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Full-Text Articles in Public Health

Burnout And Employee Satisfaction Of Mental Health Clinicians In Corrections, Jeremy C. Capuyon, Lindsay Gietzen Nov 2024

Burnout And Employee Satisfaction Of Mental Health Clinicians In Corrections, Jeremy C. Capuyon, Lindsay Gietzen

Pacific Journal of Health

Approximately 1.9 million individuals are currently incarcerated within the United States. Rehabilitation and preparation for parole back into the community is common goal amongst correctional facilities. Mental health clinicians (social workers and psychologists) within the correctional facilities are providers who assist in the rehabilitation of inmates. Unfortunately, mental health clinicians in correctional facilities experience high rates of burnout and low levels of job satisfaction, resulting in an increase in turnover rates. This research project looks to investigate the impact burnout and employee satisfaction has on mental health clinicians who work in correctional settings. Furthermore, this research project compares burnout and …


Successful Application Of Craniosacral Therapy In A Case Of Colic In An 8-Week-Old Baby, Caro O’Neill, Angie Butterfield Nov 2024

Successful Application Of Craniosacral Therapy In A Case Of Colic In An 8-Week-Old Baby, Caro O’Neill, Angie Butterfield

Journal of Transformative Touch

This case study reports on the effectiveness of CranioSacral Therapy (CST) for an eight-week-old baby boy experiencing colic. A CST pediatric protocol was utilized during two sessions, a week apart, in May 2023. An improvement in symptoms was recorded after the first treatment. After the second treatment the baby was no longer presenting with symptoms related to infant colic. This case suggests that CST can be an effective support for babies experiencing infant colic.

Word count: 75


Peptide Receptor Radionuclide Therapy And Clinical Associations With Renal And Hematological Toxicities And Survival In Patients With Neuroendocrine Tumors: An Analysis From Two U.S. Medical Centers, Tao Xu, Joseph S. Dillon, Mary A. Maluccio, Dawn E. Quelle, Sarah H. Nash, Hyunkeun Cho, Kristen E. Limbach, Nicholas J. Skill, Yvette Bren-Mattison, Michael A. O’Rorke Nov 2024

Peptide Receptor Radionuclide Therapy And Clinical Associations With Renal And Hematological Toxicities And Survival In Patients With Neuroendocrine Tumors: An Analysis From Two U.S. Medical Centers, Tao Xu, Joseph S. Dillon, Mary A. Maluccio, Dawn E. Quelle, Sarah H. Nash, Hyunkeun Cho, Kristen E. Limbach, Nicholas J. Skill, Yvette Bren-Mattison, Michael A. O’Rorke

School of Medicine Faculty Publications

Purpose: Renal and hematological toxicity are side effects and dose-limiting factors of Peptide Receptor Radionuclide Therapy (PRRT). We aimed to assess the changes in renal and hematological function and associations with survival in neuroendocrine tumor (NET) patients treated with PRRT. Methods: A retrospective cohort of 448 NET patients treated with either 177Lu-DOTATATE or 90Y-DOTATOC were followed for changes of renal and hematological function. Renal function was assessed by monitoring changes in serum creatinine, blood urea nitrogen and estimated glomerular filtration rate. Hematological function was determined by examining changes in white blood cell counts (WBC), platelet counts, and hemoglobin levels over …


Protein Consumption And Risk Of Cvd Among Us Adults: The Multi-Ethnic Study Of Atherosclerosis (Mesa), Ji Yun Tark, Ruosha Li, Bing Yu, Alexis C Wood, Nikhil S Padhye, Marcia C De Oliveira Otto Nov 2024

Protein Consumption And Risk Of Cvd Among Us Adults: The Multi-Ethnic Study Of Atherosclerosis (Mesa), Ji Yun Tark, Ruosha Li, Bing Yu, Alexis C Wood, Nikhil S Padhye, Marcia C De Oliveira Otto

Faculty, Staff and Students Publications

BACKGROUND: Although some randomized trials have reported beneficial effects of protein intake on cardiometabolic risk factors, evidence from prospective studies have not supported a strong link between protein intake and cardiovascular disease (CVD) risk. It is also unclear whether diversity in protein intake plays a role in CVD risk.

