Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (13024)
- Medical Specialties (9409)
- Public Health Education and Promotion (7977)
- Life Sciences (6879)
- Community Health and Preventive Medicine (6128)
-
- Epidemiology (5749)
- Health Services Research (5352)
- Sociology (4955)
- Education (4074)
- Women's Health (4064)
- Diseases (3939)
- International Public Health (3626)
- Public Affairs, Public Policy and Public Administration (3297)
- Maternal and Child Health (3151)
- Medical Sciences (3099)
- Occupational Health and Industrial Hygiene (2968)
- Mental and Social Health (2893)
- Physical Sciences and Mathematics (2792)
- Health Services Administration (2790)
- Health and Medical Administration (2719)
- Medical Education (2475)
- Health Policy (2456)
- Environmental Public Health (2432)
- Family, Life Course, and Society (2205)
- Nursing (2205)
- Demography, Population, and Ecology (2068)
- Psychology (1795)
- Arts and Humanities (1794)
- Institution
-
- The Texas Medical Center Library (3923)
- Western Michigan University (3149)
- Population Council (2553)
- Walden University (2212)
- Henry Ford Health (2166)
-
- University of Kentucky (2087)
- Georgia Southern University (1903)
- Universitas Indonesia (1816)
- Thomas Jefferson University (1813)
- University of South Carolina (1559)
- Aga Khan University (1520)
- University of Nevada, Las Vegas (1310)
- Wayne State University (1226)
- Himmelfarb Health Sciences Library, The George Washington University (1151)
- Institut de Recherche Robert-Sauvé en santé et en sécurité du travail (1122)
- University of Nebraska Medical Center (905)
- City University of New York (CUNY) (868)
- Boise State University (805)
- Edith Cowan University (745)
- Old Dominion University (733)
- University of Nebraska - Lincoln (732)
- Western Kentucky University (541)
- LSU Health New Orleans (538)
- University of South Florida (519)
- SIT Graduate Institute/SIT Study Abroad (516)
- The Beryl Institute (500)
- Portland State University (491)
- University of Louisville (459)
- Wright State University (421)
- University of Alabama at Birmingham (417)
- Keyword
-
- COVID-19 (4866)
- Humans (3431)
- Michigan (2866)
- English (2228)
- Public health (1893)
-
- Female (1825)
- Male (1375)
- Adult (1109)
- Georgia Southern University (970)
- COVID-19 cases (852)
- Public Health (822)
- Obesity (806)
- Middle Aged (744)
- United States (719)
- Health (713)
- Pregnancy (708)
- SARS-CoV-2 (694)
- Reproductive Health (686)
- Aged (655)
- HIV (648)
- Epidemiology (645)
- Mental health (624)
- Adolescent (594)
- Hospital data (592)
- Education (548)
- Child (545)
- Family Planning (540)
- Jiann-Ping Hsu College of Public Health (534)
- Québec (517)
- Poverty Gender and Youth (511)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (2331)
- Henry Ford Hospital Medical Journal (2151)
- Walden Dissertations and Doctoral Studies (2122)
- Reproductive Health (1314)
- Faculty Publications (1215)
-
- Faculty, Staff and Students Publications (1154)
- Rapports de recherche scientifique (977)
- Patient Education Projects (959)
- Poverty, Gender, and Youth (856)
- Population Health Matters (Formerly Health Policy Newsletter) (798)
- Theses and Dissertations (757)
- Kesmas (727)
- International Journal of Physical Activity and Health (667)
- Michigan COVID-19 Hospital Data (594)
- Publications and Research (593)
- Cumulative Michigan COVID-19 Data (588)
- Journal of Health Disparities Research and Practice (550)
- College of Public Health: Faculty Syllabi (2014-2021) (537)
- Patient Experience Journal (500)
- Daily Michigan COVID-19 Update (498)
- Independent Study Project (ISP) Collection (495)
- Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.) (487)
- USF Tampa Graduate Theses and Dissertations (482)
- Michigan COVID-19 Syndromic Surveillance System Data (443)
- Capstone Experience: Master of Public Health (422)
- All ETDs from UAB (400)
- Community Health Sciences (379)
- Electronic Theses and Dissertations (379)
- Research outputs 2022 to 2026 (373)
- HIV and AIDS (354)
- Publication Type
Articles 8671 - 8700 of 55621
Full-Text Articles in Public Health
Women In Health And Their Economic, Equity And Livelihood Statuses During Emergency Preparedness And Response (Wheeler) Protocol: A Mixed Methods Study In Kenya., Evaline Chepchirchir Langat, Bilali Yusuf Mazoya, Pauline Oginga, Ferdinand Okwaro, Norah Matheka, Irene Kibara, Rhoda Otieno, Michaela Mantel, Robert Lorway, Marleen Temmerman
Women In Health And Their Economic, Equity And Livelihood Statuses During Emergency Preparedness And Response (Wheeler) Protocol: A Mixed Methods Study In Kenya., Evaline Chepchirchir Langat, Bilali Yusuf Mazoya, Pauline Oginga, Ferdinand Okwaro, Norah Matheka, Irene Kibara, Rhoda Otieno, Michaela Mantel, Robert Lorway, Marleen Temmerman
Centre of Excellence in Women and Child Health
Introduction: Kenya reported its first COVID-19 case on 13 March 2020. Pandemic-driven health system changes followed and unforeseen societal, economic and health effects reported. This protocol aims to describe the methods used to identify the gender equality and health equity gaps and possible disproportional health and socioeconomic impacts experienced by paid and unpaid (community health volunteer) female healthcare providers in Kilifi and Mombasa Counties, Kenya during the COVID-19 pandemic.
