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Full-Text Articles in Public Health

Characteristics And International Enlightenment Of Adolescent Physical Literacy Cultivation In Wales, Han Meng, Zhihua Yin Feb 2023

Characteristics And International Enlightenment Of Adolescent Physical Literacy Cultivation In Wales, Han Meng, Zhihua Yin

International Journal of Physical Activity and Health

School education has focused on the fields of students’ literacy instead of specific subjects. The cultivation of physical literacy (PL) is gaining more and more attention in western countries, but few studies on this topic were found in China. The purpose of this research was to unfold the experience of Welsh adolescent PL and to provide enlightenment to China. This study analyzed the cultivation of Welsh adolescents’ PL through literature, logical analysis, and semi-structured interviews with eleven experts. The constant comparative method was used to analyze interview transcripts for common themes. During analysis, triangulation, negative case checks, member checks, and …


Effects Of High Intensity Interval Training On Children’S Health And Physical Fitness, Jinlong Xie, Yilan Li Feb 2023

Effects Of High Intensity Interval Training On Children’S Health And Physical Fitness, Jinlong Xie, Yilan Li

International Journal of Physical Activity and Health

The effect of high intensity interval training on children’s health is the focus of experts and scholars worldwide. After the outline of “Building a Strong Country in Sports” was issued in 2019, China’s attention to sports has reached a peak. However, the proportion of obese or myopic children in schools at all levels is still high, and the problem of low physical fitness of Chinese students is still serious. The purpose of this study was to review previous studies to explore the effects of high intensity interval training on children’s health and physical fitness. We reviewed relevant literature both in …


Measuring Invariance Of Theory Of Planned Behavior Model On Online Fitness Program Participation During The Covid-19 Pandemic, Ran Wei, Yuanlong Liu, Brooks Applegate, Colin Cork Feb 2023

Measuring Invariance Of Theory Of Planned Behavior Model On Online Fitness Program Participation During The Covid-19 Pandemic, Ran Wei, Yuanlong Liu, Brooks Applegate, Colin Cork

International Journal of Physical Activity and Health

Theory of Planned Behavior (TPB) is one of the most frequently cited and most influential models to explain and predict human intentions and behaviors (Ajzen, 1991, 2011; Kim & James, 2016), which include physical activity and exercise. However, the dimensionality of TPB has not been examined in the context of online fitness program (OFP) participation during the COVID-19 pandemic. The purpose of this study was to examine the TPB measurement parameters of the factorial models and determine the generalizability of the psychological constructs of the TPB model on gender groups and whether COVID-19 affected annual income groups. The participants were …


Research On Evaluation Index System Of Sports Events Over Urban Development Based On Symbiosis Theory, Hanzhi Dai Feb 2023

Research On Evaluation Index System Of Sports Events Over Urban Development Based On Symbiosis Theory, Hanzhi Dai

International Journal of Physical Activity and Health

With the development of economic globalization, sports events have become a strategic tool that is used for enhancing the competitiveness of the city and achieving the government’s goal. Nowadays, a myriad of cities takes organizing sports events as the goal of urban development. However, what is the relationship between sporting events and urban development? How to build an evaluation index system to measure the relationship between urban development and sports events? How are sports events coordinated with urban development? These issues have not yet been thoroughly investigated. This study attempts to analyze the relationship and mechanism between urban development and …


History, Development, And Enlightenment Of Adapted Physical Education National Standards, Yuting Song, Cuixiang Dong, Liu Ji Feb 2023

History, Development, And Enlightenment Of Adapted Physical Education National Standards, Yuting Song, Cuixiang Dong, Liu Ji

International Journal of Physical Activity and Health

As the total number and proportion of individuals with disabilities worldwide are increasing, the international community is paying more and more attention to the equal education rights of individuals with disabilities. Since the Individuals with Disabilities Education Act issued in 1975, physical education (PE) played a significant part in special education. According to the requirements of the United States federal legislation, a national certification examination system has been established and developed subsequently to better promote the development of physical education for children with disabilities. The National Consortium for Physical Education for Individuals with Disabilities (NCPEID) has formulated the Adapted Physical …


Relationship Between Physical Activity And Mental Health In Chinese Engineering College Students During Covid-19, Zongyu Liu, Xiuhan Zhao Feb 2023

Relationship Between Physical Activity And Mental Health In Chinese Engineering College Students During Covid-19, Zongyu Liu, Xiuhan Zhao

