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Full-Text Articles in Public Health

Stay At Work After A Period Of Disability Due To An Occupational Injury: A Complex Process Marked By Social Exchanges, Alexandra Lecours, Marie-José Durand, Marie-France Coutu, Charles Groleau, Roxanne Bédard-Mercier Jan 2022

Stay At Work After A Period Of Disability Due To An Occupational Injury: A Complex Process Marked By Social Exchanges, Alexandra Lecours, Marie-José Durand, Marie-France Coutu, Charles Groleau, Roxanne Bédard-Mercier

Études primaires

Purpose Rooted in a social exchange lens, this study aimed to explore the interactions between the factors influencing stay at work after a period of disability due to an occupational injury. Methods Based on a descriptive interpretative research design, interviews with 15 participants (i.e., representatives of workers, workplaces, insurers, and the health care system) were conducted to gather their perspectives about stay at work. Qualitative data was analyzed through thematic analysis. Results Ten different factors interacting together and influencing stay at work were identified. These factors prevail either during stay at work or previously. They are either related to the …


Health Policy, Equity, And The Lead Poisoning Crisis: A Conversation With Dr. Mona Hanna-Attisha, Mona Hanna-Attisha Jan 2022

Health Policy, Equity, And The Lead Poisoning Crisis: A Conversation With Dr. Mona Hanna-Attisha, Mona Hanna-Attisha

Center for Policy Research

Dr. Mona Hanna-Attisha delivered the 33rd Annual Herbert Lourie Memorial Lecture on Health Policy on Thursday, September 23, 2021. This year's lecture was titled, "Health Policy, Equity, and the Lead Poisoning Crisis: A Conversation with Dr. Mona Hanna-Attisha"

Mona Hanna-Attisha, MD, MPH, FAAP, is founder and director of the Michigan State University and Hurley Children’s Hospital Pediatric Public Health Initiative, an innovative and model public health program in Flint, Michigan.

A pediatrician, scientist, activist, and author, Dr. Hanna-Attisha has testified three times before the United States Congress and was awarded the Freedom of Expression Courage Award by PEN America. She …


Associations Between Mothers’ Use Of Food To Soothe, Feeding Mode, And Infant Weight During Early Infancy, Megan K. Hupp, Peggy C. Papathakis, Suzanne Phelan, Alison K. Ventura Jan 2022

Associations Between Mothers’ Use Of Food To Soothe, Feeding Mode, And Infant Weight During Early Infancy, Megan K. Hupp, Peggy C. Papathakis, Suzanne Phelan, Alison K. Ventura

Kinesiology and Public Health

Weight status and rate of weight gain in the first six months postpartum are strong predictors of later obesity; thus, infant feeding practices are an important target for obesity prevention efforts. The use of food to soothe (FTS) is associated with less-favorable eating habits and weight outcomes for older infants and children. However, few studies have examined correlates of use of FTS during early infancy. The primary aim of this cross-sectional study was to explore associations between use of FTS and infant weight status in the first 6 months postpartum. A secondary aim was to identify the combination of maternal …


Effect Of Care Environment On Educational Attainment Among Orphaned And Separated Children And Adolescents In Western Kenya, Dorothy Apedaile, Allison Delong, Edwin Sang, David Ayuku, Lukoye Atwoli, Omar Galárraga, Paula Braitstein Jan 2022

Effect Of Care Environment On Educational Attainment Among Orphaned And Separated Children And Adolescents In Western Kenya, Dorothy Apedaile, Allison Delong, Edwin Sang, David Ayuku, Lukoye Atwoli, Omar Galárraga, Paula Braitstein

Internal Medicine, East Africa

Background: There are approximately 140 million orphaned and separated children (OSCA) around the world. In Kenya, many of these children live with extended family while others live in institutions. Despite evidence that orphans are less likely to be enrolled in school than non-orphans, there is little evidence regarding the role of care environment. This evidence is vital for designing programs and policies that promote access to education for orphans, which is not only their human right but also an important social determinant of health. The purpose of this study was to compare educational attainment among OSCA living in Charitable …


