Epidemiology Commons^™

Spatial Analysis Of The Distribution Of Covid-19 Vulnerable Groups To Covid-19 Cases In Brebes Regency, Fatimatuzzahro Fatimatuzzahro, Rara Warih Gayatri

Preventia: The Indonesian Journal of Public Health

The number of COVID-19 cases in Brebes Regency within a year is still quite high. The elderly, Hypertension and Diabetes Mellitus are the most important COVID-19 vulnerable groups and have the highest risk of death. The purpose of this study is to determine the distribution of COVID-19 vulnerable groups and their spatial relationship to COVID-19 cases in Brebes Regency. This study used a correlation or ecology study design. The data used is secondary data obtained from the Brebes Regency Health Office, namely the number of COVID-19 cases, the number of elderly, people with hypertension and diabetes mellitus in 2021. The …

Bivariate Spatial Pattern Based On The Characteristics Of Women Smokers In Indonesia, Diana Rohmandani Putri, Rudi Safarudin, Ammad Khokar, Konain Tayab, Muhammad Taaha Kashif, Erni Astutik

Preventia: The Indonesian Journal of Public Health

The increasing prevalence of smoking among women globally has become a critical public health issue. World Health Organization (WHO) data shows 20 percent of women use tobacco. Women smokers face an increased risk of various diseases. Spatial studies need to be conducted as a basis for planning and providing targeted interventions to reduce the spread of diseases caused by smoking. The study aimed to determine the spatial description of smoking among women in Indonesia. This study analyzed the 2017 IDHS data and used an ecological study design with a descriptive approach and a spatial analysis model. The results are Papua …

Systematic Review Of The Relationship Between Hygiene Practice And The Incidence Of Ascaris Lumbricoides Infection In Southeast Asian Children, Anastasia Rouli Alodia, Ririn Arminsih Wulandari

Preventia: The Indonesian Journal of Public Health

Soil-Transmitted Helminth (STH) infection is one of the Neglected Tropical Diseases (NTDs) that affects around 1.5 billion people worldwide, including regions like Southeast Asia. The most common species infecting humans is Ascaris lumbricoides. Preschool-age and school-age children are particularly vulnerable to STH infection due to their living environments in areas where STH is prevalent. Infection of STH, especially Ascaris lumbricoides, can hinder physical and cognitive development and, in severe cases, cause obstruction of the small intestine. Various factors, such as hygiene practices, can influence the transmission of Ascaris lumbricoides infection in children. This study aims to explore the association between …

Peningkatan Pengetahuan Dan Keterampilan Analisis Data Surveilans Hipertensi Di Tingkat Puskesmas Kota Bukittinggi Tahun 2022, Meilisa Meilisa, Ratna Djuwita, Eka Budi Satria

Jurnal Epidemiologi Kesehatan Indonesia

Masalah penyakit tidak menular prioritas di Kota Bukittinggi adalah hipertensi, namun cakupan SPM (25,62%) dan deteksi dini nya (9,20%) masih rendah. Evaluasi sistem surveilans menunjukkan salah satu fungsi pokok surveilans (analisis data) tidak terlaksana. Penelitian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan analisis data surveilans hipertensi bagi petugas puskesmas. Desain penelitian adalah NonExperimental Pre – Post Test Design dengan total sampling sebanyak 14 orang yang dilaksanakan pada bulan November 2022 s/d Januari 2023. Intervensi dalam penelitian ini berupa pelatihan dengan metoda ceramah dan latihan pratikum. Analisis data menggunakan uji T dependen (Paired t test) dan Mc-Nemar. Hasil penelitian menunjukkan latar …

Hubungan Tingkat Kebisingan Dengan Tekanan Darah Pada Penduduk Di Sekitar Bandar Udara Halim Perdanakusuma Tahun 2023, Neva Azzahra, Fajaria Nurcandra

