Public Health Commons^™

Tocilizumab In Patients Hospitalised With Covid-19 Pneumonia: Efficacy, Safety, Viral Clearance, And Antibody Response From A Randomised Controlled Trial (Covacta), Ivan O Rosas, Norbert Bräu, Michael Waters, Ronaldo C Go, Atul Malhotra, Bradley D Hunter, Sanjay Bhagani, Daniel Skiest, Sinisa Savic, Ivor S Douglas, Julia Garcia-Diaz, Mariam S Aziz, Nichola Cooper, Taryn Youngstein, Lorenzo Del Sorbo, David J De La Zerda, Andrew Ustianowski, Antonio Cubillo Gracian, Kevin G Blyth, Jordi Carratalà, Bruno François, Thomas Benfield, Derrick Haslem, Paolo Bonfanti, Cor H Van Der Leest, Nidhi Rohatgi, Lothar Wiese, Charles Edouard Luyt, Rebecca N Bauer, Fang Cai, Ivan T Lee, Balpreet Matharu, Louis Metcalf, Steffen Wildum, Emily Graham, Larry Tsai, Min Bao

Faculty, Staff and Students Publications

BACKGROUND: In COVACTA, a randomised, placebo-controlled trial in patients hospitalised with coronavirus disease-19 (COVID-19), tocilizumab did not improve 28-day mortality, but shortened hospital and intensive care unit stay. Longer-term effects of tocilizumab in patients with COVID-19 are unknown. Therefore, the efficacy and safety of tocilizumab in COVID-19 beyond day 28 and its impact on Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) clearance and antibody response in COVACTA were investigated.

METHODS: Adults in Europe and North America hospitalised with COVID-19 (

FINDINGS: By day 60, 24·5% (72/294) of patients in the tocilizumab arm and 25·0% (36/144) in the placebo arm died (weighted …

Novel And Extendable Genotyping System For Human Respiratory Syncytial Virus Based On Whole-Genome Sequence Analysis, Jiani Chen, Xueting Qiu, Vasanthi Avadhanula, Samuel S Shepard, Do-Kyun Kim, James Hixson, Pedro A Piedra, Justin Bahl

Faculty, Staff and Student Publications

BACKGROUND: Human respiratory syncytial virus (RSV) is one of the leading causes of respiratory infections, especially in infants and young children. Previous RSV sequencing studies have primarily focused on partial sequencing of G gene (200-300 nucleotides) for genotype characterization or diagnostics. However, the genotype assignment with G gene has not recapitulated the phylogenetic signal of other genes, and there is no consensus on RSV genotype definition.

METHODS: We conducted maximum likelihood phylogenetic analysis with 10 RSV individual genes and whole-genome sequence (WGS) that are published in GenBank. RSV genotypes were determined by using phylogenetic analysis and pair-wise node distances.

RESULTS: …

A D2 To D1 Shift In Dopaminergic Inputs To Midbrain 5-Ht Neurons Causes Anorexia In Mice, Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong Xu

Faculty, Staff and Students Publications

Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HT

Examining The Effects Of Oral Contraceptive Use On Thermoregulation, Whitley C. Atkins

Graduate Theses and Dissertations

Purpose: The purpose of this investigation was to evaluate the effects of combined (estradiol and progestin) monophasic oral contraceptive pill (OCP) use on thermoregulation. Further, we sought to evaluate OCP use on acute rehydration post-exercise in the heat using recommended rehydration guidelines. Methods: Twelve healthy, aerobically trained (VO2peak = 47.8 ± 4.7 mL/kg/min), long term female oral contraceptive users completed a familiarization trial and two experimental days separated by ≥ 7 days. The two experimental trials were identical except for the hormone dosing phase. One trial was completed during the third week of active pill dosing (ACT) and one during …

The Effects Of Alcohol Intoxication And Threats To Masculinity On Engagement In Sexual Aggression: Results From A Web-Based Survey Design And Alcohol Administration Study, Tiffany Lynn Marcantonio

Graduate Theses and Dissertations

Background: Research examining the combined effects of men’s alcohol consumption and perceptions of their masculinity as precarious (e.g., viewing masculinity as easily threatened) on sexual aggression (SA) is lacking. The goal of this dissertation study was to assess if alcohol consumption and precarious masculinity are related to men’s SA via a web-administered survey (Study 1) and an in-person alcohol administration experiment (Study 2).