Review Of Evidence For Environmental Causes Of Uveal Coloboma, Evan B Selzer, Delphine Blain, Robert B Hufnagel, Philip J Lupo, Laura E Mitchell, Brian P Brooks Jan 2022

Review Of Evidence For Environmental Causes Of Uveal Coloboma, Evan B Selzer, Delphine Blain, Robert B Hufnagel, Philip J Lupo, Laura E Mitchell, Brian P Brooks

Faculty, Staff and Student Publications

Uveal coloboma is a condition defined by missing ocular tissues and is a significant cause of childhood blindness. It occurs from a failure of the optic fissure to close during embryonic development and may lead to missing parts of the iris, ciliary body, retina, choroid, and optic nerve. Because there is no treatment for coloboma, efforts have focused on prevention. While several genetic causes of coloboma have been identified, little definitive research exists regarding the environmental causes of this condition. We review the current literature on environmental factors associated with coloboma in an effort to guide future research and preventative …


Effects Of Covid-19 On Ventilator Associated Events (Vaes) Due To Multi-Drug Resistant Organisms (Mdros), Jeffery Asiedu Jan 2022

Effects Of Covid-19 On Ventilator Associated Events (Vaes) Due To Multi-Drug Resistant Organisms (Mdros), Jeffery Asiedu

All ETDs from UAB

The aim of this study was to assess the association between the coronavirus disease (COVID-19) and the odds of ventilator associated events (VAEs). Retrospective analysis on prospectively collected data from 11,307 patients admitted to the intensive care unit (ICU) at the University of Alabama at Birmingham hospital between January 2018 and June 2022 was used. Outcomes considered were Any VAE, IVAC/PVAP, PVAP and MDRO PVAP. Crude and adjusted logistic regression models were used to evaluate the association between COVID-19 and the outcome variables. When a patient has Prior COVID-19, the odds of getting any VAE during the delta period is …


The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron Jan 2022

The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron

All ETDs from UAB

A major obstacle to the advancement of our understanding of the metabolically healthy obesity (MHO) phenotype is the inconsistent definition of metabolic health and obesity among studies. A harmonized definition of MHO in adults has been proposed based on the diagnosis of obesity (BMI > 30 k/m2) and meeting the cardio-metabolic criteria for triglycerides, high-density lipoprotein (HDL) cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), no antihypertensive treatment, fasting blood glucose, and no drug treatment with glucose-lowering agents. In addition, waist circumference can be associated with increased disease risk when WC is >94 cm in men and >80 cm in …


Child Schooling And Other Factors Associated With Covid-19 Vaccine Hesitancy Among Adults That Had Not Been Vaccinated In The Fall Of 2021, Ryan M. Fischer Jan 2022

Child Schooling And Other Factors Associated With Covid-19 Vaccine Hesitancy Among Adults That Had Not Been Vaccinated In The Fall Of 2021, Ryan M. Fischer

All ETDs from UAB

Although COVID-19 vaccine hesitancy decreased noticeably over time during the first months of 2021, there was still a high degree of vaccine hesitancy in the United States at the time that the vaccine first became available to adolescents. Data from Phase 3.2 of the U.S. Census Bureau’s Household Pulse Survey (July 21 – October 11th, 2021) was used to conduct an ecological study on COVID-19 vaccine hesitancy that investigated associations between vaccine hesitancy and socio-demographic characteristics as well as child school type (public school, private school, homeschool). Subjects that had not received a vaccine at the time of survey data …


Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang Jan 2022

Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang

All ETDs from UAB

Background: The food truck industry in the U.S. has rapidly expanded, with an average growth of 7.9 % from 2017 to 2022. Food truck workers are potentially exposed to harmful airborne contaminants such as particulate matter (PM) and aldehydes produced during cooking process. Kitchen exhaust hoods are designed to capture the cooking emissions, but it is not well understood whether the commercial kitchen exhaust hoods in food trucks are properly, efficiently operated to reduce the workers' exposure to such harmful contaminants. The purpose of the study was to evaluate food truck workers' exposure to respirable particulates generated from cooking process …


