Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Physical Sciences and Mathematics (1302)
- Statistics and Probability (1099)
- Public Health Education and Promotion (1011)
- Biostatistics (968)
- Life Sciences (882)
-
- Social and Behavioral Sciences (881)
- Medical Specialties (705)
- Diseases (665)
- Environmental Public Health (611)
- Community Health and Preventive Medicine (598)
- Health Services Research (517)
- Public Affairs, Public Policy and Public Administration (448)
- Women's Health (438)
- Occupational Health and Industrial Hygiene (424)
- Nutrition (414)
- Health Policy (411)
- Virus Diseases (302)
- International Public Health (301)
- Medical Sciences (301)
- Other Public Health (217)
- COVID-19 (206)
- Sociology (205)
- Clinical Epidemiology (186)
- Mental and Social Health (184)
- Health Information Technology (178)
- Translational Medical Research (156)
- Arts and Humanities (154)
- Institution
-
- Universitas Indonesia (692)
- Walden University (596)
- University of South Carolina (355)
- University of Nebraska Medical Center (311)
- University of Kentucky (258)
-
- University of Louisville (228)
- The Texas Medical Center Library (203)
- Aga Khan University (161)
- Himmelfarb Health Sciences Library, The George Washington University (153)
- University at Albany, State University of New York (151)
- Virginia Commonwealth University (148)
- Georgia Southern University (143)
- COBRA (139)
- Edith Cowan University (131)
- University of Nevada, Las Vegas (126)
- Western Kentucky University (121)
- University of South Florida (91)
- Old Dominion University (83)
- Chapman University (76)
- City University of New York (CUNY) (70)
- Western University (69)
- LSU Health New Orleans (57)
- East Tennessee State University (54)
- Illinois State University (48)
- Montclair State University (45)
- Dartmouth College (40)
- University of Texas Rio Grande Valley (39)
- West Virginia University (39)
- Loma Linda University (33)
- Thomas Jefferson University (32)
- Keyword
-
- COVID-19 (507)
- Humans (465)
- Epidemiology (329)
- Female (242)
- Male (222)
-
- SARS-CoV-2 (192)
- Adult (165)
- Pandemics (161)
- HIV (143)
- Coronavirus (141)
- Obesity (121)
- Western Kentucky University (116)
- Covid-19 (114)
- Adolescent (107)
- Middle Aged (105)
- United States (101)
- Public health (96)
- Aged (93)
- Cancer (91)
- Mortality (88)
- Child (81)
- Prevalence (77)
- Risk factors (77)
- Depression (74)
- Pregnancy (73)
- Mental health (68)
- Diabetes (67)
- Risk Factors (61)
- Georgia Southern University (60)
- Hypertension (60)
- Publication Year
- Publication
-
- Walden Dissertations and Doctoral Studies (581)
- Kesmas (433)
- Theses and Dissertations (255)
- Journal Articles: Epidemiology (234)
- Faculty Publications (229)
-
- Faculty, Staff and Student Publications (170)
- The University of Louisville Journal of Respiratory Infections (165)
- Jurnal Epidemiologi Kesehatan Indonesia (149)
- Legacy Theses & Dissertations (2009 - 2024) (132)
- Research outputs 2022 to 2026 (112)
- Epidemiology Faculty Publications (105)
- Epidemiology and Environmental Health Faculty Publications (98)
- USF Tampa Graduate Theses and Dissertations (87)
- Electronic Theses and Dissertations (83)
- Student/Alumni Personal Papers (78)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (59)
- Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018) (58)
- Epidemiology and Biostatistics Publications (53)
- Jurnal Nasional Kesehatan Lingkungan Global (53)
- Makara Journal of Health Research (51)
- Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications (50)
- Capstone Experience: Master of Public Health (38)
- GW Biostatistics Center (38)
- Annual Symposium on Biomathematics and Ecology Education and Research (37)
- Department of Public Health Scholarship and Creative Works (37)
- Journal of Health Disparities Research and Practice (36)
- Harvard University Biostatistics Working Paper Series (34)
- Theses & Dissertations (34)
- U.C. Berkeley Division of Biostatistics Working Paper Series (34)
- Dartmouth Scholarship (33)
- Publication Type
- File Type
Articles 2251 - 2280 of 5503
Full-Text Articles in Epidemiology
Slowing The Spread Of Covid-19: Review Of “Social Distancing” Interventions Deployed By Public Transit In The United States And Canada, Camille Kamga, Penny Eickemeyer
Slowing The Spread Of Covid-19: Review Of “Social Distancing” Interventions Deployed By Public Transit In The United States And Canada, Camille Kamga, Penny Eickemeyer
Publications and Research
This paper presents a review of social distancing measures deployed by transit agencies in the United States and Canada during the COVID-19 pandemic and discusses how specific operators across the two countries have implemented changes. Challenges and impacts on their operations are also provided.