Methodology: In Study 1, two samples of young adult men (aged 18-30) were collected, 1) a community sample of 492 men and 2) a college sample of 478 men, to complete a 20-minute survey; participants answered questions …

The Complexities Of Guilt, Shame, Stigma, And Substance Use Among A Sample Of United States Substance Using Adults, Nicole A. Doyle

Graduate Theses and Dissertations

Background: Guilt, shame, stigma, substance use (problematic/nonproblematic), and help-seeking intention, are complex interrelated constructs that have not been collectively examined in community substance using adults, with mere pieces of each construct previously studied in various populations. Guilt pertains to an action (i.e., I did something bad) whereas shame pertains to the person (i.e., I am bad). Guilt has been shown to function adaptively by prompting individuals to repair transgressive behavior where shame has been shown to function maladaptively by prompting individuals to withdraw and compound the global negative feelings of the self. Stigma of substance use is pervasive and leads …

Exploring Higher Weight Women's Experiences Of Provider Weight Stigma, Meredith W. Moore

Graduate Theses and Dissertations

The purpose of this phenomenological study is to explore the phenomena of weight stigma as experienced by higher weight women in mental health treatment who also engage in restrictive eating behaviors. Women in larger bodies who are emotionally or behaviorally restrictive in their eating behaviors face a unique set of challenges and barriers. These include challenges due the disordered eating behaviors themselves, along with barriers related to weight stigma perpetuated by the mental health providers treating them (Harrop, 2019). Distinct hurdles to proper treatment including delay of diagnosis, longer duration of symptoms, and increased distress related to eating and body …

Nurses Leading In Bridging The Culture Gap: Communicating With The Deaf Community, Veronica C. Leftridge

Electronic Theses and Dissertations

Nurses provide patient care in clinics, hospitals, homes, churches, schools, communities, and military, as well as on emergency medical helicopters. When a nurse is assigned to care for a patient, the patient expects the nurse to be culturally competent, communicate effectively, and provide safe quality care. However, cultural incompetence is observed when nurses provide care for Deaf patients, but they are unfamiliar with Deaf culture. In addition, communication is a fundamental skill nurses learn in nursing school, but course content in nursing programs rarely touches on how to communicate effectively with Deaf patients. Of the approximately 325 million people in …

What Is The Prevalence Of Dirofilaria Immitis (Dog Heartworm) In Invasive Aedes Mosquitoes?, Leen Yousef, Johan Espinoza Corrales, Daniela H. Dolar, Taylor K. Trieu, Aisha Popalzai, Agamchat Dhami

Pacific Undergraduate Research and Creativity Conference (PURCC)

No abstract provided.

Factors Associated With Independent National Health Insurance Ownership Among Reproductive Aged Women In Indonesia, Ika Putri Widiarti, Haerawati Idris

Makara Journal of Health Research

Background: Indonesia has been aiming toward universal health coverage since 2019, but it has yet to be achieved. The National Health Insurance (NHI) program provides individual services for women of reproductive age who require health care before pregnancy, during pregnancy, and at the time of labor. This study aims to analyze factors associated with independent NHI ownership among women of reproductive age in Indonesia.

Methods: Secondary data from the Wave 5 Indonesia Family Life Survey (IFLS) involving 2,084 women of reproductive age were used. The chi-square test and logistic regression test were used for data analysis.