Jurnal Epidemiologi Kesehatan Indonesia

Pada tahun 2021, terdapat 252,553 penderita hipertensi di Jakarta Timur. Salah satu faktor penyebab hipertensi adalah kebisingan. Penelitian ini bertujuan untuk melihat hubungan antara kebisingan dengan tekanan darah penduduk yang tinggal di sekitar Bandara Halim Perdanakusuma. Penelitian dilakukan pada Mei 2023 dengan menggunakan metode observasional analitik dengan desain penelitian cross sectional. Jumlah sampel yaitu 86 responden dengan teknik sampling random walk. Alat ukur yang digunakan adalah sound level meter dan tensimeter digital. Kuesioner yang digunakan dalam penelitian ini yaitu IPAQ untuk aktivitas fisik dan Recall 24 jam untuk konsumsi lemak. Pada analisis bivariat dan multivariat menggunakan uji cox regresi. Dari …

Faktor Determinan Hipertensi Pada Jemaah Haji Usia Lebih Dari 40 Tahun Di Provinsi Dki Jakarta Tahun 2022, Danny Danny, Mondastri Korib Sudaryo

Jurnal Epidemiologi Kesehatan Indonesia

Di seluruh dunia, hipertensi adalah penyakit tidak menular paling umum yang menyebabkan kematian. Hipertensi menjadi penyakit yang mendominasi pada jemaah haji Indonesia dengan prevalensi yang terus meningkat. Jemaah haji merupakan populasi khusus yang cukup rentan karena ibadah haji membutuhkan kemampuan fisik dan mental yang baik sehingga penyelenggaraan kesehatan haji menjadi tugas penting bagi pemerintah. Penelitian ini bertujuan untuk mengetahui faktor determinan kejadian hipertensi pada jemaah haji usia lebih dari 40 tahun di provinsi DKI Jakarta tahun 2022. Penelitian ini menggunakan desain studi potong lintang dengan sampel sebanyak 3.339 orang. Penelitian ini menggunakan data sekunder dari pemeriksaan kesehatan tahap 2 jemaah …

Epidemiologi Difteri Di Indonesia Tahun 2020-2022: Distribusi Kasus, Tingkat Keparahan Gejala, Riwayat Imunisasi Dan Risiko Kematian, Sekar Astrika Fardani, Tri Yunis Miko Wahyono

Jurnal Epidemiologi Kesehatan Indonesia

Difteri menjadi salah satu penyebab utama kematian anak dan dewasa pada era pre-vaksin. Insiden difteri secara global kembali meningkat pada beberapa tahun terakhir dengan case fatality rate (CFR) mencapai 10%. Manusia tidak memiliki kekebalan alami terhadap difteri, sehingga pemberian imunisasi sangat penting untuk memberikan perlindungan terhadap infeksi difteri, mengurangi tingkat keparahan dan risiko kematian. Penelitian ini bertujuan memberikan gambaran distribusi kasus, tingkat keparahan gejala, riwayat imunisasi difteri dan risiko kematian pada penderita difteri di Indonesia tahun 2020 s.d 2022. Penelitian dilakukan dengan desain studi cross-sectional dengan menggunakan data sekunder laporan kasus difteri nasional tahun 2020 s.d 2022. Dari 563 responden, …

Faktor-Faktor Yang Berhubungan Dengan Ketidakpatuhan Minum Antiretroviral Pada Orang Dengan Hiv Di Rumah Sakit Umum Daerah Balaraja Kabupaten Tangerang, Dessi Marantika Nilam Sari, Mondastri Korib Sudaryo, Qotrun Nada, Ilham Ahmadi