OBJECTIVE: We investigated prospective associations of (1) protein intake, overall and by food source and (2) diversity of protein sources with risk of CVD, coronary heart disease (CHD), and stroke.

METHODS: In a multi-ethnic cohort of 5879 U.S. adults (45-84 years), who were free of CVD at baseline, protein intake was …


Encouraging Movement Opportunities Through Theory-Informed Video Education Among Undergraduate Students: The Move Study, Carmen Labadie, Nia Contini, Varsha Vasudevan, Matthew Bourke, Shauna Burke, Patricia Tucker, Jennifer Irwin Nov 2024

Encouraging Movement Opportunities Through Theory-Informed Video Education Among Undergraduate Students: The Move Study, Carmen Labadie, Nia Contini, Varsha Vasudevan, Matthew Bourke, Shauna Burke, Patricia Tucker, Jennifer Irwin

Health Studies Publications

Objective: To explore the impact of a theory-informed educational video on undergraduates’: motivational readiness, self-efficacy, and decisional balance about changing sedentary time; sedentary time; and perceptions of sedentarism over time and compared to a control. Participants: Undergraduates (N = 160) from a Canadian institution. Methods: A single-blind randomized controlled trial using an intervention (sedentary video) and control (sleep video) group. Participants completed two validated questionnaires at baseline, immediate post-intervention, and one-month follow-up plus open-ended questions. Linear mixed models and content analysis were used. Results: No significant differences were observed between groups. Increases in self-efficacy (p = .016; d = 0.27) …


Mccormack, Joseph Nathaniel, 1847-1922 And Arthur Thomas Mccormack, 1872-1943, Manuscripts & Folklife Archives Nov 2024

Mccormack, Joseph Nathaniel, 1847-1922 And Arthur Thomas Mccormack, 1872-1943, Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and scans (Click on "Additional Files" below) for Manuscripts Small Collection 3738. Arrest warrants issued by the Bowling Green, Kentucky Police Court charging Dr. J. N. McCormack, then Secretary of the State Board of Health, and Dr. A. T. McCormack with permitting a “nuisance, source of filth & cause of sickness” by erecting a privy over an open drain or sewer to serve the McCormack Building on State Street. Includes a letter, 29 September 1907, from Dr. J. N. McCormack to Governor J. C. W. Beckham requesting a pardon and describing his ongoing efforts to dispose of waste …


The Hockey Fans In Training Intervention For Men With Overweight Or Obesity: A Pragmatic Cluster Randomised Trial, Robert Petrella, Dawn Gill, Nárlon C. Boa Sorte Silva, Brendan Riggin, Wendy Blunt, Marisa Kfrerer, Melissa Majoni, Jacquelyn Marsh, Jennifer Irwin, Saverio Stranges, Merrick Zwarenstein, Guangyong Zou Nov 2024

The Hockey Fans In Training Intervention For Men With Overweight Or Obesity: A Pragmatic Cluster Randomised Trial, Robert Petrella, Dawn Gill, Nárlon C. Boa Sorte Silva, Brendan Riggin, Wendy Blunt, Marisa Kfrerer, Melissa Majoni, Jacquelyn Marsh, Jennifer Irwin, Saverio Stranges, Merrick Zwarenstein, Guangyong Zou

Health Studies Publications

Background: Obesity disproportionately impacts men’s health yet fewer men engage in preventive healthcare. We examined the effectiveness of Hockey Fans in Training (Hockey FIT), a gender-sensitised lifestyle intervention that engages men with overweight/obesity through their passion as fans of a local sports team, on weight change and other health indicators.Methods: Pragmatic, cluster randomised trial (aged 35–65 years, body mass index ≥ 27 kg/m2 ) within 42 community-based sites in Canada and the United States, randomly assigned (1:1) to intervention (Hockey FIT) or control (waitlist) and stratified by region. Sites were selected based on partnerships with local major junior/professional hockey teams …


Using Causal Diagrams Within The Grading Of Recommendations, Assessment, Development And Evaluation Framework To Evaluate Confounding Adjustment In Observational Studies, Kevin Mcintyre, Karina N Tassiopoulos, Curtis Jeffrey, Saverio Stranges, Janet Martin Nov 2024