Results: …

Trends And Determinants Of Using Delivery Assistance By Health Workers: A Secondary Analysis Using The 2007–2017 Indonesian Health And Demographics Survey, Haerawati Idris, Willyana Syafriyanti

Makara Journal of Health Research

Background: The World Health Organization reports that approximately 295,000 women died during or after their pregnancy and delivery in 2017. However, such deaths can be prevented by using delivery assistance from health workers. This study aims to analyze the trends and determinants of using delivery assistance by health workers in Indonesia.

Methods: A quantitative cross-sectional design is adopted to analyze secondary data from the Indonesian Health Demographic Surveys in 2007, 2012, and 2017. The sample includes married women that are selected according to inclusion and exclusion criteria: 15.011 respondents in 2007, 14.989 in 2012, and 15.179 in 2017. …

Exercise Motivations, Barriers, And Preferences Of Tahfiz Students: A Qualitative Study, Farah Wahida Ibrahim, Arimi Fitri Mat Ludin, Nur Aqilah Marzuki, Ismarulyusda Ishak, Mohd Sham Othman, Nor Malia Abdul Warif, Mohd Zaharen Md. Zahir, Muhamad Toriq Yaacob

Makara Journal of Health Research

Background: In Malaysia, the increasing prevalence of physical inactivity is alarming. The effects of adopting a sedentary lifestyle have led to health problems such as coronary heart disease and type II diabetes mellitus, as well as increased mortality rates. Young adults, including tahfiz students, tend to be physically inactive due to much time spent sitting during lectures or studying. Therefore, an active lifestyle must be encouraged. This study aims to identify the factors that influence tahfiz students to exercise.

Methods: Data from 12 male and 19 female students were collected through in-depth interviews, which were recorded and transcribed …

Identification Of Risk Factors Associated With Nasopharyngeal Carcinoma (Npc) In The Pahang State Of Malaysia Hospitals, Azmir Ahmad, Muzaitul Akma Mustapa Kamal Basha, Wardah Mohd. Yassin, Nor Azlina A. Rahman, Wan Ishlah Leman, Luqman Rosla, Sharifah Nor Ezura Syed Yussof, Mark Paul, Kamariah Mohamed Awang, Kahari Abdullah, Mohd. Arifin Kaderi

Makara Journal of Health Research

Background: Nasopharyngeal carcinoma (NPC) is the fifth most common cancer reported in Malaysia. Although several studies on NPC have been carried out, the risk factors associated with NPC in Malaysia are unknown. Therefore, this study was designed to investigate the risk factors associated with NPC cases in Pahang state.

Methods: NPC cases that were diagnosed between 2012 and 2017 were recruited from two referral hospitals in Pahang. An interview was conducted using adapted questionnaires, which included demographic data, family history of cancer, and lifestyle. The data were analyzed statistically to identify the associations between the selected variables and …

Identification Of Community Knowledge On Lead Contamination And Analysis Of Lead Level In Fish, Sita Nurwulan, Sophi Damayanti, Lia Amalia

Pharmaceutical Sciences and Research

Poisoning is an event of human exposure to poisonous substances that are harmful to the body at certain doses. Lead is a heavy metal that can cause toxicity, including neurotoxic effects, hypertension, digestive system disorders, bone and tooth growth disorders, immune system disorders, infertility, and fetal disorders. Fish is a source of nutrients that are often consumed by people, however can also accumulate lead. This study aimed to analyze the lead level in fish and identify the community knowledge level regarding lead contamination in fish. Identification of community knowledge levels regarding lead. Identification of community knowledge levels regarding lead contamination …

Prevalence And Risk Factors Of Hypertension And Diabetes Mellitus Among The Indonesian Elderly, Prisilia Oktaviyani, Salman Salman, Marlynda Happy Nurmalita Sari, Melisa Frisilia, Munazar Munazar, Ana Satria, Maretalinia Maretalinia

Makara Journal of Health Research

Background: Epidemiological and demographic transitions lead to the emergence of non-communicable diseases (NCD) among the elderly. This study aimed to examine the risk factors of hypertension and diabetes mellitus (DM) among the elderly by using secondary data (Basic Health Research 2018).

