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Full-Text Articles in Public Health

Chronic Illness Education 2024: Resources For A Transgender Person Living With Hiv Using The Chronic Illness Model., Alec Landau, Emma Keer, Francis Hernandez, Meena Kian, Reid Gordon, Vanessa Parada Dec 2024

Chronic Illness Education 2024: Resources For A Transgender Person Living With Hiv Using The Chronic Illness Model., Alec Landau, Emma Keer, Francis Hernandez, Meena Kian, Reid Gordon, Vanessa Parada

Patient Education Projects

No abstract provided.


Chronic Illness Education 2024: Comprehensive Care For Patients With Hiv, Annie Hillenberg, Ibrahim Malik, Reema Smadi, Sanjeev Bola, Sean Carroll Dec 2024

Chronic Illness Education 2024: Comprehensive Care For Patients With Hiv, Annie Hillenberg, Ibrahim Malik, Reema Smadi, Sanjeev Bola, Sean Carroll

Patient Education Projects

No abstract provided.


Chronic Illness Education 2024: Chronic Kidney Disease Management: Low-Sodium Protocol Outcomes, Andrew Hannoudi, Harshini Muthukumar, Jacob Dougherty, Melanie Rofoo, Miranda Goodson, Reid Becker, Trae Hill Dec 2024

Chronic Illness Education 2024: Chronic Kidney Disease Management: Low-Sodium Protocol Outcomes, Andrew Hannoudi, Harshini Muthukumar, Jacob Dougherty, Melanie Rofoo, Miranda Goodson, Reid Becker, Trae Hill

Patient Education Projects

No abstract provided.


Predictors Of Belongingness In First-Year College Students: Examining Mental Health And Adjustment, Jordan D. Foreman-Black Dec 2024

Predictors Of Belongingness In First-Year College Students: Examining Mental Health And Adjustment, Jordan D. Foreman-Black

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The initial transition to college is a pivotal moment for emerging adults, often influencing whether a student will remain successful. Students face a significant challenge adapting to the new environment that has been compounded by their experiences through the COVID-19 pandemic. Despite these challenges, a sense of belonging for students has been shown to be a key aspect of a successful transition to college. Students are often confronted with increasing levels of mental health challenges throughout the transition, specifically experiencing increasing mental health difficulties or challenges throughout their initial adjustment to college. Moreover, parents have become increasingly involved in students’ …


Chronic Illness Education 2024: Patient Education On Potassium Supplementation To Prevent And Treat Hypertension, Abeer Abukamil, Joseph Hanania, Michael Nunu, Samar Chehab, Vipul Taxak, Yeonju Kim Dec 2024

Chronic Illness Education 2024: Patient Education On Potassium Supplementation To Prevent And Treat Hypertension, Abeer Abukamil, Joseph Hanania, Michael Nunu, Samar Chehab, Vipul Taxak, Yeonju Kim

Patient Education Projects

No abstract provided.


The Life And Discoveries Of Yellapragada Subbarow, Nikhil R, Varuni Pragya, Subramanian Ramaswamy, Shiva Prasad B N, Mahabaleshwar Mamadapur Dec 2024

The Life And Discoveries Of Yellapragada Subbarow, Nikhil R, Varuni Pragya, Subramanian Ramaswamy, Shiva Prasad B N, Mahabaleshwar Mamadapur

Digital Journal of Clinical Medicine

Dr. Yellapragada Subbarow was a researcher, teacher, and a wizard of wonder drugs who constantly made efforts in the discoveries/ inventions such as vitamins, anti-vitamins, antibiotics, and many more by disentangling the mysteries of nature for the betterment of the people. He inspired the youngsters to take up the challenges and to stand up above mediocrity. The reward for his achievement was delayed. The article describes a true humanist's journey, discoveries, and his achievements that are largely unknown to date.


