Public Health Commons^™

Childhood Vaccination And Autism, Peggy K. Brinkman

International Journal of Global Health and Health Disparities

In March, 2008, parents of a girl in Georgia were ruled to be entitled to compensation because their daughter developed autistic symptoms after being vaccinated with childhood vaccines (Doheny, 2008). This ruling truly questions the necessity of vaccination for childhood diseases and puts the question in the mind of every parent as to if they should vaccinate their child or not. The purpose of this study is to review literature on the epidemiologic relationship between childhood vaccinations and the development of autism.

Infidelity, Trust, And Condom Use Among Latino Youth In Dating Relationships, S. S. Brady, Jeanne M. Tschann, J. M. Ellen, Elena Flores

School of Education Faculty Research

Background: Latino youth in the United States are at greater risk for contracting sexually transmitted infections (STIs) in comparison with non-Hispanic white youth.

Methods: Sexually active heterosexual Latino youth aged 16 to 22 years (N = 647) were recruited for interviews through a large health maintenance organization or community clinics.

Results: Adjusting for gender, age, ethnic heritage, and recruitment method, woman’s consistent use of hormonal contraceptives, ambivalence about avoiding pregnancy, longer length of sexual relationship, and greater overall trust in main partner were independently associated with inconsistent condom use and engagement in a greater number of sexual intercourse acts that …

Uncompensated Care Cost: A Pilot Study Using Hospitals In A Texas County, Alberto Coustasse, Andrea L. Lorden, Vishal Nemarugommula, Karan P. Singh

Management Faculty Research

The financial ramifications of uncompensated care cost (UCC) on the healthcare industry have been difficult to quantify. With the lack of a standardized definition of uncompensated care and the need to account for the uninsured, indigent, and immigrant populations, the authors identified $190 million of UCC from Southwestern border hospitals for emergency room treatment of undocumented immigrants and $934 million of uncompensated care charges for 23 hospitals in a Texas county, which translated to $353 million of UCC. Although lawmakers passed the Medicare Prescription Drug Improvement and Modernization Act (2003) to address the growing imbalance, the shortfall of funds highlights …

Interventions To Reduce Recidivism Rates Among Juvenile Offenders, Rebecca Arnold

International Journal of Global Health and Health Disparities

This paper will review epidemiologic literature on interventions that contribute favorably to reducing rates of recidivism among juvenile offenders. In this context, the exposures are the various interventions and treatment modalities that may be used in an attempt to prevent recidivism; the disease (outcome) is recidivism. Recidivism is defined as "the tendency to relapse into a previously undesirable type of behavior, especially crime." For the purpose of this review, "juvenile offender" includes boys and girls aged 12-21 who can be classified as juvenile delinquents and/or who have committed at least one violent crime; the juvenile offenders in the studies reviewed …

Influence Of Direct Contact With Poultry On Acquisition Of Avian Influenza (H5n1): A Literature Review, Catherine M. Betts

International Journal of Global Health and Health Disparities

Avian influenza, otherwise known as the disease associated with H5N1 virus, has been a public health concern for many years. Especially in the past decade, researchers have struggled to find effective treatments for this disease because of the severe symptoms it causes. In 1997, it was found that this virus infected both birds and humans, and the first documented case of transmission from birds to humans occurred. In 1999 in Hong Kong, further cases were documented in which poultry was responsible for transmitted the disease to humans, and it was established that poultry was the main mode of transmission of …

Pomegranate (Punica Graantum) Peels As An Agricultural Waste For Removing Of Cd(Ii), Cr(Vi), Cu(Ii), Ni(Ii), Pb(Ii) And Zn(Ii) From Their Aqueous Solutions, G. M. Taha, A. E. Arifien, S. El-Nahas

International Journal of Global Health and Health Disparities

Pomegranate (Punica graantum) peels as an agricultural waste was used as an adsorbent for removal of Cd, Cr, Cu, Ni, Pb and Zn ions from simulated aqueous solutions. The adsorption process was carried out using the batch method. Various effective parameters such as pH, initial metal ion concentration, and adsorbent dose, shaking time, particle size and temperature were investigated. Fourier Transform Infrared (FTIR) and Scanning Electron Microscopy (SEM) of Punica graantum peels were done. The efficiency of Punica graantum peels toward removal of metal ions was ordered as Pb²⁺ < Cr⁶⁺ < Cu²⁺ < Cd²⁺ < Zn²⁺ < Ni²⁺, with the …

