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Articles 2341 - 2370 of 55609

Full-Text Articles in Public Health

Proteogenomics In Cerebrospinal Fluid And Plasma Reveals New Biological Fingerprint Of Cerebral Small Vessel Disease, Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Muralidharan Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Markus Munter, Daniel Auld, Iana Astafeva, Raquel Puerta, Jerome I Rotter, Bruce M Psaty, Joshua C Bis, W T Longstreth, Thierry Couffinhal, Pablo García-González, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore J Launer, Joanna M Wardlaw, Myriam Heiman, Agustin Ruiz, Paul M Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip L De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga, Stéphanie Debette Dec 2025

Proteogenomics In Cerebrospinal Fluid And Plasma Reveals New Biological Fingerprint Of Cerebral Small Vessel Disease, Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Muralidharan Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Markus Munter, Daniel Auld, Iana Astafeva, Raquel Puerta, Jerome I Rotter, Bruce M Psaty, Joshua C Bis, W T Longstreth, Thierry Couffinhal, Pablo García-González, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore J Launer, Joanna M Wardlaw, Myriam Heiman, Agustin Ruiz, Paul M Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip L De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga, Stéphanie Debette

Faculty, Staff and Student Publications

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific treatment, of which molecular mechanisms remain poorly understood. To identify potential biomarkers and therapeutic targets, we applied Mendelian randomization to examine over 2,500 proteins measured in plasma and, uniquely, cerebrospinal fluid, in relation to magnetic resonance imaging (MRI) markers of cSVD in more than 40,000 individuals. Here we show that 49 proteins are associated with MRI markers of cSVD, most prominently in cerebrospinal fluid. We highlight associations that are consistent across platforms and ancestries, and supported by complementary observational analyses, and we explore differences …


Engaging Longitudinal Cohort Participants In A Research Priority Setting Process For The Raine Study, Michaela De Paolis, Saniya Abdul, Anne Mckenzie, Rebecca Glauert, Gracie Cayley, Romola S. Bucks, Diane Wood Dec 2025

Engaging Longitudinal Cohort Participants In A Research Priority Setting Process For The Raine Study, Michaela De Paolis, Saniya Abdul, Anne Mckenzie, Rebecca Glauert, Gracie Cayley, Romola S. Bucks, Diane Wood

Research outputs 2022 to 2026

Background: The Raine Study, one of the world’s longest-running multigenerational cohort studies, has consistently engaged participants in shaping specific research projects within the Raine Study. While participant involvement has been integral to study operations, there has not previously been an opportunity for participants to actively help shape the overall research agenda. The Participant Priority Setting Project (the Project) was developed to address this gap, providing a structured process to establish participant-led research priorities that will guide future study directions. Methods: The Project utilised a modified version of the James Lind Alliance (JLA) Priority Setting Partnerships (PSP) Framework to engage Generation …


Partners, Coordinators And High-Level Leaders’ Perspectives On A Consumer And Community Involvement Program In Australia: A Qualitative Evaluation Using Template Analysis, James Smith, Howard Lance, Susan Hayes Dec 2025

Partners, Coordinators And High-Level Leaders’ Perspectives On A Consumer And Community Involvement Program In Australia: A Qualitative Evaluation Using Template Analysis, James Smith, Howard Lance, Susan Hayes

Research outputs 2022 to 2026

A Consumer and Community Involvement program located in Australia supports consumers, community members and researchers to work in partnership with health research priorities, policy and practice. The program is positioned to enhance Consumer and Community Involvement (CCI) at individual, organisational, and system levels. Partners are key to the program’s development, growth and sustainment. This study explored various partner perspectives on their involvement within the CCI program, including individuals (consumers, researchers) organisations (universities, medical research institutes) and the system level (funding organisations) alongside CCI program coordinators (delivering the program) and high-level leaders (decision-makers/executive leaders/directors). Data were collected via two focus groups …


Source-Specific Nitrate Intake And Incident Dementia In The Danish Diet, Cancer And Health Study, Catherine P. Bondonno, Pratik Pokharel, Dorit Wielandt Erichsen, Liezhou Zhong, Jörg Schullehner, Cecilie Kyrø, Kirsten Frederiksen, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Lauren C. Blekkenhorst, Stephanie R. Rainey-Smith, Samantha L. Gardener, Torben Sigsgaard, Ole Raaschou-Nielsen, Anne Tjønneland, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Nicola P. Bondonno Dec 2025