Social distancing is one of the community mitigation measures traditionally implemented during influenza pandemics and the novel coronavirus pandemic. Research has shown that social distancing is effective in containing the spread of disease. This is applicable to the current situation with the novel coronavirus, given the lack of effective vaccines and treatments in the United States …
Mental Health Of Children And Adolescents Amidst Covid-19 And Past Pandemics: A Rapid Systematic Review, Salima Meherali, Neelam Punjani, Samantha Louie-Poon, Komal Abdul Rahim, Jai K. Das, Rehana A. Salam, Zohra S. Lassi
Mental Health Of Children And Adolescents Amidst Covid-19 And Past Pandemics: A Rapid Systematic Review, Salima Meherali, Neelam Punjani, Samantha Louie-Poon, Komal Abdul Rahim, Jai K. Das, Rehana A. Salam, Zohra S. Lassi
School of Nursing & Midwifery
Background: The COVID‑19 pandemic and associated public health measures have disrupted the lives of people around the world. It is already evident that the direct and indirect psychological and social effects of the COVID‑19 pandemic are insidious and affect the mental health of young children and adolescents now and will in the future. The aim and objectives of this knowledge-synthesis study were to identify the impact of the pandemic on children's and adolescent's mental health and to evaluate the effectiveness of different interventions employed during previous and the current pandemic to promote children's and adolescents' mental health.
Methodology: We conducted …
Facial Mask Use And Covid-19 Protection Measures In Jefferson County, Kentucky: Results From An Observational Survey, November 5−11, 2020, Seyed M. Karimi, Sonali S. Salunkhe, Kelsey B. White, Sahal A. Alzahrani, Bert Little, William P. Mckinney, Natalie Dupre, Riten Mitra, Yuting Chen, Martha M Popescu, Emily R. Adkins, Julia A. Barclay, Emmanuel Ezekekwu, Caleb.He X. He, Dylan M Hurst, Aravindreddy Kothagadi, Shaminul H. Shakib, Devin N. Swinney, David A. Johnson, Rebecca Hollenbach, Sarah Moyer
Facial Mask Use And Covid-19 Protection Measures In Jefferson County, Kentucky: Results From An Observational Survey, November 5−11, 2020, Seyed M. Karimi, Sonali S. Salunkhe, Kelsey B. White, Sahal A. Alzahrani, Bert Little, William P. Mckinney, Natalie Dupre, Riten Mitra, Yuting Chen, Martha M Popescu, Emily R. Adkins, Julia A. Barclay, Emmanuel Ezekekwu, Caleb.He X. He, Dylan M Hurst, Aravindreddy Kothagadi, Shaminul H. Shakib, Devin N. Swinney, David A. Johnson, Rebecca Hollenbach, Sarah Moyer
The University of Louisville Journal of Respiratory Infections
Introduction: The transmission of respiratory infectious diseases such as COVID-19 can significantly decrease by mask-wearing. However, accurate information about the extent and proper use of the facial mask is scarce. This study’s main objective was to observe and analyze mask-wearing behavior and the level of COVID-19 protection measures in indoor public areas (PAs) of Jefferson County, Kentucky.
Methods: For conducting the observational survey study, targets were indoor PAs, and zip codes were defined as surveying clusters. The number of selected PAs in each zip code was proportional to the population and the total number of PAs in that zip code. …
The Impact Of Covid-19 On Disability Services And Systems: Perspectives From The Field, Ronda Jenson, John Tschida
The Impact Of Covid-19 On Disability Services And Systems: Perspectives From The Field, Ronda Jenson, John Tschida
Developmental Disabilities Network Journal
No abstract provided.