International Journal of Physical Activity and Health

The issue of mental health among college students is concerning during COVID-19 outbreak. Since engineering college students are vulnerable to mental health issues, the objectives of this study were: (1) to analyze the relationship between physical activity, parental psychological control, basic psychological needs, anxiety, and mental health in Chinese engineering college students during COVID-19 pandemic; and (2) to examine the mediation effect of anxiety between the relationship of basic psychological needs and mental health. A cross-sectional study was conducted among several universities in Shandong Province, China. We randomly selected 254 Chinese engineering college students. Participants completed the Physical Activity Rating …


The Restrictive Factors And Practical Path Of Sports-Medical Integration Under The Background Of Covid-19 Pandemic, Yonghuan Chen, Yanan Jiang, Xiangning Yan Feb 2023

The Restrictive Factors And Practical Path Of Sports-Medical Integration Under The Background Of Covid-19 Pandemic, Yonghuan Chen, Yanan Jiang, Xiangning Yan

International Journal of Physical Activity and Health

This paper explored the restrictive factors of realizing the integration of sports and medicine in China under the background of “COVID-19 pandemic” and analyzed the path of realizing the integration of sports and medicine by combining it with “Healthy China” strategy and “National Fitness Program”. We used document and expert interview method. In the new era, people’s desire for a better life has become the most extensive demand, and the sudden outbreak of epidemic makes people’s demand for health become the first demand. The importance of people’s health raises “Healthy China” as the national development strategy, which has become the …


Experimental Research On The Teaching Mode Of Cooperation And Competition In Physical Education, Xuelin Pang, Zhengze Zhang Feb 2023

Experimental Research On The Teaching Mode Of Cooperation And Competition In Physical Education, Xuelin Pang, Zhengze Zhang

International Journal of Physical Activity and Health

There are great differences in skill levels among students in the class. It should be the focus of our work to improve students to the greatest extent through teaching, gradually narrow the gap between individuals, and improve the overall teaching quality. Therefore, the purpose of this study was to examine the effects of the teaching mode of cooperation and competition. The research group conducted two rounds of teaching experiments in Harbin Engineering University. The first round of experiments adopted an equal group pre-test and post-test experimental design. Solomon’s four group design was used in the second round of experiment. The …


Effects Of Peer Support On Body Composition And Circumference In Chinese University Students, Chuhao Li, Lin Chen, Yi Xiang, Yongshen Lu, Shiwei Mo Feb 2023

Effects Of Peer Support On Body Composition And Circumference In Chinese University Students, Chuhao Li, Lin Chen, Yi Xiang, Yongshen Lu, Shiwei Mo

International Journal of Physical Activity and Health

This study aimed to understand the effects of adopting peer support in physical education (PE) class on university students’ body composition and circumference. Two university PE classes were recruited and assigned randomly to class with peer support (CWP; n=41; 8 underweight, 23 normal weight, 5 overweight, and 5 obesity; mean age=19.6±1.3yrs; height=169.5±8.0 cm) or class without peer support (CWOP; n=41; 9 underweight, 23 normal weight, 4 overweight, 5 obesity; mean age=19.3±1.1yrs; height=169.1±6.7 cm). Both classes adopted 16 weeks the same bodyweight management program for fitness promotion for 90 min/session/week (15 min warm-up, 60 min main training, 15 min cool-down). Students …


Difficulties And Solutions Of Intelligent Fitness Assistance Device To Help Students With Weak Physical Fitness, Yucai Liu Feb 2023

Difficulties And Solutions Of Intelligent Fitness Assistance Device To Help Students With Weak Physical Fitness, Yucai Liu

International Journal of Physical Activity and Health

Intelligent fitness assistance device is an intelligent (electromechanical or other power) assistance device. According to the actual situation of students with weak physical fitness, the device gives intelligent help. In order to reduce the difficulty of fitness and improve the fitness efficiency, this study introduced the relevant theories and technologies in the field of intelligent electromechanical into students' fitness. We collected and sorted out corresponding theories and technologies from the field of physical fitness and the field of intelligent electromechanical assistance, sought the integration point of the two interdisciplinary disciplines, took electromechanical assistance as the main technical support, take students …


Theoretical Discussions And Pathways Of Including Physical Education In The College Entrance Examination, Xiaoqiang Qian Feb 2023

Theoretical Discussions And Pathways Of Including Physical Education In The College Entrance Examination, Xiaoqiang Qian