Locating Health Inequities: Understanding The Dynamic Role Of ‘Place’ In The Social Determinants Of Health And Healthcare Accessibility, Abbie Sudduth Page Dec 2024

Locating Health Inequities: Understanding The Dynamic Role Of ‘Place’ In The Social Determinants Of Health And Healthcare Accessibility, Abbie Sudduth Page

Graduate Theses and Dissertations

Objective. The social determinants of health (SDH) are various non-medical factors that influence health behaviors and health outcomes, and they are measured in variety of different ways. The purpose of this dissertation is to explore the relationship SDH items that may group to form a new domain and may be associated with outcomes of health care accessibility. This dissertation seeks to explain a novel understanding of social determinants of health and healthcare accessibility through the lens of the socioecological model and place-based SDH items.
Methodology. This retrospective study design utilized data from the baseline survey and year-22 wave of the …


Us Or Them: How Covid-19 Vaccine Priority Influences Perceptions Of Local-Migrant Worker Relations, Tengjiao Huang, Haochen Zhou, Liz Jones, Chin Wen Cong Dec 2024

Us Or Them: How Covid-19 Vaccine Priority Influences Perceptions Of Local-Migrant Worker Relations, Tengjiao Huang, Haochen Zhou, Liz Jones, Chin Wen Cong

Research Collection School of Social Sciences

The COVID-19 pandemic laid bare pre-existing societal fault lines, placing immense strain on intergroup relations and giving rise to xenophobic sentiments. Drawing on Realistic Conflict Theory (RCT) and Social Identity Approach (SIA), our study examined how the public allocation of COVID-19 variant vaccines could influence the dynamics between local citizens and migrant workers, and under what conditions. One key idea is that valued resource distribution that favour migrant workers may produce increased perceptions of realistic threats among local citizens which could lead to exacerbated negative attitudes and behaviours of high-status local citizens towards low-status migrants, whereas higher fairness perceptions of …


Trends In Family Planning Uptake In Tanzania: An Analysis Of National Survey Data 2021-2022, Harun Yussuf Ayoub, Sabarinah Prasetyo Nov 2024

Trends In Family Planning Uptake In Tanzania: An Analysis Of National Survey Data 2021-2022, Harun Yussuf Ayoub, Sabarinah Prasetyo

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

The purpose of this study is to uncover the socioeconomic and demographic factors that influence the usage of contraceptives by analysing trends and patterns in Tanzania's family planning uptake using data from national surveys. The results show that while Tanzania has made progress in increasing contraceptive prevalence from 27% in 2010 to 39% in 2021-22, disparities persist across socioeconomic and demographic lines. Women in urban areas, from higher wealth quintiles, and with higher educational attainment have significantly higher contraceptive prevalence rates compared to their counterparts. The study also reveals that the majority of women are aware of family planning methods, …


Gambaran Perilaku Merokok Siswa Smp Negeri, R Nasrullah Nur Nugroho Nov 2024

Gambaran Perilaku Merokok Siswa Smp Negeri, R Nasrullah Nur Nugroho

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Remaja mudah terjerumus pada perilaku berisiko, seperti merokok, karena mereka tidak tahu banyak, mudah dipengaruhi, dan ingin mencoba hal-hal baru. Pada tahun 2018, proporsi merokok pada remaja berusia 10–14 tahun adalah 2,1%, dan mereka rata-rata menghisap 6–7 batang setiap hari. Dengan menggunakan konsep penelitian cross-sectional dari 406 siswa laki-laki SMP negeri di kelurahan Kebayoran Lama Utara, penelitian ini memberikan gambaran tentang perilaku merokok siswa SMP negeri. Besar sampel yang digunakan adalah 117 orang yang menjawab. Dalam penelitian ini, teknik quota sampling digunakan untuk pengambilan sampel. Data penelitian ini dikumpulkan melalui kuesioner yang diisi langsung oleh responden. Hasil analisis menunjukkan bahwa …


Faktor Kontributor Prevalensi Stunting: Studi Kasus Jawa Timur Tahun 2022, Sofiyulloh Sofiyulloh, Martya Rahmaniati Nov 2024

Faktor Kontributor Prevalensi Stunting: Studi Kasus Jawa Timur Tahun 2022, Sofiyulloh Sofiyulloh, Martya Rahmaniati

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Malnutrisi, termasuk stunting, masih menjadi masalah kesehatan yang mempengaruhi kemajuan pembangunan berkelanjutan. Stunting, akibat kekurangan gizi berkepanjangan dan infeksi berulang, menghambat pertumbuhan anak. Di Indonesia, prevalensi stunting pada tahun 2022 adalah 21,6% dan masih belum mencapai target. Dan Jawa timur, angka stunting di 2022 adalah 19,2%, mendekati angka nasional pun masih belum mencapai target. Penelitian ini bertujuan mengidentifikasi faktor-faktor yang berkontribusi terhadap stunting di Jawa Timur, dengan fokus pada faktor soial ekonomi dan kesehatan. Data sekunder dari Kementerian Kesehatan, dan Dinas Kesehatan Jawa Timur dianalisis menggunakan uji korelasi. Hasil menunjukkan bahwa Indeks Pembangunan Manusia (IPM) dan rata-rata lama sekolah memiliki …