Source-Specific Nitrate Intake And Incident Dementia In The Danish Diet, Cancer And Health Study, Catherine P. Bondonno, Pratik Pokharel, Dorit Wielandt Erichsen, Liezhou Zhong, Jörg Schullehner, Cecilie Kyrø, Kirsten Frederiksen, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Lauren C. Blekkenhorst, Stephanie R. Rainey-Smith, Samantha L. Gardener, Torben Sigsgaard, Ole Raaschou-Nielsen, Anne Tjønneland, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Nicola P. Bondonno

Research outputs 2022 to 2026

Introduction: Dietary nitrate, through conversion to nitric oxide, which supports vascular and nervous system function, may lower dementia risk but may also form neurodegenerative N-nitrosamines, depending on the nitrate source. Methods: We investigated associations between source-specific nitrate and nitrite intake and incident and early-onset dementia (< 65 years) in 54,804 dementia-free participants from the Danish Diet, Cancer and Health Cohort Study over ∼27 years. Nitrate and nitrite intakes were derived from food frequency questionnaires and nitrate and nitrite databases. Results: Higher plant-sourced nitrate intake was non-linearly associated with lower rates of incident dementia (fifth vs first quintile hazard ratio 95% confidence interval: 0.90 [0.83, 0.98]), while increased risk was seen for higher intakes of animal-sourced, additive-permitted meat-sourced, and tap water-sourced nitrate. Similar associations were seen for source-specific nitrite intake and were more pronounced for early-onset dementia. No clear effect modification was observed. Discussion: These findings highlight the importance of nitrate source in dementia risk and warrant further investigation. Highlights: Plant nitrate is associated with a lower risk of incident and early-onset dementia. Animal and tap water nitrate are associated with an increased risk of dementia. Encouraging consumption of plant-based nitrate sources may lower risk of dementia.


A Cross-Sectional Audit Of The Australian Community Food Environment Highlights The Prominent Role Of Chain Food Outlets, Claire Elizabeth Pulker, Lucy Meredith Butcher, Frith Klug, Clare Whitton, Gina S.A. Trapp Dec 2025

A Cross-Sectional Audit Of The Australian Community Food Environment Highlights The Prominent Role Of Chain Food Outlets, Claire Elizabeth Pulker, Lucy Meredith Butcher, Frith Klug, Clare Whitton, Gina S.A. Trapp

Research outputs 2022 to 2026

Background: Food retail and food service outlets can be part of a chain, or independently operated. Chain food outlets are likely to have the most influence over community food environments but have not been routinely identified in studies which map and monitor access to food, highlighting an important knowledge gap. This study aimed to identify the food retail and food service outlets present within metropolitan Perth, including presence of chain and independent food outlets; and examine differences across local governments. Methods: A nutrition-focused classification framework was applied to all food businesses registered by 32 local governments in Perth, Western Australia, …


The Impact Of Social Media Use On Postpartum Depression, Jaila Randle Dec 2025

The Impact Of Social Media Use On Postpartum Depression, Jaila Randle

Capstone Experience: Master of Public Health

Postpartum depression (PPD) is a serious form of depression that affects one in eight women. Symptoms include feeling sad all the time, being anxious, and having trouble bonding with their child. As social media sites like Facebook and Twitter become more important for moms to find support and health information, it has become a public health concern to learn how they affect mental health after giving birth. This literature review explores the positive and negative impacts of social media use on postpartum depression among mothers. A systematic search identified peer-reviewed studies published between 2014 and 2025. Studies were selected using …


Analysis Of The Hospital Medical Surge Preparedness Index In Relation To Hospital Characteristics And Social Determinants Of Health, Philipp Lirk Dec 2025

Analysis Of The Hospital Medical Surge Preparedness Index In Relation To Hospital Characteristics And Social Determinants Of Health, Philipp Lirk

Capstone Experience: Master of Public Health

Objective

Substantial investments have been made in hospital emergency preparedness. The Hospital Medical Surge Preparedness Index (HMSPI) has been proposed as a metric to assess health system readiness. This index summarizes hospital system characteristics, space and facilities, staff availability, and supply planning.

