebrate species. Most damage occurs as a result of clipping and browsing new seedlings, which reduces stocking density and delays stand development. An integrated approach using trapping and a registered toxicant (baiting) has been suggested as the most efficacious means to reduce seedling loss during stand initiation. We evaluated this management strategy in intensively managed conifer stands across two mountain ranges in …

Principal Economic Effects Of Cormorant Predation On Catfish Farms, Carole R. Engle, Terrel W. Christie, Brian S. Dorr, Ganesh Kumar, Luke A. Roy, Anita M. Kelly

United States Department of Agriculture Wildlife Services: Staff Publications

Substantial economic losses of farmed catfish to fish-eating birds such as the double-crested cormorant, Phalacrocorax auritus, continue to be reported on U.S. catfish farms. An economic analysis was conducted of the on-farm effects of both the increased expenditures to scare fish-eating birds from catfish farms and of the value of the catfish that were consumed by cormorants. A survey was conducted of U.S. catfish farmers in the Delta region of Mississippi and Arkansas, to obtain farm-level data on expenditures to scare birds. Estimations of the lost revenue from catfish consumed by cormorants were developed from a concurrent study on …

Variation In Angiostrongylus Cantonensis Infection In Definitive And Intermediate Hosts In Hawaii, A Global Hotspot Of Rat Lungworm Disease, Chris Niebuhr, Shane R. Siers, Israel Leinbach, Lisa M. Kaluna, Susan I. Jarvi

United States Department of Agriculture Wildlife Services: Staff Publications

Angiostrongylus cantonensis (rat lungworm) is a tropical and subtropical parasitic nematode, with infections in humans causing angiostrongyliasis (rat lungworm disease), characterized by eosinophilic meningitis. Hawaii has been identified as a global hotspot of infection, with recent reports of high infection rates in humans, as well as rat definitive and snail intermediate hosts. This study investigated variation in A. cantonensis infection, both prevalence and intensity, in wild populations of two species of rats (Rattus exulans and R. rattus) and one species of snail (Parmarion martensi). An overall infection prevalence of 86.2% was observed in P. martensi and …

Peptide Elisa And Fret-Qpcr Identified A Significantly Higher Prevalence Of Chlamydia Suis In Domestic Pigs Than In Feral Swine From The State Of Alabama, Usa, Md Monirul Hoque, Folasade Adekanmbi, Subarna Barua, Kh. Shamsur Rahman, Virginia Aida, Brian Anderson, Anil Poudel, Anwar Kalalah, Sara Bolds, Steven Madere, Steven Kitchens, Stuart Price, Vienna Brown, B. Graeme Lockaby, Constantinos S. Kyriakis, Bernhard Kaltenboeck, Chengming Wang

United States Department of Agriculture Wildlife Services: Staff Publications

Chlamydia suis is an important, highly prevalent, and diverse obligate intracellular pathogen infecting pigs. In order to investigate the prevalence and diversity of C. suis in the U.S., 276 whole blood samples from feral swine were collected as well as 109 fecal swabs and 60 whole blood samples from domestic pigs. C. suis-specific peptide ELISA identified anti-C. suis antibodies in 13.0% of the blood of feral swine (26/276) and 80.0% of the domestic pigs (48/60). FRET-qPCR and DNA sequencing found C. suis DNA in 99.1% of the fecal swabs (108/109) and 21.7% of the whole blood (13/60) of …

Behavioral State Resource Selection In Invasive Wild Pigs In The Southeastern United States, Lindsay M. Clontz, Kim M. Pepin, Kurt C. Vercauteren, James C. Beasley

United States Department of Agriculture Wildlife Services: Staff Publications

Elucidating correlations between wild pig (Sus scrofa) behavior and landscape attributes can aid in the advancement of management strategies for controlling populations. Using GPS data from 49 wild pigs in the southeastern U.S., we used hidden Markov models to define movement path characteristics and assign behaviors (e.g., resting, foraging, travelling). We then explored the connection between these behaviors and resource selection for both sexes between two distinct seasons based on forage availability (i.e., low forage, high forage). Females demonstrated a crepuscular activity pattern in the high-forage season and a variable pattern in the low-forage season, while males exhibited nocturnal activity …

Efficacy And Risks From A Modified Sodium Nitrite Toxic Bait For Wild Pigs, Nathan P. Snow, Jason Wishart, Justin A. Foster, Linton D. Staples, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