Keunggulan Dan Tantangan Dalam Penggunaan Computer Vision Untuk Diagnosis Pneumonia Pediatri: A Systematic Review, Hafshah Farah Fadhilah, Rico Kurniawan Nov 2024

Keunggulan Dan Tantangan Dalam Penggunaan Computer Vision Untuk Diagnosis Pneumonia Pediatri: A Systematic Review, Hafshah Farah Fadhilah, Rico Kurniawan

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Pneumonia pediatrik merupakan penyebab utama kematian anak-anak di bawah usia lima tahun. Teknologi computer vision menawarkan potensi besar untuk meningkatkan diagnosis pneumonia pediatrik dengan menganalisis gambar radiografi dada secara otomatis. Penelitian ini menggunakan metode systematic literature review dengan pendekatan PRISMA, meninjau artikel dari database IEEE Xplore, Science Direct, dan Scopus yang diterbitkan antara tahun 2020 hingga 2024. Studi ini menemukan bahwa algoritma deep learning seperti Convolutional Neural Networks (CNN) menunjukkan akurasi tinggi dalam diagnosis pneumonia pediatrik. Namun, tantangan seperti kebutuhan akan data berkualitas tinggi, interpretasi hasil AI, dan integrasi teknologi ini dengan sistem kesehatan yang ada masih perlu diatasi. Penggunaan …


Early Detection Of Risk Factor For Suicidal Ideation Among Senior High School Students In Jakarta: Updated Measurement, Nova R. Yusuf, Sabarinah Prasetyo, Byron J. Good Nov 2024

Early Detection Of Risk Factor For Suicidal Ideation Among Senior High School Students In Jakarta: Updated Measurement, Nova R. Yusuf, Sabarinah Prasetyo, Byron J. Good

Kesmas

The key strategy to address suicide in adolescents is school-based suicidal prevention by adapting a screening instrument to the local culture and policymakers’ perception of suicide. This study aimed to develop an instrument for the early detection of risk for suicidal ideation and identify influential risk factors for suicidal ideation among high school students in Jakarta, Indonesia. This study was conducted in 2018 with a mixed-method design (quantitative and qualitative approaches). It was found that 5% of students had suicidal ideation in July–November 2018, and 13.8% had a high-risk factor for suicidal ideation. The instrument developed in this study consisted …


Household Food Expenditure Typology And Its Association With Child Stunting And Anemia In Indonesia, Ratu Ayu Dewi Sartika, Yusnita Yusnita, Winda M. Ningsih, Ririn Arminsih Wulandari, Siti A. Pujonarti, Fadila Wirawan Nov 2024

Household Food Expenditure Typology And Its Association With Child Stunting And Anemia In Indonesia, Ratu Ayu Dewi Sartika, Yusnita Yusnita, Winda M. Ningsih, Ririn Arminsih Wulandari, Siti A. Pujonarti, Fadila Wirawan

Kesmas

Stunting and anemia remain the coexisting nutritional problems among Indonesian children. However, evidence of household-level food expenditure and its association with child stunting and anemia is limited. This study aimed to observe the association between household food expenditure typology and child stunting and anemia in Indonesia. Data was obtained from the 2007 and 2014 Indonesia Family Life Survey (IFLS). The household food expenditure, child nutritional status, and anemia were observed in 2007 and 2014. Latent class analysis was taken to identify the food expenditure pattern. Binary logistic regression was applied to analyze the association between household food expenditure patterns and …


Dietary Diversity As A Dominant Factor Of Energy Intake Among Breastfeeding Mothers In Depok City, Indonesia, Cornelia Lugita Santoso, Ratu Ayu Dewi Sartika, Sandra Fikawati, Fadila Wirawan, Primasti Nuryandari Putri, Nurul Husna Mohd Shukri Nov 2024

Dietary Diversity As A Dominant Factor Of Energy Intake Among Breastfeeding Mothers In Depok City, Indonesia, Cornelia Lugita Santoso, Ratu Ayu Dewi Sartika, Sandra Fikawati, Fadila Wirawan, Primasti Nuryandari Putri, Nurul Husna Mohd Shukri