Ethical Considerations Of Genetic Presymptomatic Testing For Huntington's Disease, Alberto Coustasse, Alicia Pekar, Andrew Sikula Sr., Sue Lurie

Management Faculty Research

The aim of this literature review was to determine if there is adequate ethical justification for presymptomatic genetic testing on potential Huntington's disease patients. Huntington's disease is a neurological genetic disorder characterized by midlife onset which consists of cognitive, physical, and emotional deterioration. Although genetic testing has traditionally been guided by the principle of autonomy, severe psychological consequences such as depression, anxiety, survival guilt, and suicide have complicated the ethical issue of providing a presymptomatic yet definitive diagnosis for an incurable disease. An analysis of available articles yielded inconclusive findings, namely due to insufficient evidence, self-selection bias of test participants, …

Dodge This: Do Environmental Chemicals Impact Your Health?, Gale B. Carey

The University Dialogue

No abstract provided.

Reasons For Urban Trail Use Predict Levels Of Trail-Related Physical Activity, Genevieve Dunton, Donna Spruijt-Metz, Jennifer Wolch, Chih-Ping Chou, Michael Jerrett, Jason Byrne, Susan Weaver, Kim D. Reynolds

CGU Faculty Publications and Research

Background:

Efforts to increase community levels of physical activity through the development of multiuse urban trails could be strengthened by information about factors predicting trail use. This study examined whether reasons for trail use predict levels of physical activity on urban trails.

Methods:

Adults (N = 335) living within a 1-mile buffer zone of urban trails in Chicago, Dallas, and Los Angeles completed a self-report measure assessing demographics, reason for trail use, and physical activity on the trail. Accelerometers measured total daily moderate-to-vigorous physical activity (MVPA). Environmental features of the urban trail were assessed with the Systematic Pedestrian and Cyclist …

Ua94/6/1 Student / Alumni Personal Papers Western Kentucky University Small Collections, Wku Archives

WKU Archives Collection Inventories

Small collections of personal papers and oral histories relating to the Western Kentucky University.

Ua12/4 Stall Street Journal, Vol. 1, Wku Health Services

WKU Administration Documents

Broadsides developed by WKU Health Services to convey public health information in students in bathroom stalls. Incomplete run.

Affective Decision-Making Predictive Of Chinese Adolescent Drinking Behaviors, Lin Xiao, Antoine Bechara, Jerry L. Grenard, Alan W. Stacy, Paula Palmer, Yonglan Wei, Yong Jia, Xiaolu Fu, C. Anderson Johnson

CGU Faculty Publications and Research

The goal of the current investigation was to address whether affective decision making would serve as a unique neuropsychological marker to predict drinking behaviors among adolescents. We conducted a longitudinal study of 181 Chinese adolescents in Chengdu city, China. In their 10th grade (ages 15–16), these adolescents were tested for their affective decision-making ability using the Iowa Gambling Task (IGT) and working memory capacity using the Self-Ordered Pointing Test. Self-report questionnaires were used to assess academic performance and drinking behaviors. At 1-year follow-up, questionnaires were completed to assess drinking behaviors, and the UPPS Impulsive Behavior Scale was used to examine …

Risk Assessment For Suicide Behaviour : Clinical Challenges, Amresh Srivastava, Charles Nelson

Data and Test Instruments

This is an audio-visual about risk assessment of suicide behavior. Part 1. Reformulating the concept of RISK and a New instrument for assessment: Risk assessment is an important clinical responsibility, which can be ‘life-saving’. Literature on risk factors has become voluminous; however a traditional risk assessment does not take into account the most relevant factors. This reflects the prevailing conceptualization of risk, which has not been fully and completely tied to clinical outcomes. Psychopathology is currently understood in biopsychosocial terms. A more progressive conceptualization of risk should consider the interplay of both, risk and protective factors. The present work proposes …

School-Based Screening To Identify At-Risk Students Not Already Known To School Professionals: The Columbia Suicide Screen, Michelle A. Scott, Holly C. Wilcox, Irvin Sam Schonfeld, Mark Davies, Roger C. Hicks, J. Blake Turner, David Shaffer

Publications and Research

Objectives.Wesought todeterminethedegreeofoverlapbetweenstudents identified through school-based suicide screening and those thought to be at risk by school administrative and clinical professionals. Methods. Students from7 high schools in theNewYorkmetropolitan area completed the Columbia Suicide Screen; 489 of the 1729 students screened had positive results. The clinical status of 641 students (73% of those who had screened positive and 23%of thosewho had screened negative) was assessedwithmodules from the Diagnostic Interview Schedule for Children. School professionals nominated by their principal and unaware of students’ screening and diagnostic status were asked to indicate whether they were concerned about the emotional well-being of each participating student. …

Assessing A Smoking Cessation Program For Veterans In Substance Use Disorder Treatment., Theodore Cooper, Y. Hunt, R. Burke, C. Stoever

Departmental Papers (Psych)

No abstract provided.