Methods: Secondary data from Basic Health Research (N = 88,911) were used. Cut-off values for measurement were WHO standard of 126 mg/dl for fasting and 200 mg/dl for non-fasting for DM and 140 mmHg for systole and 90 mmHg for diastole for hypertension. Univariate, bivariate, and multivariate (binary logistic regression) analyses were conducted using STATA version 15. …

Investigating The Links Between Body Composition And Female University Students’ Night Eating Habits And Sleep Quality, Hanisah Rosli, Arimi Fitri Mat Ludin, Amanda Priscilla Lim, Vimalah Vallavan, Lew Sze Yuen, Norizatul Hidayah Yusop, Nur Athirah Razali, Amerull Daneal Amran, Nurfarahin Asmadi, Mohd Sham Othman

Makara Journal of Health Research

Background: Malaysia has the highest prevalence of obesity among Southeast Asian countries, and the current number is expected to increase further. In particular, the rate of obesity is reportedly increasing among females and young adults in Malaysia. Modern lifestyle habits, which include night eating and poor sleep quality, have been shown to increase the risk of obesity and high body fat. This study aims to determine the link between female university students’ body composition and their night eating habits and sleep quality.

Methods: Body composition was measured using a Bioelectrical Impedance Analysis (BIA) analyzer. Night eating syndrome and …

Exploring The Experience Of Stigma Among People Living With Hiv In Bali, Indonesia: Qualitative Phenomenological Study, Jufri Hidayat, Xuan-Yi Huang, Hung-Ru Lin, Shiow-Jing Wei, Miao-Yen Chen, Satriya Pranata

Makara Journal of Health Research

Background: Human immunodeficiency virus (HIV)-related stigma continues to be a serious problem for people living with HIV (PLWH). This study aimed to explore stigma experience among PLWH in Bali, Indonesia.

Methods: This research was a qualitative descriptive phenomenological study. With the help of a local clinician–researcher and the staff of the United Nations Program on AIDS Commission, Bali, 10 participants were recruited by purposive sampling and participated in semi-structured interviews via WhatsApp online audio from April to December 2021. Data were analyzed using Colaizzi’s process.

Results: The following three themes emerged: (1) experiencing discrimination, (2) getting stronger …

Emotional Eating Among Final Year Undergraduate Female Students Of Faculty Of Public Health Universitas Indonesia During Covid-19 Pandemic In 2021, Adinda Safira Salsabiela, Wahyu Kurnia Yusrin Putra

Indonesian Journal of Public Health Nutrition (IJPHN)

Emotional eating is defined as the tendency to excessively consuming food which often high in sugar, salt, and fat levels in response to negative emotions. Uncontrolled emotional eating will increase the risk of eating disorders such as bulimia nervosa and binge-eating disorder, obesity, cardiovascular diseases, and type II diabetes. This study aims to find out about the relationship between perceived stress, anxiety, academic stressors, social media engagement, COVID-19 infection history in respondent and their family members, and mindfulness with emotional eating among 106 final year undergraduate female students of the Faculty of Public Health Universitas Indonesia during the COVID-19 pandemic …

Effect Of Health And Nutrition Education On Blood Pressure, Knowledge And Compliance Among Hypertensive Patients In Bogor District, Indonesia: A Control Quasi-Experiment, Nurul Dina Rahmawati, Hasbullah Thabrany, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

With a high prevalence of hypertension (25.8% in 2013 and 34.1% in 2018), Indonesia currently deals with a tremendous health economic burden with the implementation of National Health Insurance (JKN). Hypertension is known to lead to severe complications and productivity loss. This study aimed to evaluate the effect of health and nutrition education on blood pressure knowledge and compliance among hypertension patients. The study was conducted over a period of 6 months in Bogor District. A total of 179 patients (64%) completed the study (intervention n = 88, control n = 91). Compared to the control group, patients in the …

