Public Health Commons^™

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Cushing's Disease: Spontaneous Remission Following Severe Headache, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

A young woman was found to have persistent Cushing's syndrome one year after surgical removal of both hyperplastic adrenal glands. Improvement followed pituitary irradiation butshe developed skin pigmentation. Remission of the adrenal hyperfunction occurred only after several months of therapy with o,p'-DDD. Within 15 months, the recurrent disorder required a second course of DDD with resulting adrenal insufficiency. Eighteen months later, however, steroid supplements were no longer required and increasing Cortisol levels indicated still another imminent relapse. There was no enlargement of the sella turcica. The patient had received no treatment whatever for nearly nine months when she experienced a …

Endoscopic Retrograde Pancreatic Duct Cannulation (Erpc): An Aid To Pancreatic Surgery, C. Grodsinsky, B. Schuman, B. E. Brush

Henry Ford Hospital Medical Journal

Retrograde endoscopic pancreatic duct cannulation for evaluation of patients with chronic pancreatitis is reviewed over the last two years. Of 40 patients that were endoscoped, 30 had a successful pancreatogram. The X-ray findings fell into three groups: 1) single and multiple stenosis, 2) diffuse narrowing, and 3) apparently normal duct. This procedure proved of value in ruling out or delaying surgical operation in 10 persons. Twenty-one patients underwent operations. Thirteen had a 95% pancreatectomy, one had drainage of a necrotic collection thought to be a pseudocyst and one had a pseudocyst resected. One had a gastrojejunostomy and vagotomy bypassing a …

Multiple Myeloma In A 23-Year-Old Man: A Case Report, C. K. Ma, K. Maeda, R. Waldmann, J. W. Rebuck

Henry Ford Hospital Medical Journal

A case is reported of multiple myeloma in a 23-year-old man, including extensive clinical studies and postmortem examination. Multiple myeloma for this age group is considered to be extremely rare.

Infections Due To Trichosporon Cutaneum, An Uncommon Systemic Pathogen, Tom Madhavan, John Eisses, Edward L. Quinn

Henry Ford Hospital Medical Journal

Multiple isolations of T. Cutaneum from the blood stream of two patients enabled the authors to characterize the morphology, biochemical reactions and antibiotic susceptibility of T. Cutaneum. This organism appears to be an opportunistic pathogen and responds promptly to intravenous Amphotericin B or oral 5-Fluorocytosine.

Bupivacaine As A Local Anesthetic For Hernia Repair, Joseph L. Ponka, James A. Sapala

Henry Ford Hospital Medical Journal

Bupivacaine hydrochloride is a safe, useful local anesthetic agent for repair of groin hernias. Prolonged anesthesia, lasting six hours or longer, was observed In 94 of WO patients. No toxic effects involving the central nervous system were observed using a 0.25% solution with epinephrine. Hypotension and cardiac arrhythmia occurred in one patient. Wound complications, such as hematomas and ecchymosis, were more common with Bupivacaine than when Chlorprocaine was used. However, painstaking hemostasis, which required ligation of even the tiniest blood vessels, reduced the wound complications. As experience is gained in the use of Bupivacaine, complications will be reduced to a …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Some Of The Effects Of Domestic Sewage Discharged Into Hickman And Jessamine Creeks In Jessamine County, Kentucky, Henry H. Howell, Mike W. Jones, Robert A. Kuehne

KWRRI Research Reports

A 6-week study was made in the summer of 1971 as an initial effort to determine the extent of pollution that the three sewage disposal plants in Jessamine County, Kentucky, are contributing to its streams. With the rapid population increase in Lexington and nearby municipalities, this study should furnish a basis of comparison for future investigations. Eighteen collecting stations were established in riffle areas of Hickman and Jessamine Creeks, and coliform bacteria, macro-invertebrate populations, fish populations and chemical water quality of each riffle area were studied.

Hickman Creek's flow was augmented by approximately 3,100,000 gallons/day (11,735 -m³/day) from …

Comparative Analysis Of Hospital Utilization In Urban And Rural Counties, James R. Dingels

Journal of the Minnesota Academy of Science

Hospital utilization, when measured as patient days per population, exhibited generally insignificant relationships with factors concerning population characteristics, hospital resources, financial assistance, and degree of urbanization. Adjusted multivariate linear regression results indicated that number of physicians per population did possess significant effects, while other independent variables remained significant. Additional research, as well as refinement of present data, appear paramount to further validation procedures.

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1945-1976) T1101-T1200, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1101. TRANSLATION FROM RUSSIAN. SUMMARY. MIRONOV, P. (1953). Hemorrhagic fever in Burgas Region. Suvrem. Med., Sof., 6:62-73. (In Bulgarian).