Methods and analysis: Participatory mixed methods framed by gender analysis and human-centred design will be used. Research implementation will follow four of the five phases of the human-centred design approach. Community …
Profiles Of Activity Engagement And Depression Trajectories As Covid-19 Restrictions Were Relaxed, Jonathan L. Chia, Andree Hartanto, William Tov
Profiles Of Activity Engagement And Depression Trajectories As Covid-19 Restrictions Were Relaxed, Jonathan L. Chia, Andree Hartanto, William Tov
Research Collection School of Social Sciences
Given elevated depression rates since the onset of the pandemic and potential downstream implications, this research examined the association between activity engagement and depression among middle-aged and older adults postlockdown. This study aimed to (a) identify activity engagement profiles among middle-aged and older adults, (b) understand factors associated with profile memberships, and (c) compare depression trajectories across profiles as COVID-19 restrictions eased over 16 months in Singapore. This longitudinal study involved 6,568 middle-aged and older adults. Latent growth analysis was first conducted to obtain estimates of depression trajectories for each individual. Latent profile analysis was then conducted to identify different …
Public Service Motivation And Job Satisfaction Amid Covid-19: Exploring The Effects Of Work Environment Changes, Seulki Lee, Chongmin Na
Public Service Motivation And Job Satisfaction Amid Covid-19: Exploring The Effects Of Work Environment Changes, Seulki Lee, Chongmin Na
Research Collection School of Social Sciences
The COVID-19 pandemic has brought critical changes to job demands and resources, which in turn affect employee motivation and outcomes. This study explores how COVID-19–induced work intensity and COVID-19–related organizational support influence public service motivation (PSM) and job satisfaction. Using survey data from a nationally representative sample of 1,430 South Korean central government employees collected during the pandemic (May–June 2020), we find that COVID-19–induced work intensity is positively associated with PSM, which in turn has a positive association with job satisfaction. We also find that COVID-19–related organizational support has both direct and indirect associations with job satisfaction through PSM. These …
The Primary Care Np's Guide To Prevention And Management Of Falls In Older Adults, Janice Mark
The Primary Care Np's Guide To Prevention And Management Of Falls In Older Adults, Janice Mark
Nursing and Health Professions Faculty Research and Publications
Falls are a growing health concern affecting older adults (defined as ages 65 years and older) that can lead to devastating consequences. NPs in primary care settings play an important role in the prevention and management of older adult falls. Methods and resources to screen for fall risk, assess risk factors, and manage falls in older adults are discussed.
Improved Mortality Prediction For Pediatric Acute Liver Failure Using Dynamic Prediction Strategy, Ruosha Li, Jingyan Wang, Cuihong Zhang, James E Squires, Steven H Belle, Jing Ning, Jianwen Cai, Robert H Squires
Improved Mortality Prediction For Pediatric Acute Liver Failure Using Dynamic Prediction Strategy, Ruosha Li, Jingyan Wang, Cuihong Zhang, James E Squires, Steven H Belle, Jing Ning, Jianwen Cai, Robert H Squires
Faculty, Staff and Student Publications
OBJECTIVES: To develop and validate a prediction tool for pediatric acute liver failure (PALF) mortality risks that captures the rapid and heterogeneous clinical course for accurate and updated prediction.
METHODS: Data included 1144 participants with PALF enrolled during three phases of the PALF registry study over 15 years. Using joint modeling, we built a dynamic prediction tool for mortality by combining longitudinal trajectories of multiple laboratory and clinical variables. The predictive performance for 7-day and 21-day mortality was assessed using the area under curve (AUC) through cross-validation and split-by-time validation.
RESULTS: We constructed a prognostic joint model that combines the …
Implementation And Evaluation Of A Mhealth-Based Community Health Worker Feedback Loop For Hispanics With And At Risk For Diabetes, Elizabeth M Vaughan, Victor J Cardenas, Wenyaw Chan, Amber B Amspoker, Craig A Johnston, Salim S Virani, Christie M Ballantyne, Aanand D Naik
Implementation And Evaluation Of A Mhealth-Based Community Health Worker Feedback Loop For Hispanics With And At Risk For Diabetes, Elizabeth M Vaughan, Victor J Cardenas, Wenyaw Chan, Amber B Amspoker, Craig A Johnston, Salim S Virani, Christie M Ballantyne, Aanand D Naik
Faculty, Staff and Student Publications
BACKGROUND: Gaps in accessibility and communication hinder diabetes care in poor communities. Combining mobile health (mHealth) and community health workers (CHWs) into models to bridge these gaps has great potential but needs evaluation.
