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Articles 14431 - 14460 of 55626
Full-Text Articles in Public Health
Survival Of Epithelial Ovarian Cancer In Black Women: A Society To Cell Approach In The African American Cancer Epidemiology Study (Aaces), Joellen M. Schildkraut, Courtney Johnson, Lauren F. Dempsey, Bo Qin, Paul Terry, Maxwell Akonde, Edward S. Peters, Hannah Mandle, Michele L. Cote, Lauren Peres, Patricia Moorman, Ann G. Schwartz, Micheal Epstein, Jeffrey Marks, Melissa Bondy, Andrew B. Lawson, Anthony Alberg, Elisa V. Bandera
Survival Of Epithelial Ovarian Cancer In Black Women: A Society To Cell Approach In The African American Cancer Epidemiology Study (Aaces), Joellen M. Schildkraut, Courtney Johnson, Lauren F. Dempsey, Bo Qin, Paul Terry, Maxwell Akonde, Edward S. Peters, Hannah Mandle, Michele L. Cote, Lauren Peres, Patricia Moorman, Ann G. Schwartz, Micheal Epstein, Jeffrey Marks, Melissa Bondy, Andrew B. Lawson, Anthony Alberg, Elisa V. Bandera
Faculty Publications
Purpose
The causes for the survival disparity among Black women with epithelial ovarian cancer (EOC) are likely multi-factorial. Here we describe the African American Cancer Epidemiology Study (AACES), the largest cohort of Black women with EOC.
Methods
AACES phase 2 (enrolled 2020 onward) is a multi-site, population-based study focused on overall survival (OS) of EOC. Rapid case ascertainment is used in ongoing patient recruitment in eight U.S. states, both northern and southern. Data collection is composed of a survey, biospecimens, and medical record abstraction. Results characterizing the survival experience of the phase 1 study population (enrolled 2010–2015) are presented.
Results …
Prevalence And Predictors Of Burnout Syndrome Among Italian Psychologists Following The First Wave Of The Covid-19 Pandemic: A Cross-Sectional Study, Pietro Crescenzo, Francesco Chirico, Giuseppe Ferrari, Lukasz Szarpak, Gabriella Nucera, Raffaella Marciano, Livio Tarchi, Diego Denicolo, Assunta Maiorino, Kavita Batra, Manoj Sharma
Prevalence And Predictors Of Burnout Syndrome Among Italian Psychologists Following The First Wave Of The Covid-19 Pandemic: A Cross-Sectional Study, Pietro Crescenzo, Francesco Chirico, Giuseppe Ferrari, Lukasz Szarpak, Gabriella Nucera, Raffaella Marciano, Livio Tarchi, Diego Denicolo, Assunta Maiorino, Kavita Batra, Manoj Sharma
School of Medicine Faculty Research
Introduction: The main objective of this study was to assess the prevalence and predictors of Burnout Syndrome (BOS) among Italian psychologists following the first wave of COVID-19 pandemic. As a secondary objective, geographical differences in the prevalence of BOS symptoms were investigated across regional macro-areas in this category of workers. Methods: Using a non-probabilistic convenience sample, four-hundred sixty-eight participants responded to an online survey which included psychometric valid questions from the Maslach Burnout Inventory and The Big Five Inventory-10. Descriptive and inferential statistics were utilized to analyze the data. Results: The overall prevalence of BOS in the study sample was …
The Challenges And Opportunities Of Scrna-Seq In Covid-19 Research And Clinical Translation, Wendao Liu, Xiaohua Ye, Zhiqiang An, Zhongming Zhao
The Challenges And Opportunities Of Scrna-Seq In Covid-19 Research And Clinical Translation, Wendao Liu, Xiaohua Ye, Zhiqiang An, Zhongming Zhao
Faculty, Staff and Student Publications
The application of single-cell RNA sequencing in COVID-19 research has greatly improved our understanding of COVID-19 pathogenesis and immunological characteristics. In this commentary, we discuss the current challenges, limitations, and perspectives in harnessing the power of single-cell RNA sequencing to accelerate both basic research and therapeutic development for COVID-19 and other emerging infectious diseases.
2022-12-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2022-12-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.
2022-12-14_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services
2022-12-14_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services
Michigan COVID-19 Vaccine Data
The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.
First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.
Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.
This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).