BACKGROUND: Wild pigs (Sus scrofa) are a destructive invasive species throughout many regions of the world. In 2018, a field evaluation of an early prototype of a sodium nitrite (SN) toxic bait in the United States revealed wild pigs dropped large amounts of the toxic bait outside the pig-specific bait stations while feeding, and thus subsequent hazards for non-target animals. We modified the SN-toxic bait formulation, the design of the bait station, and the baiting strategy to reduce dropped bait. We tested the modifications in Queensland, Australia (December 2018), Alabama, USA (August 2019), and Texas, USA (March 2020) …

Daily And Landscape Influences Of Species Visitation To Toxic Bait Sites For Wild Pigs, Nathan P. Snow, Joseph M. Halseth, Michael P. Glow, Michael Lavelle, Justin Fischer, Eric H. Vannatta, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Toxic baiting of wild pigs (Sus scrofa) is a potential new tool for population control and damage reduction in the United States. Use of toxic bait sites by non‐target species is concerning because of the risks posed from exposure to a toxic bait. A 2018 field trial in northern Texas, USA, examining the efficacy of a prototype toxic bait (HOGGONE®, containing 10% sodium nitrite) revealed unexpected hazards to non‐target species, primarily passerine birds, from consuming toxic bait spilled outside of bait stations by wild pigs. The hazards jeopardize the ability to register HOGGONE as a tool for controlling …

Effects Of Social Structure And Management On Risk Of Disease Establishment In Wild Pigs, Anni Yang, Peter E. Schlichting, Bethany Wight, Wesley M. Anderson, Sarah M. Chinn, Mark Q. Wilber, Ryan S. Miller, James C. Beasley, Raoul Boughton, Kurt C. Vercauteren, George Wittemyer, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

1. Contact heterogeneity among hosts determines invasion and spreading dynamics of infectious disease, thus its characterization is essential for identifying effective disease control strategies. Yet, little is known about the factors shaping contact networks in many wildlife species and how wildlife management actions might affect contact networks.

2. Wild pigs in North America are an invasive, socially structured species that pose a health concern for domestic swine given their ability to transmit numerous devastating diseases such as African swine fever (ASF). Using proximity loggers and GPS data from 48 wild pigs in Florida and South Carolina, USA, we employed a …

Distribution And Abundance Of Scaup Using Baitfish And Sportfish Farms In Eastern Arkansas, Stephen A. Clements, Brian S. Dorr, Brian Davis, Luke A. Roy, Carole R. Engle, Katie C. Hanson-Dorr, Anita M. Kelly

United States Department of Agriculture Wildlife Services: Staff Publications

Arkansas' bait- and sportfish facilities are commonly used by various piscivorous bird species, including lesser scaup (Aythya affinis) and greater scaup (A. marila) that consume substantial quantities of fish. To mediate this predation, farmers implement extensive bird harassment programs that create additional costs to fish loss, thus research investigating the distribution and abundance of scaup is needed to help farmers allocate their bird harassment efforts more efficiently. In winters 2016–2017 and 2017–2018 we conducted 1,368 pond surveys to investigate pond use by scaup on farms during birds' regular wintering period (i.e., November–March). We used intrinsic and …

Avian Influenza A Viruses Reassort And Diversify Differently In Mallards And Mammals, Ketaki Ganti, Anish Bagga, Juliana Dasilva, Samuel S. Shepard, John R. Barnes, Susan A. Shriner, Katia Koelle, Anice C. Lowen

United States Department of Agriculture Wildlife Services: Staff Publications

Reassortment among co-infecting influenza A viruses (IAVs) is an important source of viral diversity and can facilitate expansion into novel host species. Indeed, reassortment played a key role in the evolution of the last three pandemic IAVs. Observed patterns of reassortment within a coinfected host are likely to be shaped by several factors, including viral load, the extent of viral mixing within the host and the stringency of selection. These factors in turn are expected to vary among the diverse host species that IAV infects. To investigate host differences in IAV reassortment, here we examined reassortment of two distinct avian …

Recolonizing Carnivores: Is Cougar Predation Behaviorally Mediated By Bears?, Kristin N. Engebretsen, Jon P. Beckmann, Carl W. Lackey, Alyson M. Andreasen, Cody Schroeder, Pat Jackson, Julie K. Young

