Public Health Commons^™

Development Of A Novel Metallo-Lipid Microparticle Delivery System For A Leishmania Mexicana Dna Vaccine Candidate, Joanna B. Valencia

Open Access Theses & Dissertations

ABSTRACT

Background and Significance.

The leishmaniases are an important group of neglected tropical parasitic diseases caused by parasitic protozoa of the genus Leishmania. International health authorities estimate that 350 million people around the world are at risk for contracting leishmaniasis. Two million new cases occur each year and 12 million people are presently infected worldwide. Leishmaniasis is endemic throughout the Americas region including all of Central America, most of South America, Mexico and southern Texas. Leishmania is also considered a threat to the military readiness of U.S. troops deployed to the Middle East or Latin America.

First- and second-line treatments …

Optimal Control Applied To A Discrete Time Influenza Model, Paula Andrea Gonzalez Parra

Open Access Theses & Dissertations

For the last decades, mathematical epidemiological models have been used to understand the dynamics of infectious diseases and guide public health policy.

In particular, several continuous models have been considered to study influenza outbreaks and their controls policies. However, most epidemiological data is discrete; therefore, a discrete formulation is more convenient to compare collected data with the output of the model. We introduce a discrete time model in order to study optimal control strategies for influenza transmission.

In our model, we divide the population into four classes: susceptible, infectious, treated, and recovered individuals.

In particular, we evaluate the potential effect …

Development And Evaluation Of A Personalized Normative Feedback Intervention For Hispanic Youth At High Risk Of Smoking, Holly Mata

Open Access Theses & Dissertations

Despite reductions in overall smoking rates, data show that adolescents continue to smoke at higher rates than adults and that adolescents living in the Texas-Mexico border area are more likely than their counterparts living elsewhere in Texas to smoke. While adult smoking in the Paso del Norte Region has decreased significantly over the past decade, area youth smoking rates exceed both state and national averages. Recent estimates report cigarette smoking among El Paso youth in the past month to be slightly more than 28% as compared with 21% among Texas youth participating in the 2009 statewide Youth Risk Behavior Survey …

Gender Differences In Food Habits, Beliefs, And Fast Food Consumption Among A Predominantly Hispanic College Student Population, Alma Xochitl Ortega Gomez

Open Access Theses & Dissertations

Fast food consumption in the United States (U.S.) has been increasing steadily during the last decades. This trend has been linked to the increased prevalence of overweight and obesity among the population (Barnard, 2010; Currie, Della Vigna, Moretti & Pathania, 2009). Several sociodemographic characteristics that have been associated with the likelihood of frequent fast food consumption include income, ethnicity, gender and age (Block, Scribner, DeSalvo, 2004; Bowman & Vinyard, 2004; Drewnoski & Darmon, 2005; Driskell et al., 2006; Morse & Diskell, 2009; Paeratakul et al., 2003). Most studies related to fast food consumption have been conducted in adult population, only …

Relationships Between Central Obesity, Fructose Intake, And Non-Alcoholic Fatty Liver Disease In Overweight Hispanic Adolescents, Hector Reyes

Open Access Theses & Dissertations

Introduction: The purpose of this study was to evaluate whether central (visceral) fat measured as waist circumference and daily fructose intake were associated with measures of non-alcoholic fatty liver disease (NAFLD) in Hispanic overweight adolescents.

Methodology: Thirty four obese boys (n=15) and girls (n=19) between the ages of 13 and 18 years were measured for body composition, waist circumference, and dietary fructose intake. Fasting alanine (ALT) and aspartate (AST) aminotransferase levels in blood, ALT/AST ratio, and hepatic fat fraction (HFF) by magnetic resonance imaging were measured and used as surrogates for NAFLD. Pearson Product-Moment correlation analyses were used …

Assessment Of Intra-Urban Traffic-Related Air Pollution On Asthmatic Children's Exposure At Schools In The Paso Del Norte Region, Amit Ugamraj Raysoni

Open Access Theses & Dissertations

Traffic-related air pollution can be a major public health concern in any urban area. This problem is compounded in the Paso del Norte region that has experienced rapid economic growth, and a substantial number of people living in close vicinity of major roadways. The desert surroundings, arid weather, frequent temperature inversions, heavy border traffic at the international ports of entry between El Paso and Ciudad Juárez, and poorly maintained vehicle fleet further exacerbates this problem. A growing body of air quality and epidemiologic research has discerned the linkage between traffic emissions and respiratory disorders.