Jurnal Epidemiologi Kesehatan Indonesia

Kurangnya kepatuhan terhadap pengobatan menjadi faktor risiko munculnya jenis HIV yang resisten terhadap obat, yang dapat ditularkan kepada orang lain. Kepatuhan terhadap pengobatan yang buruk tidak hanya membahayakan kesehatan individu tetapi juga meningkatkan penularan. Penelitian ini bertujuan untuk mengamati faktor-faktor yang berhubungan dengan terjadinya ketidakpatuhan minum obat ARV pada ODHIV yang mendapatkan terapi ARV di Rumah Sakit Umum Daerah Balaraja. Jenis penelitian ini menggunakan penelitian observasional dengan rancangan cross sectional. Penelitian dilakukan di poli HIV Rumah Sakit Umum Daerah Balaraja Kabupaten Tangerang dan waktu penelitian dilakukan pada bulan Juli 2023 menggunakan data sekunder. Populasi penelitian berjumlah 382 ODHIV yang aktif …

Predictors Of Prescription Opioid Misuse Based On Type Of Healthcare Insurance, Keon Green Drph, Mba, Hca, C.J. Schumaker Phd Lfache

Journal of Social, Behavioral, and Health Sciences

The misuse and abuse of prescription opioid (PO) medications has garnered the attention of lawmakers, healthcare professionals, and public health experts since the opioid epidemic was declared a national public health emergency in 2017. Our purpose in this study was to investigate the types of healthcare insurance that predict PO misuse. We also sought to inform stakeholders of potentially needed changes to the existing inconsistent drug utilization rules necessary to achieve parity among all types of healthcare insurance and minimize loopholes. We performed a secondary data analysis on the 2019 National Survey on Drug Use and Health data of noninstitutionalized …

Dampak Asuhan Berkelanjutan Pada Ibu Hamil Terhadap Kematian Neonatus Di Perkotaan Dan Pedesaan: Analisis Demographic And Health Surveys Indonesia 2017, Sonia Miyajima Anjani, Asri C. Adisasmita

Jurnal Epidemiologi Kesehatan Indonesia

Upaya menurunkan angka kematian neonatus (AKN) membutuhkan suatu pelayanan kesehatan yang berkesinambungan, dikenal dengan istilah asuhan berkelanjutan atau Continuum of care. Asuhan berkelanjutan pada ibu hamil di daerah perkotaan bisa saja berbeda dengan di pedesaan. Penelitian ini ingin mengetahui dampak asuhan berkelanjutan pada ibu hamil terhadap kematian neonatus, serta peran tempat tinggal ibu hamil terhadap hubungan tersebut. Studi ini merupakan studi potong lintang menggunakan set data Demographic and Health Surveys (DHS) Indonesia tahun 2017. Variabel dependen pada studi ini adalah kematian neonatus dari anak terakhir yang dilahirkan responden antara 2012 hingga 2017. Variabel independennya adalah asuhan berkelanjutan pada ibu hamil …

Situation Analysis Of Health Problems In Depok City In 2021, Murti Utami Putri, Asri C. Adisasmita, Hidayat Nuh Ghazali Djajuli

Jurnal Epidemiologi Kesehatan Indonesia

Based on 2021 data, from the results of problem identification, 16 health problems in Depok City were assessed. Maternal mortality was selected as a priority problem with 65 cases of maternal death or 155.58 per 100,000 live births. COVID-19 infection is the most common cause of maternal death. This study aims to provide an overview of maternal death circumstances in Depok because of prioritization following situation analysis of health problems. This situation analysis was conducted in Depok with a quantitative and qualitative approach analyzed using the PAHO-adapted Hanlon involving the participation of 17 respondents from the Health Office and the …

Trend Epidemiologi Kematian Jemaah Haji Indonesia Tahun 2017-2023, Nooridha Febriyanti, Asri C. Adisasmita

Jurnal Epidemiologi Kesehatan Indonesia

Ibadah haji adalah ibadah wajib bagi umat islam yang mampu secara finansial, mental dan fisik. Dalam pelaksanaan ibadah haji, terjadi kumpulan massa yang sangat masif sehingga berpotensi menimbulkan kematian pada jemaah haji akibat beberapa faktor, diantaranya faktor kesehatan, kepadatan, dan cuaca panas. Angka kematian jemaah haji Indonesia masih dinilai tinggi yaitu mencapai 200 kematian diantara 100.000 jemaah haji yang berangkat. Penelitian ini bertujuan untuk menggambarkan kematian jemaah haji Indonesia berdasarkan variabel orang, waktu dan tempat. Studi ini dilakukan dengan desain case series yang dianalisis secara deskriptif menggunakan data sekunder pelayanan kesehatan haji melalui Sistem Komputerisasi Haji Terpadu Bidang Kesehatan (Siskohatkes) …