Guided Exploration Of Military Servicewomen's Healthcare Experiences And Related Outcomes (Gems Hero), Princess Victoria Jane Nash Jan 2022

Guided Exploration Of Military Servicewomen's Healthcare Experiences And Related Outcomes (Gems Hero), Princess Victoria Jane Nash

All ETDs from UAB

Purpose: This study focuses on factors related to healthcare seeking behaviors and utilization of Veterans Affairs primary care services by female African American Veterans. The purpose of this mixed methods study is to assess what factors influence seeking care at VA healthcare facilities. Research Design: This study used a modified explanatory sequential mixed methods design to assess health services utilization and healthcare experiences of African American female Veterans. This research utilized items from the Health Belief model as a guiding framework to highlight factors that could impact VA healthcare utilization. Methodology: Health services utilization analysis used national data from the …


Multilevel Influences On Physical Activity Participation In Rural And Cancer Populations With Obesity, Nashira Inika Brown Jan 2022

Multilevel Influences On Physical Activity Participation In Rural And Cancer Populations With Obesity, Nashira Inika Brown

All ETDs from UAB

espite the strong evidence of physical activity benefits, the prevalence of physical inactivity and associated obesity continues to increase. Rural and cancer survivor populations with obesity, in particular, remain highly inactive and are at increased risk of comorbidities. Thus, physical activity interventions are needed to promote active lifestyles. However, before developing or adapting existing multi-level physical activity interventions, more research is needed to understand the necessary components to meet the needs and preferences of these unique populations. Therefore, this project involved identifying the gaps in literature followed by three studies to investigate the multilevel influences on physical activity in rural …


Socioeconomic Status, Hbb, And Ttr Variants, And Cardiorenal Outcomes: The Regards Study, Onika E. Abrams Jan 2022

Socioeconomic Status, Hbb, And Ttr Variants, And Cardiorenal Outcomes: The Regards Study, Onika E. Abrams

All ETDs from UAB

Blacks are disproportionately affected by heart failure (HF) and end-stage renal disease (ESRD). While poorer health outcomes in Blacks have been associated with social determinants of health, there are some biological differences worth noting, namely genetic risk variants for both TTR and HBB. These genetic risk variants are known to confer additional risk in the development of heart failure and end-stage renal disease, respectively. While we understand these genetic variants aren’t fully penetrant, and genetics and are not deterministic, we aimed to examine additional factors and mechanisms responsible for the increased risk in HF and ESRD in Blacks. Neighborhood socioeconomic …


Association Between Regional Covid-19 Vaccine Hesitancy And Reported Positive Covid-19 Cases In The Southern United States, Orielle Caudle Jan 2022

Association Between Regional Covid-19 Vaccine Hesitancy And Reported Positive Covid-19 Cases In The Southern United States, Orielle Caudle

All ETDs from UAB

The use of vaccinations has been shown to be beneficial in pandemics in the past, and in some cases, it has led to elimination of a particular disease (i.e. polio). The COVID-19 vaccination can also serve the same purpose, however, vaccine hesitancy within specific regions of the country may prevent and/or dilute the effectiveness of the vaccine. Vaccine hesitancy can be defined as a delay in acceptance, or refusal despite the availability of vaccine services. Southern regions have consistently had the lower vaccination rates compared to its other regional counterparts, even as the pandemic progressed and death rates increased over …


Physical And Mental Health Of Family Caregivers Of Older Parents And Grandchildren In China, Yujun Liu, M. Courtney Hughes, Karen A. Roberto, Jyoti Savla Jan 2022

Physical And Mental Health Of Family Caregivers Of Older Parents And Grandchildren In China, Yujun Liu, M. Courtney Hughes, Karen A. Roberto, Jyoti Savla

Faculty Articles, Papers, and Other Scholarship

Background: Families have been recognized as the primary source of care for younger and older family members in Chinese tradition. The aim of this study was to examine the association between informal caregiving for aging parents and/or grandchildren and health outcomes of family caregivers in mainland China.