Initial health investigations in the Paso …

Community Cancer Services, Clinical Trials, And Quality Initiatives—Year 1 Ncccp At Lehigh Valley Health Network, Gregory R. Harper Md, Phd, Ada M. Rivera Ba, Eliot L. Friedman Md, Kathleen A. Leies Rn, Ocn, Nadesda Mack Rn, Bsn, Mba, Ocn, Lenore Mcgonigle Med, Suresh G. Nair Md, Tara Namey Ms, Cgc, Debbie Salas-Lopez Md, Mph, Facp, Ronald W. Swinfard Md, Facp

Department of Medicine

No abstract provided.

Maternal Exposure To The Holocaust And Health Complaints In Offspring, Janine D. Flory, Linda M. Bierer, Rachel Yehuda

Publications and Research

Although the link between chronic stress and the development of cardiovascular and metabolic diseases of adulthood has been known for some time, there is growing recognition that early environmental influences may result in developmental programming via epigenetic mechanisms, thereby affecting the developmental trajectory of disease progression. Previous studies support the idea that offspring of Holocaust survivors may have been subjected to early developmental programming. We evaluated the relationship between parental exposure to the Holocaust and selfreported health ratings and disorders made by their adult offspring (i.e., second generation Holocaust survivors). A total of 137 subjects were evaluated. Regression analyses demonstrated …

Development Of Fetal Movement Between 26 And 36 Weeks’ Gestation In Response To Vibroacoustic Stimulation, Marybeth Grant-Beuttler, Laura M. Glynn, Amy L. Salisbury, Elyssia Poggi Davis, Carol Holliday, Curt A. Sandman

Psychology Faculty Articles and Research

BACKGROUND: Ultrasound observation of fetal movement has documented general trends in motor development and fetal age when motor response to stimulation is observed. Evaluation of fetal movement quality, in addition to specific motor activity, may improve documentation of motor development and highlight specific motor responses to stimulation.

AIM: The aim of this investigation was to assess fetal movement at 26 and 36-weeks gestation during three conditions (baseline, immediate response to vibro-acoustic stimulation (VAS), and post-response).

DESIGN: A prospective, longitudinal design was utilized.

SUBJECTS: Twelve normally developing fetuses, eight females and four males, were examined with continuous ultrasound imaging.

OUTCOME MEASURES: …

The Relationship Of Race And Social Integration On The Health Status Of Older Adults In An Urban City, Thomas T. Jordan

Dissertations, Theses, and Capstone Projects

Durkheim argues that an individual is more vulnerable to self-destruction the more s/he is detached from the collective. This dissertation will explore the relative impact of social integration on older adults who have transitioned into their new roles in the social structure in relationship to their physical (obesity) and psychological (stress) health status. Additionally, the dissertation examines how social integration varies in its impact from one racial group to another, and how such variations influence the health status of the older adults who are members of these groups.

This dissertation employs data from the Brookdale Center for Healthy Aging and …

The Sun Safety Attitudes Of Parents And The Effects On Their Children, Matthew Welch

Theses : Honours

Parents are seen as the most important role models in the development of health practice behaviours, including sun safety for their children. The aim of the current study is to explore the experiences and sun protection knowledge, attitudes and behaviours of a parent of a child who has seen a UV photograph of both themselves and their child. By utilising UV flash photography, parents were able to see the damage done to their face and their child’s face caused by overexposure to the sun. The study was conducted through a qualitative, phenomenological approach, with the data analysed through the process …

Feedback Control For Exergames, Jeff Sinclair

Theses: Doctorates and Masters

The concept of merging exercise equipment with video games, known as exergaming, has the potential to be one of the main tools used in addressing the current rising obesity epidemic. Existing research shows that exergaming can help improve fitness and additionally motivate people to become more active. The two key elements of attractiveness - how much people want to play or use the exergaming system; and effectiveness – how effective the exergaming system is in actually increasing or maintaining physical fitness, need to be maximised to obtain the best outcomes from an exergaming system; we put this forward as the …