Methods

The primary objective was to evaluate the relationship between the HMSPI and characteristics of the respective hospitals, including size, type, location, performance on the Hospital Resilience Index (HRI), and Social Determinants of Health (SDoH).

Results

Higher HMSPI scores were found in suburban compared to rural hospitals, a higher HMSPI in larger hospitals with greater patient volumes and …


A Replication Study- Frequent Social Media Use And Experiences With Bullying Victimization, Persistent Feelings Of Sadness Or Hopelessness, And Suicide Risk Among High School Students- Youth Risk Behavior Survey, United States (2023), Diana C. Andrade Dec 2025

A Replication Study- Frequent Social Media Use And Experiences With Bullying Victimization, Persistent Feelings Of Sadness Or Hopelessness, And Suicide Risk Among High School Students- Youth Risk Behavior Survey, United States (2023), Diana C. Andrade

Capstone Experience: Master of Public Health

This replication study examines the association between frequent social media (SM) use and bullying victimization, persistent feelings of sadness or hopelessness, and suicide risk among U.S. young adults using data from the 2023 Youth Risk Behavior Survey. The study replicates the findings of Young et al. (2024), the first CDC report to incorporate SM into national adolescent behavioral surveillance. Using a weighted, cross-sectional sample of 15,203 students, the replication analysis estimated unadjusted and adjusted odds ratios for outcomes, controlling for age, sex, race/ethnicity, and sexual identity. 77% of students reported frequent SM use. It was significantly associated with higher odds …


Wildfire Smoke And Public Health: Comparing 2023 Canadian Wildfire Events With Hospital Admissions In Douglas County, Nebraska, Jeremy Poell Dec 2025

Wildfire Smoke And Public Health: Comparing 2023 Canadian Wildfire Events With Hospital Admissions In Douglas County, Nebraska, Jeremy Poell

Capstone Experience: Master of Public Health

Wildfires are becoming increasingly common in Canada and the United States. Smoke produced from these fires creates a multitude of air pollution constituents that can cause breathing and other health issues for humans, particularly those with asthma and other respiratory conditions. Of these pollutants, PM2.5 (particulate matter that is 2.5 microns or smaller) is particularly problematic as these particles are inhaled deep into lung tissue, where they create inflammation and oxidative stress. Poor air quality can also trigger asthma and respiratory issues, leading to an increase in emergency department admissions for breathing treatments. The goal of this study is to …


Evaluating Knowledge Of Emergency Procedures For Top Hazards Among Hospital Staff, Aisha Zahid Dec 2025

Evaluating Knowledge Of Emergency Procedures For Top Hazards Among Hospital Staff, Aisha Zahid

Capstone Experience: Master of Public Health

Hospitals serve as frontline responders during public health emergencies, but the effectiveness of their response relies heavily on staff awareness and engagement with emergency preparedness training. This capstone project assesses hospital staff’s baseline knowledge of procedures for responding to the top emergency hazards. These hazards were selected based on Nebraska Medicine’s biannual Hazard Vulnerability Analysis (HVA), which identifies fire, severe weather events, and winter storms as high-priority risks requiring consistent staff readiness. Despite the existence of emergency procedures and training materials, literature reveals limited data on staff knowledge of these procedures across different hazards. This study, conducted at a large …


The Road To Regulation: A Literature Review Of The Influences On The Updated Silica Standards, Skye M. Medcraft Dec 2025

The Road To Regulation: A Literature Review Of The Influences On The Updated Silica Standards, Skye M. Medcraft

Capstone Experience: Master of Public Health

Silica is a hazardous compound that poses a risk to human health resulting from dust creating activities across various industries. Several agencies, including OSHA (Occupational Health and Safety Administration) and MSHA (Mine Safety and Health Administration) have adopted regulatory oversight of silica exposure in the workplace. As more research has been conducted on silica exposure, the health effects are becoming better described, which has led to the creation and updating of exposure regulations to protect worker health. The objective of this literature study is to review the data presented to the Department of Labor and discuss how the factors that …


Acceptability Of Corticosteroid Use In The Treatment Of Infant Bronchiolitis: Utilizing The Theoretical Framework Of Acceptability To Design Research Instruments, Caroline R. Smetanka Dec 2025