Kesmas

Maternal nutritional needs increase during lactation. However, the energy intake of breastfeeding mothers usually still falls short of the recommended adequacy levels. This study aimed to identify the dominant factor of energy intake in breastfeeding mothers in Sawangan District, Depok City, Indonesia. This quantitative study used a cross-sectional design from July 2022 to February 2023. Energy intake, dietary diversity, and eating frequency were collected using 24-hour food recall. Other variables were collected through interviews with structured questionnaires. Data were analyzed using the Chi-square test and binary logistic regression. A total of 217 breastfeeding mothers participated in this study. This study …


Assessment Of Free Drinking Water Facilities And Its Potential Health Risks: A Study In The University X, Indah Actry Zane Lumbantobing, Bambang Wispriyono, Fitri Kurniasari, Sifa Fauzia, Muhammad Nur Ihsan Ayyasy, Alissa Siti Haura, Ghina Labibah, Muhammad Abiyyu Akmal, Kirana Mahadewi Heryadi, Firda Alfianti, Nuranida Fauziyah Nov 2024

Assessment Of Free Drinking Water Facilities And Its Potential Health Risks: A Study In The University X, Indah Actry Zane Lumbantobing, Bambang Wispriyono, Fitri Kurniasari, Sifa Fauzia, Muhammad Nur Ihsan Ayyasy, Alissa Siti Haura, Ghina Labibah, Muhammad Abiyyu Akmal, Kirana Mahadewi Heryadi, Firda Alfianti, Nuranida Fauziyah

Kesmas

University X offers free drinking water facilities. However, it has a significant problem in accessing safe drinking water. This study aimed to examine the microbial and chemical parameters of the free drinking water facilities at University X. The microbial quality was assessed by evaluating the total coliform bacteria, and the chemical parameter assessment, substances such as nitrate, iron, manganese, hexavalent chromium, and fluoride were analyzed across 12 water samples from various locations within the university. Among these, only total coliform and fluoride levels exceeded the guidelines of the World Health Organization (WHO) and the Indonesian Ministry of Health. An Environmental …


Home Births Among Ethnic Minority Communities In Bokeo Province, Lao People's Democratic Republic, Jukkrit Wungrath, Rungrasami Sriwongphan, Krissana Kapheak, Wanchalerm Ritthimon Nov 2024

Home Births Among Ethnic Minority Communities In Bokeo Province, Lao People's Democratic Republic, Jukkrit Wungrath, Rungrasami Sriwongphan, Krissana Kapheak, Wanchalerm Ritthimon

Kesmas

Home births among ethnic minorities in developing countries pose significant risks to maternal and neonatal health. In Lao PDR, the government has taken steps to manage home births through training traditional birth attendants, improving transportation, and establishing referral systems. However, high home birth rates in regions like Bokeo remain concerning. This review emphasized the need for more skilled birth attendants and better access to emergency obstetric care in rural, ethnic minority areas. This review used 40 articles published between 2000 and 2023 and highlighted gaps in research regarding healthcare access, cultural practices, socioeconomic barriers, and the role of traditional birth …


Economic Growth, Poverty Gap, And Health Inequality: Implications Based On Panel Analysis Of Organization For Economic Cooperation And Development Data, Sangik Han Nov 2024

Economic Growth, Poverty Gap, And Health Inequality: Implications Based On Panel Analysis Of Organization For Economic Cooperation And Development Data, Sangik Han

Kesmas

This study investigated the impact of economic growth and income distribution on health inequality using data from the Organization for Economic Cooperation and Development (OECD). Employing a panel analysis, this study amalgamated 21 years of data (spanning from 2000 to 2020) from 37 OECD countries. The dependent variables (life expectancy and avoidable mortality) were scrutinized against independent variables (gross domestic product and poverty gap). Control variables encompassed body mass index, consumption patterns, smoking rates, health workers availability, number of beds in health facilities, national medical expenses, and unemployment rates. This study revealed significant associations between economic growth, poverty gap, and …


Social Determinants Of Neonatal Health Outcomes In Indonesia: A Multilevel Regression Analysis, Rooswanti Soeharno, Amal Chalik Sjaaf Nov 2024

Social Determinants Of Neonatal Health Outcomes In Indonesia: A Multilevel Regression Analysis, Rooswanti Soeharno, Amal Chalik Sjaaf