Scald Burn Admissions To Princess Margaret Hospital In 1998 And 2008: A Comparative Analysis, Lisa Martin

Theses: Doctorates and Masters

Scald is the most common form of burn in young children, accounting for over 50% of all paediatric burn admissions in Western Australia (WA). Interventions implemented over the past few years focussed on prevention, first aid, and improved services postinjury (Department of Health Western Australia, 2009). The population of children in WA is rising and an epidemiological study was undertaken to assess changes in the profile of scald injury among WA children and to assess priorities for future action. Data were collected from all acute inpatient admissions presenting with scald injury for 1998 and 2008. These data were compared with …

Creating Persuasive Messages To Promote Abstinence From Alcohol During Pregnancy, Kathryn France

Theses: Doctorates and Masters

While the rates of Fetal Alcohol Spectrum Disorder within Australia are unknown, the rates of alcohol use during pregnancy and at-risk alcohol use by women of childbearing age highlight the need for universal prevention strategies addressing prenatal alcohol exposure. Though many awareness-raising campaigns for alcohol use during pregnancy have been conducted, predominantly in North America, they have rarely been developed using formative research nor have they been comprehensively evaluated (Saskatchewan Prevention Institute, 2009; Elliott et al., 2008). This lack of published information on the development and evaluation of campaigns makes it difficult to determine what communication elements are most credible …

Occupational Respiratory Health Surveillance At Minara Resources, Murrin Murrin Mine Site, Martyn Cross

Theses: Doctorates and Masters

This thesis outlines the results of occupational respiratory health surveillance at Minara Resources, Murrin Murrin mine site. The research was conducted as part of a collaborative agreement between Edith Cowan University and Minara Resources, the overarching title of which was ‗Establishing best practice protocols in the management of occupational and environmental health in a high-risk mining and ore-processing environment‘. To form the basis of this research it was hypothesised that although the chemical hazards had been adequately identified, and the occupational exposures in each work area at Murrin Murrin were generally well below their respective occupational exposure levels, it was …

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

USF Tampa Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We …

The Mozambique Eyecare Programme – A Partnership Which Addresses Avoidable Blindness In Lusophone Africa, Aoife Phelan, James Loughman, Eva Doyle

Conference Papers

According to the WHO about 831 million people are visually impaired worldwide, 45 million of them are blind. Most people with visual impairment are older, and females are more at risk at every age, in every part of the world. Uncorrected Refractive Error accounts for over half of all visual impairment. About 87% of the worlds visually impaired live in developing countries. The Mozambique Eyecare Programme (MEP) is a cross institutional collaboration between governments, higher education institutions, non-governmental organisations and corporations. The aims of this Programme are to collaborate to provide a sustainable solution to the problem of avoidable blindness …

Gangguan Akibat Kekurangan Yodium Pada Wanita Usia Subur Di Kecamatan Baturaden Kabupaten Banyumas, Jawa Tengah, Endo Dardjito, Setiyowati Rahardjo

Kesmas

Gangguan Akibat Kekurangan Yodium (GAKY) merupakan salah satu masalah gizi di Kabupaten Banyumas. GAKY disebabkan oleh defisiensi kronik asupan yodium, konsumsi goitrogenik, penggunaan kontrasepsi KB hormonal, faktor genetik, dan pengetahuan penderita. Prevalensi penyakit gondok di Kecamatan Baturaden, Kabupaten Banyumas, terus meningkat mencapai 35,38% pada tahun 2007 sehingga daerah ini tergolong endemis berat GAKY. Untuk menganalisis faktor-faktor risiko GAKY di Kecamatan Baturaden, suatu penelitian penjelasan dengan desain kasus kontrol telah dilakukan dengan melibatkan 30 orang wanita usia subur (15-45 tahun) yang menderita GAKY sebagai kasus dan 30 orang WUS lain yang tidak menderita GAKY sebagai sebagai kontrol. Kedua kelompok adalah penduduk …

Kontaminasi Bakteri Escherichia Coli Pada Makanan Pedagang Kaki Lima Di Sepanjang Jalan Margonda Depok, Jawa Barat, Dewi Susanna, Yvonne M. Indrawani, Zakianis Zakianis