OBJECTIVE: To evaluate a mHealth-based, Participant-CHW-Clinician feedback loop in a real-world setting.
DESIGN: Quasi-experimental feasibility study with intervention and usual care (UC) groups.
PARTICIPANTS: A total of 134 participants (n = 67/group) who were all low-income, uninsured Hispanics with or at-risk for type 2 diabetes.
INTERVENTION: A 15-month study with a weekly to semimonthly mHealth Participant-CHW-Clinician feedback loop to identify participant issues and provide participants monthly diabetes …
Challenges And Opportunities For Improving Access To Adolescent And Youth Sexual And Reproductive Health Services And Information In The Coastal Counties Of Kenya: A Qualitative Study., Evaline Chepchirchir Langat, Abdu Mohiddin, Flaura Kidere, Anisa Omar, Job Akuno, Violet Naanyu, Marleen Temmerman
Challenges And Opportunities For Improving Access To Adolescent And Youth Sexual And Reproductive Health Services And Information In The Coastal Counties Of Kenya: A Qualitative Study., Evaline Chepchirchir Langat, Abdu Mohiddin, Flaura Kidere, Anisa Omar, Job Akuno, Violet Naanyu, Marleen Temmerman
Centre of Excellence in Women and Child Health
Background: Globally, adolescents and youth experience high unmet need for sexual and reproductive health (SRH) information and services. In Kenya, evidence shows that more than half of teenage pregnancies are unintended and that half of all new HIV infections occur in people ages 15-24-year-olds, with the majority of those being female. The coastal counties in Kenya record a relatively high adolescent pregnancy rate and higher rates of unmet need for contraception for all women of reproductive age compared to the national average. This study focused on gaining a deeper understanding of the existing challenges to and opportunities for accessing SRH …
Invisible Hand Of Socioeconomic Factors In Rising Trend Of Maternal Mortality Rates In The U.S., Disha Kanada
Invisible Hand Of Socioeconomic Factors In Rising Trend Of Maternal Mortality Rates In The U.S., Disha Kanada
Dissertations, Theses, and Capstone Projects
Maternal death is a tragedy with devastating effect on families and serves as an important indicator of the quality of a health system. Worldwide, the maternal mortality rate has fallen; however, the maternal mortality rate is increasing in the United States in comparison to other wealthy developed countries. The United States spends a lot of resources on healthcare funds and therefore, the increasing maternal mortality rate is alarming. Apart from this, the birth rates are decreasing, so, it is hard to understand the relationship between declining birth rates (and fertility rates) and inclining mortality rates – logically, this does not …
Girth-Based Administered Activity For Pediatric 99mtc-Dmsa Spect, Ye Li, Justin L Brown, Jingyan Xu, Junyu Chen, Michael Ghaly, Monet Dugan, Xinhua Cao, Yong Du, Frederic H Fahey, Wesley Bolch, George Sgouros, Eric C Frey
Girth-Based Administered Activity For Pediatric 99mtc-Dmsa Spect, Ye Li, Justin L Brown, Jingyan Xu, Junyu Chen, Michael Ghaly, Monet Dugan, Xinhua Cao, Yong Du, Frederic H Fahey, Wesley Bolch, George Sgouros, Eric C Frey
Faculty, Staff and Student Publications
Background: Pediatric molecular imaging requires a balance between administering an activity that will yield sufficient diagnostic image quality while maintaining patient radiation exposure at acceptable levels. In current clinical practice, this balance is arrived at by the current North American Consensus Guidelines in which patient weight is used to recommend the administered activity (AA).
Purpose: We have previously demonstrated that girth (waist circumference at the level of the kidneys) is better at equalizing image quality than patient weight for pediatric Tc-99m DMSA renal function imaging. However, the correlation between image quality (IQ), AA, and patient girth has not been rigorously …
Limited Independent Follow-Up With Germline Testing Of Variants Detected In Brca1 And Brca2 By Tumor-Only Sequencing, Carol J Nowlen, Molly Daniels, Burak Uzunparmak, Ecaterina E Ileana Dumbrava, Ying Yuan, Keyur P Patel, Nadine Rayes, Jacqueline Harkenrider, Chetna Wathoo, Jennifer Veazie, Krystle A Luna, Wanlin Wang, Chacha Horombe, Milind Javle, Jordi Rodon Ahnert, Timothy A Yap, Banu Arun, Karen H Lu, Funda Meric-Bernstam
Limited Independent Follow-Up With Germline Testing Of Variants Detected In Brca1 And Brca2 By Tumor-Only Sequencing, Carol J Nowlen, Molly Daniels, Burak Uzunparmak, Ecaterina E Ileana Dumbrava, Ying Yuan, Keyur P Patel, Nadine Rayes, Jacqueline Harkenrider, Chetna Wathoo, Jennifer Veazie, Krystle A Luna, Wanlin Wang, Chacha Horombe, Milind Javle, Jordi Rodon Ahnert, Timothy A Yap, Banu Arun, Karen H Lu, Funda Meric-Bernstam
Faculty, Staff and Student Publications
Introduction
Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator. However, because many of the genes analyzed on tumor profiling overlap with those known to be associated with hereditary cancer predisposition syndromes (HCPS), tumor-only profiling can unknowingly uncover germline pathogenic (P) and likely pathogenic variants (LPV). In this study, we evaluated the number of patients with P/LPVs identified in BRCA1 and BRCA2 (BRCA1/2) via tumor-only profiling, then determined the germline testing outcomes for those patients.