Methods: Using data from the 2013 and 2018 waves of China Health and Retirement Longitudinal Study (CHARLS), we conducted univariate comparisons of demographics characteristics between informal caregivers and non-caregivers using t -test and chi square test. We used linear regression and negative binomial regression to examine the physical and mental health outcomes of …


Barriers And Facilitators To Conducting Physical Activity Interventions In Children's Camps, Silvia Q. Giraudo, Jordan Merideth, Barbara M. Grossman Jan 2022

Barriers And Facilitators To Conducting Physical Activity Interventions In Children's Camps, Silvia Q. Giraudo, Jordan Merideth, Barbara M. Grossman

Journal of the Georgia Public Health Association

Background: Previous research has sought to uncover various behavior factors that contribute to childhood physical activity, but have primarily relied on quantitative methods or within the context of schools. Summer day camps offered potential for increasing activity of youth, but research is required to determine how best to convert camp activity into outreach interventions.

Methods: The University of Georgia Institutional Review Board (IRB) approved all methods and procedures prior to the start of the study (STUDY00004692, MOD00005513). A total of 112 campers ages 9-13 participated in the data collection. This research used semi-structured interviews, surveys, and observations to …


Prolonged Prone Positioning For Covid-19-Induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study, David Brian Page Jan 2022

Prolonged Prone Positioning For Covid-19-Induced Acute Respiratory Distress Syndrome: A Randomized Pilot Study, David Brian Page

All ETDs from UAB

ationale: Prone positioning is one of the few interventions shown in a robust, randomized, controlled clinical trial to reduce mortality in severe ARDS. Ideal duration of prone positioning is unknown. A 16-hour prone positioning period has been studied and is considered standard, although longer duration may be beneficial. Objectives: Determine if a prolonged prone positioning strategy for patients with COVID-19-induced ARDS is feasible and safe. Methods: We performed a pilot, randomized, parallel-arm feasibility study in patients with COVID-19-induced ARDS. Patients were randomized to either a prolonged 24-hour or a traditional 16-hour prone positioning strategy. Measurements & Main Results: 52 patients …


Photothermal Desorption Of Volatile Organic Compounds From Buckypaper Sorbents, For Occupational Exposure Assessment, Jacob S. Shedd Jan 2022

Photothermal Desorption Of Volatile Organic Compounds From Buckypaper Sorbents, For Occupational Exposure Assessment, Jacob S. Shedd

All ETDs from UAB

Volatile organic compounds (VOCs) are a common source of occupational exposures. To prevent adverse health effects in employees, industrial hygienists must regularly conduct occupational air sampling to ensure exposures remain below regulatory limits. As such, the need for sensitive and reliable exposure assessment methodologies becomes apparent. Currently, diffusive sampling is popular and well-established exposure assessment method amongst professionals. However, its reliance on diffusion-driven mass uptake and chemical extraction, results in limited analytical sensitivity. In response to this, a pre-analytical technology, known as photothermal desorption (PTD), has been in development over the past decade. PTD uses pulses of high-energy light to …


Covid-19 Mortality May Be Reduced Among Fully Vaccinated Solid Organ Transplant Recipients, Micaela Sandoval, Duc T Nguyen, Howard J Huang, Stephanie G Yi, R Mark Ghobrial, A Osama Gaber, Edward A Graviss Jan 2022

Covid-19 Mortality May Be Reduced Among Fully Vaccinated Solid Organ Transplant Recipients, Micaela Sandoval, Duc T Nguyen, Howard J Huang, Stephanie G Yi, R Mark Ghobrial, A Osama Gaber, Edward A Graviss

Faculty, Staff and Student Publications

BACKGROUND: Solid organ transplant (SOT) recipients are at increased risk for morbidity and mortality from COVID-19 due to their immunosuppressed state and reduced immunogenicity from COVID-19 mRNA vaccines. This investigation examined the association between COVID-19 mRNA vaccination status and mortality among SOT recipients diagnosed with COVID-19.