Club Drug Use In Hispanic College Students, Michelle Resor, Theodore Cooper

Departmental Papers (Psych)

No abstract provided.

Hyperandrogenism And Obesity: Ominous Co-Morbidities, Amit M. Deokar, Shawn J. Smith, Amanda J. Goodwin, Hatim A. Omar

Pediatrics Faculty Publications

This review has a two-fold objective. One, it addresses the association of hyperandrogenism and obesity and the complex metabolic derangements that are part of the problem. Clinical management of these co-morbidities is challenging and complex. Second, this article will aid health care providers with the key features to an early diagnosis and intervention to decrease the morbidities in the short as well as long term. Method: Systematic review of articles and information on the topic of interest that were published in the last 15 years. Conclusion: Obesity and hyperandrogenism are integral parts of Metabolic Syndrome/Polycystic Ovarian Syndrome (PCOS)/Hyperandrogenism, Insulin resistance, …

Induction Of Endogenous Γ-Globin Gene Expression With Decoy Oligonucleotide Targeting Oct-1 Transcription Factor Consensus Sequence, Xiaoxin S. Xu, Xin Hong, Gan Wang

Wayne State University Associated BioMed Central Scholarship

Abstract

Human β-globin disorders are relatively common genetic diseases cause by mutations in the β-globin gene. Increasing the expression of the γ-globin gene has great benefits in reducing complications associated with these diseases. The Oct-1 transcription factor is involved in the transcriptional regulation of the γ-globin gene. The human γ-globin genes (both Aγ and Gγ-globin genes) carry three Oct-1 transcription factor consensus sequences within their promoter regions. We have studied the possibility of inducing γ-globin gene expression using decoy oligonucleotides that target the Oct-1 transcription factor consensus sequence. A double-stranded 22 bp decoy oligonucleotide containing the Oct-1 consensus sequence was …

Pharmacists’ And Pharmacy Students’ Ability To Identify Drug-Related Problems Using Timer (Tool To Improve Medications In The Elderly Via Review), Sarah Snyder Lee, Ann K. Schwemm, Jeffrey Reist, Matthew Cantrell, Michael Andreski, William R. Doucette, Elizabeth A. Chrischilles, Karen B. Farris

United States Public Health Resources

Objective. Determine the effectiveness of TIMER (Tool to Improve Medications in the Elderly via Review) in helping pharmacists and pharmacy students identify drug-related problems during patient medication reviews.
Methods. In a randomized, controlled study design, geriatric patient cases were sent to 136 pharmacists and 108 third-year pharmacy students who were asked to identify drug related-problems (DRPs) with and without using TIMER.
Results. Pharmacists identified more tool-related DRPs using TIMER (p 5 0.027). Pharmacy students identified more tool-related DRPs using TIMER in the first case (p 5 0.02), but not in the second.
Conclusion. TIMER increased the number of DRPs identified …

Children’S Exposure To Violence: A Comprehensive National Survey, David Finkelhor, Heather Turner, Richard Ormrod, Sherry Hamby, Kristen Kracke

United States Public Health Resources

This Bulletin discusses the National Survey of Children’s Exposure to Violence (NatSCEV), the most comprehensive nationwide survey of the incidence and prevalence of children’s exposure to violence to date, sponsored by the Office of Juvenile Justice and Delinquency Prevention (OJJDP) and supported by the Centers for Disease Control and Prevention (CDC). Conducted between January and May 2008, it measured the past-year and lifetime exposure to violence for children age 17 and younger across several major categories: conventional crime, child maltreatment, victimization by peers and siblings, sexual victimization, witnessing and indirect victimization (including exposure to community violence and family violence), school …

Launching A Novel Preclinical Infrastructure: Comparative Oncology Trials Consortium Directed Therapeutic Targeting Of Tnfα To Cancer Vasculature, Melissa C. Paoloni, Anita Tandle, Christina Mazcko, Engy Hanna, Stefan Kachala, Amy Leblanc, Shelley Newman, David Vail, Carolyn Henry, Douglass Thamm, Karin Sorenmo, Amin Hajitou, Renata Pasqualini, Wadih Arap, Chand Khanna, Steven K. Libutti

United States Public Health Resources

Background: Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncology Trials Consortium (COTC). The COTC is a novel infrastructure to integrate cancers that naturally develop in pet dogs into the development path of new human drugs. Trials are designed to address questions challenging in conventional preclinical models and early phase human trials. Large animal spontaneous cancer models can be a valuable addition to successful studies of cancer biology and novel therapeutic drug, imaging and device development.