Kesmas

Menteri Kesehatan menetapkan bahwa makanan dan minuman tidak boleh mengandung bakteri Escherichia coli (E. coli). Namun, kebanyakan pemerintah daerah tidak menindaklanjutinya dengan menerapkan peraturan yang lebih teknis untuk mencegah penyakit-penyakit yang ditularkan lewat makanan. Penelitian ini bertujuan untuk mengukur kontaminasi E. coli dalam makanan yang dijual oleh pedagang kaki lima (PKL). Seratus PKL di sepanjang Jalan Margonda Kota Depok, Jawa Barat, dipilih secara acak sebagai sampel. Sebanyak 100 PKL, E. coli pada sampel berbagai jenis makanan diukur dengan metode most probable number, sementara sanitasi PKL dan kehigienisan penjamah makanan diamati. Ditemukan secara umum bahwa air bersih yang digunakan untuk memasak, …

Kualitas Hidup Anak Remaja Pada Keluarga Dengan Hiv/Aids Di Indonesia, Toha Muhaimin

Kesmas

Epidemi HIV/AIDS mempunyai dampak pada sosial ekonomi keluarga, terutama terhadap kualitas hidup anak remaja (12-18 tahun). Untuk melihat dampak HIV/AIDS dalam keluarga terhadap kualitas hidup remaja dan untuk mengidentifikasi berbagai faktor yang mempengaruhi besar dampak itu, telah dilakukan penelitian dengan menggunakan data survei tentang AIDS yang dikumpulkan tahun 2007 oleh Pusat Penelitian Kesehatan Universitas Indonesia. Variabel komposit yang terdiri variabel pendidikan, lingkungan sosial, dan aktivitas fisik, yang dikategorikan menjadi kurang baik dan baik, digunakan untuk mengukur kualitas hidup. Variabel-variabel ini kemudian dianalisis dengan regresi logistik untuk melihat besar dampak HIV/AIDS dalam keluarga, rumah tangga, dan anak terhadap kualitas hidup remaja. …

Analisis Ketahanan Hidup Lima Tahun Penderita Kanker Ovarium Epithelial Di Rumah Sakit Kanker Dharmais Jakarta, Indang Trihandini, Dieta Nurrika

Kesmas

Kanker ovarium merupakan salah satu penyebab utama kematian wanita. Dalam kasus kanker, jumlah serum albumin adalah indikator prognostik bertahan hidup yang penting, sementara probabilitas global pasien kanker ovarium dengan serum albumin ³ 3,6 g/dL dan ² 3,5 g/dL untuk bertahan hidup lima tahun masing-masing 23% and 10%. Namun di Indonesia, ketahanan hidup pasien-pasien kanker ovarium epithelial belum diteliti secara intensif. Penelitian yang dilaporkan ini bertujuan untuk menentukan probabilitas ketahanan hidup pasien-pasien kanker ovarium epithelial menurut tingkat serum albumin tertentu. Dengan menggunakan rancangan studi kohort retrospektif dan analisis ketahanan hidup, 48 orang pasien Rumah Sakit Kanker Dharmais Jakarta diamati sejak pertama …

Self-Insurance And The Potential Effects Of Health Reform On The Small-Group Market, Kathryn Linehan

National Health Policy Forum

The Patient Protection and Affordable Care Act (PPACA) as amended by the Health Care Education Reconciliation Act of 2010 makes landmark changes to health insurance markets. Individual and small-group insurance plans and markets will see the biggest changes, but PPACA also affects large employer and self-insured plans by imposing rules for benefit design and health plan practices. Over half of workers—most often those in very large firms—are covered by self-insured health plans in which employers (or employee groups) bear all or some of the risk of providing insurance coverage to a defined population of workers and their dependents. As PPACA …

Mathematical Modeling, Simulation, And Time Series Analysis Of Seasonal Epidemics., Eric Shu Numfor