METHODS & FINDINGS: A retrospective, registry-based chart review was conducted investigating COVID-19 mortality among immunosuppressed solid organ transplant (SOT) recipients in a large metropolitan healthcare system in Houston, Texas, USA. Electronic health record data was collected from consecutive SOT recipients who received a diagnostic SARS-CoV-2 test between March 1, 2020, and October 1, 2021. …


Desired Resources For Changing Diet Among Persons With Multiple Sclerosis: Qualitative Inquiry Informing Future Dietary Interventions, Stephanie L Silveira, Emma V Richardson, Robert W Motl Jan 2022

Desired Resources For Changing Diet Among Persons With Multiple Sclerosis: Qualitative Inquiry Informing Future Dietary Interventions, Stephanie L Silveira, Emma V Richardson, Robert W Motl

Faculty, Staff and Student Publications

BACKGROUND: There are approximately 1 million adults in the United States with multiple sclerosis (MS). Persons with MS are interested in diet as a second-line therapy for improving MS symptoms and disease progression. Examination of desired resources regarding diet among persons with MS is necessary for supporting behavior change.

METHODS: Twenty-five adults with MS completed 1-on-1, online semistructured interviews. An inductive, 6-phase, semantic thematic analysis was applied to identify themes associated with participant preferences for dietary behavior change.

RESULTS: The research team crafted 4 key themes from the data that encompassed participants' desired resources for dietary behavior change. Theme 1, …


2022 Annual Report For Ebp Workforce Development, Evidence To Practice, Cep Annual Reports, Lisa Staples, Ronnie Rubin, Brooke Dupre, Gabrielle Gonzalez, Willandra Whiting, J. Henning, Sonita Singh, Stephen Phillippi Jan 2022

2022 Annual Report For Ebp Workforce Development, Evidence To Practice, Cep Annual Reports, Lisa Staples, Ronnie Rubin, Brooke Dupre, Gabrielle Gonzalez, Willandra Whiting, J. Henning, Sonita Singh, Stephen Phillippi

Policy & Position Papers

No abstract provided.


The Healthy Native Youth Implementation Toolbox: Using Implementation Mapping To Adapt An Online Decision Support System To Promote Culturally-Relevant Sexual Health Education For American Indian And Alaska Native Youth, Christine M Markham, Stephanie Craig Rushing, Jane Manthei, Michelle Singer, Cornelia Jessen, Gwenda Gorman, Melissa F Peskin, Belinda F Hernandez, Lea Sacca, Gabrielle S Evans, Claudia Luna-Meza, Zoe Merritt, Ross Shegog Jan 2022

The Healthy Native Youth Implementation Toolbox: Using Implementation Mapping To Adapt An Online Decision Support System To Promote Culturally-Relevant Sexual Health Education For American Indian And Alaska Native Youth, Christine M Markham, Stephanie Craig Rushing, Jane Manthei, Michelle Singer, Cornelia Jessen, Gwenda Gorman, Melissa F Peskin, Belinda F Hernandez, Lea Sacca, Gabrielle S Evans, Claudia Luna-Meza, Zoe Merritt, Ross Shegog

Faculty, Staff and Student Publications

BACKGROUND: American Indian and Alaska Native (AI/AN) youth experience serious disparities in sexual and reproductive health, including the highest teen birth rate among racial/ethnic groups, and disproportionate rates of sexually transmitted infections (STI), including HIV. A growing number of evidence-based programs (EBPs) that integrate the strengths and cultural teachings of Native communities exist. Yet, multiple factors, including lack of trained personnel, limited resources, and geographic isolation, may hinder their adoption and implementation. Innovative implementation strategies that facilitate the adoption and implementation of sexual health EBPs in Native communities may help reduce these disparities.