United States Department of Agriculture Wildlife Services: Staff Publications

Conservation and management efforts have resulted in population increases and range expansions for some apex predators, potentially changing trophic cascades and foraging behavior. Changes in sympatric carnivore and dominant scavenger populations provide opportunities to assess how carnivores affect one another. Cougars (Puma concolor) were the apex predator in the Great Basin of Nevada, USA, for over 80 years. Black bears (Ursus americanus) have recently recolonized the area and are known to heavily scavenge on cougar kills. To evaluate the impacts of sympatric, recolonizing bears on cougar foraging behavior in the Great Basin, we investigated kill sites of 31 cougars between …

The Consequences Of Predators Without Prey, Mitchell A. Parsons, Thomas M. Newsome, Julie K. Young

United States Department of Agriculture Wildlife Services: Staff Publications

Rapid and ongoing environmental change is leading to scenarios where marine and terrestrial predators are persisting without prey, either by scavenging or using anthropogenic foods. Despite investigations into the effects of predator presence or absence on prey behavior and ecology, little research has assessed the effect of prey absence on predators. Here, we synthesize research on scavenging and the use of anthropogenic resources by marine and terrestrial predators; hypothesize how the use of these resources may change predator behavior with respect to their social structure, space use, life history, and individual behavioral traits; and illustrate how these changes are likely …

Improving Evaluation Of Nonlethal Tools For Carnivore Management And Conservation: Evaluating Fladry To Protect An Endangered Species From A Generalist Mesocarnivore, R. M. Windell, L. L. Bailey, J. K. Young, T. M. Livieri, D. A. Eads, S. W. Breck

United States Department of Agriculture Wildlife Services: Staff Publications

Carnivore conservation and management are global research priorities focused on reversing population declines of imperiled species and identifying more effective and humane management of generalist carnivores with thriving populations. Nonlethal methods to mitigate conflict are increasingly used to advance conservation objectives; however, there is limited knowledge about the effectiveness of many nonlethal methods. We tested a nonlethal tool (fladry), that serves as a barrier to deter wolves Canis lupus and coyotes Canis latrans, for its efficacy at preventing coyotes from using prairie dog Cynomys ludovicianus colonies, the primary prey for critically endangered black-footed ferrets Mustela nigripes. We used …

Social Media As A Window Into Human-Wildlife Interactions And Zoonotic Disease Risk: An Examination Of Wild Pig Hunting Videos On Youtube, Hailey E. Mclean, Lauren M. Jaebker, Aaron M. Anderson, Tara L. Teel, Alan D. Bright, Stephanie A. Shwiff, Keith M. Carlisle

United States Department of Agriculture Wildlife Services: Staff Publications

Wild pigs (Sus scrofa) damage agriculture and the environment, as well as transmit diseases to animals and people. Hunters are particularly vulnerable to zoonotic disease risks when harvesting wild pigs. Management agencies have endeavored to inform the public about disease risks associated with wild pigs and best practices for mitigating such risks. However, the extent that this guidance has reached hunters and influenced their practices is unclear. We approached this topic through an analysis of wild pig hunting videos on YouTube. We found evidence of relatively few behaviors and communications regarding disease risks and best practices for personal …

Relative Acceptance Of Brodifacoum Pellets And Soft Bait Sachets By Polynesian Rats (Rattus Exulans) On Wake Atoll, Peter J. Kappes, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

Removing invasive rats from island ecosystems using rodenticides has proven conservation benefits and is an important management tool for conserving and restoring island ecosystems. However, rodenticide-based eradications can fail if not all rats consume enough bait to result in lethal toxicosis. A recent post-operational review of a failed attempt to eradicate rats from Wake Atoll suggested that some individuals may not have ingested a lethal dose of rodenticide due to potential dietary and/or sensory preferences developed via regular access to anthropogenic food sources. These food sources may be higher in fats and oils, possessing different sensory properties (e.g., softer, chewier, …

Welfare Performance Of Three Foothold Traps For Capturing North American River Otters Lontra Canadensis, Matthew J. Lovallo, H. B. White, J. D. Erb, M. S. Peek, Thomas J. Deliberto

United States Department of Agriculture Wildlife Services: Staff Publications

Foothold traps are effective tools for the live capture and restraint of wildlife for management and research. Successful river otter Lontra canadensis restoration programs throughout North America used them extensively. Restoration programs used a variety of methods and models of foothold traps, but comprehensive efforts to describe and quantify injuries associated with river otter captures have been limited. We evaluated injuries of river otters caught in three commercially available models of foothold traps including the number 11 double long-spring with standard jaws, the number 11 double long-spring with double jaws, and the number 2 coil-spring trap. Based on examinations of …