Electronic Theses and Dissertations

Seasonal and non-seasonal Susceptible-Exposed-Infective-Recovered-Susceptible (SEIRS) models are formulated and analyzed. It is proved that the disease-free steady state of the non-seasonal model is locally asymptotically stable if R_v < 1, and disease invades if R_v > 1. For the seasonal SEIRS model, it is shown that the disease-free periodic solution is locally asymptotically stable when R̅_v < 1, and I(t) is persistent with sustained oscillations when R̅_v > 1. Numerical simulations indicate that the orbit representing I(t) decays when R̅_v < 1 < R_v. The seasonal SEIRS model with routine and pulse vaccination is simulated, and results depict an unsustained decrease …

Perceptions Of Maternal Stress And Neonatal Patient Outcomes In A Single Private Room Versus Open Room Neonatal Intensive Care Unit Environment., Lisa M. Smithgall

Electronic Theses and Dissertations

Limited clinical evidence exists regarding whether the single private room Neonatal Intensive Care Unit (NICU) environment of care delivery has a positive, negative, or neutral impact on health outcomes for the high risk neonate and on maternal stress as compared to the open room design. The study purpose was to examine whether a difference exists in health outcomes in the open room versus single private room NICU environment. The factors considered were weight gain, ventilator days, hospital length of stay, incidence and grade of intraventricular hemorrhage (IVH), the number of parental visits, and perceptions of maternal stress. Infants hospitalized in …

The Influence Of Neurocognitive Impairment On Treatment Outcomes Among Drug-Involved People Living With Hiv/Aids, Ifeoma O. Ezeabogu

Master's Theses

Drug- and sex-related HIV risk behaviors and sub-optimal adherence to HIV medication regimens can jeopardize the health of HIV–infected injection drug users (IDUs) and threaten community health. Findings to date indicate that it is feasible to deliver a brief behavioral risk reduction/medication adherence group intervention to HIV-infected IDUs in a community-based setting. Being adherent to HAART or being able to successfully participate in behavioral interventions targeting adherence and harm reduction often requires a relatively high level of cognitive abilities. HIV infection and substance abuse are known to independently affect the central nervous system and this can result in neuro-cognitive impairment. …

Racial Disparities In Healthcare: Challenges Faced By Hispanic Populations, Kaitlin Mcdowell

Honors Projects

No abstract provided.

Communities, Birth Attendants And Health Facilities: A Continuum Of Emergency Maternal And Newborn Care (The Global Network's Emonc Trial), Omrana Pasha, Robert L. Goldenberg, Elizabeth M. Mcclure, Sarah Saleem, Shivaprasad S. Goudar, Fernando Althabe, Archana Patel, Fabian Esamai, Ana Garces, Elwyn Chomba, Manolo Mazariegos, Bhala Kodkany, Jose M. Belizan, Richard J. Derman, Patricia L. Hibberd, Waldemar A. Carlo, Edward A. Liechty, K. Michael Hambidge, Pierre Buekens, Dennis Wallace, Lisa Howard-Grabman, Suzanne Stalls, Marion Koso-Thomas, Alan H. Jobe, Linda L. Wright

Community Health Sciences

Background: Maternal and newborn mortality rates remain unacceptably high, especially where the majority of births occur in home settings or in facilities with inadequate resources. The introduction of emergency obstetric and newborn care services has been proposed by several organizations in order to improve pregnancy outcomes. However, the effectiveness of emergency obstetric and neonatal care services has never been proven. Also unproven is the effectiveness of community mobilization and community birth attendant training to improve pregnancy outcomes. Methods/Design: We have developed a cluster-randomized controlled trial to evaluate the impact of a comprehensive intervention of community mobilization, birth attendant training and …

The Ingredients Of Change: A Political Ecology Approach To Diabetes In The Somali Community Of Minnesota, Mina Tehrani

Geography Capstone Projects

In the early 1990’s, due to political circumstances at home, Somali immigrants and refugees began arriving in the state of Minnesota in large numbers. Over the past two decades, Somali immigrants have come to comprise one of the most populous ethnic groups in the Twin Cities, and are the largest Somali population in the world outside of Eastern Africa. Although quantitative data is unavailable, qualitative evidence and testimonies of healthcare professionals support the conclusion that Somali immigrants in Minnesota suffer from higher rates of diabetes than non-immigrant groups and than they likely did before migration. Why might this be the …