The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …
Investigating The Relationships Between Concentrated Disadvantage, Place Connectivity, And Covid-19 Fatality In The United States Over Time, Fengrui Jing, Zhenlong Liu, Shan Qiao, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.
Investigating The Relationships Between Concentrated Disadvantage, Place Connectivity, And Covid-19 Fatality In The United States Over Time, Fengrui Jing, Zhenlong Liu, Shan Qiao, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.
Faculty Publications
Background Concentrated disadvantaged areas have been disproportionately affected by COVID-19 outbreak in the United States (US). Meanwhile, highly connected areas may contribute to higher human movement, leading to higher COVID-19 cases and deaths. This study examined the associations between concentrated disadvantage, place connectivity, and COVID-19 fatality in the US over time. Methods Concentrated disadvantage was assessed based on the spatial concentration of residents with low socioeconomic status. Place connectivity was defined as the normalized number of shared Twitter users between the county and all other counties in the contiguous US in a year (Y = 2019). COVID-19 fatality was measured …
2022-12-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
2022-12-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
Michigan COVID-19 Long Term Care Data
The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.
This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.
The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …
2022-12-13_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services
2022-12-13_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services
Michigan COVID-19 Confirmed Cases by Date of Onset Data
Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/stats.
Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.
2022-12-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2022-12-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Tuesdays.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …
2022-12-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2022-12-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.
Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …
2022-12-13_Michiganoverview_Isdreporting, Michigan Department Of Health & Human Services
2022-12-13_Michiganoverview_Isdreporting, Michigan Department Of Health & Human Services
Michigan COVID-19 Outbreak Reports
The K-12 Aged ISD Reporting page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/k-to-12-aged-isd-reporting.
This report is created from data reported by the Michigan Disease Surveillance System (MDSS) the Michigan Department of Health and Human Services' web-based communicable disease reporting system. Data is updated every week.
The purpose of the dashboard is to report the 7 day average of COVID-19 cases in Michigan school students aged 5 through 18 at the intermediate school district and school district levels, as well as display trends over time to better illustrate the changing nature of the COVID-19 pandemic. Cases are attributed to …
Covid-19 Newsletter (Vol. 149), Center For Disaster Medicine, New York Medical College
Covid-19 Newsletter (Vol. 149), Center For Disaster Medicine, New York Medical College
COVID-19 Newsletter
No abstract provided.
Back To The Roots: Black Veganism, Kiara R. Thomas
Back To The Roots: Black Veganism, Kiara R. Thomas
Capstones
Only 3% of Americans in general, but 8% of Black Americans are strict vegan or vegetarian. Whether it’s to reduce animal cruelty, manage a chronic illness, or connect with their heritage and build a social movement, Black people are embracing plant-based diets. https://kiarathomas429.github.io/portfolio/
Association Of Fabry Disease With Hearing Loss, Tinnitus, And Sudden Hearing Loss: A Nationwide Population-Based Study, Yen-Fu Cheng, Sudha Xirasagar Mbbs., Ph.D., Chin-Shyan Chen, Dau-Ming Niu, Herng-Ching Lin
Association Of Fabry Disease With Hearing Loss, Tinnitus, And Sudden Hearing Loss: A Nationwide Population-Based Study, Yen-Fu Cheng, Sudha Xirasagar Mbbs., Ph.D., Chin-Shyan Chen, Dau-Ming Niu, Herng-Ching Lin
Faculty Publications
Hearing loss and the related otologic manifestations are receiving increased scrutiny as significant causes of morbidity in Fabry disease. However, the relative risks of auditory deficits among patients with Fabry disease relative to the general population without a diagnosis of Fabry disease have not been studied. This study aims to explore the associations between Fabry disease and hearing-related manifestations using a nationwide population-based dataset. We identified study patients for this cross-sectional study from the 2015–2017 claims databases of the Taiwan Longitudinal Health Insurance Database 2005. We first identified 2312 patients aged over 20 years with a diagnosis of Fabry disease. …
Using Patient Flow Analysis With Real-Time Patient Tracking To Optimize Radiation Oncology Consultation Visits, Shane Mesko, Julius Weng, Prajnan Das, Albert C Koong, Joseph M Herman, Dorothy Elrod-Joplin, Ashley Kerr, Thomas Aloia, John Frenzel, Katy E French, Wendi Martinez, Iris Recinos, Abdulaziz Alshaikh, Utpala Daftary, Amy C Moreno, Quynh-Nhu Nguyen
Using Patient Flow Analysis With Real-Time Patient Tracking To Optimize Radiation Oncology Consultation Visits, Shane Mesko, Julius Weng, Prajnan Das, Albert C Koong, Joseph M Herman, Dorothy Elrod-Joplin, Ashley Kerr, Thomas Aloia, John Frenzel, Katy E French, Wendi Martinez, Iris Recinos, Abdulaziz Alshaikh, Utpala Daftary, Amy C Moreno, Quynh-Nhu Nguyen
Faculty, Staff and Student Publications
PURPOSE: Clinical efficiency is a key component of the value-based care model and a driver of patient satisfaction. The purpose of this study was to identify and address inefficiencies at a high-volume radiation oncology clinic.