Using Causal Diagrams Within The Grading Of Recommendations, Assessment, Development And Evaluation Framework To Evaluate Confounding Adjustment In Observational Studies, Kevin Mcintyre, Karina N Tassiopoulos, Curtis Jeffrey, Saverio Stranges, Janet Martin

Epidemiology and Biostatistics Publications

BACKGROUND AND OBJECTIVES: The current Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system instructs appraisers to evaluate whether individual observational studies have sufficiently adjusted for confounding. However, it does not provide an explicit, transparent, or reproducible method for doing so. This article explores how implementing causal graphs into the GRADE framework can help appraisers and end-users of GRADE products to evaluate the adequacy of confounding control from observational studies.

METHODS: Using modern epidemiological theory, we propose a system for incorporating causal diagrams into the GRADE process to assess confounding control.

RESULTS: Integrating causal graphs into the GRADE framework enables …


A Time-Stratified, Case–Crossover Study Of Heat Exposure And Perinatal Mortality From 16 Hospitals In Sub-Saharan Africa, Claudia Hanson, Jeroen De Bont, Kristi Sidney Annerstedt, Maria Del Rosario Alsina, Federica Nobile, Nathalie Roos, Peter Waiswa, Andrea Pembe, Jean-Paul Dossou, Claudia Hanson, Hussein Kidanto Nov 2024

A Time-Stratified, Case–Crossover Study Of Heat Exposure And Perinatal Mortality From 16 Hospitals In Sub-Saharan Africa, Claudia Hanson, Jeroen De Bont, Kristi Sidney Annerstedt, Maria Del Rosario Alsina, Federica Nobile, Nathalie Roos, Peter Waiswa, Andrea Pembe, Jean-Paul Dossou, Claudia Hanson, Hussein Kidanto

Brain and Mind Institute

Growing evidence suggests that extreme heat events affect both pregnant women and their infants, but few studies are available from sub-Saharan Africa. Using data from 138,015 singleton births in 16 hospitals in Benin, Malawi, Tanzania and Uganda, we investigated the association between extreme heat and early perinatal deaths, including antepartum and intrapartum stillbirths, and deaths within 24 h after birth using a time-stratified case–crossover design. We observed an association between an increase from the 75th to the 99th percentile in mean temperature 1 week (lag 0–6 d) before childbirth and perinatal mortality (odds ratio (OR) = 1.34 (95% confidence interval …


Act With Cf: A Randomized Trial Of Acceptance And Commitment Therapy Vs Supportive Psychotherapy For Adults With Cystic Fibrosis, C. Virginia O'Hayer, Patrick J. Smith, Christopher F. Drescher, Heather Bruschwein, Chelsi N. Nurse, Hallie M. Kushner, Krista Ingle, Michael J. Stephen, Jeffrey B. Hoag Nov 2024

Act With Cf: A Randomized Trial Of Acceptance And Commitment Therapy Vs Supportive Psychotherapy For Adults With Cystic Fibrosis, C. Virginia O'Hayer, Patrick J. Smith, Christopher F. Drescher, Heather Bruschwein, Chelsi N. Nurse, Hallie M. Kushner, Krista Ingle, Michael J. Stephen, Jeffrey B. Hoag

Department of Psychiatry and Human Behavior Faculty Papers

PURPOSE: Psychological distress, including anxiety and depression, is common among adults with CF, associating with poor quality of life, lung function, and healthcare utilization. This 3-year, multi-site, telehealth-delivered randomized trial sought to determine whether Acceptance and Commitment Therapy (ACT with CF) is superior to supportive psychotherapy (SP), in improving psychological functioning for adults with CF.