Sleep Diagnoses And Low Back Pain In U.S. Military Veterans, Kenneth A. Taylor
Sleep Diagnoses And Low Back Pain In U.S. Military Veterans, Kenneth A. Taylor
USF Tampa Graduate Theses and Dissertations
Low back pain (LBP) is a common problem that is the primary contributor to years lived with disability worldwide. In the U.S. LBP is disproportionately experienced by military veterans. In recent years interest has grown in the impact of sleep and sleep-related diagnoses on musculoskeletal pain complaints (including LBP) and despite growth in the scientific literature investigating this, gaps in our understanding of how sleep diagnoses impact LBP remain. To that end, this dissertation uses administrative electronic health record data from veterans seeking care through the Veterans Health Administration in three manuscripts to address the following specific aims: (1) investigate …
Prevalence Of Liver Cirrhosis And Its Association With Obesity Among Hispanics And Mexican Americans: An Evidence Synthesis, Alexa Perlick, Abaigeal Thompson, Colton Wayne, Angel Rendon, Jose Campo Maldonado
Prevalence Of Liver Cirrhosis And Its Association With Obesity Among Hispanics And Mexican Americans: An Evidence Synthesis, Alexa Perlick, Abaigeal Thompson, Colton Wayne, Angel Rendon, Jose Campo Maldonado
MEDI 9331 Scholarly Activities Clinical Years
INTRODUCTION
The obesity epidemic is a growing public health concern. In addition to the already known complications and comorbidities associated with obesity, data suggest that obesity is an independent risk factor for the development of liver disease.1,2 However, there is a paucity of data regarding the clinical correlation of obesity and cirrhosis in a predominantly Hispanic population of South Texas. The aim of this systematic literature review is to investigate the prevalence of cirrhosis stratified by obesity in Hispanic populations.
MATERIALS AND METHODS
PubMed was used to perform a thorough literature search. The terms liver cirrhosis and obesity were …
Sars-Cov-2 Transmission In Alberta, British Columbia, And Ontario, Canada, December 25, 2019, To December 1, 2020, Isaac Chun-Hai Fung, Yuen Wai Hung, Sylvia Ofori, Kamalich Muniz-Rodriguez, Po-Ying Lai, Gerardo Chowell
Sars-Cov-2 Transmission In Alberta, British Columbia, And Ontario, Canada, December 25, 2019, To December 1, 2020, Isaac Chun-Hai Fung, Yuen Wai Hung, Sylvia Ofori, Kamalich Muniz-Rodriguez, Po-Ying Lai, Gerardo Chowell
Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
Objective:
This study aimed to investigate coronavirus disease (COVID-19) epidemiology in Alberta, British Columbia, and Ontario, Canada.
Methods:
Using data through December 1, 2020, we estimated time-varying reproduction number, R t , using EpiEstim package in R, and calculated incidence rate ratios (IRR) across the 3 provinces.
Results:
In Ontario, 76% (92 745/121 745) of cases were in Toronto, Peel, York, Ottawa, and Durham; in Alberta, 82% (49 878/61 169) in Calgary and Edmonton; in British Columbia, 90% (31 142/34 699) in Fraser and Vancouver Coastal. Across 3 provinces, R t dropped to ≤ 1 after April. …
International Respiratory Infections Society Covid Research Conversations: Podcast 2 With Dr. Michael S. Niederman And Dr. Edward J. Schenck, Julio A. Ramirez, Michael S. Niederman, Edward J. Schenck
International Respiratory Infections Society Covid Research Conversations: Podcast 2 With Dr. Michael S. Niederman And Dr. Edward J. Schenck, Julio A. Ramirez, Michael S. Niederman, Edward J. Schenck
The University of Louisville Journal of Respiratory Infections
Section(s) Topics
1–4 Introductions
5 COVID-19 in New York City
6–7 Telemedicine, long-term sequelae
8 Development of a multi-disciplinary ICU team
9–10 Treatment of ARDS, COVID-19 pathogenesis
11–12 Prioritizing treatment at research
13 Challenges in tracing the natural history of severe COVID-19
14–15 Experience with mechanically ventilated patients; non-pulmonary organ failure
16–17 Mapping COVID-19 trajectories by SOFA score
18–20 Findings: additive organ dysfunction, improving vs. worsening trajectory
21 ARDS therapeutic approaches
22 Clinical trials involving Cornell
23–25 Lessons learned: patient care, research, education, caring for critical care workers
26–30 2021 predictions: improved therapies and research, endemic COVID-19, vaccines
31–33 Prioritizing …
Characterization, Bio-Uptake And Toxicity Of Polymer-Coated Silver Nanoparticles And Their Interaction With Human Peripheral Blood Mononuclear Cells, Sahar Pourhoseini, Reilly T. Enos, Angela E. Murphy, Bo Cai Ph.D., Jamie Lead
Characterization, Bio-Uptake And Toxicity Of Polymer-Coated Silver Nanoparticles And Their Interaction With Human Peripheral Blood Mononuclear Cells, Sahar Pourhoseini, Reilly T. Enos, Angela E. Murphy, Bo Cai Ph.D., Jamie Lead
Faculty Publications
Silver nanoparticles (AgNPs) are widely used in medical applications due to their antibacterial and antiviral properties. Despite the extensive study of AgNPs, their toxicity and their effect on human health is poorly understood, as a result of issues such as poor control of NP properties and lack of proper characterization. The aim of this study was to investigate the combined characterization, bio-uptake, and toxicity of well-characterized polyvinylpyrrolidone (PVP)-coated AgNPs in exposure media during exposure time using primary human cells (peripheral blood mononuclear cells (PBMCs)). AgNPs were synthesized in-house and characterized using a multimethod approach. Results indicated the transformation of NPs …
Examining The Impact Of Socioeconomic Variables On Covid-19 Death Rates At The State Level, James L. Doti