Acceptability Of Corticosteroid Use In The Treatment Of Infant Bronchiolitis: Utilizing The Theoretical Framework Of Acceptability To Design Research Instruments, Caroline R. Smetanka

Capstone Experience: Master of Public Health

Bronchiolitis is the leading cause of hospitalization among infants under six months, yet treatment remains largely supportive due to clinical guidelines that discourage pharmacologic intervention. Recent research suggests that bronchiolitis is not a uniform condition, and a subgroup of infants (those classified within “Profile A”) may benefit from targeted corticosteroid therapy. However, these treatments remain outside current clinical guidelines, and their successful adoption depends on stakeholder acceptability. This Capstone project developed and refined four data collection instruments- two questionnaires and two interview guides- designed to assess how healthcare providers and caregivers perceive the acceptability of corticosteroid treatment for Profile A …


Utilization Of Tricare’S Childbirth And Breastfeeding Support Demonstration: Access To Lactation Services Among Military Families, Holly Johnson Dec 2025

Utilization Of Tricare’S Childbirth And Breastfeeding Support Demonstration: Access To Lactation Services Among Military Families, Holly Johnson

Capstone Experience: Master of Public Health

In January 2022, the Department of Defense launched a five-year pilot program called the TRICARE Childbirth and Breastfeeding Support Demonstration. This demonstration aimed to cover lactation services for Tricare beneficiaries. This project included an electronic survey and was created and completed by 577 participants. Eligible participants needed to have given birth in the last 24 months and have TRICARE as their primary insurance. Participants completed this survey to help understand if they were aware of lactation benefits, if they utilized the service, and if it improved their breastfeeding experience.

Out of the 577 participants, 485 were eligible for the project. …


Influence Of Food Insecurity On Adolescent Mental Health: A Comprehensive Literature Review, Sarah Foss Dec 2025

Influence Of Food Insecurity On Adolescent Mental Health: A Comprehensive Literature Review, Sarah Foss

Capstone Experience: Master of Public Health

Food insecurity is a growing public health concern with significant implications for adolescent mental health. This literature review provides an overview of current research on the relationship between food insecurity and adolescents’ mental health in the United States. A literature review was completed to identify studies examining the association between food insecurity and anxiety, depression, or attention deficit disorder (ADD)/Attention Deficit Hyperactivity Disorder (ADHD). Evidence shows that the experience of food insecurity in adolescence is associated with a higher risk of developing or experiencing an exacerbation of anxiety, depression, or ADD/ ADHD. This review utilizes the socioecological model to explain …


Creating Actionable, Culturally Appropriate Interventions From Survey Data: A Community-Driven Capstone Pilot Project, Nicole Placke Dec 2025

Creating Actionable, Culturally Appropriate Interventions From Survey Data: A Community-Driven Capstone Pilot Project, Nicole Placke

Capstone Experience: Master of Public Health

The Community-Driven Capstone Track is a pilot program designed as an alternative to the traditional capstone track. With this track, students are able to engage with community partners through an integrative learning experience. The goal is to address real organizational needs in a way that demonstrates the mastery of foundational and concentration competencies.

Unlike the traditional capstone track, the CDC offers flexibility in both project type and deliverables. Rather than one formal written report, students might produce a series of products or tools. Deliverables are decided collaboratively between the student, community partners, and the faculty committee to ensure they are …


A Literature Review: Back Injuries Affecting Certified Nursing Assistants In Nursing Facilities, Nesta Nsembene-Ntoutoume Dec 2025

A Literature Review: Back Injuries Affecting Certified Nursing Assistants In Nursing Facilities, Nesta Nsembene-Ntoutoume

Capstone Experience: Master of Public Health

Certified nursing assistants (CNAs) are at a higher risk of back injuries in healthcare, particularly in long-term care settings. This literature review assessed the primary causes of these injuries and the efficacy of current interventions, particularly Safe Patient Handling and Mobility (SPHM) programs. A total of 26 peer-reviewed articles were published between 2014 and 2025, including experimental simulations, cross-sectional and longitudinal studies, quasi-experimental training interventions, and evaluations of SPHM programs. Across the literature, the primary contributors to back injuries included high physical workload, inadequate ergonomic design, limited access to assistive devices, and staff shortage.