METHODS: One hundred twenty-four adults with CF and elevated anxiety and/or depressive symptoms were recruited coincident with the first COVID lockdown, from Thomas Jefferson University Hospitals, University of Virginia, Augusta University, Duke University Medical Center, and social media. Participants were randomized to 6 weeks of …


Functional Measures In Non-Copd Chronic Respiratory Diseases: A Systematic Review, Camile Ludovico Zamboti, Heloise Angélico Pimpão, Larissa Dragonetti Bertin, Gabriela Garcia Krinski, Tathielle Garcia, Sandro Laerth Souza Dos Santos Filho, Vinicius Cavalheri, Fabio Pitta, Carlos Augusto Camillo Nov 2024

Functional Measures In Non-Copd Chronic Respiratory Diseases: A Systematic Review, Camile Ludovico Zamboti, Heloise Angélico Pimpão, Larissa Dragonetti Bertin, Gabriela Garcia Krinski, Tathielle Garcia, Sandro Laerth Souza Dos Santos Filho, Vinicius Cavalheri, Fabio Pitta, Carlos Augusto Camillo

Research outputs 2022 to 2026

Background/Objectives: The extensive range of instruments designed for evaluating functional performance (FP) in chronic respiratory diseases (CRD) other than chronic obstructive pulmonary disease (COPD) presents a challenge in selecting the most appropriate one. Therefore, this systematic review aimed to summarise FP instruments, their measurement properties, their minimum clinically important differences, and their associations with CRD course-related events or prognosis in non-COPD CRD. Methods: Studies employing patient-reported or performance-based instruments to assess FP in non-COPD CRD were systematically identified in the PubMed, PEDro, Embase, and Cochrane Library databases. COPD-exclusive studies or those solely reporting exercise capacity tests were excluded. Examination focused …


Characterising The Chemical Composition Of Bushfire Smoke And Implications For Firefighter Exposure In Western Australia, Kiam Padamsey, Adelle Liebenberg, Ruth Wallace, Jacques Oosthuizen Nov 2024

Characterising The Chemical Composition Of Bushfire Smoke And Implications For Firefighter Exposure In Western Australia, Kiam Padamsey, Adelle Liebenberg, Ruth Wallace, Jacques Oosthuizen

Research outputs 2022 to 2026

This study evaluates bushfire smoke as a workplace hazard for firefighters by characterising its chemical composition and potential health risks in Western Australia. Portable Fourier Transform Infrared (FTIR) spectrometry was used to measure airborne chemical concentrations at prescribed burns across five regions, including peat (acid sulphate) fire events. Samples were collected during both flaming and smouldering phases, as well as in perceived “clear” air resting zones. Results indicated that carbon monoxide (CO) was the dominant gas, reaching concentrations of 205 ppm at the fire front, followed by nitrogen monoxide (26 ppm) and methane (19 ppm). Peat fires produced distinct profiles, …


Disparities In Cognitive Decline Along The Texas-Mexico Border: Insights From The 2021 Brfss, Bianca D. Valenzuela Nov 2024

Disparities In Cognitive Decline Along The Texas-Mexico Border: Insights From The 2021 Brfss, Bianca D. Valenzuela

Health and Kinesiology Theses

The aging global population has brought increased attention to cognitive health and early detection of cognitive decline. Subjective Cognitive Decline (SCD), defined as self-reported memory or thinking problems, is an early marker of neurodegenerative diseases. Despite growing research, gaps remain in understanding how geographic disparities influence SCD prevalence and contributing factors. The Texas-Mexico border region, predominantly Hispanic and facing unique socioeconomic and health care challenges, offers a unique context to explore these influences. The purpose of this study was to examine the prevalence of SCD and related functional limitations in Texas-Mexico border counties versus non-border counties, using 2021 Behavioral Risk …


Association Of Chronic Malnutrition, And Not Anemia, With Cognitive Development In Ethiopian Schoolchildren: A Cross-Sectional Study, Befikadu Tariku Gutema, Muluken Bekele Sorrie, Sifray Batire, Tadiwos Hailu Zewdie, Bruno Levecke, Amina Abubakar, Stefaan De Henauw, Souheila Abbeddou Nov 2024

Association Of Chronic Malnutrition, And Not Anemia, With Cognitive Development In Ethiopian Schoolchildren: A Cross-Sectional Study, Befikadu Tariku Gutema, Muluken Bekele Sorrie, Sifray Batire, Tadiwos Hailu Zewdie, Bruno Levecke, Amina Abubakar, Stefaan De Henauw, Souheila Abbeddou

Institute for Human Development, East Africa

This study assesses the associations between nutritional statusand cognitive development of schoolchildren. A unit increase inheight-for-age Z-score was associated with 0.12 SD, 0.08 SD and0.12 SD increase in standardized digit span, Raven’s coloredprogressive metrics, and performance index of visual searchtask, respectively. A unit increase in body-mass-index-for-ageZ-score was associated with 0.11 SD increase in standardizeddigit span. Hemoglobin concentration was not associated withany of the cognitive outcomes. Chronic malnutrition was asso-ciated with cognitive development in schoolchildren while thin-ness and hemoglobin concentrations were associated withselected or no cognitive outcomes, respectively.