Examining The Impact Of Socioeconomic Variables On Covid-19 Death Rates At The State Level, James L. Doti
Economics Faculty Articles and Research
This study uses a step-wise regression model to identify the socioeconomic variables most significant in explaining COVID-19 death rates on a state-level basis. The regression tests cover the 1/1/2020 to 12/1/2020 period as well as the first and second halves of 2020. This study also uses the Oxford stringency index to measure more precisely the efficacy of governmental mandates at the state level. The results in this study rigorously showed that while the density variables were the most significant explanatory variables during the first half of the year, their significance fell during the second half. Use of the Oxford stringency …
Bait-And-Kill: Targeting A Novel Heme Biochemical Pathway In Hundreds Of Cancers, Christopher G. Marinescu
Bait-And-Kill: Targeting A Novel Heme Biochemical Pathway In Hundreds Of Cancers, Christopher G. Marinescu
USF Tampa Graduate Theses and Dissertations
Cancer cells are characterized by their ability to grow and proliferate in rates that far exceed normal cells by modifying their iron/heme metabolisms to levels higher than normal. This imbalance of heme biosynthesis can lead to cancer cells having a flux of heme intermediates to the point where they enter a state called heme-overdrive. Heme-overdrive is a process unique to a variety of cancers but absent in normal tissues. With this enhanced production, heme can act as an epigenic regulator for signaling proliferation (18). Through the novel strategy called ‘bait-and-kill,’ cancer cells will be coerced into a state of heme …
Defining Early And Late Clinical Outcomes In Patients With Sars-Cov-2 Pneumonia, Julio A. Ramirez, Jose Bordon, Rodrigo Cavallazzi, Stephen P. Furmanek, Jiapeng Huang, Timothy L. Wiemken, Forest W. Arnold
Defining Early And Late Clinical Outcomes In Patients With Sars-Cov-2 Pneumonia, Julio A. Ramirez, Jose Bordon, Rodrigo Cavallazzi, Stephen P. Furmanek, Jiapeng Huang, Timothy L. Wiemken, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Cat Flea Infestation, Evolution And Endosymbionts, And Community Awareness Towards Fleas And Flea-Borne Diseases, Noor Azrizal Abdul Wahid
Cat Flea Infestation, Evolution And Endosymbionts, And Community Awareness Towards Fleas And Flea-Borne Diseases, Noor Azrizal Abdul Wahid
Student Works (2020-2029)
The cat flea Ctenocephalides felis is the cosmopolitan ectoparasite infesting cats. Occurrence of this flea on cats has led to several disease problems resulted from its ectoparasitic activity and associated pathogens. For prevention measure, study on its prevalence and genetic structure can help in identifying the infestation risk factors and its vectorial capability. In this study, infestation survey indicated overall high prevalence (71.8 %) of C. felis on cats sampled from four different regions in Peninsular Malaysia and the prevalence was associated (p < 0.05) with several risk factors including age, body weight, hair length, body condition and status of the cats. Among the regions, infestation rate was significantly highest on cat population in western region (28.9 %). Moreover, an assessment of knowledge, attitudes and practices (KAP) among cat owners showed possession of moderate level for knowledge on fleas and relatively low level for knowledge on flea-borne diseases. However, there were positive attitudes and good practices shown by the community in regard to prevention measures. Principle Component Analysis of KAP level, nevertheless, did not exert any variability among the respondents from different regions. Furthermore, analysis of cat flea mtDNA inferred from barcoding genes (cox1 and cox2) showed genetic variations between the four regions with western demonstrated the highest genetic diversity (Hd = 0.7833, Pi = 0.0127, Nh = 9). However, in overall, this study observed low nucleotide and haplotype diversities, indicating high homogeneity in genetic content among flea populations resulted from high gene flow. There were 15 haplotype numbers (AB1 – AB15) revealed in cat flea populations in Malaysia. Global comparison, however, indicated that Malaysian cat fleas had limited geographical distribution within Southeast Asian region while had genetic proximity with population from tropical region. Analyses of endosymbiont bacteria showed that cat fleas in Peninsular Malaysia carry Bartonella and Rickettsia bacteria with 28 % of flea samples were positive for Bartonella DNA and 14 % for Rickettsia DNA. Meanwhile, the tested flea populations were negative for Mycoplasma infection. Three Bartonella species were recorded including B. clarridgeiae, B. hensalae and the first record in Malaysia, B. koehlerae. Meanwhile, Rickettsia asembonensis was the only rickettsial bacteria identified in the present study. Statistical analyses revealed no association on the bacterial infection towards the mtDNA diversity of the cat fleas. However, in overall pathogen infection, infected population demonstrated lower haplotype and nucleotide diversities and showed lower number of haplotypes. Ultimately, the finding from this study will be beneficial in flea management and control program related to veterinary practices by providing insights on flea infestation, community awareness, evolution and its associated pathogens. The present findings highlighted the need for ongoing public health programs, given the relatively low possession of flea related knowledge among cat owners, and high infection rates of pathogens in cat flea populations in Peninsular Malaysia.