Current Intake And Infection Status Were Not Good Predictive Factors Of Stunting Among Children Aged 6-59 Months In Babakan Madang Sub-District, Bogor District, West Java, Indonesia, Ruth Desinta Purnamasari, Ratu Ayu Dewi Sartika, Trini Sudarti

Indonesian Journal of Public Health Nutrition (IJPHN)

This study aims to discover the prevalence of stunting and determine the associations between the history of pulmonary tuberculosis disease with the prevalence of stunting among children under five years of age (6-59 months) in Babakan Madang Sub-District, Bogor District 2019. This study uses a cross-sectional design with a quantitative approach. The sample in this research was 194 children under five obtained by cluster sampling. Data collection was conducted through May 2019. The data collection process includes anthropometric measurements using calibrated microtoise and digital length board, dietary assessment using 1 x 24-h food recall, and a self-administered questionnaire. Data analyses …

Nutrition Analysis Of Wood Apple (Limonia Acidissima), Yuliana Noor Setiawati Ulvie, Hapsari Sulistya Kusuma, Erma Handarsari

Indonesian Journal of Public Health Nutrition (IJPHN)

Wood apple or Limonia acidissima contains fruit acid, vitamins, and minerals. The dry fiber of the fruit contains 15% citric acid, potassium, calcium, and iron salt. The seed and pulp contain fats and protein. The fats consist of palmitic acid, oleic acid, linoleic acid, and linolenic acid, despite palmitoleic and stearic acid traces. β-sitosterol, β-Amirin, lupeol, and stigmasterol are from the unsaponifiable matter of seed oil. It was descriptive research that employed a laboratory experiment approach to determine the composition of total carbohydrate, total protein, total fats, water, ash content, and the crude fiber of wood apple. The research found …

Carbohydrate Intake Is Associated With Learning Concentration Among High School Students In Jember Regency, East Java Province, Indonesia, Nadya Parahita Handini, Triyanti Triyanti, Kusharisupeni Djokosujono

Indonesian Journal of Public Health Nutrition (IJPHN)

Low learning concentration will have impact on low academic performance. This study aims to determine the relationship between learning concentration and several factors and to find the most dominant factor in the students of SMAN 1 Jember. In this study, learning concentration was the dependent variable, while breakfast habits, nutrient intake (energy, carbohydrates, protein, fat, iron, zinc, vitamin B12, vitamin C), sleep quality, and physical activity were independent variables. This research is a quantitative study with cross-sectional design. This study conducted in June 2021 at SMAN 1 Jember with a total of 200 respondents who were selected using the quota …

Family Perspectives On Developmental Monitoring: A Qualitative Study, Sarah Behrens, Evan Dean, Marisol Torres

Developmental Disabilities Network Journal

Developmental monitoring, an ongoing process to identify children at risk for developmental delays, is an essential component to the identification of a developmental disability in young children. In collaboration with families, medical professionals are expected to monitor the development of a child; however, current research focuses on screening with less attention on developmental monitoring and the role of the family. Here, we show the experiences of families with medical professionals specific to developmental monitoring and how families obtain and develop knowledge on child development. We analyze qualitative data from a sample of family caregivers using semi-structured interviews. With a thematic …

Experiential Learning Through Participatory Action Research In An Interdisciplinary Leadership Training Program, Jessica L. Franks, Stephanie D. Baumann, Marvin So, Angela M. Miles, Jorge M. Verlenden, Teal Benevides, Mark Crenshaw, Stephen Truscott, Daniel Crimmins

Developmental Disabilities Network Journal

Background: Experience in multidisciplinary collaboration among healthcare providers, leaders in public health, and educators is essential to effectively address the diverse needs of children with intellectual and developmental disabilities (I/DD) and their families.