International Journal of Physical Activity and Health

Under the background of the integration of sports and education, the study explored the feasibility and path of including physical education in the College Entrance Examination. Comprehensive literature and expert interviews and other methods were used to analyze the needs of including physical education in the College Entrance Examination. The specific theories are as follows: (a) “including physical education in the College Entrance Examination” can be an important entry point to promote the integration of sports and education and plays a key role of the test baton; (b) Policies that satisfy most stakeholders and conform to public interests at the …


Analysis And Prospect Of Research Progress Of Health Education Curriculum In China, Xue Wan, Haohui Liu, Zhihua Yin Feb 2023

Analysis And Prospect Of Research Progress Of Health Education Curriculum In China, Xue Wan, Haohui Liu, Zhihua Yin

International Journal of Physical Activity and Health

The purpose of this study was twofold: 1) review research results of health education in China and help readers gain a better understanding of the current profiles of research in health education curriculum and 2) provide a theoretical basis for future research in health education curriculum. Using key words such as health education curriculum on Chinese National Knowledge Infrastructure (CNKI), we searched and finally obtained 7287 articles. By using the visual analysis function of CNKI, we also analyzed the overall trend of research in Health Education Curriculum. Review of the articles found that the overall trend of research in health …


Exercise Prescription In Patient With Different Complications Of Leukemia: Recommendations For Clinical Practice, Yanzhong Chen Feb 2023

Exercise Prescription In Patient With Different Complications Of Leukemia: Recommendations For Clinical Practice, Yanzhong Chen

International Journal of Physical Activity and Health

Common treatment of leukemia will have side effects on nerve function, affecting the patient's physical function, which makes patients often accompanied by infection, bone and joint pain, fatigue and other symptoms. Exercise can improve the level of body function, enable patients to tolerate stronger chemotherapy during treatment, help improve the survival rate and recovery chances of patients, and has been used as an effective means to promote recovery. Recommendations for leukemia and exercise have been primarily based on the results of existing relevant studies. To provide more targeted recommendations for the leukemia, we gathered evidence for the efficacy of exercise …


Construction Of Evaluation System Of Effectiveness Of Supply Based On Spatial Perspective, Tienan Song, Haikuo Yu Feb 2023

Construction Of Evaluation System Of Effectiveness Of Supply Based On Spatial Perspective, Tienan Song, Haikuo Yu

International Journal of Physical Activity and Health

The requirement of "building a higher-level National Fitness Public Service system centering on meeting the needs of the people" by the Chinese State Council is to guarantee and satisfy the demand of public through effective supply. However, despite of the clear purpose of the task, there is still a gap between the actual and the expected status of National Fitness Public Service supply. Based on the characteristics of the perspective of space, the purpose of this study is to examine how to measure and achieve the effectiveness of National Fitness Public Service’s supply. By reviewing the literature, relevant results of …


Effect Of Physical Exercise On Life Satisfaction Of Chinese Primary Students: The Chain Mediating Role Of Self-Confidence And Resilience, Huan-Yu Li, Bo Shen, Jun Yan, Ai-Guo Chen, Ting Zhang Feb 2023

Effect Of Physical Exercise On Life Satisfaction Of Chinese Primary Students: The Chain Mediating Role Of Self-Confidence And Resilience, Huan-Yu Li, Bo Shen, Jun Yan, Ai-Guo Chen, Ting Zhang

International Journal of Physical Activity and Health

Life satisfaction is an overall cognitive evaluation of an individual's living condition for the most of time or over a certain period of time according to the standard of one’s own choice. It is an important psychological variable in the developmental stage of children and adolescents. Some studies had shown that life satisfaction was closely related to children's and adolescents' mental health levels, including their emotional and behavioral conditions. However, the Blue Book for Children: China Children's Development Report (2020) published by China Children's Center stated that Chinese students did not fare well in terms of life satisfaction. Previous studies …


Sit Less, Move More: A National Study Of Physical-Activity Behavior And Cancer, Stella O. Nwogugu Feb 2023

Sit Less, Move More: A National Study Of Physical-Activity Behavior And Cancer, Stella O. Nwogugu

Dissertations, Theses, and Capstone Projects

Background: Physical activity is associated with lower risks of cancer, the second leading cause of death among Americans. Yet, sedentary behavior is the prevailing lifestyle for about 80% of American adults. Additionally, cancer survivors remain significantly inactive, even though physical activity has been shown to decrease risk of cancer and cancer recurrence, improve tolerance of cancer therapy, and reduce mortality. This research explores the relative impact of personal agency, social support, and key demographic variables on physical-activity behavior for a national sample of adults as well as how these relationships differ for cancer survivors and their counterparts.