Meeting Minutes, Wku Council Of Academic Deans
Meeting Minutes, Wku Council Of Academic Deans
Council of Academic Deans
Meeting regarding eSports, first destination survey, Respondus Monitor, DELO funds, graduate assistant instructors, salaries and working remotely.
Relationship Between Diet Quality Scores And The Risk Of Frailty And Mortality In Adults Across A Wide Age Spectrum, Kulapong Jayanama, Olga Theou, Judith Godin, Leah Cahill, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert, Michael David Wirth Msph, Phd, Yong-Moon Park, Teresa T. Fung, Kenneth Rockwood
Relationship Between Diet Quality Scores And The Risk Of Frailty And Mortality In Adults Across A Wide Age Spectrum, Kulapong Jayanama, Olga Theou, Judith Godin, Leah Cahill, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert, Michael David Wirth Msph, Phd, Yong-Moon Park, Teresa T. Fung, Kenneth Rockwood
Faculty Publications
Background
Beyond intakes of total energy and individual nutrient, eating patterns may influence health, and thereby the risk of adverse outcomes. How different diet measures relate to frailty—a general measure of increased vulnerability to unfavorable health outcomes—and mortality risk, and how this might vary across the life course, is not known. We investigated the associations of five dietary indices (Nutrition Index (NI), the energy-density Dietary Inflammatory Index (E-DII™), Healthy Eating Index-2015 (HEI-2015), Mediterranean Diet Score (MDS), and Dietary Approaches to Stop Hypertension (DASH)) with frailty and mortality.
Methods
We included 15,249 participants aged ≥ 20 years from the 2007–2012 cohorts …
Using A Hybrid Agent-Based And Equation Based Model To Test School Closure Policies During A Measles Outbreak, Elizabeth Hunter, John D. Kelleher
Using A Hybrid Agent-Based And Equation Based Model To Test School Closure Policies During A Measles Outbreak, Elizabeth Hunter, John D. Kelleher
Articles
Background
In order to be prepared for an infectious disease outbreak it is important to know what interventions will or will not have an impact on reducing the outbreak. While some interventions might have a greater effect in mitigating an outbreak, others might only have a minor effect but all interventions will have a cost in implementation. Estimating the effectiveness of an intervention can be done using computational modelling. In particular, comparing the results of model runs with an intervention in place to control runs where no interventions were used can help to determine what interventions will have the greatest …
H1n1 Influenza Virus (Swine Flu): A Comprehensive Insight Into Escalating Catch-22 Scenarios, Muhammad Shahzaib, Ehsan Ul Haq
H1n1 Influenza Virus (Swine Flu): A Comprehensive Insight Into Escalating Catch-22 Scenarios, Muhammad Shahzaib, Ehsan Ul Haq
The University of Louisville Journal of Respiratory Infections
Introduction: Viruses have always been a major cause of various disastrous pandemics in mankind’s history. H1N1 became a threat when its original strain was first discovered back in the swine flu pandemic of 2009. It became highly catastrophic on a large scale because none of the therapeutic interventions and methodologies that were already present at the time were effective against the virus.
