Public Health Commons^™

Features Of Acute Covid-19 Associated With Post-Acute Sequelae Of Sars-Cov-2 Phenotypes: Results From The Impacc Study, Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E Milliren, Jingjing Qi, Linda N Geng, Grace A Mccomsey, Charles B Cairns, Lindsey R Baden, Joanna Schaenman, Albert C Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P Shannon, Rafick P Sekaly, Lauren I R Ehrlich, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Harm Van Bakel, Seunghee Kim-Schulze, David A Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K Haddad, Carolyn S Calfee, David J Erle, Charles R Langelier, Walter Eckalbar, Steven E Bosinger, Bjoern Peters, Steven H Kleinstein, Elaine F Reed, Alison D Augustine, Joann Diray-Arce, Holden T Maecker, Matthew C Altman, Ruth R Montgomery, Patrice M Becker, Nadine Rouphael

Faculty, Staff and Students Publications

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B …

Heat Shock Factor 1 Directly Regulates Transsulfuration Pathway To Promote Prostate Cancer Proliferation And Survival, J Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang

Faculty, Staff and Students Publications

There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the conversion of homocysteine to cystathionine in the transsulfuration pathway by altering levels of cystathionine-β-synthase (CBS). We find that HSF1 directly binds the CBS gene and upregulates CBS mRNA levels. Targeting CBS decreases PCa growth and induces tumor cell death while benign prostate cells are largely unaffected. Combined inhibition of HSF1 and CBS results in more pronounced inhibition of PCa cell …

The Use Of Cardiac Magnetic Resonance In Hypertrophic Cardiomyopathy Over The Past 10 Years [2013-2023]: A Citespace-Based Bibliometric Analysis, Mengyao Hu, Yu Shen, Yipei Song, Shuhao Li, Pei Yang, Ao Kan, Qiming Fang, Yun Peng, Haibo Ren, Yajing Zhang, Lianggeng Gong

Faculty, Staff and Student Publications

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder characterized by the hypertrophy of a segment of the myocardium. Cardiac magnetic resonance (CMR) has been widely used in the assessment of HCM. However, no bibliometric assessment has been conducted on the progress of research in this field. This study thus aimed to examine the current state of research into the application of CMR in HCM and the hotspots and trends that have emerged in this field over the past decade.

METHODS: A systematic search was conducted on the Web of Science regarding CMR in the assessment of HCM. The …

Mastitis And Mammary Abscess Management Audit (Mamma) In The Uk And Ireland, Alona Courtney, Jonathon Clymo, Ruth Parks, Alexander Wilkins, Ruth Brown, Rachel O'Connell, Rajiv Dave, Marianne Dillon, Hiba Fatayer, Rachel Gallimore, Ashu Gandhi, Matthew Gardiner, Victoria Harmer, Lyndsey Hookway, Gareth Irwin, Charlotte Ives, Helen Mathers, Juliette Murray, D Peter O'Leary, Neill Patani, Sophie Paterson, Shelley Potter, Ruth Prichard, Giovanni Satta, T G Teoh, Paul Ziprin, Stuart Mcintosh, Michael R Boland, Daniel Richard Leff, Mamma Research Collaborative

Faculty, Staff and Student Publications

BACKGROUND: The aim of this multicentre prospective audit was to describe the current practice in the management of mastitis and breast abscesses in the UK and Ireland, with a specific focus on rates of surgical intervention.

METHODS: This audit was conducted in two phases from August 2020 to August 2021; a phase 1 practice survey and a phase 2 prospective audit. Primary outcome measurements for phase 2 included patient management pathway characteristics and treatment type (medical/radiological/surgical).

RESULTS: A total of 69 hospitals participated in phase 2 (1312 patients). The key findings were a high overall rate of incision and drainage …

Group Reflection: Barrier Of The White Coat, Abrielle Fretz, Anusha Vavilikolanu, Cassandra Pecarski, Daphne Pate, Peter Nolan, Trisha Ray, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Patient Scheduling, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Gabrielle Cowen, Kassim Salami, Simran Brar, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Administrators: Scheduling Conflicts With Administration, Constance Cleveland, Deepa Raghavan, Dipra Debnath, Jay Maixner, Ranya Krayem, Vikash Mehan, Zane Mustafa, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administrator Makes An Offensive Or Inappropriate Comment, Emily Smith, Joseph Mccormick, Lukas Biel, Melissa Elmali, Mura Abdul-Nabi, Nitya Deshpande, Sahalia Rashid

Patient Education Projects

No abstract provided.