T1102. TRANSLATION FROM RUSSIAN. MATEVOSYAN, K. Sh., KARASEVA, P. S., RESHETNIKOV, I. A. and SEMENOV, B. F. (1972). Investigation of arboviruses transmitted through ticks in Armenian SSR. In: Actual problems of virology and prophylaxis of viral diseases, edited by Chumakov, M. P. Tezisy 17. Nauch. Sess. Inst. Posvyashch. Aktual. Probl. Virus. Profilakt. Virus. Zabolev. (Moscow, October 1972), p. 303.

T1103. TRANSLATION FROM RUSSIAN. SKOFERTSA, P. G., GAIDAMOVICH, S. Ya., OBUKHOVA, V. O., KORCHMAR'. N. D., YAROVOI, P. I., KLISENKO, G. A. …

The Stanford Heart Disease Prevention Program, Nathan Maccoby

Consumer Behavior in the Health Marketplace: Symposium Proceedings

This afternoon I want to tell you about the results of a major study we have been doing as a part of the Stanford Heart Disease Prevention Program. The Stanford Heart Disease Prevention Program is an interdisciplinary project directed by Dr. John W. Farquhar, Professor of Medicine at Stanford University and I am co-director. This paper was really co-authored by fifteen people as part of an interdisciplinary team. With a group of different people like this, we had to spend a significant amount of time trying to teach each other our respective professional languages. Initially, communication within our group was …

Private Water Supplies, Maine Department Of Human Services

Maine Collection

Private Water Supplies

Department of Human Services, Augusta, Me. (Reprinted 1976).

Contents: Introduction / General Requirements / Types of Private Water Supplies / Procurement of Safe Water / Distribution / Appendix A & B

Evaluation In Dentistry : A System For Assessing The Quality Of A School-Based Dental Program, Wendy Corn Friedman

Public Health Theses

A school-based dental program was established at the Mary Hooker Elementary School under a grant from the Robert Wood Johnson Foundation. Administration was under the auspices of the University of Connecticut, Department of Pediatrics. The author participated in the organization of the program. Pertinent literature on evaluation of health care and dental care in particular are reviewed. An evaluation system for this program is developed, which can be extended to other dental care facilities.

As part of the system, the author recommends: that an evaluator be cognizant of the program objectives; that he determine which aspects to evaluate; that he …

Patterns Of Fatty Acid Release From Endogenous Substrates By Human Platelet Homogenates And Membranes, A Derksen, P Cohen

Faculty, Staff and Students Publications

We describe a method for measuring the release of fatty acids from endogenous substrates of human platelet homogenates and membranes. The method depends on the availability of lipids whose fatty acids are odd-chained and therefore suitable as internal reference compounds that, at the time of lipid extraction, can be added to an incubation to permit subsequent quantification of the content of free fatty acids or fatty acids esterified to specific lipids. We found four types of lipolytic activities in human platelets. In homogenates at pH 4.0 a triglyceride lipase operated as shown by the synchrony of triglyceride degradation and release …

Lymphangiography In Staging Carcinoma Of The Prostate. A Comparison With Operative Findings, Joseph C. Cerny, Malcolm Weckstein, Riad Farah

Henry Ford Hospital Medical Journal

Pedal lymphangiography was performed In 30 patients who subsequently underwent radical retropubic prostatectomy, and radical pelvic lymphadenectomy. In 24 of 30 patients, lymphangiograms correctly predicted the presence or absence of nodal Involvement. In spite of certain limitations of the technique. It is considered an essential diagnostic study in patients considered for possible radical prostatic surgery, or in patients who may be candidates for external megavoltage radiotherapy to the prostate gland and its lymphatic drainage.

Palliative Urinary Diversion In Adenocarcinoma Of The Prostate, R. C. Youngman, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Ten patients with inoperable prostatic carcinoma, producing ureteral obstruction and azotemia, underwent palliative urinary diversion. Good quality survivals of two months to three years were obtained. These results compare favorably with the good results seer) In gynecologic neoplasm of the bladder, colon and breast. In selected cases of carcinoma of the prostate, palliative urinary diversion is indicated when the prospects exist for further benefit from chemotherapy or radiotherapy.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Radical Retropubic Prostatectomy And Pelvic Lymphadenectomy In Carcinoma Of The Prostate, Riad N. Farah, Joseph C. Cerny

Henry Ford Hospital Medical Journal

An operative technique Is described which combines regional pelvic lymphadenectomy with radical prostatectomy. The technique has been used on 30 patients with no operative mortality. Morbidity has been within acceptable limits. Thus far, only one patient has shown recurrence of the neoplasm.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Advances In The Radiation Therapy Of Carcinoma Of The Prostate, Joel Elliot White

Henry Ford Hospital Medical Journal

Basic principles of radiation biology and radiation tolerance are reviewed. The Implications for radiation therapy of newer staging techniques in carcinoma of the prostate such as exploratory laparotomy, lymphangiography, and bone marrow acid prosphatase are discussed. A technique for treating the prostate and para-aortic lymph nodes in continuity is presented. Complications and results of therapy are discussed.