Methods
A retrospective chart review was performed …
Facilitators To Cervical Cancer Screening In A Minority, Urban, Underserved Population, Noel Higgason, Linh Nguyen, Yen-Chi Le, Ogochukwu Juliet Ezeigwe, Tong Han Chung, Natalia Williams, Xochitl K Olguin, Abigail S Zamorano
Facilitators To Cervical Cancer Screening In A Minority, Urban, Underserved Population, Noel Higgason, Linh Nguyen, Yen-Chi Le, Ogochukwu Juliet Ezeigwe, Tong Han Chung, Natalia Williams, Xochitl K Olguin, Abigail S Zamorano
Faculty, Staff and Student Publications
OBJECTIVES: Cervical cancer has markedly declined due to widespread use of screening, but Hispanic women continue to bear a disproportionate amount of the cervical cancer burden due to under-screening. Previous studies have explored barriers to screening but have failed to identify targetable facilitators in this group. We aimed to assess facilitators to cervical cancer screening among a predominantly urban, Hispanic population who presented to a no-cost, community-based clinic.
METHODS: Patients completed demographic and health information, a validated social determinants of health (SDOH) screen, and a self-reported facilitators survey on factors which enabled them to present to clinic. Descriptive statistics were …
The Human Vaginal Microbiota: From Clinical Medicine To Models To Mechanisms, Samantha Ottinger, Clare M Robertson, Holly Branthoover, Kathryn A Patras
The Human Vaginal Microbiota: From Clinical Medicine To Models To Mechanisms, Samantha Ottinger, Clare M Robertson, Holly Branthoover, Kathryn A Patras
Faculty, Staff and Students Publications
The composition of the vaginal microbiota is linked to numerous reproductive health problems, including increased susceptibility to infection, pregnancy complications, and impaired vaginal tissue repair; however, the mechanisms contributing to these adverse outcomes are not yet fully defined. In this review, we highlight recent clinical advancements associating vaginal microbiome composition and function with health outcomes. Subsequently, we provide a summary of emerging models employed to identify microbe-microbe interactions contributing to vaginal health, including metagenomic sequencing, multi-omics approaches, and advances in vaginal microbiota cultivation. Last, we review new in vitro, ex vivo, and in vivo models, such as organoids and humanized …
Effectiveness Of Antibiotic Stewardship For Healthcare Providers At Urgent Care Clinics, Helen T. Adewole
Effectiveness Of Antibiotic Stewardship For Healthcare Providers At Urgent Care Clinics, Helen T. Adewole
Electronic Theses and Dissertations
Antibiotics have revolutionized modern medicine; however, the overuse in urgent care and primary care significantly contributes to the global burden of infections resistant to available antimicrobial medicines. Approximately 30% of the antimicrobials prescribed in acute care settings are unnecessary. Patient demand for antibiotics has seemingly skyrocketed following the recent COVID-19 pandemic. Practitioners must be knowledgeable about antibiotic stewardship initiatives, such as the wait-and-see approach, to reduce antibiotic overuse and improve the trajectory of antibiotic resistance and patient health outcomes. The gap in practice was the limited awareness of scientific evidence-based tools to partner with patients and improve antibiotic prescription patterns. …
Improving Veteran Engagement With Virtual Care Technologies: A Veterans Health Administration State Of The Art Conference Research Agenda, Taona P Haderlein, Jenice Guzman-Clark, Navid S Dardashti, Nicholas Mcmahon, Elizabeth L Duran, Jolie N Haun, Stephanie A Robinson, Amanda C Blok, Sarah L Cutrona, Jan A Lindsay, Christina M Armstrong, Kim M Nazi, Stephanie L Shimada, Nancy R Wilck, Erin Reilly, Eric Kuhn, Timothy P Hogan
Improving Veteran Engagement With Virtual Care Technologies: A Veterans Health Administration State Of The Art Conference Research Agenda, Taona P Haderlein, Jenice Guzman-Clark, Navid S Dardashti, Nicholas Mcmahon, Elizabeth L Duran, Jolie N Haun, Stephanie A Robinson, Amanda C Blok, Sarah L Cutrona, Jan A Lindsay, Christina M Armstrong, Kim M Nazi, Stephanie L Shimada, Nancy R Wilck, Erin Reilly, Eric Kuhn, Timothy P Hogan
Faculty, Staff and Students Publications