Conflict With Administrators: Excused Absence Policy, Ashley Frei, Cameron Bear, Grant Zydeck, Justin Hassen, Madison Meyer, Mithil Gudi, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Professionalism Conflict With Administrator, Jessica Long, Jovan Jande, Krishni Kumaresan, Mohammad Al-Hadidi, Molly Dahle, Trevor Ruesch, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Scheduling Conflicts In The Workplace, Alisha Williams, Hovhannes Hayrapetyan, John Gallagher, Julia Malewicz, Kirsten Brinkmeier, Nasser Junedi, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Conflict Resolution And Professionalism, Abrielle Fretz, Anusha Vavilikolanu, Cassandra Pecarski, Daphne Pate, Peter Nolan, Trisha Ray, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Dissemination Of Information, Chase Aaron, Max Jones, Arhan Shetty, Ingrid Rocha, Jane Dow, Karamoja Monchamp, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Admin Will Not Cover A Procedure, Anthony Bally, Manahil Shaikh, Nadeen Sukhon, Petar Martinovski, Sarah Chamdin, Yousif Jafar, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Harassment In The Workplace, Alexander Minos, Carline Dugue, Ethan Mathew, Katherine Sommers, Lauren Fleckenstein, Peter Zakaria, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Staffing Concerns, Noor Sulaiman, Emma Breukink, Hussein Bazzi, Ranganath Kathawate, Ron Lukose, Vikram Rajan, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Conflict Resolution Approaching Admin, Amjad El Othmani, Bethany Lyche, Hafsah Umerani, Issac Anderson, Katie Clark, Nikhil Navathe, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Different Generations, Abbie Bauer, Anna Rowell, Joseph Wun, Kiersten Walsworth, Parker Fitzgerald, Peter Martin, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Administrators Fail To Communicate, Anjani Raja, Armaan Naghdi, Blaise Deschamps, Jack Mao, Noor Sulieman, Stephanie Barna, Amanah Fatima

Patient Education Projects

No abstract provided.

Conflict With Administrators: Violation Of Hippa, Michael Wang, Alexander Eskandarian, Grace Markey, Hamza Ali, Sesilia Kammo, Sonja Klumpp, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Time Off Conflict, Demetrius Moncrease, Parshva Salvi, Basel Mhaimeed, Fadumo Yusuf, Marissa Yaldo, Sneha Bhargava, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.

Conflict With Administrators: Receiving Negative Feedback From An Administrator, Saachi Mittal, Arifbillah Sarowar, Connor Sakis, Karthik Babu Kolisetty, Markiesha Baines, Meaghan Osborne, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Inappropriate Comment, Akarsh Lal, Damian Daryl Nucum, Elizabeth Choi, Emily Falkowski, Ramneet Chauhan, Shawn O'Malley, Ayman Salem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Lack Of Communication, Abigail Jaczkowski, Angie Achkar, Brandon Doan, Diana Mcmahon, Julian Johnson, Kevin Tran, Sahalia Rashid, Rahul Vyas

Patient Education Projects

No abstract provided.

Conflict With Administrators: Roles And Responsibilities, Alyssa Rogers, James Burtka, Kaitlin Verkuilen, Maria Tjilos, Nelson Pinto, Siddharth Tirumala, Amanah Fatima, Fadi Kathawa

Patient Education Projects

No abstract provided.

Conflict With Administrators: Disagreement Over Patient Quotas, Era Cobani, Angelica Cabatu, Carly Abrahams, Curtis Mack, Michal Ruprecht, Nicholas Apostolakis, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Medical Supplies And Patient Care, Sujit Prasad, Ahmad Khatib, Dana Josifoski, Joyce Li, Kevin Cobty, Sarah Bdeir, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.

Conflict With Administrators: Addressing Negative Evaluations, Derya Turk, Izma Khaliq, Katherine Gavagan, Morolayo Ilori, Nabeel Sumbal, Srikanth Pillai, Wassim Mohamad-Said

Patient Education Projects

No abstract provided.

Conflict With Administrators: Effecting Quality Patient Care, Dhiraj Tadikamalla, Lara Rostomian, Meet Patel, Neil Garg, Sara Naessig, Sohini Pandit, Mariam Raheem

Patient Education Projects

No abstract provided.

Conflict With Administrators: Surgery Under The Influence, David Allen, Elena Busuito, Emma Burke, Rebekah Pitpitan, Rubi Walker, Zachary Chen, Kenan Abou Chaer, Astha Saini

Patient Education Projects

No abstract provided.