Gambaran Faktor Risiko Pasien Hiv Dengan Tuberkulosis Di Rsud Kota Bogor, Leni Haryani, Nur Rizky Ramadhani, Rizky Fajar Meirawan, Bram Burmanajaya

Jurnal Epidemiologi Kesehatan Indonesia

Tuberkulosis merupakan infeksi opportunistik yang mematikan. WHO melaporkan bahwa TB menjadi penyebab kematian 187.000 pasien HIV. Penelitian ini bertujuan untuk mengetahui gambaran faktor risiko pasien HIV yang menderita TB berdasarkan karakteristik demografi, stadium klinis HIV, status sosial ekonomi dan faktor risiko HIV/AIDS di RSUD Kota Bogor tahun 2016-2021. Penelitian ini merupakan penelitian deskriptif dengan desain studi cross sectional. Pengambilan sampel dilakukan cara purposive sampling dan didapatkan sampel sebanyak 60 responden. Data dianalisis menggunakan uji Chi Square. Hasil penelitian menunjukan jumlah pasien HIV TB (+) periode 2016-2021 di RSUD Kota Bogor sebagian besar berusia < 35 Tahun (73,7%), berjenis kelamin laki laki (90,2%), belum menikah (82,8%) tingkat pendidikan tinggi (71,7%), status tidak bekerja (80%), berada pada stadium klinis 3 dan 4 (82,6%) dan memiliki status sosial ekonomi kurang mampu (81,6%) serta faktor risiko perilaku seksual (72,4%). Hasil analisis menunjukan bahwa terdapat tiga karakteristik yang dapat menyebabkan perbedaan status infeksi TB pada pasien HIV yaitu jenis kelamin dengan p value

Pemetaan Stunting, Wasting, Dan Obesitas Berdasarkan Kondisi Geografis Di Kota Palembang, Athiyah Ashilah, Najmah Najmah, Feri Fahrizal, Trisnawarman Trisnawarman, Sri Rahayu, Rahma Zahara

Jurnal Epidemiologi Kesehatan Indonesia

Saat ini Indonesia mengalami masalah “triple burden”, yaitu tingginya kasus stunting dan wasting serta masalah gizi berupa obesitas dan kekurangan zat gizi mikro. Prevalensi stunting di Kota Palembang berada pada angka 14,3%, wasting 7,8%, dan obesitas 5,6%. Secara tidak langsung, kondisi geografis merupakan salah satu faktor yang mempengaruhi status gizi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pemetaan kejadian stunting, wasting, dan obesitas di Kota Palembang berdasarkan kondisi geografisnya. Penelitian ini merupakan penelitian kuantitatif dengan desain studi ekologi deskriptif menggunakan data sekunder yang kemudian dianalisis dengan software QGIS. Populasi pada penelitian ini adalah seluruh balita yang ada di Kota …

Cognitive Decline Associated With Longitudinal Changes In 24-H Ambulatory Blood Pressure Variability, Jesus D. Melgarejo, Kristina P. Vatcheva, Luis J. Mena, Carlos A. Chavez, Egle Silva, Gustavo E. Calmon, Rosa P. Mavarez, Joseph H. Lee, Joseph D. Terwilliger, Gladys E. Maestre

School of Medicine Publications

Background: Cognitive decline has been associated with variability in blood pressure (BP). However, whether the increment of the BP variability during follow-up precedes cognitive decline remains undocumented. We aimed this study to investigate cognitive decline in relation to longitudinal changes in 24-h reading-to-reading BP variability.