Although the availability of virtual care technologies in the Veterans Health Administration (VHA) continues to expand, ensuring engagement with these technologies among Veterans remains a challenge. VHA Health Services Research & Development convened a Virtual Care State of The Art (SOTA) conference in May 2022 to create a research agenda for improving virtual care access, engagement, and outcomes. This article reports findings from the Virtual Care SOTA engagement workgroup, which comprised fourteen VHA subject matter experts representing VHA clinical care, research, administration, and operations. Workgroup members reviewed current evidence on factors and strategies that may affect Veteran engagement with virtual …
Gut Microbiome Of Patients With Breast Cancer In Vietnam, Sang M Nguyen, Huong T T Tran, Jirong Long, Martha J Shrubsole, Hui Cai, Yaohua Yang, Lan M Nguyen, Giang H Nguyen, Chu V Nguyen, To V Ta, Jie Wu, Qiuyin Cai, Wei Zheng, Thuan V Tran, Xiao-Ou Shu
Gut Microbiome Of Patients With Breast Cancer In Vietnam, Sang M Nguyen, Huong T T Tran, Jirong Long, Martha J Shrubsole, Hui Cai, Yaohua Yang, Lan M Nguyen, Giang H Nguyen, Chu V Nguyen, To V Ta, Jie Wu, Qiuyin Cai, Wei Zheng, Thuan V Tran, Xiao-Ou Shu
Faculty, Staff and Student Publications
PURPOSE: Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with breast cancer.
MATERIALS AND METHODS: Stool samples were collected before chemotherapy, with 162 pre- and 194 postsurgery. The gut microbiome was measured by shotgun metagenomic sequencing. Associations of gut microbial diversity, taxa abundance, and gut microbiome health index (GMHI) with sociodemographic, clinical factors, and tumor characteristics were evaluated.
RESULTS: Postsurgery samples were associated with significantly lower α- and β-diversities (
CONCLUSION: Our …
Knowledge And Attitudes On Contraception And Reproductive Health In Women With Hiv, Anna Henricks, Samantha Singal, Dana Hughes, Sean Kelly, Jessica L Castilho, Jamison Norwood
Knowledge And Attitudes On Contraception And Reproductive Health In Women With Hiv, Anna Henricks, Samantha Singal, Dana Hughes, Sean Kelly, Jessica L Castilho, Jamison Norwood
Faculty, Staff and Student Publications
BACKGROUND: For reasons not fully explained to date, contraception usage among women with HIV remains low. The aim of our study was to understand attitudes toward and lifetime use of contraception among women with HIV.
METHODS: We administered an anonymous, community-informed, voluntary survey to cisgender, English-speaking women with HIV (≥18 years of age) at a Southern urban HIV clinic. It included multiple choice and Likert-scale questions on reproductive health. Participants reported contraception use, recollection of provider conversations about contraception, and perceived empowerment and knowledge regarding reproductive health. We used chi-square and Fisher exact tests to compare attitudes and prior conversations …
Anatomy Of The Female Reproductive Tract Organs Of The Brown Anole (Anolis Sagrei), Bonnie K Kircher, Edward L Stanley, Richard R Behringer
Anatomy Of The Female Reproductive Tract Organs Of The Brown Anole (Anolis Sagrei), Bonnie K Kircher, Edward L Stanley, Richard R Behringer
Faculty, Staff and Student Publications
Female reproduction in squamate reptiles (lizards and snakes) is highly diverse and mode of reproduction, clutch size, and reproductive tract morphology all vary widely across this group of ~11,000 species. Recently, CRISPR genome editing techniques that require manipulation of the female reproductive anatomy have been developed in this group, making a more complete understanding of this anatomy essential. We describe the adult female reproductive anatomy of the model reptile the brown anole (Anolis sagrei). We show that the brown anole female reproductive tract has three distinct anterior-to-posterior regions, the infundibulum, the glandular uterus, and the nonglandular uterus. The infundibulum has …
Genetic Architecture And Biology Of Youth-Onset Type 2 Diabetes, Soo Heon Kwak, Shylaja Srinivasan, Ling Chen, Jennifer Todd, Josep M Mercader, Elizabeth T Jensen, Jasmin Divers, Amy K Mottl, Catherine Pihoker, Rachelle G Gandica, Lori M Laffel, Elvira Isganaitis, Morey W Haymond, Lynne L Levitsky, Toni I Pollin, Jose C Florez, Jason Flannick, Progress In Diabetes Genetics In Youth (Prodigy) Consortium
Genetic Architecture And Biology Of Youth-Onset Type 2 Diabetes, Soo Heon Kwak, Shylaja Srinivasan, Ling Chen, Jennifer Todd, Josep M Mercader, Elizabeth T Jensen, Jasmin Divers, Amy K Mottl, Catherine Pihoker, Rachelle G Gandica, Lori M Laffel, Elvira Isganaitis, Morey W Haymond, Lynne L Levitsky, Toni I Pollin, Jose C Florez, Jason Flannick, Progress In Diabetes Genetics In Youth (Prodigy) Consortium
Faculty, Staff and Students Publications