Methodology/Principal Findings: Through this established infrastructure, the first trial of …

The Role Of Glutamate And Its Receptors In Mesocorticolimbic Dopaminergic Regions In Opioid Addiction, Yuan Guo, Hui-Ling Wang, Xiao-Hui Xiang, Yan Zhao

United States Public Health Resources

Accumulating evidence suggests that glutamate, as one of the most important excitatory neurotransmitters in the brain, plays a key role in drug addiction including opioid addiction. There is substantial evidence for glutamatergic projections into mesocorticolimbic dopaminergic neurons, which are associated with opioid psychological dependence and are also the key regions of enhancement effect. Glutamate may be involved in the process of opioid addiction not only by acting on its ionotropic and metabotropic glutamate receptors that activate several signal transduction pathways, but also by interacting with other neurotransmitters or neuropeptides such as opioids, dopamine, y-aminobutyric acid and substance P in the …

Comparison Of Video Laryngoscopy Technologies, C. Chiesa, N. Miljkovic, N. Schulte, J. B. Callahan, Jr., D. J. Miller, B. H. Boedeker

United States Public Health Resources

Indirect laryngoscopy allows practitioners to “see around the corner” of a patient’s airway during intubation. Inadequate airway management is a major contributor to patient injury, morbidity and mortality. The purpose of the present study was to evaluate the video quality of commercially available video laryngoscopy systems. A team of four investigators at the University of Nebraska at Omaha and the Peter Kiewit Institute performed intubation simulations using a number of video laryngoscopy systems. Testing was done with a Laerdal Difficult Airway Manikin (Laerdal Medical Corp., Wappingers Falls, NY) in a setting that simulated difficult airways, adverse lighting conditions and various …

Children's Behavioral Traits And Risk Of Injury: Analyses From A Case-Control Study Of Agricultural Households, Kathleen F. Carlson, Susan G. Gerberich, Bruce H. Alexander, Ann S. Masten, Timothy R. Church, John M. Shutske, Andrew D. Ryan, Colleen M. Renier

United States Public Health Resources

Problem: Children on family agricultural operations have high risk of injury. The association between children's behavioral traits and their risk of injury is not well understood. Method: Data from the Regional Rural Injury Study-II were used to assess behavioral risk factors for injury to children ages six to <20 years. A total of 379 injury events (cases) and 1,562 randomly selected controls were identified. Adjusted odds ratios (OR) and 95% confidence intervals (CI), calculated using logistic regression, were used to estimate injury risk in reference to behavioral traits. Results: Injury risks were greater for children with high levels of depressive symptoms (OR=1.9, CI=1.0-3.7) and aggression (OR=1.6, CI=0.9-2.7), and low levels of careful/cautious behavior (OR=1.8, CI=1.1-2.9). Children with low levels of self-regulation had reduced risks (OR=0.4, CI=0.2-0.8). Discussion: Results suggest that children's behaviors affect their risk of agricultural injury. Additional research …

Carbon Tetrachloride-Induced Liver Damage In Asialoglycoprotein Receptor-Deficient Mice, Shana R. Dalton, Serene M.L. Lee, Rachel N. King, Amin A. Nanji, Kusum K. Kharbanda, Carol A. Casey, Benita L. Mcvicker

United States Public Health Resources

The asialoglycoprotein (ASGP) receptor is an abundant hepatocyte-specific receptor involved in receptor-mediated endocytosis. This receptor’s abundance and function is decreased by chronic ethanol administration prior to the appearance of pathology such as necrosis or inflammation. Hence, this study aimed to determine if ASGP receptor function is required to protect against liver injury by utilizing a knockout mouse model lacking functional ASGP receptor in the setting of carbon tetrachloride (CCl₄) hepatotoxicity. Briefly, ASGP receptor-deficient (RD) mice and wild-type (WT) mice were injected with 1 ml/kg body weight of CCl₄. In the subsequent week, mice were monitored for …