Symposium On Carcinoma Of The Prostate — Introduction, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

Radionuclide Bone Imaging In The Evaluation Of Prostatic Cancer, Daniel S. Marks, William R. Eyler

Henry Ford Hospital Medical Journal

Radionuclide bone imaging is a rapid, easily performed, noninvasive method for evaluation of skeletal disease in carcinoma of the prostate, or any other malignancy. In a significant number of cases, it may provide the only evidence of metastases and frequently demonstrates more widespread Involvement than previously suspected. Thus, it may redirect the chosen course of therapy or localize sources of bone pain that are not radiographically apparent. Sixty-two percent of 42 patients studied were abnormal, of which 12% had no radiographic evidence of disease.

Bone Marrow Acid Phosphatase In The Evaluation Of Patients With Carcinoma Of The Prostate, Ronald Kabler, Riad Farah, Kenneth Greenawald, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Based on experience with 30 men having clinical stage A and B adenocarcinoma of the prostate, the authors conclude that elevation of bone marrow acid phosphatase (BMAP) is a sensitive indicator of the disease state. BMAP revealed periprostatic or nodal Involvement when osseous metastases seemed absent. BMAP is considered essential in the evaluation of all patients with prostatic carcinoma. Patients who have false negative BMAP (and are not candidates for radical prostatectomy), should undergo lymphangiography and bone scan before radiation therapy or hormonal treatment is planned.

Immunologic Assessment In Patients With Prostatic Carcinoma, Richard C. Klugo

Henry Ford Hospital Medical Journal

The role of immune mechanisms in the development and control of prostatic carcinoma appears to be complicated by the endocrine response of some tumors. The progression of endocrine-independent tumors is more directly related to host-immune response. Evaluation of the role of chemotherapeutic agents must include their effect on the host-immune response. The use of BCC in patients with metastatic prostatic carcinoma produces no alteration in cell-mediated immunity but produces local tumor necrosis. The use of nonspecific antigens to enhance host-immune response may be more effective when used as adjuvant therapy in earlier stages of prostatic adenocarcinoma.

Hormonal And Chemotherapeutic Management Of Disseminated Carcinoma Of The Prostate, Robert W. Brownlee

Henry Ford Hospital Medical Journal

The management of disseminated prostatic carcinoma with hormonal and chemotherapeutic agents is discussed. Hormonal manipulation consists of ablative as well as additive modalities. A new agent, Adriamycin, has shown some effectiveness In selected cases. Significant difficulties are encountered in assessing the objective state of remission of patients undergoing therapy. Further advances through co-operative, randomized clinical trials must be sought. The development of additional chemotherapeutic agents will hopefully expand our horizons.

Changes In Serum Testosterone After Bilateral Orchiectomy In Patients With Metastatic Carcinoma Of The Prostate, Richard Senn, Riad Farah, Julius Ohorodnik, Joseph C. Cerny

Henry Ford Hospital Medical Journal

From a study of 38 patients, it may be concluded that, first, changes in serum testosterone levels of patients undergoing orchiectomy for metastatic carcinoma of the prostate are unrelated to the clinical course of the patient; second, no clear correlation exists between quantitative Leydig cell counts and levels of plasma testosterone; and, third, exacerbation of metastatic disease is observed while plasma testosterone remains in the castrate range. These observations question the exact function of the Leydig cell and its role in androgen production, and indicate that prostatic neoplasms have varying degrees of response to reduced androgen levels and/or androgen-Iike substances …

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

The Effects Of Immobility On Long Bone Remodelling In The Rhesus Monkey, Charles C. Schock, Frank R. Noyes, Michael M. Crouch, Catharina H. E. Mathews

Henry Ford Hospital Medical Journal

Using Frost's method for undecalcified bone sections, long bones of the lower extremities of ten rhesus monkeys were examined following two months' immobilization and compared with thirteen controls. A decrease in appositional rate and in the surface extent of the ossification process were noted in the immobilized animals. No typical change in resorption was noted. The immobilized animals showed a decreased cortical-total area ratio. These findings suggest that a decrease in activity affects bone by depressing functions mediated by the osteoblast without necessarily evoking an Increased remodelling response.

Sjogren's Syndrome: Relationship Between Ocular Findings And Parotid Sialograms, A. O. Carbone, C. F. Petrozzi, J. Delcarpio, J. A. Zegarra

Henry Ford Hospital Medical Journal

This study evaluates the incidence and severity of the ocular findings and its correlation with the parotid gland changes, as demonstrated by sialography, in 82 patients with Sjogren's syndrome. It is shown that the ocular component of the syndrome manifests rather autonomously with respect to the accompanying collagen disease and that there seems to be only a tentative trend towards a positive correlation between the ocular and parotid findings. Sjogren's syndrome immunologically is closer to the collagen diseases than to the so-called organ-specific autoimmune diseases.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.