The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1, producing a growing public health concern1 that disproportionately affects minority groups2. The genetic basis of youth-onset T2D and its relationship to other forms of diabetes are unclear3. Here we report a detailed genetic characterization of youth-onset T2D by analysing exome sequences and common variant associations for 3,005 individuals with youth-onset T2D and 9,777 adult control participants matched for ancestry, including both males and females. We identify monogenic diabetes variants in 2.4% of individuals and three exome-wide significant ( …
Proteome Analysis For Inflammation Related To Acute And Convalescent Infection, Tara K Sigdel, Swastika Sur, Patrick Boada, Suzanne M Mcdermott, Cecilia S Lindestam Arlehamn, Kristy O Murray, Linda K Bockenstedt, Maggie Kerwin, Elaine F Reed, Eva Harris, Ken Stuart, Bjoern Peters, Ana Sesma, Ruth R Montgomery, Minnie M Sarwal
Proteome Analysis For Inflammation Related To Acute And Convalescent Infection, Tara K Sigdel, Swastika Sur, Patrick Boada, Suzanne M Mcdermott, Cecilia S Lindestam Arlehamn, Kristy O Murray, Linda K Bockenstedt, Maggie Kerwin, Elaine F Reed, Eva Harris, Ken Stuart, Bjoern Peters, Ana Sesma, Ruth R Montgomery, Minnie M Sarwal
Faculty, Staff and Students Publications
Infectious diseases are a significant burden in global healthcare. Pathogens engage with different host defense mechanisms. However, it is currently unknown if there are disease-specific immune signatures and/or if different pathogens elicit common immune-associated molecular entities to common therapeutic interventions. We studied patients enrolled through the Human Immunology Project Consortium (HIPC), which focuses on immune responses to various infections. Blood samples were collected and analyzed from patients during infection and follow-up time points at the convalescent stage. The study included samples from patients with Lyme disease (LD), tuberculosis (TB), malaria (MLA), dengue virus (DENV), and West Nile virus (WNV), as …
Nonchromosomal Birth Defects And Risk Of Childhood Acute Leukemia: An Assessment In 15 000 Leukemia Cases And 46 000 Controls From The Childhood Cancer And Leukemia International Consortium, Philip J Lupo, Tiffany M Chambers, Beth A Mueller, Jacqueline Clavel, John D Dockerty, David R Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E Heck, Claire Infante-Rivard, Alice Y Kang, Corrado Magnani, Carlotta Malagoli, Erin L Marcotte, Catherine Metayer, Helen D Bailey, Ana M Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S Pombo-De-Oliveira, Wafaa M Rashed, Eve Roman, Joachim Schüz, Catharina Wesseling, Logan G Spector, Michael E Scheurer
Nonchromosomal Birth Defects And Risk Of Childhood Acute Leukemia: An Assessment In 15 000 Leukemia Cases And 46 000 Controls From The Childhood Cancer And Leukemia International Consortium, Philip J Lupo, Tiffany M Chambers, Beth A Mueller, Jacqueline Clavel, John D Dockerty, David R Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E Heck, Claire Infante-Rivard, Alice Y Kang, Corrado Magnani, Carlotta Malagoli, Erin L Marcotte, Catherine Metayer, Helen D Bailey, Ana M Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S Pombo-De-Oliveira, Wafaa M Rashed, Eve Roman, Joachim Schüz, Catharina Wesseling, Logan G Spector, Michael E Scheurer
Faculty, Staff and Students Publications
Although recent studies have demonstrated associations between nonchromosomal birth defects and several pediatric cancers, less is known about their role on childhood leukemia susceptibility. Using data from the Childhood Cancer and Leukemia International Consortium, we evaluated associations between nonchromosomal birth defects and childhood leukemia. Pooling consortium data from 18 questionnaire-based and three registry-based case-control studies across 13 countries, we used multivariable logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between a spectrum of birth defects and leukemia. Our analyses included acute lymphoblastic leukemia (ALL, n = 13 115) and acute myeloid leukemia …
A Public Health Perspective On Mitigating The Global Burden Of Chronic Liver Disease, Maya Balakrishnan, Jürgen Rehm
A Public Health Perspective On Mitigating The Global Burden Of Chronic Liver Disease, Maya Balakrishnan, Jürgen Rehm
Faculty, Staff and Students Publications