Methods: A vast amount of literature and research is available regarding H1N1 influenza from different reputable sources online. The data were gathered with the contrasting and relative situations of 1918 and 2009 pandemics in mind. The overall extracted …
Heterogeneous Contributions Of Change In Population Distribution Of Body Mass Index To Change In Obesity And Underweight, Ncd Risk Factor Collaboration (Ncd-Risc), Maria Lc Iurilli, Bin Zhou, James E. Bennett, Rodrigo M. Carrillo-Larco, Marisa K. Sophiea, Andrea Rodriguez-Martinez, Honor Bixby, Bethlehem D. Solomon, Zulfiqar Ahmed Bhutta
Heterogeneous Contributions Of Change In Population Distribution Of Body Mass Index To Change In Obesity And Underweight, Ncd Risk Factor Collaboration (Ncd-Risc), Maria Lc Iurilli, Bin Zhou, James E. Bennett, Rodrigo M. Carrillo-Larco, Marisa K. Sophiea, Andrea Rodriguez-Martinez, Honor Bixby, Bethlehem D. Solomon, Zulfiqar Ahmed Bhutta
Woman and Child Health
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape …
Lag Effects Of Ozone, Pm2.5, And Meteorological Factors On Covid-19 New Cases At The Disease Epicenter In Queens, New York, Atin Adhikari, Jingjing Yin
Lag Effects Of Ozone, Pm2.5, And Meteorological Factors On Covid-19 New Cases At The Disease Epicenter In Queens, New York, Atin Adhikari, Jingjing Yin
Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
The influences of environmental factors on COVID-19 may not be immediate and could be lagged for days to weeks. This study investigated the choice of lag days for calculating cumulative lag effects of ozone, PM2.5, and five meteorological factors (wind speed, temperature, relative humidity, absolute humidity, and cloud percentages) on COVID-19 new cases at the epicenter of Queens County, New York, before the governor’s executive order on wearing of masks in public places (1 March to 11 April 2020). Daily data for selected air pollutants and meteorological factors were collected from the US EPA Air Quality System, weather observation station …
Nih Funding For Vaccine Readiness Before The Covid-19 Pandemic, Anthony E. Kiszewski, Ekaterina Galkina Cleary, Matthew J. Jackson, Fred D. Ledley
Nih Funding For Vaccine Readiness Before The Covid-19 Pandemic, Anthony E. Kiszewski, Ekaterina Galkina Cleary, Matthew J. Jackson, Fred D. Ledley
Natural & Applied Sciences Faculty Publications
Rapid development of vaccines for COVID-19 has relied on the application of existing vaccine technologies. This work examines the maturity of ten technologies employed in candidate vaccines (as of July 2020) and NIH funding for published research on these technologies from 2000–2019. These technologies vary from established platforms, which have been used successfully in approved products, to emerging technologies with no prior clinical validation. A robust body of published research on vaccine technologies was supported by 16,358 fiscal years of NIH funding totaling $17.2 billion from 2000–2019. During this period, NIH funding for published vaccine research against specific pandemic threats …
Factors Associated With Chronic Kidney Disease Of Non-Traditional Causes Among Children In Guatemala, Alejandro Cerón, Brooke M. Ramay, Luis Pablo Méndez-Alburez, Randall Lou-Meda
Factors Associated With Chronic Kidney Disease Of Non-Traditional Causes Among Children In Guatemala, Alejandro Cerón, Brooke M. Ramay, Luis Pablo Méndez-Alburez, Randall Lou-Meda
Anthropology: Faculty Scholarship
Objective. To identify factors associated with chronic kidney disease of non-traditional causes among children in Guatemala. Methods. A cross-sectional survey was conducted. The study population was all pediatric patients with stage 5 chronic kidney disease active in FUNDANIER’s pediatric nephrology unit (N = 156). Simple random sampling led to a total of 100 participants. Data collection consisted of a questionnaire addressing individual and household characteristics, access and utilization of health care, and place of residence when the disease began. Chronic kidney disease etiology was obtained from medical records. Municipality-level secondary data were collected. Descriptive statistics were estimated. Logistic regression was …
Protecting P-Glycoprotein At The Blood-Brain Barrier From Degradation In An Alzheimer's Disease Mouse Model, Yujie Ding, Yu Zhong, Andrea Baldeshwiler, Erin L. Abner, Björn Bauer, Anika M. S. Hartz
Protecting P-Glycoprotein At The Blood-Brain Barrier From Degradation In An Alzheimer's Disease Mouse Model, Yujie Ding, Yu Zhong, Andrea Baldeshwiler, Erin L. Abner, Björn Bauer, Anika M. S. Hartz
Sanders-Brown Center on Aging Faculty Publications
BACKGROUND: Failure to clear Aβ from the brain is partly responsible for Aβ brain accumulation in Alzheimer's disease (AD). A critical protein for clearing Aβ across the blood-brain barrier is the efflux transporter P-glycoprotein (P-gp). In AD, P-gp levels are reduced, which contributes to impaired Aβ brain clearance. However, the mechanism responsible for decreased P-gp levels is poorly understood and there are no strategies available to protect P-gp. We previously demonstrated in isolated brain capillaries ex vivo that human Aβ40 (hAβ40) triggers P-gp degradation by activating the ubiquitin-proteasome pathway. In this pathway, hAβ40 initiates P-gp ubiquitination, leading to internalization and …
International Respiratory Infections Society Covid Research Conversations: Podcast 1 With Dr. Francesco Blasi, Julio A. Ramirez Md, Francesco Blasi Md, Phd
International Respiratory Infections Society Covid Research Conversations: Podcast 1 With Dr. Francesco Blasi, Julio A. Ramirez Md, Francesco Blasi Md, Phd