Methods: We conducted an observational longitudinal study that included 717 dementia-free participants from the Maracaibo Aging Study who underwent follow-up assessment in both 24-h ambulatory BP monitoring and cognitive tests between 1998 and 2015. Cognitive domains consisted of selective reminding tests (total, long-term, short-term, and recognition memory) and the Mini-Mental State Examination (MMSE). …

Cancer Survivorship And Subjective Cognitive Decline In The Us: Results From A Nationally Representative Sample, Monique J. Brown, Ally Hucek, Jingkai Wei, Loretta Anderson, Muzi Na

Faculty Publications

Cancer may be associated with objective cognitive decline. However, studies examining the link between cancer and subjective cognitive decline (SCD), which occurs earlier during cognitive trajectories, are lacking. In addition, research assessing risk factors for SCD among cancer survivors is scant. Therefore, this study aimed to examine the association between cancer and SCD in the past year, and assess the association between age of diagnosis, cancer treatment, and SCD among cancer survivors. Data were obtained from the 2021 Behavioral Risk Factor Surveillance System (N=15,447). Crude and adjusted logistic regression models, controlling for sociodemographic characteristics, were used to determine the association …

Assessment Of Deficits In Specific Cognitive Domains In Older Adults Living With Hiv., Andrea Reyes-Vega, Harideep Samanapally, Rishikesh Rijal, Stephen P. Furmanek, Christopher B. Shields, Brandon C. Dennis, Smita Ghare, Shirish Barve

Faculty and Staff Scholarship

A significant proportion of people living with HIV (PLWH) have cognitive impairment. Moreover, approximately 70% of PLWH in the United States will be ≥50 years old by 2030, raising concerns of a higher incidence of dementia as they age. Accordingly, there is a clinical need to monitor their cognitive status. The aim of this study was to delineate specific cognition areas impacted in OALWH with a clinical diagnosis of neurocognitive impairment. We used a comprehensive set of tests (paper and NIH Toolbox Cognition Battery), to assess different cognitive domains in a total of 25 OALWH ≥ 50 years. 64% were …

Association Of Covid-19 Coinfection With Increased Mortality Among Patients With Pseudomonas Aeruginosa Bloodstream Infection In The Veterans Health Administration System, Leila S. Hojat, Brigid M. Wilson, Federico Perez, Maria F. Mojica, Mendel E. Singer, Robert A. Bonomo

Faculty Scholarship

Objective: Pseudomonas aeruginosa bloodstream infection (PA-BSI) and COVID-19 are independently associated with high mortality. We sought to demonstrate the impact of COVID-19 coinfection on patients with PA-BSI. Design: Retrospective cohort study. Setting: Veterans Health Administration. Patients: Hospitalized patients with PA-BSI in pre-COVID-19 (January 2009 to December 2019) and COVID-19 (January 2020 to June 2022) periods. Patients in the COVID-19 period were further stratified by the presence or absence of concomitant COVID-19 infection. Methods: We characterized trends in resistance, treatment, and mortality over the study period. Multivariable logistic regression and modified Poisson analyses were used to determine the association between COVID-19 …

Lifestyle Behaviors Before And After Diagnosis Of Type 2 Diabetes: Findings From The Nurses’ Health Studies, Amelia E. Roebuck

Dissertations and Theses (Open Access)

Short- and long-term changes in diet or physical activity in relation to type 2 diabetes mellitus (T2DM) and factors associated with behavior change with adequate inclusion of relevant confounding and effect-modifying variables have been minimally explored. The objective of this research was to examine changes in diet and physical activity following a diagnosis of T2DM and identify sociodemographic, medical, psychosocial, and lifestyle factors associated with changes in dietary or physical activity behaviors. This dissertation utilized two prospective cohorts of U.S. female nurses participating in the Nurses’ Health Study (1976-2016) and Nurses’ Health Study II (1989-2017). Linear mixed effects modeling was …

Dna Methylation-Based Epigenetic Biomarkers In Cell-Type Deconvolution And Tumor Tissue Of Origin Identification, Ze Zhang