METHODS AND MATERIALS: Patient flow analysis (PFA) was used to create process maps and optimize the workflow of consultation visits in a gastrointestinal radiation oncology clinic at a large academic cancer center. Metrics such as cycle times, waiting times, and rooming times were assessed by using a real-time patient status function in the electronic medical record for 556 consults and compared between before vs after …
One Man's Pregnancy Story, Yvonne S. Marquez, Paige A. Perez
One Man's Pregnancy Story, Yvonne S. Marquez, Paige A. Perez
Capstones
Pregnancy is a challenging time for anyone. For LGBTQ people there are unique obstacles that make it especially difficult to navigate a medical system that was not built for them. Finn Schubert is trans and six months pregnant. He’s loving the experience but stressed by insurance claim denials, concerns for his safety, and medical incompetence.
This capstone project includes a 20-minute documentary, text, and a photo essay.
Super-Enhanced Marco Variant Drives Triple-Negative Breast Cancer Progression, Weei-Chin Lin, Fang-Tsyr Lin
Super-Enhanced Marco Variant Drives Triple-Negative Breast Cancer Progression, Weei-Chin Lin, Fang-Tsyr Lin
Faculty, Staff and Students Publications
No abstract provided.
2022-12-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2022-12-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.
2022-12-12_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services
2022-12-12_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services
Michigan COVID-19 Outbreak Reports
The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.
This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.
COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …
Analisis Faktor Risiko Keluhan Fatigue Pada Pramudi Brt (Bus Rapid Transit) Transjakarta Tahun 2022, Stefany Avelliana Megaranti, Chandra Satrya
Analisis Faktor Risiko Keluhan Fatigue Pada Pramudi Brt (Bus Rapid Transit) Transjakarta Tahun 2022, Stefany Avelliana Megaranti, Chandra Satrya
National Journal of Occupational Health and Safety
There were 508 cases of Transjakarta Bus accidents in 2021. Investigation results by the National Transportation Safety Committee (KNKT) revealed that one of the causes was driver fatigue. This study aims to describe fatigue complaints and analyze fatigue-related risk factors in Drivers of Transjakarta BRT (Bus Rapid Transit) and Non-BRT in 2022. This research is a quantitative study with an analytical descriptive research design. The research sample was 124 Drivers of Transjakarta BRT and Non-BRT. The independent variables in this study are work-related risk factors (Work Duration, Shift Work, Rest Time, Commuting Time, and Workload). The covariates in this study …
Gambaran Faktor Psikososial Dan Distress Pada Guru Sekolah Luar Biasa (Slb) Di Kota Depok Saat Pandemi Covid-19 Tahun 2022, Azka Hafia, Dadan Erwandi
Gambaran Faktor Psikososial Dan Distress Pada Guru Sekolah Luar Biasa (Slb) Di Kota Depok Saat Pandemi Covid-19 Tahun 2022, Azka Hafia, Dadan Erwandi
National Journal of Occupational Health and Safety
This study aims to obtain an overview of psychosocial factors and distress among special education teachers in Depok during the COVID-19 pandemic in 2022. This study used a cross-sectional study design with a semi-quantitative approach through filling out questionnaires and interviews. A total of 67 special education teachers in Depok participated in this study. The results showed that 34.3% of teachers experienced moderate distress, and 16.4% of teachers experienced significant distress. Then, it was found that distress is more experienced by female teachers (52.7%), aged > 30 years (52.4%), came from non-PLB study programs (52.5%), did not have personality type A …
Analisis Stres Kerja Pada Pengemudi Truk Pengantar Produk Pt Xyz Tahun 2022, Riska Oktaviana, Hendra Hendra
Analisis Stres Kerja Pada Pengemudi Truk Pengantar Produk Pt Xyz Tahun 2022, Riska Oktaviana, Hendra Hendra
National Journal of Occupational Health and Safety
Drivers are one of the occupational groups with the highest risk of experiencing workplace stress. This can happen to truck drivers who play an important role in the PT XYZ product delivery process. This study aims to describe the work stress level in PT XYZ product delivery truck drivers and the risk factors associated with work stress. The factors studied include individual factors (age, marital status, place of residence, number of children, and length of service), psychosocial factors related to job context (job control, social support, and home-work interface), and job content (physical environment of the cabin, workload, and working …
The Hypertension Cascade Of Care In The Midst Of Conflict: The Case Of The Gaza Strip, Bassam A. Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P. Vamos, Sanjay Basu, John S. Yudkin, Mohammed Jawad, Christopher Millett, Hala Ghattas Ph.D.