Identifying Ordinal Categories For The Water Insecurity Experiences Scales, Edward A. Frongillo Jr., Hilary J. Bethancourt, Joshua D. Miller, Sera L. Young, The Household Water Insecurity Experiences Scales (Hwise)-Research Coordination Network (Rcn) Nov 2024

Identifying Ordinal Categories For The Water Insecurity Experiences Scales, Edward A. Frongillo Jr., Hilary J. Bethancourt, Joshua D. Miller, Sera L. Young, The Household Water Insecurity Experiences Scales (Hwise)-Research Coordination Network (Rcn)

Faculty Publications

The Household Water Insecurity Experiences (HWISE) and Individual Water Insecurity Experiences (IWISE) Scales are globally suitable tools for comparably measuring water insecurity experiences among households and adults, respectively. The potential range for HWISE and IWISE scores is 0–36. When the WISE Scales were first published, scores of 12 and higher were considered indicative of water insecurity, but additional cut-points are needed to provide more nuanced insights. We therefore sought to develop a practical set of cut-points for the WISE Scales using HWISE data from 13 sites across 12 countries (n = 3,293) and nationally representative samples of IWISE data …


Community Perspectives Of Heat And Weather Warnings For Pregnant And Postpartum Women In Kilifi, Kenya, Adelaide Lusambili, Veronique Filippi, Britt Nakstad, Julian Natukunda, Cathryn Birch, John Marsham, Nathalie Roos, Peter Khaemba, Sari Kovats Nov 2024

Community Perspectives Of Heat And Weather Warnings For Pregnant And Postpartum Women In Kilifi, Kenya, Adelaide Lusambili, Veronique Filippi, Britt Nakstad, Julian Natukunda, Cathryn Birch, John Marsham, Nathalie Roos, Peter Khaemba, Sari Kovats

Institute for Human Development, East Africa

Background: Extreme weather is a recognised risk factor for stillbirth and preterm birth, disrupts women’s access to healthcare during pregnancy and childbirth, and negatively affects the care of newborns. Reliable and accessible heat and weather warning systems are key in alerting individuals to undertake protective measures. There is a notable gap in understanding how women and caregivers in rural East Africa perceive and utilize weather information. We investigated community members’ heat and weather warning information-seeking behaviour, identified available sources, assessed their reliability and utility, and examined their influence on behaviour.

Settings: Our research was conducted in rural Kilifi County in …


A Study Of Management Of Marine Oil Spills In Malaysia, Mohd Arma Noramin Bin A Rashid Nov 2024

A Study Of Management Of Marine Oil Spills In Malaysia, Mohd Arma Noramin Bin A Rashid

World Maritime University Dissertations

No abstract provided.


Dementia Risk Reduction In The African Context: Multi-National Implementation Of Multimodal Strategies To Promote Healthy Brain Aging In Africa (The Africa-Fingers Project), Chinedu Momoh, Rachel Maina, Lukoye Atwoli, Karen Blackmon, Edna Bosire, Gloria Chemutai, Linda Khakali, Sylvia Mbugua, Zul Merali, Olivera Nesic Taylor,, Anthony Ngugi, Cyprian Mostert, Eunice Muthoni, Roselyter Riang’A, Mansoor Saleh, Shahin Sayed, Jasmit Shah Nov 2024

Dementia Risk Reduction In The African Context: Multi-National Implementation Of Multimodal Strategies To Promote Healthy Brain Aging In Africa (The Africa-Fingers Project), Chinedu Momoh, Rachel Maina, Lukoye Atwoli, Karen Blackmon, Edna Bosire, Gloria Chemutai, Linda Khakali, Sylvia Mbugua, Zul Merali, Olivera Nesic Taylor,, Anthony Ngugi, Cyprian Mostert, Eunice Muthoni, Roselyter Riang’A, Mansoor Saleh, Shahin Sayed, Jasmit Shah