Kesmas

Indonesia’s neonatal mortality rate remains alarmingly high. This study addressed the determinants of neonatal outcomes in Indonesia, including the effects of a decentralized health system, socioeconomic disparities, and geographic variations. The analysis used 2018 national survey data across 34 provinces, 513 cities/districts, and 300,000 households, with a sample of 73,864 women aged 10-54 years who have given birth in the preceding five years. The multilevel regression was used to assess the impact of social determinants and systemic inequalities on neonatal health. Key findings revealed a neonatal mortality rate that, despite being preventable in many cases, remained high with significant disparities. …


Telemedicine Adoption In Developing Economies: A Systematic Review On The Enablers And Barriers, Zaidbren Macabato, Lemuel Clark Velasco, Art Brian Escabarte, Mae-Lanie Ong Poblete, Armando Isla Jr., Rentor Cafino, Sarah Lizette Aquino-Cafino, Frevy Teofilo-Orencia Nov 2024

Telemedicine Adoption In Developing Economies: A Systematic Review On The Enablers And Barriers, Zaidbren Macabato, Lemuel Clark Velasco, Art Brian Escabarte, Mae-Lanie Ong Poblete, Armando Isla Jr., Rentor Cafino, Sarah Lizette Aquino-Cafino, Frevy Teofilo-Orencia

Kesmas

Telemedicine’s adoption has been effective in certain contexts despite being controversial in certain settings because of its tendency to cause misdiagnosis and concerns about data privacy. This study aimed to synthesize the research findings on the factors leading to the adoption of telemedicine among developing economies. The study utilized Preferred Reporting Items for Systematic Reviews and Meta-Analysis methodology to analyze 27 related literature and the Unified Theory of Acceptance and Use of Technology to map out the factors considered enablers and barriers in adopting telemedicine. Results showed that performance expectancy, effort expectancy, social influence, and facilitating conditions were significant predictors. …


Risk Factors Of Covid-19 Infection Among Health Workers Post-Vaccination In Jakarta, Rahmat Saputra, Nurhayati Adnan Prihartono, Mondastri Korib Sudaryo, Renti Mahkota, Yeni Devita, Ni Wayan Deisy Arisanti Nov 2024

Risk Factors Of Covid-19 Infection Among Health Workers Post-Vaccination In Jakarta, Rahmat Saputra, Nurhayati Adnan Prihartono, Mondastri Korib Sudaryo, Renti Mahkota, Yeni Devita, Ni Wayan Deisy Arisanti

Kesmas

One of the best approaches to stop the COVID-19 pandemic is vaccination. In Indonesia, the first round of vaccinations was prioritized for health workers on January 14, 2021 (first dose) and March 1, 2021 (second dose). However, some health workers who have been vaccinated were found to be reinfected after receiving the second dose. This cross-sectional study examined the risk factors for COVID-19 infection among health workers after vaccination using secondary and primary data. The data analysis was carried out in univariate (examining the frequency distribution and proportion of independent variables), bivariate (Chi-square test to explore the relationship between independent …


Mortalidad Por Cirrosis En Guatemala 2018: Patrones E Inequidades, Cristian Ramírez, Luis Pablo Méndez-Alburez, María Fernanda Piedrasanta, Alejandro Cerón Nov 2024

Mortalidad Por Cirrosis En Guatemala 2018: Patrones E Inequidades, Cristian Ramírez, Luis Pablo Méndez-Alburez, María Fernanda Piedrasanta, Alejandro Cerón

Anthropology: Faculty Scholarship

El presente estudio busca analizar la mortalidad por cirrosis en Guatemala. El propósito es identificar posibles criterios epidemiológicos que orienten la priorización de acciones de salud pública. El riesgo de morir por cirrosis en Guatemala muestra marcadas desigualdades por departamento, las cuales son mayores al comparar por municipio. El riesgo de morir es también más alto en hombres, en personas mestizas o ladinas, en niveles educativos bajos, y en personas que se dedican a ocupaciones elementales. Las medidas de salud pública orientadas a los municipios y grupos en mayor riesgo son de suma importancia para la prevención de muerte por …


Mortality Disparities Amongst African American Infants In Wisconsin, Enica C. Saffold Nov 2024

Mortality Disparities Amongst African American Infants In Wisconsin, Enica C. Saffold