Experimental and biomechanical studies have demonstrated …


Infectious Disease Crisis Communication After The Covid-19 Pandemic, Macy Lloyd Dec 2025

Infectious Disease Crisis Communication After The Covid-19 Pandemic, Macy Lloyd

Capstone Experience: Master of Public Health

Since the COVID-19 pandemic, the United States has experienced a proliferation of mis- and disinformation, an increasing politicization of health and science, and growing distrust in government, science, and institutions. While these trends present challenges for normal public health communications, during a public health emergency, such as an infectious disease outbreak, these challenges are even more acute. To address challenges at the local level, health departments need plans, products, and tools that adapt health crisis communications to the current media environment and meet community members where they are across the trust continuum. To develop an infectious disease incident communication plan, …


The Effectiveness Of Interventions In Reducing Sexually Transmitted Infections Among African American Adolescents: A Comprehensive Literature Review, Brandy M. Leaver Dec 2025

The Effectiveness Of Interventions In Reducing Sexually Transmitted Infections Among African American Adolescents: A Comprehensive Literature Review, Brandy M. Leaver

Capstone Experience: Master of Public Health

In the United States, an estimated 20 million new sexually transmitted infections occur annually, with half of the cases occurring in adolescents. The infection rate among African American adolescents is four times higher than that among white adolescents. Although many types of interventions exist, few are specifically designed for African American adolescents. In conducting this comprehensive literature review and synthesis, I examined the effectiveness of existing interventions in creating behavioral change among African American adolescents by applying the health belief model to interpret and organize the findings. The databases PubMed, Embase, and Google Scholar were searched on October 1, 2025. …


Linking Training To Confidence: A Literature Review On Advancing Nutrition Environments In Child Care Programs, Jeanne M. Vanorsdal Dec 2025

Linking Training To Confidence: A Literature Review On Advancing Nutrition Environments In Child Care Programs, Jeanne M. Vanorsdal

Capstone Experience: Master of Public Health

This comprehensive literature review examined child care nutrition training interventions using the Health Belief Model (HBM) to understand how to increase providers’ ability to serve nutritious food. By analyzing HBM constructs such as perceived severity, benefits, and barriers, the review assessed how training influences provider abilities and identified barriers and facilitators to consistently offering healthy meals and snacks. Studies were 1) published in English; 2) research conducted in the United States; 3) population involved home-based or center-based child care providers caring for children from birth to age 5; 4) articles published from January 1, 2015, to October 5, 2025; 5) …


Reducing Sleep-Related Infant Deaths In Douglas County, Lauren J. Maskin Dec 2025

Reducing Sleep-Related Infant Deaths In Douglas County, Lauren J. Maskin

Capstone Experience: Master of Public Health

Douglas County, including the city of Omaha, covers 339.6 square miles along the border of the Missouri River in Nebraska with a population of 517,110 (https://www.douglascounty-ne.gov/) and is one of seven large urban counties in the state. There are approximately 8,000 infants born in Douglas County annually (Nebraska Vital Statistics Birth Dashboard). The Douglas County Health Department (DCHD), established in 1854, is one of the oldest county health departments in the state and manages multiple public health projects annually. In 2024-2025, a renewed focus for DCHD has been its infant mortality rate (IMR). In 2024, 44 infant mortalities occurred in …


Lilrb4 Regulates Circadian Disruption-Induced Mammary Tumorigenesis Via Non-Canonical Wnt Signaling Pathway, Olajumoke Ogunlusi, Mrinmoy Sarkar, Kayla Carter, Arhit Chakrabarti, Devon J Boland, Tristan Nguyen, James Sampson, Christian Nguyen, Danielle Fails, Yava Jones-Hall, Loning Fu, Gus Wright, Da Mi Kim, James J Cai, Bani Mallick, Alex C Keene, Jeff R Jones, Tapasree Roy Sarkar Dec 2025