Brain and Mind Institute

Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker …


Metastatic Recurrence In Women Diagnosed With Non-Metastatic Breast Cancer: A Systematic Review And Meta-Analysis, Eileen Morgan, Colette O’Neill, Richa Shah, Oliver Langselius, Yaqi Su, Clara Frick, Hanna Fink, Aude Bardot, Miriam Mutebi, Paul Walsh Nov 2024

Metastatic Recurrence In Women Diagnosed With Non-Metastatic Breast Cancer: A Systematic Review And Meta-Analysis, Eileen Morgan, Colette O’Neill, Richa Shah, Oliver Langselius, Yaqi Su, Clara Frick, Hanna Fink, Aude Bardot, Miriam Mutebi, Paul Walsh

General Surgery, East Africa

Background: To assess proportions of metastatic recurrence in women initially diagnosed with non-metastatic breast cancer by stage at diagnosis, breast cancer subtype, calendar period and age.

Methods: A systematic search of MEDLINE and Web of Science databases (January 2010–12 May 2022) was conducted. Studies reporting the proportion of distant metastatic recurrence in women with non-metastatic breast cancer were identified and outcomes and characteristics were extracted. Risk of bias was assessed independently by two reviewers. Random-effects meta-analyses of proportions were used to calculate pooled estimates and 95% confidence intervals (CIs).

Results: 193 studies covering over 280,000 patients were included in the …


Adverse Childhood Experiences And Psychological Correlates Of Substance Use Disorders Among Black Sexual Minority Women, Shemeka Thorpe, Kaylee A Palomino, Natalie Malone, Danelle Stevens-Watkins Nov 2024

Adverse Childhood Experiences And Psychological Correlates Of Substance Use Disorders Among Black Sexual Minority Women, Shemeka Thorpe, Kaylee A Palomino, Natalie Malone, Danelle Stevens-Watkins

Kinesiology and Health Promotion Faculty Publications

This study examined the influence of adverse childhood experiences (ACEs) on Black sexual minority women's mental health and substance use disorders in adulthood. Secondary data analysis was conducted using N = 149 Black sexual minority women's reports from the Generations Study. Study variables included psychological distress, chronic strains, stressful life events, ACEs, and substance use disorders, including alcohol use disorder and drug use disorder. Quantitative data analysis consisted of descriptives and bivariate correlations. Participants' total ACE scores were positively significantly correlated with increased alcohol misuse, chronic life strains, and stressful life events. Exposure to household interpersonal violence and household mental …


Vol 4 November '24 Cover, Publishing And Table Of Contents, Donna L. Williams Nov 2024

Vol 4 November '24 Cover, Publishing And Table Of Contents, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.


Vol 4 November '24 Full Issue, Donna L. Williams Nov 2024

Vol 4 November '24 Full Issue, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.


Upside Down World, Donna L. Williams Nov 2024

Upside Down World, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.


The Impact Of The Covid-19 Pandemic Among Latinos In Northwest Louisiana, Deborah G. Smith, Carolina O. Ochoa, Jillian L. Sandoz, Jennifer A. Deleon, Jason C. Hoosier, Corey D. Smith, Raimunda H.M. Macena Nov 2024

The Impact Of The Covid-19 Pandemic Among Latinos In Northwest Louisiana, Deborah G. Smith, Carolina O. Ochoa, Jillian L. Sandoz, Jennifer A. Deleon, Jason C. Hoosier, Corey D. Smith, Raimunda H.M. Macena

Journal of the Louisiana Public Health Association

No abstract provided.