Walden Dissertations and Doctoral Studies

African American mothers have the highest infant mortality rate of any other racial group, in the United States. In Milwaukee, the rates for non-Hispanic African Americans were two to three times higher than those for non-Hispanic Whites and Hispanics between 2016 and 2018. According to the Wisconsin Department of Health Services in 2022, the infant mortality rate in 2021 was 12.9 for every 1,000 live births. This cross-sectional quantitative epidemiological study explores risk factors correlated with high infant mortality rates among Wisconsin African American mothers who gave birth to live infants between 2011 and 2021. To determine whether there is …


Site-Specific Prevalence Of Human Papillomavirus Infection In Malaysian Men, Mohd Khairul Anwar Shafii Nov 2024

Site-Specific Prevalence Of Human Papillomavirus Infection In Malaysian Men, Mohd Khairul Anwar Shafii

Student Works (2020-2029)

Human papillomavirus (HPV) infection is among one of the common infections among the female population and is closely associated with cervical cancer. It has gained attention since the introduction of prophylactic HPV vaccines. However, the epidemiology of HPV infection among the male population in the Asian context remains largely unknown. The worldwide report on the prevalence of HPV infection among men varies depending on the target population and method of sampling. This study aims to determine the knowledge, and site-specific prevalence of anogenital HPV infection, and its associated factors among sexually active men in an urban middle-income Asian setting. The …


A Comprehensive Analysis Of In-Hospital Adverse Events After Scopolamine Administration: Insights From A Retrospective Cohort Study Using A Large Nationwide Inpatient Database, George Sun, Marc Torjman, Kevin Min Nov 2024

A Comprehensive Analysis Of In-Hospital Adverse Events After Scopolamine Administration: Insights From A Retrospective Cohort Study Using A Large Nationwide Inpatient Database, George Sun, Marc Torjman, Kevin Min

Department of Anesthesiology Faculty Papers

BACKGROUND: Scopolamine is a widely used antiemetic in anesthetic practice, particularly for postoperative and post-discharge nausea and vomiting. Despite its frequent usage and recognized efficacy, concerns have emerged regarding the potential for increased side effects, particularly in elderly patients. Further research is needed to assess safety and determine age thresholds for adverse events. This study hypothesizes associations between perioperative scopolamine use, worse clinical outcomes, increased pneumonia, delirium, urinary retention, and readmissions.

METHODS: A large, retrospective cohort study was performed using the TriNetX Analytics Network database on patients undergoing major surgical procedures between Jan 1, 2009, and March 21, 2018, to …


The Laboratory Opossum (Monodelphis Domestica) Is A Unique Model For Research On Zika Virus: Robust Immune Response, Widespread Dissemination, And Long-Term Persistence, André Filipe Pastor, Susan M. Mahaney, Juan Garcia Jr., Marisol Morales, Oscar Quintanilla, Marco Arriaga, John M. Thomas, John L. Vandeberg Nov 2024

The Laboratory Opossum (Monodelphis Domestica) Is A Unique Model For Research On Zika Virus: Robust Immune Response, Widespread Dissemination, And Long-Term Persistence, André Filipe Pastor, Susan M. Mahaney, Juan Garcia Jr., Marisol Morales, Oscar Quintanilla, Marco Arriaga, John M. Thomas, John L. Vandeberg

School of Medicine Publications

The Zika virus (ZIKV) epidemic elicited a rapid commitment to the development of animal models for ZIKV research. Non-human primates (NHPs) and mice have made significant contributions to this research, but NHPs are expensive, have a long gestation period, and are available only in small numbers; non-genetically modified mice are resistant to infection. To address these deficiencies, we have established the laboratory opossum, Monodelphis domestica, as a small animal model that complements the mouse and monkey models. We developed and validated an indirect ELISA for measuring antibodies to ZIKV in opossums, as well as an immunohistochemistry (IHC) method to detect …


Strategies To Enhance Diagnostic Capabilities For The New Drug-Resistant Tuberculosis (Dr-Tb) Drugs, Antonia Morita Iswari Saktiawati, Anca Vasiliu, Francesca Saluzzo, Onno W Akkerman Nov 2024

Strategies To Enhance Diagnostic Capabilities For The New Drug-Resistant Tuberculosis (Dr-Tb) Drugs, Antonia Morita Iswari Saktiawati, Anca Vasiliu, Francesca Saluzzo, Onno W Akkerman