Lilrb4 Regulates Circadian Disruption-Induced Mammary Tumorigenesis Via Non-Canonical Wnt Signaling Pathway, Olajumoke Ogunlusi, Mrinmoy Sarkar, Kayla Carter, Arhit Chakrabarti, Devon J Boland, Tristan Nguyen, James Sampson, Christian Nguyen, Danielle Fails, Yava Jones-Hall, Loning Fu, Gus Wright, Da Mi Kim, James J Cai, Bani Mallick, Alex C Keene, Jeff R Jones, Tapasree Roy Sarkar

Faculty, Staff and Students Publications

Epidemiological studies have shown that circadian rhythm disruption (CRD) is associated with the risk of breast cancer. However, the role of CRD in mammary gland morphology and aggressive basal mammary tumorigenesis and the molecular mechanism underlying CRD-induced carcinogenesis remain unknown. To investigate the effect of CRD on aggressive tumorigenesis, a genetically engineered mouse model of aggressive breast cancer was used. The impact of CRD on the tumor microenvironment was investigated using the tumors from LD12:12 and CRD mice via scRNA-seq, flow cytometry, multiplexing immunostaining, and realtime PCR. The effect of LILRB4-immunotherapy on CRD-induced tumorigenesis was also investigated. Here we investigated …


Sars-Cov-2 Rna-Binding Protein Suppresses Extracellular Mirna Release, Hyejin Mun, Chang Hoon Shin, Qingxuan Fei, Andrea Estefania Lopez Giraldo, Kyoung-Min Choi, Ji Won Lee, Kyungmin Kim, Kyung-Won Min, Leilei Shi, Mark T Bedford, Dong-Chan Kim, Yoo Lim Chun, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Ryan T Westrope, Michelle Shay, Edward Nguyen, Junho K Hur, Abigail Agyenda, Nam Chul Kim, Sung-Ung Kang, Woonghee Lee, Je-Hyun Yoon Dec 2025

Sars-Cov-2 Rna-Binding Protein Suppresses Extracellular Mirna Release, Hyejin Mun, Chang Hoon Shin, Qingxuan Fei, Andrea Estefania Lopez Giraldo, Kyoung-Min Choi, Ji Won Lee, Kyungmin Kim, Kyung-Won Min, Leilei Shi, Mark T Bedford, Dong-Chan Kim, Yoo Lim Chun, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Ryan T Westrope, Michelle Shay, Edward Nguyen, Junho K Hur, Abigail Agyenda, Nam Chul Kim, Sung-Ung Kang, Woonghee Lee, Je-Hyun Yoon

Faculty, Staff and Student Publications

SARS-CoV-2 is the betacoronavirus causing the COVID-19 pandemic. Although the SARS-CoV-2 genome and transcriptome were reported previously, the function of individual viral proteins is largely unknown. Utilizing biochemical and molecular biology methods, we identified that four SARS-CoV-2 RNA-binding proteins (RBPs) regulate the host RNA metabolism by direct interaction with mature miRNA let-7b revealed by Nuclear Magnetic Resonance spectroscopy (NMR). SARS-CoV-2 RBP Nsp9 primarily binds mature miRNA let-7b, a direct ligand of the Toll-like Receptor 7 (TLR7), one of the potential SARS-CoV-2 therapeutics. Nsp9 suppresses host gene expression possibly by promoting let-7b-mediated silencing of a cellular RNA polymerase, POLR2D. In addition, …


A National Survey Of Osteopaths’ Conceptions Of Practice In France: Structural Validity Of The Osteo-Taqfr And The Tendency Toward Technical Rationality, Oliver P. Thomson, Loïc Treffel, Agathe Wagner, Erwann Jacquot, Jerry Draper-Rodi, Chantal Morin, Brett Vaughan Dec 2025

A National Survey Of Osteopaths’ Conceptions Of Practice In France: Structural Validity Of The Osteo-Taqfr And The Tendency Toward Technical Rationality, Oliver P. Thomson, Loïc Treffel, Agathe Wagner, Erwann Jacquot, Jerry Draper-Rodi, Chantal Morin, Brett Vaughan

Research outputs 2022 to 2026

Background: Despite the growing popularity of osteopathy in France, little is known about how French osteopaths conceptualise key aspects of their practice, including skills, knowledge, and decision-making. This study aimed to adapt and validate the Osteopaths' Therapeutic Approaches Questionnaire (Osteo-TAQ) for use in a French osteopathic population (Osteo-TAQfr) and to examine the professional profile and core elements of clinical practice among French osteopaths. The first objective was to establish the psychometric properties of the Osteo-TAQfr within a French osteopathic population. The second aim was to explore French osteopaths’ conceptions of practice and their approach to patient care, thereby contributing to …