METHODS: We applied Implementation Mapping, a systematic …


Perceptions Of Physical Activity Guidelines Among Wheelchair Users With Multiple Sclerosis, Stephanie L Silveira, Brenda Jeng, Gary Cutter, Robert W Motl Jan 2022

Perceptions Of Physical Activity Guidelines Among Wheelchair Users With Multiple Sclerosis, Stephanie L Silveira, Brenda Jeng, Gary Cutter, Robert W Motl

Faculty, Staff and Student Publications

BACKGROUND: Physical activity guidelines provide prescriptive resources for population-level promotion of behavior change to improve health outcomes. The National Multiple Sclerosis Society (NMSS) recently created and disseminated physical activity guidelines for persons with multiple sclerosis (MS) across the disease spectrum.

OBJECTIVE: This study aimed to assess perceptions of the updated NMSS Physical Activity Guidelines among wheelchair users with MS.

METHODS: One hundred thirty-four wheelchair users with MS participated in a cross-sectional study examining health behaviors. Outcomes were measured using an online questionnaire that included items related to demographic and clinical characteristics and a battery of questions regarding perceptions of the …


Application Of Artificial Intelligence And Machine Learning For Hiv Prevention Interventions, Yang Xiang, Jingcheng Du, Kayo Fujimoto, Fang Li, John Schneider, Cui Tao Jan 2022

Application Of Artificial Intelligence And Machine Learning For Hiv Prevention Interventions, Yang Xiang, Jingcheng Du, Kayo Fujimoto, Fang Li, John Schneider, Cui Tao

Faculty, Staff and Student Publications

In 2019, the US Government announced its goal to end the HIV epidemic within 10 years, mirroring the initiatives set forth by UNAIDS. Public health prevention interventions are a crucial part of this ambitious goal. However, numerous challenges to this goal exist, including improving HIV awareness, increasing early HIV infection detection, ensuring rapid treatment, optimising resource distribution, and providing efficient prevention services for vulnerable populations. Artificial intelligence has had a pivotal role in revolutionising health care and has shown great potential in developing effective HIV prevention intervention strategies. Although artificial intelligence has been used in a few HIV prevention intervention …


A Qualitative Investigation Of Organizational Challenges And Facilitators To Screening Individuals Experiencing Homelessness For Hepatitis C Virus (Hcv) In Houston, Texas, Alane Celeste-Villalvir, J Michael Wilkerson, Christine Markham, Lourdes Rodriguez, Vanessa Schick Jan 2022

A Qualitative Investigation Of Organizational Challenges And Facilitators To Screening Individuals Experiencing Homelessness For Hepatitis C Virus (Hcv) In Houston, Texas, Alane Celeste-Villalvir, J Michael Wilkerson, Christine Markham, Lourdes Rodriguez, Vanessa Schick

Faculty, Staff and Student Publications

BACKGROUND: Individuals experiencing homelessness may be at a disproportionately high risk for hepatitis C (HCV) because they may be more likely to engage in HCV risk behaviors. Community organizations that provide services to these vulnerable individuals can effectively screen, diagnose, and navigate them into HCV care. However, screening people experiencing homelessness for HCV at such organizations is limited by various challenges that remain understudied, including budgetary considerations and strategies to improve teamwork and communication. Accordingly, this study investigated the organizational challenges and facilitators to HCV screening of individuals experiencing homelessness as reported by homeless services providers.

METHODS: Staff (N = …


The Neighborhood Environment And Hispanic/Latino Health, Natalia I Heredia, Tianlin Xu, Minjae Lee, Lorna H Mcneill, Belinda M Reininger Jan 2022

The Neighborhood Environment And Hispanic/Latino Health, Natalia I Heredia, Tianlin Xu, Minjae Lee, Lorna H Mcneill, Belinda M Reininger

Faculty, Staff and Student Publications

PURPOSE: Hispanic/Latino adults on the Texas-Mexico border have high rates of chronic disease. Neighborhoods can influence health, though there is a limited research on neighborhood environment and health in Hispanics/Latinos. The purpose of this study was to assess the relation of neighborhood environment with health variables in Hispanic/Latino adults, including physical activity [PA], depression, anxiety, and lab-assessed conditions (type 2 diabetes, metabolic syndrome, and chronic inflammation).