The Hypertension Cascade Of Care In The Midst Of Conflict: The Case Of The Gaza Strip, Bassam A. Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P. Vamos, Sanjay Basu, John S. Yudkin, Mohammed Jawad, Christopher Millett, Hala Ghattas Ph.D.
Faculty Publications
Although hypertension constitutes a substantial burden in conflict-affected areas, little is known about its prevalence, control, and management in Gaza. This study aims to estimate the prevalence and correlates of hypertension, its diagnosis and control among adults in Gaza. We conducted a representative, cross-sectional, anonymous, household survey of 4576 persons older than 40 years in Gaza in mid-2020. Data were collected through face-to-face interviews, anthropometric, and blood pressure measurements. Hypertension was defined in anyone with an average systolic blood pressure ≥140 mmHg or average diastolic blood pressure ≥90 mmHg from two consecutive readings or a hypertension diagnosis. The mean age …
Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison
Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison
Seton Hall University Dissertations and Theses (ETDs)
Background: Dementia is a public health problem that is estimated to triple by 2050.Globally, dementia is the seventh leading cause of death among all diseases and one of the major causes of disability and dependency among older people. The direct medical costs and indirect social and economic costs of dementia are burdensome to society, and by 2030 it is projected to cost more than $2.8 TRILLION dollars worldwide. African Americans are two to four times more likely to be diagnosed with dementia than White Americans; and more likely to rely on informal care from family and friends. African …
Gambaran Faktor Kegagalan Laten Dan Kegagalan Aktif Pada Kecelakaan Transportasi Darat Di Indonesia Tahun 2019 – 2021, Rahma Laili Khairina, Dadan Erwandi
Gambaran Faktor Kegagalan Laten Dan Kegagalan Aktif Pada Kecelakaan Transportasi Darat Di Indonesia Tahun 2019 – 2021, Rahma Laili Khairina, Dadan Erwandi
National Journal of Occupational Health and Safety
Road transportation accidents are the eighth leading cause of death worldwide, reaching 1.35 million people annually (WHO, 2021). Data from the NTMC Korlantas Polri for 2019-2021 shows that the number of road transportation accidents in Indonesia is above 100 thousand every year. This study identifies latent and active failure factors contributing to Indonesia's land transportation accidents to determine the causes of accidents comprehensively. This study uses secondary data with 320,084 traffic accident case reports in 2019-2021 belonging to the NTMC Korlantas Polri. The method used is qualitative by analyzing based on the Swiss Cheese Model. The results of this study …
Analisis Faktor Yang Berhubungan Dengan Fatigue Pada Pegawai Dinas Kesehatan Provinsi Dki Jakarta Tahun 2022, Halimatuzzahra Halimatuzzahra, Dadan Erwandi
Analisis Faktor Yang Berhubungan Dengan Fatigue Pada Pegawai Dinas Kesehatan Provinsi Dki Jakarta Tahun 2022, Halimatuzzahra Halimatuzzahra, Dadan Erwandi
National Journal of Occupational Health and Safety
In 2020 cases of Covid-19 were found in various parts of the world, one of which was in Indonesia. Since it was first discovered, this case has continued to increase, with DKI Jakarta Province being the highest contributor to daily positive cases of Covid-19 in Indonesia. The Indonesian government continues to make efforts and cooperation between institutions. One of the institutions it has is the Health Agency. However, the arrangements and working conditions that have changed following the development of the Covid-19 case can cause fatigue for employees of the DKI Jakarta Health Agency.. This study aims to analyze the …
Place Cells Dynamically Refine Grid Cell Activities To Reduce Error Accumulation During Path Integration In A Continuous Attractor Model, Jose A Fernandez-Leon, Ahmet Kerim Uysal, Daoyun Ji