Interventions, Programmes And Resources That Address Culturally And Linguistically Diverse Consumer And Carers’ Cancer Information Needs: A Mixed Methods Systematic Review, Lisa Whitehead, Deborah Kirk, Pelden Chejor, Weiting Liu, Minh Nguyen, Caroline Balczer, Charlene Lan, Melissa Evans Dec 2025

Interventions, Programmes And Resources That Address Culturally And Linguistically Diverse Consumer And Carers’ Cancer Information Needs: A Mixed Methods Systematic Review, Lisa Whitehead, Deborah Kirk, Pelden Chejor, Weiting Liu, Minh Nguyen, Caroline Balczer, Charlene Lan, Melissa Evans

Research outputs 2022 to 2026

Background: Culturally and linguistically diverse (CaLD) consumers and carers have been identified as experiencing high levels of unmet needs relating to information and support across the cancer journey. This review identified and evaluated the effectiveness of strategies to meet the cancer information needs of consumers and carers from CaLD backgrounds. Methods: This review followed Joanna Briggs Institute (JBI) methodology for systematic reviews. Databases searched included MEDLINE, CINAHL Ultimate, PsycINFO and AMED, ProQuest Dissertations and Theses, and GreyNet. Published and unpublished studies between 2013 - May 2024 on interventions, programmes or resources developed for adults (aged 18 years and over) from …


The Importance Of Aged Care Policies In Assisting Older Adults Transition From Home To Permanent Residential Aged Care: A Focused Ethnographic Study, Stacey M. Scott, Annette J. Raynor, Julie S. Dare, Jennifer M. Grieve, Leesa N. Costello Dec 2025

The Importance Of Aged Care Policies In Assisting Older Adults Transition From Home To Permanent Residential Aged Care: A Focused Ethnographic Study, Stacey M. Scott, Annette J. Raynor, Julie S. Dare, Jennifer M. Grieve, Leesa N. Costello

Research outputs 2022 to 2026

Background: The Royal Commission into Aged Care Quality and Safety (RCAC) recommended a redesign of the Australian aged care system to ensure high quality care, respect, and dignity for residents. Responding to the RCAC recommendations, the Aged Care Quality Standards have been strengthened and continue to guide the delivery of safe, high quality care in Australia. This study investigated the experiences of new residents transitioning into an Australian residential care-facility, concentrating on how their experiences aligned with the core principles of the Aged Care Quality Standards. Methods: A focused ethnographic approach was used to address the aim of this study. …


Prevalence And Molecular Types Of Clostridioides (Clostridium) Difficile On Australian Retail Vegetables And Household Surfaces, Deirdre A. Collins, Su Chen Lim, Jessica Chisholm, Molly Lattin, Linda Selvey, Simon Reid, Thomas V. Riley Dec 2025

Prevalence And Molecular Types Of Clostridioides (Clostridium) Difficile On Australian Retail Vegetables And Household Surfaces, Deirdre A. Collins, Su Chen Lim, Jessica Chisholm, Molly Lattin, Linda Selvey, Simon Reid, Thomas V. Riley

Research outputs 2022 to 2026

Objectives: Community-onset Clostridioides (Clostridium) difficile infection (CDI) has risen to >80 % of all CDI cases in Australia. High prevalence of C. difficile contamination has been reported in many community sources including retail root vegetables. Household surfaces may become contaminated with C. difficile when storing and handling contaminated vegetables. This study aimed to determine the prevalence and molecular types of C. difficile present on retail root vegetables and household surfaces. Methods: From April 2023 to March 2024, retail potatoes (n = 255) and onions (n = 305) were sampled at 3-monthly intervals. Environmental samples were collected from homes of householders …


Public Views Towards Lifespan, Healthspan, And Healthy Longevity Medicine In Singapore: A Qualitative Study From The Healthy Longevity (Helo) Initiatives, Belinda Wang, Anna Szucs, Elena Sandalova, Zhi Meng Lim, E. J. Horberg, Paul A. O’Keefe, Louis Island, Sonny Rosenthal, Andrea B. Maier Dec 2025