METHODS: Participants were randomly-selected from a Hispanic/Latino cohort on the Texas-Mexico border. Neighborhood environment, self-reported PA, anxiety, and depression were assessed through questionnaires. Laboratory values determined Type 2 diabetes, metabolic syndrome, and C-reactive protein …


Maternal Occupational Exposures And Fetal Growth In A Spanish Birth Cohort, Jennifer Ish, David Gimeno Ruiz De Porras, Elaine Symanski, Ferran Ballester, Maribel Casas, George L Delclos, Mònica Guxens, Jesús Ibarluzea, Carmen Iñiguez, Loreto Santa-Marina, Michael D Swartz, Kristina W Whitworth Jan 2022

Maternal Occupational Exposures And Fetal Growth In A Spanish Birth Cohort, Jennifer Ish, David Gimeno Ruiz De Porras, Elaine Symanski, Ferran Ballester, Maribel Casas, George L Delclos, Mònica Guxens, Jesús Ibarluzea, Carmen Iñiguez, Loreto Santa-Marina, Michael D Swartz, Kristina W Whitworth

Faculty, Staff and Student Publications

While the epidemiologic literature suggests certain maternal occupational exposures may be associated with reduced measures of size at birth, the occupational literature employing fetal biometry data to assess fetal growth is sparse. The present study examines associations between maternal occupational exposures and ultrasound-measured fetal growth. We included 1,739 singleton pregnancies from the INfancia y Medio Ambiente (INMA) project (2003-2008). At 32 weeks of pregnancy, interviewers ascertained mothers' employment status and assessed job-related physical loads, work schedules, and job strain during pregnancy. Job titles were linked to a job-exposure matrix to estimate exposure to 10 endocrine disrupting chemical (EDC) groups. We …


Covid-19 Outcomes In Myasthenia Gravis Patients: Analysis From Electronic Health Records In The United States, Youngran Kim, Xiaojin Li, Yan Huang, Minseon Kim, Aziz Shaibani, Kazim Sheikh, Guo-Qiang Zhang, Thy Phuong Nguyen Jan 2022

Covid-19 Outcomes In Myasthenia Gravis Patients: Analysis From Electronic Health Records In The United States, Youngran Kim, Xiaojin Li, Yan Huang, Minseon Kim, Aziz Shaibani, Kazim Sheikh, Guo-Qiang Zhang, Thy Phuong Nguyen

Faculty, Staff and Student Publications

BACKGROUND: Myasthenia gravis (MG) is an autoimmune, neuromuscular condition and patients with MG are vulnerable due to immunosuppressant use and disease manifestations of dyspnea and dysphagia during the coronavirus disease 2019 (COVID-19) pandemic.

METHODS: We conducted a retrospective cohort study using the Optum® de-identified COVID-19 Electronic Health Record (EHR) dataset. Primary outcomes, such as hospitalization, ventilator use, intensive care unit (ICU) admission, and death in COVID-19 patients with MG, were compared with those of COVID-19 patients without MG: the subgroups of non-MG included those with rheumatoid arthritis (RA), systemic lupus (SLE), and multiple sclerosis (MS). We further analyzed factors affecting …


Associations Between Vascular Diseases And Alzheimer's Disease Or Related Dementias In A Large Cohort Of Men And Women With Colorectal Cancer, Xianglin L Du, Lulu Song, Paul E Schulz, Hua Xu, Wenyaw Chan Jan 2022

Associations Between Vascular Diseases And Alzheimer's Disease Or Related Dementias In A Large Cohort Of Men And Women With Colorectal Cancer, Xianglin L Du, Lulu Song, Paul E Schulz, Hua Xu, Wenyaw Chan

Faculty, Staff and Student Publications

BACKGROUND: Long term risk of Alzheimer's disease (AD) and related dementias (ADRD) associated with vascular diseases in people with colorectal cancer is unknown.