Place Cells Dynamically Refine Grid Cell Activities To Reduce Error Accumulation During Path Integration In A Continuous Attractor Model, Jose A Fernandez-Leon, Ahmet Kerim Uysal, Daoyun Ji
Faculty, Staff and Students Publications
Navigation is one of the most fundamental skills of animals. During spatial navigation, grid cells in the medial entorhinal cortex process speed and direction of the animal to map the environment. Hippocampal place cells, in turn, encode place using sensory signals and reduce the accumulated error of grid cells for path integration. Although both cell types are part of the path integration system, the dynamic relationship between place and grid cells and the error reduction mechanism is yet to be understood. We implemented a realistic model of grid cells based on a continuous attractor model. The grid cell model was …
Experiences Of Parents With Opioid Use Disorder During Their Attempts To Seek Treatment: A Qualitative Analysis, Christine Bakos-Block, Angela J Nash, A Sarah Cohen, Tiffany Champagne-Langabeer
Experiences Of Parents With Opioid Use Disorder During Their Attempts To Seek Treatment: A Qualitative Analysis, Christine Bakos-Block, Angela J Nash, A Sarah Cohen, Tiffany Champagne-Langabeer
Faculty, Staff and Student Publications
In the U.S., 12.3% of children live with at least one parent who has a substance use disorder. Prior research has shown that men are more likely to seek treatment than women and that the barriers are different; however, there is limited research focusing specifically on opioid use disorder (OUD). We sought to understand the barriers and motivators for parents with OUD. We conducted a qualitative study by interviewing parents with OUD who were part of an outpatient treatment program. Interviews followed a semi-structured format with questions on access to and motivation for treatment. The interviews were recorded and transcribed …
Trib3 Mediates Fibroblast Activation And Fibrosis Though Interaction With Atf4 In Ipf, Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O Rosas, Guoying Yu
Trib3 Mediates Fibroblast Activation And Fibrosis Though Interaction With Atf4 In Ipf, Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O Rosas, Guoying Yu
Faculty, Staff and Students Publications
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase 3 (TRIB3), a well-known stress and metabolic sensor, in IPF. TRIB3 is down-regulated in the lungs of IPF patients in comparison to control subjects. Deficiency of TRIB3 markedly inhibited A549 epithelial cells’ proliferation and migration, significantly reducing wound healing. Conversely, overexpression of TRIB3 promoted A549 cell proliferation and transmigration while it inhibited its apoptosis. Meanwhile, overexpressed TRIB3 inhibited fibroblast activation and decreased ECM …
Sector Rural Colombiano, Salud Y Plaguicidas, Sandra Patricia Carmona Urueña, Maria Nieves Avila Avila, Claudia Del Rocío Contreras Rodríguez, Sindy Alejandro Cifuentes Guerrero, José Ever Ramírez Calderón
Sector Rural Colombiano, Salud Y Plaguicidas, Sandra Patricia Carmona Urueña, Maria Nieves Avila Avila, Claudia Del Rocío Contreras Rodríguez, Sindy Alejandro Cifuentes Guerrero, José Ever Ramírez Calderón
Ciencias de la Salud
La región del Sumapaz de Colombia es conocida como la despensa agrícola de Cundinamarca tiene una importante actividad económica en la producción de frutas y hortalizas, por lo que se debe conocer el estado sociocultural, demográfico, ambiental, laboral y de salud de los productores. Otro aspecto es la composición del suelo y el agua que se enfrenta a la degradación debido al abuso de plaguicidas, la deforestación, los monocultivos, la falta de cultura ambiental y presencia institucional, y los proyectos comunitarios ecoamigables. Los campesinos de la región se caracterizan por bajos niveles de educación, lo que afecta su capacidad para …