Chronic liver disease is a significant global health problem. Epidemiological trends do not show improvement in chronic liver disease incidence but rather a shift in etiologies, with steatotic liver disease (SLD) from metabolic dysfunction and alcohol becoming increasingly important causes. Consequently, there is a pressing need to develop a comprehensive public health approach for SLD. To that end, we propose a public health framework for preventing and controlling SLD. The framework is anchored on evidence linking physical inactivity, unhealthy dietary patterns, alcohol use, and obesity with both incidence and progression of SLD. Guided by the framework, we review examples of …
Correlates Of Risk For Disinhibited Behaviors In The Million Veteran Program Cohort, Peter B Barr, Tim B Bigdeli, Jacquelyn L Meyers, Roseann E Peterson, Sandra Sanchez-Roige, Travis T Mallard, Danielle M Dick, K Paige Harden, Anna Wilkinson, David P Graham, David A Nielsen, Alan C Swann, Rachele K Lipsky, Thomas R Kosten, Mihaela Aslan, Philip D Harvey, Nathan A Kimbrel, Jean C Beckham
Correlates Of Risk For Disinhibited Behaviors In The Million Veteran Program Cohort, Peter B Barr, Tim B Bigdeli, Jacquelyn L Meyers, Roseann E Peterson, Sandra Sanchez-Roige, Travis T Mallard, Danielle M Dick, K Paige Harden, Anna Wilkinson, David P Graham, David A Nielsen, Alan C Swann, Rachele K Lipsky, Thomas R Kosten, Mihaela Aslan, Philip D Harvey, Nathan A Kimbrel, Jean C Beckham
Faculty, Staff and Students Publications
Importance: Many psychiatric outcomes share a common etiologic pathway reflecting behavioral disinhibition, generally referred to as externalizing (EXT) disorders. Recent genome-wide association studies (GWASs) have demonstrated the overlap between EXT disorders and important aspects of veterans' health, such as suicide-related behaviors and substance use disorders (SUDs).
Objective: To explore correlates of risk for EXT disorders within the Veterans Health Administration (VA) Million Veteran Program (MVP).
Design, setting, and participants: A series of phenome-wide association studies (PheWASs) of polygenic risk scores (PGSs) for EXT disorders was conducted using electronic health records. First, ancestry-specific PheWASs of EXT PGSs were conducted in the …
Fibroblast Heterogeneity In Pulmonary Fibrosis: A New Target For Therapeutics Development?, Konstantin Tsoyi, Ivan O Rosas
Fibroblast Heterogeneity In Pulmonary Fibrosis: A New Target For Therapeutics Development?, Konstantin Tsoyi, Ivan O Rosas
Faculty, Staff and Students Publications
No abstract provided.
Examining Media Reports Of Pediatric Unintentional Firearm Injury Deaths For Prevention Messaging Concerning Secured Storage Of Firearms: Us, 2021-2022, Bart Hammig, Abigali Bordelon, Corrine Chandler
Examining Media Reports Of Pediatric Unintentional Firearm Injury Deaths For Prevention Messaging Concerning Secured Storage Of Firearms: Us, 2021-2022, Bart Hammig, Abigali Bordelon, Corrine Chandler
Public Policy Faculty & Graduate Student Publications and Presentations
Background
Media outlets that report on firearm injuries and deaths may provide an important role in emphasizing safe storage practices, particularly when unintentional firearm injuries and deaths occur among young children. There has been a scarcity of research on aspects of media reports on injuries, particularly concerning prevention messaging. The objective of the present study was to examine prevention messaging on the safe storage of firearms among media outlets when reporting on unintentional firearm injury deaths among children aged 0–11.
Methods
The Gun Violence Archive collects information from media sources regarding firearm injuries and deaths. We analyzed data from 2021 …
Serum Exosomal Microrna Pathway Activation In Placenta Accreta Spectrum: Pathophysiology And Detection, Jessian L Munoz, Brett D Einerson, Robert M Silver, Sureshkumar Mulampurath, Lauren S Sherman, Pranela Rameshwar, Egle Bytautiene Prewit, Patrick S Ramsey
Serum Exosomal Microrna Pathway Activation In Placenta Accreta Spectrum: Pathophysiology And Detection, Jessian L Munoz, Brett D Einerson, Robert M Silver, Sureshkumar Mulampurath, Lauren S Sherman, Pranela Rameshwar, Egle Bytautiene Prewit, Patrick S Ramsey
Faculty, Staff and Students Publications
BACKGROUND: Placenta accreta spectrum disorders are a complex range of placental pathologies that are associated with significant maternal morbidity and mortality. A diagnosis of placenta accreta spectrum relies on ultrasonographic findings with modest positive predictive value. Exosomal microRNAs are small RNA molecules that reflect the cellular processes of the origin tissues.
OBJECTIVE: We aimed to explore exosomal microRNA expression to understand placenta accreta spectrum pathology and clinical use for placenta accreta spectrum detection.