Purpose: We describe three participatory action research (PAR) projects from an interdisciplinary training program, which used experiential learning to enhance leadership competencies and promote inclusive services. Trainees report their leadership growth as providers and advocates for children with I/DD using experiential learning through PAR.

Approach: Trainees discuss their engagement with organizations serving children with I/DD and ways that experiential learning supported leadership skill development, …

Equitable Vaccine Access Within An Age-Based Framework, Alan B. Cobo-Lewis

Developmental Disabilities Network Journal

Objectives: When vaccine supply was limited, several states adopted age-based prioritization for Covid-19 vaccine eligibility because it is simple (especially when age is quantized by decade) and age is strongly associated with Covid-19 mortality. But this approach raises equity concerns based in law and ethics. I propose data-driven solutions for equitable policy within an age-based framework. Methods: Using CDC and Census Bureau data, I analyzed 538,627 U.S. Covid-19 deaths by age and race-ethnicity through February 2021 and compared the risk ratios to published data on risk ratios for other conditions. Results: Covid-19 mortality rose 2.56-fold per decade of life. Down …

2022-04-29 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Examining Social Determinants Of Health During A Pandemic: Clinical Application Of Z Codes Before And During Covid-19, Xueying Yang Ph.D., Brooks Yelton, Shujie Chen, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Shan Qiao Ph.D., Xiaoming Li Ph.D., Daniela B. Friedman Ph.D.

Faculty Publications

Recognition of the impact of social determinants of health (SDoH) on healthcare outcomes, healthcare service utilization, and population health has prompted a global shift in focus to patient social needs and lived experiences in assessment and treatment. The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) provides a list of non-billable “Z codes” specific to SDoH for use in electronic health records. Using population-level analysis, this study aims to examine clinical application of Z codes in South Carolina before and during the COVID-19 pandemic. The study population consists of South Carolina residents who had a healthcare visit and had …

Barriers To Public Health In Latino American Indigenous Communities, Wilzave Quiles Guzman

Honors Program Theses and Research Projects

This paper focuses on barriers to public health in Latino American Indigenous communities. Indigenous people throughout the world are at a public health disadvantage due to a lack of clearly defined practices within the decision-making processes to plan, evaluate, and control finances from governmental and non-governmental entities in charge of managing health services. I argue that political, social, and institutional changes are still needed to achieve health equity in Indigenous communities and that these changes should go beyond implementing a universal health care program. I must recognize improvements made by many Latino American countries like Brazil, which prepared a plan …

A Multimodal Intervention For Weight Loss In Primary Care, Amber Smith

Evidence-Based Practice Project Reports

Obesity is a worsening pandemic that requires immediate action. It is recommended that primary care providers screen patients for obesity and provide multimodal behavioral interventions to their patients to treat and prevent obesity (USPSTF, 2018). The purpose of this evidenced-base practice (EBP) project is to implement a multimodal intervention for weight loss in adults within primary care. Five search engines were utilized, and 16 articles were ultimately selected as evidence. The evidence supported self-monitoring and close follow-up while in active weight loss. The Iowa Model for EBP to promote quality care was used as the framework to guide the project …

Vermont: A Health-Focused Landscape Analysis, Katherine Ahrens Phd, Amanda Burgess Mppm, Mph, Carly Milkowski Mph, Louisa Munk Mph, Yvonne Jonk Phd, Erika C. Ziller Phd

Population Health

The Northern Border Regional Commission State and Region Chartbooks compile county- and state-level data related to health and health care access for the Northern Border Region and the individual states of Maine, New Hampshire, New York, and Vermont. Topics covered in the chartbooks include demographic and socioeconomic characteristics, access to care, health outcomes, mortality rates, Health Professional Shortage Areas, and the location of Rural Health Clinics, Federally Qualified Health Centers, hospitals, and substance use treatment facilities. When data allow, we highlight the counties with the worse performance on a measure, compared with the rest of the counties in the Northern …