Dartmouth College Ph.D Dissertations

DNA methylation is an epigenetic modification that regulates gene expression and is essential to establishing and preserving cellular identity. Genome-wide DNA methylation arrays provide a standardized and cost-effective approach to measuring DNA methylation. When combined with a cell-type reference library, DNA methylation measures allow the assessment of underlying cell-type proportions in heterogeneous mixtures. This approach, known as DNA methylation deconvolution or methylation cytometry, offers a standardized and cost-effective method for evaluating cell-type proportions. While this approach has succeeded in discerning cell types in various human tissues like blood, brain, tumors, skin, breast, and buccal swabs, the existing methods have major …

Timigp: An R Package To Depict The Tumor Microenvironment From Bulk Transcriptomics, Chenyang Li, Jianjun Zhang, Chao Cheng

Faculty, Staff and Students Publications

Exploring the clinical relevance of diverse immune cell types within the tumor microenvironment is pivotal for unraveling cancer intricacies and developing treatments. Here, we present a protocol for using tumor immune microenvironment illustration based on gene pairs, an R package to deduce cell-cell interactions, unveiling the association between immune cell relative abundance and patient prognoses from bulk gene expression and survival data. We describe steps for harnessing cell-type markers derived from single-cell RNA sequencing data to map the tumor immune microenvironment across a spectrum of cancer types. For complete details on the use and execution of this protocol, please refer …

Where Did All The Bed Bugs Go?, Lauren Friedman

Capstones

In the early 2000s in New York City, everyone was talking about bed bugs. The disc-shaped, bloodsucking pests had been a common domestic nuisance up to the World War II era, but in the decades since, they’d mostly faded into obscurity. That was until bed bug infestations, which are often psychologically distressing and sometimes impossible to overcome, suddenly became routine across the five boroughs, driving people from their apartments and stoking fear about everything from upholstered theater seats to thrift stores.

But then, just as quickly as bed bugs had invaded, they seemed to fade away. In a 2022 study …

Opportunities For Mental Health Interventions In Rural Mississippi Communities During The Covid-19 Pandemic: A Quantitative Analysis, Brice Fortinberry

Theses and Dissertations

COVID-19 presented unique challenges for rural Mississippi communities including impacts on the mental health of rural individuals. This research study aimed to identify opportunities for mental health interventions to provide health promotion professionals with quantitative data on the accessibility and the likelihood of engagement with mental health-fostering behaviors. A secondary objective of this research was to categorize these behaviors within the constructs of the Social Ecological Model. Demographics for rural Mississippi communities were collected and displayed, and using multivariate analyses including Spearman’s correlation and a Mann-Whitney U test the correlation between mental health fostering behaviors and demographic factors was obtained. …

Predictors Of Lung Cancer Screening Recommendation In Virginia Using The Community Health Assessment Survey, Aashish Batheja, Carrie Miller, Sunny Jung Kim, Bernard Fuemmeler F., Rajsh Balkrishnan

Virginia Journal of Public Health

Purpose: The purpose of this analysis was to determine the factors that may influence the probability of being recommended a lung cancer screening by a health professional in Virginia.

Methods: Data were obtained from the Community Health Assessment Survey conducted by the University of Virginia (UVA) Health System and Cancer System in collaboration with Virginia Commonwealth University (VCU) Cancer Center. SAS software was used to conduct a logistic regression with the following variables: age, sex, race, current smoking status, cancer history, education level, income level, insurance, and rurality.

Results: Statistically significant positive predictors included being a current smoker (OR: 3.504, …

Detection Of Suicide Clusters Using Small-Area Geographic Data From The Virginia Violent Death Reporting System, 2010 – 2015, Kurtis M. Anthony, Allison Ertl, Rachel A. Leavitt, Alexander E. Crosby, Ryan M. Diduk-Smith, Kevin A. Matthews

Virginia Journal of Public Health

Introduction: From 1999 to 2020, the suicide rate in Virginia increased from 13.1 to 15.9 per 100,000 persons aged 10 years and older. Few studies have examined spatial patterns of suicide geographies smaller than the county level.