The University of Louisville Journal of Respiratory Infections
Section(s) Topics
1–2 Introductions
3 Foundations of best practice
4 COVID-19 as stimulus for innovation
5 Adapting and evolving therapeutic approach
6 Age and comorbidities as risk factors
7 Over-capacity ICU
8 Adapting the ER for COVID-19
9 Training personnel for COVID-19
10 Psychological support, healthcare heroes, and COVID fatigue
11 Increased oxygen requirement
12–13 Milan’s multi-disciplinary unit
14 Standardizing respiratory support measures
15 Nutrition, sedation, and life support
16 CPAP successes and failures
17 Prone and lateral positioning of patients on CPAP
18 Different COVID-19 phenotypes?
19 Thromboembolism risk score, age, and comorbidities
20 Cardiorespiratory considerations: hypertension, echocardiography
21 …
An Update On The Leading Covid-19 Vaccines, Ahmed A. Eladely, Javaria Anwer Mbbs, Ashwini Gotimukul Mbbs, Manish Kc Mbbs, Jessica Petrey Msls, Alex Glynn Ma, Ruth M. Carrico Phd, Dnp, Julio A. Ramirez Md
An Update On The Leading Covid-19 Vaccines, Ahmed A. Eladely, Javaria Anwer Mbbs, Ashwini Gotimukul Mbbs, Manish Kc Mbbs, Jessica Petrey Msls, Alex Glynn Ma, Ruth M. Carrico Phd, Dnp, Julio A. Ramirez Md
The University of Louisville Journal of Respiratory Infections
We reviewed the COVID-19 vaccines that reached phase III of clinical development. For each of the 10 vaccines identified, we described the technology used for vaccine development, the available data from phase III clinical trials, data on vaccine safety, and the role of new SARS-CoV-2 variants on vaccine efficacy.
Detection Of Mutations Associated With Variants Of Concern Via High Throughput 2 Sequencing Of Sars-Cov-2 Isolated From Nyc Wastewater, Davida S. Smyth, Monica Trujillo, Kristen Cheung, Anna Gao, Irene Hoxie, Sherin Kannoly, Nanami Kubota, Michelle Markman, Kaung Myat San, Geena Sompanya, John J. Dennehy
Detection Of Mutations Associated With Variants Of Concern Via High Throughput 2 Sequencing Of Sars-Cov-2 Isolated From Nyc Wastewater, Davida S. Smyth, Monica Trujillo, Kristen Cheung, Anna Gao, Irene Hoxie, Sherin Kannoly, Nanami Kubota, Michelle Markman, Kaung Myat San, Geena Sompanya, John J. Dennehy
Publications and Research
Monitoring SARS-CoV-2 genetic diversity is strongly indicated because diversifying selection may lead to the emergence of novel variants resistant to naturally acquired or vaccine-induced immunity. To date, most data on SARS-CoV-2 genetic diversity has come from the sequencing of clinical samples, but such studies may suffer limitations due to costs and throughput. Wastewater-based epidemiology may provide an alternative and complementary approach for monitoring communities for novel variants. Given that SARS-CoV-2 can infect the cells of the human gut and is found in high concentrations in feces, wastewater may be a valuable source of SARS-CoV-2 RNA, which can be deep sequenced …
Mortalidad Por Infarto Agudo De Miocardio En Guatemala 2018: Patrones E Inequidades, Alejandro Cerón, Gila Goldstein
Mortalidad Por Infarto Agudo De Miocardio En Guatemala 2018: Patrones E Inequidades, Alejandro Cerón, Gila Goldstein
Anthropology: Faculty Scholarship
El presente estudio busca analizar la mortalidad por infarto agudo de miocardio (IAM) en Guatemala con el propósito de identificar posibles criterios epidemiológicos que orienten la priorización de acciones de salud pública. El riesgo de morir de IAM en Guatemala muestra marcadas desigualdades por departamento, las que son aún más marcadas al comparar por municipio. El riesgo de morir es también más alto en personas mestizas o ladinas, en niveles educativos bajos, y en personas que se dedican a ocupaciones elementales. Deberían implementarse medidas de salud pública orientadas a los municipios y grupos en mayor riesgo de morir de IAM. …
Incidence And Pathophysiology Of Diabetes In South Asian Adults Living In India And Pakistan Compared With Us Blacks And Whites, K M Venkat Naraya, Dimple Kondal, Natalie Daya, Unjali P. Gujral, Deepa Mohan, Shivani A. Patel, Roopa Shivashankar, Ranjit Mohan Anjana, Lisa R. Staimez, Muhammad Masood Kadir
Incidence And Pathophysiology Of Diabetes In South Asian Adults Living In India And Pakistan Compared With Us Blacks And Whites, K M Venkat Naraya, Dimple Kondal, Natalie Daya, Unjali P. Gujral, Deepa Mohan, Shivani A. Patel, Roopa Shivashankar, Ranjit Mohan Anjana, Lisa R. Staimez, Muhammad Masood Kadir
Community Health Sciences
Introduction: We compared diabetes incidence in South Asians aged ≥45 years in urban India (Chennai and Delhi) and Pakistan (Karachi), two low-income and middle-income countries undergoing rapid transition, with blacks and whites in the US, a high-income country.