STUDY DESIGN: This study was a biomarker analysis of prospectively collected samples at 2 academic institutions from 2011 to 2022. Plasma specimens were collected from patients with …
Human Zoo Healthcare At The 1904 World’S Fair, Angel Blake
Human Zoo Healthcare At The 1904 World’S Fair, Angel Blake
Undergraduate Research Symposium
Human Zoo Healthcare at the 1904 World’s Fair
Were precautions taken or put into place for the Human Zoo performers at the 1904 World’s Fair? This topic has been overlooked and understudied by historians, there are few articles written and we do not know the true death toll which shows the racism towards these indigenous peoples. The research for this project was conducted at the State Historical Society of Missouri, the St. Louis Mercantile Library, Newspapers.com, Archives.com, St. Louis Public Library, and the Missouri Historical Society, including research on primary sources such as official World’s Fair committee meeting minutes, hospital …
Prognosis Of Covid-19 On Workers With History Of Asthma: An Evidence-Based Case Report, Parmitasari Parmitasari, Dewi Yunia Fitriani, Indah S. Widyahening
Prognosis Of Covid-19 On Workers With History Of Asthma: An Evidence-Based Case Report, Parmitasari Parmitasari, Dewi Yunia Fitriani, Indah S. Widyahening
Occupational and Environmental Medicine Journal of Indonesia
Background. As the COVID-19 pandemic occurs, those with asthma were thought to have an increased risk of infection. Question arisen whether special preparation for severe clinical outcomes might be needed for remote site workers. Method. A literature search was conducted through PubMed, Scopus and ProQuest databases, as well as hand searched. The inclusion criteria were systematic review, cohort study, retrospective study, cross sectional study, COVID-19, asthma, and ICU. Then, they were critically appraised based on Center of Evidence-Based Medicine, Oxford University, Critical Appraisal for Prognostic Studies and Systematic Reviews. Result. Three systematic review studies and three retrospective cohort studies were …
Factors Affecting Superoxide Dismutase Activity In Railway Workers In Jakarta, Indonesia, Vera Winata, Muhammad Ilyas, Aria Kekalih, Suryo Wibowo, Muchtaruddin Mansyur
Factors Affecting Superoxide Dismutase Activity In Railway Workers In Jakarta, Indonesia, Vera Winata, Muhammad Ilyas, Aria Kekalih, Suryo Wibowo, Muchtaruddin Mansyur
Occupational and Environmental Medicine Journal of Indonesia
Introduction. Railway workers are exposed to many occupational health risk factors that may cause oxidative stress. Superoxide dismutase (SOD) activity is one of the response biomarkers of oxidative stress.
Methods. A cross-sectional study was conducted from July-October 2021. Eighty-four participants were included in this study. Data about participants’ characteristics, physical activity intensity as measured by the Global Physical Activity Questionnaire (GPAQ) version 2, and stress levels as measured by Holmes-Rahe Stress Inventory were collected using Google Forms. The physical examination yielded data on blood pressure, ear condition, and waist circumference. Blood Superoxide dismutase activity and HbA1c levels were determined using …
Validity And Reliability Of The Indonesian Version Of Expanded Nursing Stress Scale (Enss) As A Job-Stress Assessment Tool For Nurses, Hasto Harsono, Herqutanto Herqutanto, Suryo Wibowo, Aria Kekalih, Astrid Sulistomo
Validity And Reliability Of The Indonesian Version Of Expanded Nursing Stress Scale (Enss) As A Job-Stress Assessment Tool For Nurses, Hasto Harsono, Herqutanto Herqutanto, Suryo Wibowo, Aria Kekalih, Astrid Sulistomo
Occupational and Environmental Medicine Journal of Indonesia
ABSTRACT
Background: Job stress is a serious health problem in the 21st century because of its high incidence and impact. Nurses are known as a profession that has high risks of stress, has distinctive characteristics, and hence requires a work stress assessment instrument that suits its peculiarities. The Expanded Nursing Stress Scale (ENSS) is a nurse-specific stress assessment instrument that has high validity and reliability (Cronbach's alpha = 0.96) and is widely used in many countries but is not yet available in Indonesian. This study aims to obtain the Indonesian version of ENSS and evaluate its reliability and validity.
Method: …
The Association Between Mental Workload And Nonspecific Chronic Low Back Pain Among Operators Of An On Shore Oil And Gas Company In South Sumatera, Ardi Artanto, Suryo Wibowo, Nuri Purwito Adi
The Association Between Mental Workload And Nonspecific Chronic Low Back Pain Among Operators Of An On Shore Oil And Gas Company In South Sumatera, Ardi Artanto, Suryo Wibowo, Nuri Purwito Adi
Occupational and Environmental Medicine Journal of Indonesia
Background: Work location influences the proportion of operators with low back pain (LBP) at a South Sumatera onshore oil and gas company. This study aimed to determine the prevalence of nonspecific chronic LBP among the company's operators, as well as the association between quantitative and qualitative mental workload and nonspecific chronic LBP.
Methods: This study was cross-sectional in design, with 96 samples collected through purposive sampling. Questionnaires and physical examinations were used to collect data.
Results: Nonspecific chronic LBP was found in 32.3 percent of people. According to the multivariate analysis, moderate-heavy qualitative mental workload (OR: 5.14; 95 percent CI: …