Faculty, Staff and Students Publications

The global burden of drug-resistant tuberculosis (DR-TB) continues to challenge healthcare systems worldwide. There is a critical need to tackle DR-TB by enhancing diagnostics and drug susceptibility testing (DST) capabilities, particularly for emerging DR-TB drugs. This endeavor is crucial to optimize the efficacy of new therapeutic regimens and prevent the resistance and overuse of these invaluable weapons. Despite this urgency, there remains a lack of comprehensive review of public health measures aimed at improving the diagnostics and DST capabilities. In this review, we outline strategies to enhance the capabilities, especially tailored to address the challenges posed by resistance to new …


Host Dna Depletion On Frozen Human Respiratory Samples Enables Successful Metagenomic Sequencing For Microbiome Studies, Minsik Kim, Raymond C Parrish, Michael J Tisza, Viral S Shah, Thi Tran, Matthew Ross, Juwan Cormier, Aribah Baig, Ching-Ying Huang, Laura Brenner, Isabel Neuringer, Katrine Whiteson, J Kirk Harris, Amy D Willis, Peggy S Lai Nov 2024

Host Dna Depletion On Frozen Human Respiratory Samples Enables Successful Metagenomic Sequencing For Microbiome Studies, Minsik Kim, Raymond C Parrish, Michael J Tisza, Viral S Shah, Thi Tran, Matthew Ross, Juwan Cormier, Aribah Baig, Ching-Ying Huang, Laura Brenner, Isabel Neuringer, Katrine Whiteson, J Kirk Harris, Amy D Willis, Peggy S Lai

Faculty, Staff and Students Publications

Most respiratory microbiome studies use amplicon sequencing due to high host DNA. Metagenomics sequencing offers finer taxonomic resolution, phage assessment, and functional characterization. We evaluated five host DNA depletion methods on frozen nasal swabs from healthy adults, sputum from people with cystic fibrosis (pwCF), and bronchoalveolar lavage (BAL) from critically ill patients. Median sequencing depth was 76.4 million reads per sample. Untreated nasal, sputum, and BAL had 94.1%, 99.2%, and 99.7% host reads, respectively. Host depletion effects varied by sample type, generally increasing microbial reads, species and functional richness; this was mediated by higher effective sequencing depth. Rarefaction curves showed …


Context, Mechanisms And Community Engagement In Implementation Strategies: A Systematic Review Protocol Of Implementation Strategies Designed Using Implementation Mapping, Eunyoung Kang, Gill Ten Hoor, Derek W Craig, Serena Rodriguez, Jennifer Stockton, Maria E Fernandez Nov 2024

Context, Mechanisms And Community Engagement In Implementation Strategies: A Systematic Review Protocol Of Implementation Strategies Designed Using Implementation Mapping, Eunyoung Kang, Gill Ten Hoor, Derek W Craig, Serena Rodriguez, Jennifer Stockton, Maria E Fernandez

Faculty, Staff and Student Publications

INTRODUCTION: Implementation Mapping (IM) has increasingly been used for the design and/or selection and tailoring implementation strategies to promote the effective translation of evidence-based interventions into practice. IM is a tool for guiding the systematic, iterative, step-by-step design process that helps guide the co-creation of theory-based, evidence-informed implementation strategies. This protocol aims to describe the methods of the planned systematic review that will (1) examine the overall landscape of IM in developing implementation strategies, (2) explore the mechanisms of implementation strategies developed using IM and (3) investigate the use of IM and community engagement in the development of implementation strategies. …


The Meatpacking Industry Needs Stronger Worker Protections And Enhanced Oversight, India Luxton, Laura-Anne Minkoff-Zern Nov 2024

The Meatpacking Industry Needs Stronger Worker Protections And Enhanced Oversight, India Luxton, Laura-Anne Minkoff-Zern

Center for Policy Research

Meatpacking plants are hazardous workplaces with high injury rates and poor working conditions, negatively impacting the health of the industry’s predominately immigrant and refugee workforce. The COVID-19 pandemic illuminated ongoing concerns in the industry, including the problems associated with consolidation and concentration, worker safety, and poor public health outcomes. This brief summarizes findings from a study that used data from 39 interviews with local, state, and federal officials and bureaucrats, worker advocates, and workers to analyze meatpacking policymaking and oversight during COVID-19. The authors find that a lack of industry oversight and decreased regulation contribute to unsafe environments, and injustices …