Methods: We analyzed data from suicide decedents aged ≥10 years from 2010 through 2015 in the Virginia Violent Death Reporting System. We identified spatial clusters of high suicide rates using spatially adaptive filtering with standardized mortality ratio (SMR) significantly higher than the state SMR (p < 0.001). We compared demographic characteristics, method of injury, and suicide circumstances of decedents within each cluster to decedents outside any cluster.

Results: We identified 13 high-risk suicide clusters (SMR between 1.7 and 2.0). Suicide decedents in the clusters were …

Duchenne Muscular Dystrophy: Age, Disease Stage, And Patient-Reported Quality Of Life, Sheila Jagers

Walden Dissertations and Doctoral Studies

No abstract provided.

Models Of Shared Care For The Management Of Psychotic Disorder After First Diagnosis In Ontario., Joshua C. Wiener, Rebecca Rodrigues, Jennifer N S Reid, Kelly K. Anderson

Epidemiology and Biostatistics Publications

OBJECTIVE: To describe the provision of care for young people following first diagnosis of psychotic disorder.

DESIGN: Retrospective cohort study using health administrative data.

SETTING: Ontario.

PARTICIPANTS: People aged 14 to 35 years with a first diagnosis of nonaffective psychotic disorder in Ontario between 2005 and 2015 (N=39,449).

MAIN OUTCOME MEASURES: Models of care, defined by psychosis-related service contacts with primary care physicians and psychiatrists during the 2 years after first diagnosis of psychotic disorder.

RESULTS: During the 2-year follow-up period, 29% of the cohort received only primary care, 30% received only psychiatric care, and 32% received both primary and …

Environmental Exposures And Aging., Daniel Chris Gomes

Electronic Theses and Dissertations

In recent years, research into air pollution has shown that exposure to certain components in air pollution, primarily PM2.5 can accelerate biological aging and thereby lead to increased susceptibility to multiple diseases. We hypothesize that prolonged exposure to air pollutants can result in premature aging leading to extensive tissue dysfunction and susceptibility to diseases. To examine this, we exposed mice to PM2.5 for 9, 15, and 21 days, then measured the telomere lengths, cellular senescence, and histone methylation patterns of multiple cell types. We found consistently increased telomere attrition, cellular senescence and advanced age-consistent histone methylation patterns in groups exposed …

Genetic Risk Scores For Hypertension And Chronic Kidney Disease In African Americans., Aastha Kakar

Electronic Theses and Dissertations

Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions, disproportionally prevalent among African Americans (AA) and are influenced by multiple genetic as well as environmental factors. Genetic risk scores (GRS) enable the analysis of the combined effects of multiple single nucleotide polymorphisms (SNPs). This study investigates the association of blood pressure (BP) and CKD GRS with BP, hypertension (HT) and CKD; early-onset HT and CKD; and investigates interactions of the GRSs with environmental measures in AA. We observed a significant association between the BP-GRS with HT, SBP and DBP. The odds of HT for one standard deviation (s.d.) increase …

Associations Between Maternal Alcohol Consumption During Pregnancy And Selected Musculoskeletal Birth Defects Among Offspring In The National Birth Defects Prevention Study, Sarah Fisher

Legacy Theses & Dissertations (2009 - 2024)

Maternal alcohol consumption during pregnancy is known to be associated with poor pregnancy outcomes, including fetal alcohol spectrum disorders. However, evidence for associations between alcohol consumption during pregnancy and some major structural birth defects among offspring is conflicting or inconclusive. This dissertation used data from the National Birth Defects Prevention Study (NBDPS), a multi-site, population-based case-control study, to examine associations between maternal alcohol consumption and risk of three major musculoskeletal birth defects: gastroschisis, omphalocele, and craniosynostosis. Our analyses built upon previous analyses of these associations using NBDPS data, including larger sample sizes and more robust analytic methods to explore issues …