Public Views Towards Lifespan, Healthspan, And Healthy Longevity Medicine In Singapore: A Qualitative Study From The Healthy Longevity (Helo) Initiatives, Belinda Wang, Anna Szucs, Elena Sandalova, Zhi Meng Lim, E. J. Horberg, Paul A. O’Keefe, Louis Island, Sonny Rosenthal, Andrea B. Maier

Research Collection College of Integrative Studies

Introduction: Healthy Longevity Medicine (HLM) offers a strategy to reduce the healthspan-lifespan gap, yet public perspectives remain unclear. This study refines the Healthy Longevity (HELO) framework through a qualitative exploration of public views towards lifespan, healthspan, and HLM.Methods: Individuals living in Singapore participated in semi-structured group or individual discussions to explore (a) their understanding of lifespan and healthspan, (b) motivational factors for health behaviours, and (c) their awareness of HLM. Sampling maximised variation across age, sex, and ethnicity. Data obtained through 13 discussions were analysed with a mixed, inductive-deductive approach employing the HELO framework.Results: Thirty-six participants (mean age = 49.4 …


Understanding Hepatitis C Risk And Harm Reduction Needs Among People Who Smoke Drugs: A Client-Centered Qualitative Inquiry, Maxwell Gustin Dec 2025

Understanding Hepatitis C Risk And Harm Reduction Needs Among People Who Smoke Drugs: A Client-Centered Qualitative Inquiry, Maxwell Gustin

Anthropology

The spread of Hepatitis C virus (HCV) via non-injectable equipment is plausible, making people who smoke drugs (PWSD) at-risk for possible infection and transmission. While much research has been conducted into injection drug use (IDU), likely due to the rising opioid epidemic, limited studies focus on the risks PWSD face. Currently, state-funded syringe service programs (SSPs) provide harm reduction education and materials to combat these risks. Safer smoking initiatives have been created and are widely used by PWSD, and have access to SSPs. To gain better insight into the HCV and non-HCV-related risks and burdens PWSD face, a qualitative study …


Income Inequality And Self-Reported Health: A Difference-In-Differences Study, Kola Adegoke Dec 2025

Income Inequality And Self-Reported Health: A Difference-In-Differences Study, Kola Adegoke

Health & Biomedical Sciences Faculty Publications

Background: Health disparities in the United States (US) are closely linked to income inequality. While many studies have reported associations between income and health, causal evidence remains limited.

Objective: To estimate the causal effect of income-equalizing state policies, such as minimum wage increases, Medicaid expansion, and Earned Income Tax Credit (EITC) adjustments, on adult self-rated health using a difference-in-differences (DiD) framework.

Methods: Using the Centers for Disease Control and Prevention (CDC) Behavioral Risk Factor Surveillance System (BRFSS) data from 2018 to 2023, a 2-way fixed-effects DiD model was employed to compare changes in the proportion of adults reporting fair or …


Insecticide-Treated Net Use And Elimination Of Malaria In Sub-Saharan African Countries: Assessing The Global Technical Strategy Using An Evolutionary Game Approach, Laxmi, Tamer Oraby, Michael G. Tyshenko, Ina Danquah, Samit Bhattacharyya Dec 2025

Insecticide-Treated Net Use And Elimination Of Malaria In Sub-Saharan African Countries: Assessing The Global Technical Strategy Using An Evolutionary Game Approach, Laxmi, Tamer Oraby, Michael G. Tyshenko, Ina Danquah, Samit Bhattacharyya

School of Mathematical & Statistical Sciences Faculty Publications

Background: Malaria continues to be a major public health challenge in Sub-Saharan Africa (SSA), where the majority of the countries have not met the World Health Assembly's endorsed Global Technical Strategy (GTS) milestones in 2020 for malaria reduction. Insecticide-treated net (ITN) usage is a well-established and effective intervention, often outperforming other measures such as indoor residual spraying (IRS). However, multiple survey studies have reported improper use of ITNs across various SSA countries. This misuse likely poses an important barrier to the intervention's success, although it remains a largely untested hypothesis.

Methods: We developed a behaviour-incidence model and statistical analysis of …