OBJECTIVE: to determine the risk of ADRD in association with cardiovascular diseases (CVD), stroke, hypertension, and diabetes in a cohort of patients with colorectal cancer.

METHODS: This retrospective cohort study consisted of 210,809 patients diagnosed with colorectal cancer at age≥65 years in 1991-2015 from the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database with follow-up from 1991-2016, who were free of any ADRD at the baseline (< 30 days after the date of cancer diagnosis).

RESULTS: The crude 26-year cumulative incidence of total ADRD in …


Effect Of Tracheostomy Timing On Outcomes In Patients With Traumatic Brain Injury, Talha Mubashir, Hongyin Lai, Emmanuella Oduguwa, Rabail Chaudhry, Julius Balogh, George W Williams, Vahed Maroufy Jan 2022

Effect Of Tracheostomy Timing On Outcomes In Patients With Traumatic Brain Injury, Talha Mubashir, Hongyin Lai, Emmanuella Oduguwa, Rabail Chaudhry, Julius Balogh, George W Williams, Vahed Maroufy

Faculty, Staff and Student Publications

Tracheostomy following severe traumatic brain injury (TBI) is common, yet the outcomes associated with tracheostomy timing are unclear. The objective of this study was to assess hospital outcomes of tracheostomy timing in TBI patients. We retrospectively analyzed data from the National Inpatient Sample database of adult patients aged ≥18 years with a primary diagnosis of TBI. Indexed hospitalizations of TBI patients who underwent either percutaneous or surgical tracheostomy between 1995 and 2015 in the United States were included. The interventional groups were 1) early tracheostomy (≤7 days) vs standard tracheostomy (8-14 days), vs late tracheostomy (≥15 days), and 2) tracheostomy …


Methodology To Estimate Natural- And Vaccine-Induced Antibodies To Sars-Cov-2 In A Large Geographic Region, Stacia M Desantis, Luis G León-Novelo, Michael D Swartz, Ashraf S Yaseen, Melissa A Valerio-Shewmaker, Yashar Talebi, Frances A Brito, Jessica A Ross, Harold W Kohl, Sarah E Messiah, Steve H Kelder, Leqing Wu, Shiming Zhang, Kimberly A Aguillard, Michael O Gonzalez, Onyinye S Omega-Njemnob, David Lakey, Jennifer A Shuford, Stephen Pont, Eric Boerwinkle Jan 2022

Methodology To Estimate Natural- And Vaccine-Induced Antibodies To Sars-Cov-2 In A Large Geographic Region, Stacia M Desantis, Luis G León-Novelo, Michael D Swartz, Ashraf S Yaseen, Melissa A Valerio-Shewmaker, Yashar Talebi, Frances A Brito, Jessica A Ross, Harold W Kohl, Sarah E Messiah, Steve H Kelder, Leqing Wu, Shiming Zhang, Kimberly A Aguillard, Michael O Gonzalez, Onyinye S Omega-Njemnob, David Lakey, Jennifer A Shuford, Stephen Pont, Eric Boerwinkle

Faculty, Staff and Student Publications

Accurate estimates of natural and/or vaccine-induced antibodies to SARS-CoV-2 are difficult to obtain. Although model-based estimates of seroprevalence have been proposed, they require inputting unknown parameters including viral reproduction number, longevity of immune response, and other dynamic factors. In contrast to a model-based approach, the current study presents a data-driven detailed statistical procedure for estimating total seroprevalence (defined as antibodies from natural infection or from full vaccination) in a region using prospectively collected serological data and state-level vaccination data. Specifically, we conducted a longitudinal statewide serological survey with 88,605 participants 5 years or older with 3 prospective blood draws beginning …