Research design and methods: We computed age-specific, sex-specific and body mass index (BMI)-specific diabetes incidence from the prospective Center for Cardiometabolic Risk Reduction in South Asia Study (n=3136) and the Atherosclerosis Risk in Communities Study (blacks, n=3059; whites, n=9924). We assessed factors associated with incident diabetes using Cox proportional hazards regression.
Results: South Asians have lower BMI and waist circumference than blacks …
Estimasi Risiko Kesehatan Pajanan Besi Dan Mangan Pada Air Tanah Sebagai Air Minum Masyarakat Di Kota Depok, Jawa Barat (Hasil Survei Kualitas Air Bpp Pdam Tirta Asasta Kota Depok 2018), Marhamah Dwi Anjani, Bambang Wispriyono
Estimasi Risiko Kesehatan Pajanan Besi Dan Mangan Pada Air Tanah Sebagai Air Minum Masyarakat Di Kota Depok, Jawa Barat (Hasil Survei Kualitas Air Bpp Pdam Tirta Asasta Kota Depok 2018), Marhamah Dwi Anjani, Bambang Wispriyono
Jurnal Nasional Kesehatan Lingkungan Global
Background. Groundwater plays an important role as a source of fulfillment of daily clean water and drinking water in Depok City. Groundwater is considered to have good natural qualities, but that does not mean that all groundwater is good quality. Iron and manganese are essential but also toxic metals that are often found in groundwater. Methods. This study uses the Environmental Health Risk Assessment (EHRA) method which aims to estimate the level of iron and manganese risk exposure in groundwater as drinking water. Data collection of iron and manganese concentration was obtained from groundwater quality survey results by BPP PDAM …
Hubungan Kontaminasi Escherichia Coli Pada Makanan Dengan Kejadian Diare Pada Murid Di Sekolah Menengah Atas (Sma) Di Kecamatan Bogor Barat Tahun 2019, Inneza Rahmelia, Ema Hermawati
Hubungan Kontaminasi Escherichia Coli Pada Makanan Dengan Kejadian Diare Pada Murid Di Sekolah Menengah Atas (Sma) Di Kecamatan Bogor Barat Tahun 2019, Inneza Rahmelia, Ema Hermawati
Jurnal Nasional Kesehatan Lingkungan Global
Background. One of the contamination food in school is Escherichia coli bacteria which can cause diarrhea. Diarrhea is associated with inadequate environmental conditions and unhealthy behavior. The case of diarrhea in Bogor Barat District 2016 was 5700 cases. Prevalence of diarrhea for 15-24 years of age group is 7,2%. Senior high school students in Indonesia are required to attend a full day school. Those schools have canteens which serves food to the students and are supposed to ensure afood safety. The purpose of this study was to determine the association between Escherichia coli contamination in food and diarrhea among students …
Hubungan Antara Ruang Terbuka Hijau Dengan Prevalensi Hipertensi Di Provinsi Dki Jakarta Tahun 2018, Dwi Nutfa Liani, Laila Fitria
Hubungan Antara Ruang Terbuka Hijau Dengan Prevalensi Hipertensi Di Provinsi Dki Jakarta Tahun 2018, Dwi Nutfa Liani, Laila Fitria
Jurnal Nasional Kesehatan Lingkungan Global
Background. Study about the relationship between green space with the prevalence of hypertension in DKI Jakarta is necessary to be done considering of the availability of green spaces that are less than the minimum standard, and the prevalence of hypertension that continues to increase, The increase of urbanization in DKI Jakarta provokes many problems. One of the problems is about the availability of green spaces. The availability of green spaces in DKI Jakarta is only 10% from all the areas. Besides, according to UU No. 26 Tahun 2007 Tentang Penataan Ruang, the minimum standard of green space in city is …