Neighborhood Deprivation Negatively Affects Survival Odds Of Pediatric Oncology Patients Residing In Louisiana, Tayla D. Hunter, Gabrielle Sheets, Christian Nieves-Rivera, Sloane Clay, Jordan Doss, Michael Norman, James W. Kinchen, Zhide Fang, Pinki Prasad, Fern Tsien Nov 2024

Neighborhood Deprivation Negatively Affects Survival Odds Of Pediatric Oncology Patients Residing In Louisiana, Tayla D. Hunter, Gabrielle Sheets, Christian Nieves-Rivera, Sloane Clay, Jordan Doss, Michael Norman, James W. Kinchen, Zhide Fang, Pinki Prasad, Fern Tsien

Journal of the Louisiana Public Health Association

Background: Childhood cancer patients have experienced an increase in survivorship in the last twenty years due to improvements in treatment and supportive care. Increasing evidence shows that neighborhood socioeconomic status (nSES) significantly affects healthcare outcomes. However, limited information demonstrates the relationship between neighborhood and pediatric cancer survivorship. Methods: Participants include 308 survivors and deceased patients from Children’s Hospital of New Orleans. Area Deprivation Index (ADI) scores were obtained based on participant’s home address. Univariable logistic regression models were used to assess associations between neighborhood socioeconomic status and survival odds. Results: Living in parishes that are both rural and non-Acadian was …


The Relationship Between Social Support And Patient Characteristics Among Young Women With Breast Cancer, Lisa Moses, Evrim Oral, Donna Williams Nov 2024

The Relationship Between Social Support And Patient Characteristics Among Young Women With Breast Cancer, Lisa Moses, Evrim Oral, Donna Williams

Journal of the Louisiana Public Health Association

Background: Breast cancer is the most frequently diagnosed cancer overall and the most frequently diagnosed cancer among women in Louisiana. From 2016-2020, female breast cancer accounted for 13.9% of all cancer diagnoses and 7.2% of all cancer deaths in Louisiana. Social support (SS) positively affects quality of life and positively affects survival rates following a breast cancer diagnosis. However, young women with breast cancer (YBCS) often have difficulty finding existing services meeting their family’s needs in systems focusing on older women with breast cancer. Methods: This study explored the relationship between total SS, emotional support (ES), tangible support (TS), affectionate …


Utilizing Prams To Examine Wic And Non-Wic Participants' Smoking Prevalences In Louisiana, Almetra Granger, Tyra Gross, Ty-Runet Bryant, Amy Thierry, Michael D. Celestin Jr. Nov 2024

Utilizing Prams To Examine Wic And Non-Wic Participants' Smoking Prevalences In Louisiana, Almetra Granger, Tyra Gross, Ty-Runet Bryant, Amy Thierry, Michael D. Celestin Jr.

Journal of the Louisiana Public Health Association

Background: Cigarette and electronic cigarette use before, during, or after pregnancy increases the chances of severe health risks for both the mother and child. Quitting leads to significantly better health outcomes. Women, Infants, and Children (WIC) clinics serve large numbers of pregnant, breastfeeding, and postpartum women, offering an excellent opportunity to address tobacco cessation. But few studies assess tobacco use, particularly electronic cigarette use, among WIC participants. This study examined the relationship between WIC status and maternal tobacco use. Methods: We analyzed WIC (n=315) and non-WIC (n=152) participants smoking data from the 2016-2018 Phase 8 Louisiana Pregnancy Risk Assessment Monitoring …


Polygenic Risk Scores And Extreme Coronary Artery Calcium Phenotypes (Cac=0 And Cac≥1000) In Adults ≥75 Years Old: The Aric Study, Omar Dzaye, Alexander C Razavi, Zeina A Dardari, Frances M Wang, Yasuyuki Honda, Khurram Nasir, Josef Coresh, Candace M Howard-Claudio, Jin Jin, Bing Yu, Paul S De Vries, Lynne Wagenknecht, Aaron R Folsom, Ron Blankstein, Tanika N Kelly, Seamus P Whelton, Martin Bødtker Mortensen, Ziqiao Wang, Nilanjan Chatterjee, Kunihiro Matsushita, Michael J Blaha Nov 2024

Polygenic Risk Scores And Extreme Coronary Artery Calcium Phenotypes (Cac=0 And Cac≥1000) In Adults ≥75 Years Old: The Aric Study, Omar Dzaye, Alexander C Razavi, Zeina A Dardari, Frances M Wang, Yasuyuki Honda, Khurram Nasir, Josef Coresh, Candace M Howard-Claudio, Jin Jin, Bing Yu, Paul S De Vries, Lynne Wagenknecht, Aaron R Folsom, Ron Blankstein, Tanika N Kelly, Seamus P Whelton, Martin Bødtker Mortensen, Ziqiao Wang, Nilanjan Chatterjee, Kunihiro Matsushita, Michael J Blaha