Nitric Oxide Inhibits Insulin-Degrading Enzyme Activity And Function Through S-Nitrosylation, Crystal M. Cordes, Robert G. Bennett, Gerri L. Siford, Frederick G. Hamel

United States Public Health Resources

Insulin-degrading enzyme (IDE) is responsible for the degradation of a number of hormones and peptides, including insulin and amyloid β (Aβ). Genetic studies have linked IDE to both type 2 diabetes and Alzheimer’s disease. Despite its potential importance in these diseases, relatively little is known about the factors that regulate the activity and function of IDE. Protein S-nitrosylation is now recognized as a redox-dependent, cGMP-independent signaling component that mediates a variety of actions of nitric oxide (NO). Here we describe a mechanism of inactivation of IDE by NO. NO donors decreased both insulin and Aβ degrading activities of IDE. Insulin-degrading …

Proteomics Reveal A Concerted Upregulation Of Methionine Metabolic Pathway Enzymes, And Downregulation Of Carbonic Anhydrase-Iii, In Betaine Supplemented Ethanol-Fed Rats, Kusum K. Kharbanda, Vasanthy Vigneswara, Benita L. Mcvicker, Anna U. Newlaczyl, Kevin Bailey, Dean Tuma, David E. Ray, Wayne G. Carter

United States Public Health Resources

We employed a proteomic profiling strategy to examine the effects of ethanol and betaine diet supplementation on major liver protein level changes. Male Wistar rats were fed control, ethanol or betaine supplemented diets for 4 weeks. Livers were removed and liver cytosolic proteins resolved by onedimensional and two-dimensional separation techniques. Significant upregulation of betaine homocysteine methyltransferase-1, methionine adenosyl transferase-1, and glycine N-methyltransferase were the most visually prominent protein changes observed in livers of rats fed the betaine supplemented ethanol diet. We hypothesise that this concerted upregulation of these methionine metabolic pathway enzymes is the protective mechanism by which betaine restores …

Identification Of Francisella Tularensis Subsp. Tularensis A1 And A2 Infections By Real-Time Polymerase Chain Reaction, Claudia R. Molins, Jennifer K. Carlson, Jana Coombs, Jeannine M. Petersen

United States Public Health Resources

Francisella tularensis subsp. tularensis (type A) is subdivided into clades A1 and A2. Human tularemia infections caused by A1 and A2 differ with respect to clinical outcome; A1 infections are associated with a higher case fatality rate. In this study, we develop and evaluate TaqMan polymerase chain reaction (PCR) assays for identification of A1 and A2. Both assays were shown to be specific to either A1 or A2, with sensitivities of 10 genomic equivalents. Real-time PCR results for identification of A1 and A2 were in complete agreement with results obtained by pulsed field gel electrophoresis analysis or conventional PCR when …

Establishing Public Health Security In A Postwar Iraq: Constitutional Obstacles And Lessons For Other Federalizing States, David P. Fidler, Kumanan Wilson, Christopher W. Mcdougall, Harvey Lazar

Articles by Maurer Faculty

The public health consequences of the conflict in Iraq will likely continue after the violence has subsided. Reestablishing public health security will require large investments in infrastructure and the creation of effective systems of governance. On the question of governance, the allocation of powers in the new constitution of Iraq is critical. Given the ease with which public health threats cross borders, the constitution needs to grant to the federal government the legal authority to manage such threats and simultaneously meet international requirements. Unfortunately, the draft constitution does not accomplish this objective. If politically possible, the constitution should be amended …

Evaluation Of Hiv Counseling And Testing In Anc Settings And Adherence To Short Course Antiretroviral Prophylaxis For Pmtct In Francistown, Botswana, Carolyn Baek, Tracy Creek, Lee Ann Jones, Louis Apicella, Jennifer Redner, Naomi Rutenberg

HIV and AIDS

The vast majority of children infected with HIV are the result of mother-to-child transmission (MTCT) of the virus during pregnancy, labor, or breastfeeding. Botswana is one of the first countries in the developing world with a national prevention program (PMTCT) to reduce vertical transmission. The Horizons Program of the Population Council, in collaboration with the Centers for Disease Control and Prevention (CDC) and Premiere Personnel in Botswana, conducted an evaluation to describe the adherence of pregnant women to the current PMTCT regimen. The report recommends standardizing post-test counseling content through the use of job aids and adapting existing WHO materials, …