Scaup Depredation On Arkansas Baitfish And Sportfish Aquaculture, Stephen A. Clements, Brian S. Dorr, J. Brian Davis, Luke A. Roy, Carole R. Engle, Katie C. Hanson-Dorr, Anita M. Kelly

United States Department of Agriculture Wildlife Services: Staff Publications

Lesser scaup (Aythya affinis) and greater scaup (A. marila), hereafter scaup, consume a variety of aquatic invertebrates, plants, and occasionally small fish. Scaup have foraged on commercial aquaculture farms in the southern United States for decades. However, the types, abundance, and rate of fish exploitation by scaup on baitfish and sportfish farms are not well documented. Thus, information is needed to understand how fish and other foods influence scaup use of aquatic resources, and any potential economic effects of depredation of fish. From November–March in winters 2016–2017 and 2017–2018, we conducted 1,458 pond surveys to estimate …

Impact Of Covid-19 On The Us And Texas Economy: A General Equilibrium Approach, Lirong Liu, Steven S. Shwiff, Stephanie A. Shwiff, Maryfrances Miller

United States Department of Agriculture Wildlife Services: Staff Publications

This paper examines the impact of COVID-19 on the US and Texas economy using a computable general equilibrium model, REMI PI+. We consider three scenarios based on economic forecasts from various sources, including the University of Michigan’s RSQE (Research Seminar in Quantitative Economics), IMF, and the Wi orld Bank. We report a GDP loss of $106 million (a 6% decline) with 1.2 million jobs lost (6.6%) in Texas in 2020. At the national level, GDP loss is $996 billion (a 5% decline) with 11.5 million jobs lost (5.5%) in the same year. By 2026, the aggregate total GDP loss in …

Conflict, Coexistence, Or Both? Cougar Habitat Selection, Prey Composition, And Mortality In A Multiple-Use Landscape, David C. Stoner, Mark A. Ditmer, Dustin L. Mitchell, Julie K. Young, Michael L. Wolfe

United States Department of Agriculture Wildlife Services: Staff Publications

Western North America is experiencing remarkable human population growth and land-use change. Irrigation and associated cultivation have led to colonization of urban-wildland interface (UWI) environments by mule deer (Odocoileus hemionus), and consequently, cougars (Puma concolor). In the wake of these changes, human-wildlife conflicts have increased in tandem with questions about long-term species conservation. To address these concerns, we fit 79 cougars with radio-telemetry collars in the Oquirrh Mountains near Salt Lake City, Utah (2002–2010). Our goal was to evaluate variation in cougar habitat selection, diet, and cause-specific mortality in a landscape dominated by urban, military, and industrial activities. We used …

Predicting Tomorrow: Optimizing The Early Detection Of Disease And Disease Recovery In Dairy Calves Using Precision Technologies, Melissa Cantor

Theses and Dissertations--Animal and Food Sciences

The leading causes of morbidity and mortality in preweaned dairy calves are diarrhea and bovine respiratory disease complex (BRD). The delayed detection of these diseases in calves can also delay intervention and disease recovery. The overarching objective of this dissertation was to follow a cohort of calves daily for the first 90 days of life for naturally occurring clinical BRD bouts and diarrheal bouts. The objective answered if feeding behaviors and activity levels were different in at-risk calves during BRD development and BRD recovery from an antimicrobial intervention. Furthermore, the potential of colostrum replacer as a feeding intervention strategy to …

Of Pigs And Men: The Best-Laid Plans For Prevention And Control Of Swine Fevers, Jishu Shi, Lihua Wang, David Scott Mcvey

School of Veterinary and Biomedical Sciences: Faculty Publications

John Steinbeck drew the title of his novel “Of Mice and Men” from a line in a Robert Burns poem “To a mouse”: “The best-laid plans of mice and men/Go often awry.” Unlike John Steinbeck who used the title to mirror the characters who were struggling during the Great Depression to the mouse whose nest was accidentally destroyed by the poet (Burns 1785), we chose this line to emphasize that the best-laid plan can go wrong in infectious disease control and prevention. Here, we will discuss the contributing factors behind the global successes and failures in the prevention and control …