Faculty, Staff and Student Publications

Background: Coronary artery calcium (CAC) is heterogeneous in older age and is incompletely explained by traditional atherosclerotic cardiovascular disease risk factors. The extremes of subclinical atherosclerosis burden are strongly associated with either a low or high 10-year risk of incident atherosclerotic cardiovascular disease, respectively. However, the genetic underpinnings of differences in arterial aging remain unclear. We sought to determine the independent association of 2 polygenic scores for coronary heart disease (CHD) with CAC in adults ≥75 years of age.

Methods: There were 1865 ARIC (Atherosclerosis Risk in Communities) participants who underwent genetic testing at visit 1 (1987-1989) and CAC scans …


Addressing Barriers To Post-Graduate Research Training In Low Resource Settings: An Innovative Approach In An Institution Of Higher Learning In Kenya, Eunice Muthoni, Rosebella Iseme, Roselyter Riang’A, James Orwa, Ken Njenga, Anthony Ngugi Nov 2024

Addressing Barriers To Post-Graduate Research Training In Low Resource Settings: An Innovative Approach In An Institution Of Higher Learning In Kenya, Eunice Muthoni, Rosebella Iseme, Roselyter Riang’A, James Orwa, Ken Njenga, Anthony Ngugi

Population Health, East Africa

Background: Numerous barriers hinder health research training in Post-Graduate Medical Education Programs, especially in developing countries. Research training is pivotal for medical residency, providing essential knowledge and skills for dissertation completion, fostering evidence-based medical practice, and nurturing future independent clinical researchers. A holistic approach to research education is imperative to surmount these barriers. We describe here a dissertation-centric research curriculum, delivered longitudinally, an innovative strategy undertaken by Aga Khan University's Medical College in East Africa (AKU-MCEA) to deliver postgraduate research.

Methods: A review of AKU-MCEA post-graduate research methods curriculum was conducted based on implementing Departments' experience, institutional policies, and residency …


Bcl-Xl Is Translocated To The Nucleus Via Ctbp2 To Epigenetically Promote Metastasis, Tiantian Zhang, Sha Li, Yingcai Adrian Tan, Xiang Chen, Cheryl Zhang, Zhengming Chen, Bikash Mishra, Joseph Hyungjoon Na, Soyoung Choi, Sandra J Shin, Priyadarshan Damle, Kranthi Kumar Chougoni, Steven R Grossman, Dunrui Wang, Xuejun Jiang, Yi Li, Erika Hissong, Yao-Tseng Chen, Jenny Z Xiang, Yi-Chieh Nancy Du Nov 2024

Bcl-Xl Is Translocated To The Nucleus Via Ctbp2 To Epigenetically Promote Metastasis, Tiantian Zhang, Sha Li, Yingcai Adrian Tan, Xiang Chen, Cheryl Zhang, Zhengming Chen, Bikash Mishra, Joseph Hyungjoon Na, Soyoung Choi, Sandra J Shin, Priyadarshan Damle, Kranthi Kumar Chougoni, Steven R Grossman, Dunrui Wang, Xuejun Jiang, Yi Li, Erika Hissong, Yao-Tseng Chen, Jenny Z Xiang, Yi-Chieh Nancy Du

Faculty, Staff and Students Publications

Nuclear Bcl-xL is found to promote cancer metastasis independently of its mitochondria-based anti-apoptotic activity. How Bcl-xL is translocated into the nucleus and how nuclear Bcl-xL regulates histone H3 trimethyl Lys4 (H3K4me3) modification have yet to be understood. Here, we report that C-terminal Binding Protein 2 (CtBP2) binds to Bcl-xL via its N-terminus and translocates Bcl-xL into the nucleus. Knockdown of CtBP2 by shRNA decreases the nuclear portion of Bcl-xL and reverses Bcl-xL-induced invasion and metastasis in mouse models. Furthermore, knockout of CtBP2 not only reduces the nuclear portion of Bcl-xL but also suppresses Bcl-xL transcription. The binding between Bcl-xL and …