Methods: Using the …


Race, Gender, Physical Activity, And Cancer: A Quantitative Investigation, Shawna A. Townsend Feb 2023

Race, Gender, Physical Activity, And Cancer: A Quantitative Investigation, Shawna A. Townsend

Dissertations, Theses, and Capstone Projects

Black women are more likely to die from cancer than any other population in the United States. Physical activity is known to be associated with preventing and reducing cancer burden. However, Black women are less physically active than their White counterparts and have a higher prevalence of diseases related to lack of physical activity than any other female group. To better understand these issues, this study employed the self-and-family management framework and intersectionality as theoretical frameworks through a secondary analysis of the Health Information National Trends Survey (HINTS) dataset and hierarchical regression modeling to examine the relative impact of (a.) …


Dynamic Errors In Pulse Oximetry Preclude Use Of Correction Factor, Ashraf Fawzy, Valeria S M Valbuena, Christopher F Chesley, Tianshi David Wu, Theodore J Iwashyna Feb 2023

Dynamic Errors In Pulse Oximetry Preclude Use Of Correction Factor, Ashraf Fawzy, Valeria S M Valbuena, Christopher F Chesley, Tianshi David Wu, Theodore J Iwashyna

Faculty, Staff and Students Publications

No abstract provided.


Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorder: Onset Following Acute Covid-19 Infection, A Case Series, Mirla Avila, Yuanyuan Tan, Roberto Hernandez, Hafsa Zuberi, Victor M Rivera Feb 2023

Multiple Sclerosis And Neuromyelitis Optica Spectrum Disorder: Onset Following Acute Covid-19 Infection, A Case Series, Mirla Avila, Yuanyuan Tan, Roberto Hernandez, Hafsa Zuberi, Victor M Rivera

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: Acute COVID-19 infection has been associated with neurological involvement. We report a case series of newly diagnosed patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) developed in a short period of time after acute COVID-19 infection.

METHODS: New MS patients developing initial symptoms shortly after an acute COVID-19 infection were diagnosed based on the 2017 McDonald Criteria [Garcia-Ramos et al. in Cells, 2021]. The patients diagnosed with NMOSD met the 2015 International Panel criteria for the diagnosis of NMOSD (IPDN) [Thompson et al. in Lancet Neurol 17:162-173, 2018].

RESULTS FROM THE MS PATIENT GROUP: …


Telemedicine Use Among Physiatrists During The Early Phase Of The Covid-19 Pandemic And Potential For Future Use, Sameer Siddiqui, Ellen Farr, Nathaniel Dusto, Liqi Chen, Masha Kocherginsky, Felicia Skelton, Monica Verduzco-Gutierrez, Sujin Lee Feb 2023

Telemedicine Use Among Physiatrists During The Early Phase Of The Covid-19 Pandemic And Potential For Future Use, Sameer Siddiqui, Ellen Farr, Nathaniel Dusto, Liqi Chen, Masha Kocherginsky, Felicia Skelton, Monica Verduzco-Gutierrez, Sujin Lee

Faculty, Staff and Students Publications

No abstract provided.


Anxiety Sensitivity And Cigarette Use On Cannabis Use Problems, Perceived Barriers For Cannabis Cessation, And Self-Efficacy For Quitting Among Adults With Cannabis Use Disorder, Michael F Orr, Luke F Heggeness, Nirvi Mehta, Jacob Moya, Kara Manning, Lorra Garey, Julianna Hogan, Marcel De Dios, Michael J Zvolensky Feb 2023

Anxiety Sensitivity And Cigarette Use On Cannabis Use Problems, Perceived Barriers For Cannabis Cessation, And Self-Efficacy For Quitting Among Adults With Cannabis Use Disorder, Michael F Orr, Luke F Heggeness, Nirvi Mehta, Jacob Moya, Kara Manning, Lorra Garey, Julianna Hogan, Marcel De Dios, Michael J Zvolensky

Faculty, Staff and Students Publications

Many individuals diagnosed with cannabis use disorder (CUD) report a desire to quit using cannabis due to problems associated with use. Yet, successful abstinence is difficult for a large subset of this population. Thus, the present study sought to elucidate potential risk factors for cannabis use problems, perceived barriers for quitting, and diminished self-efficacy for remaining abstinent. Specifically, this investigation examined cigarette user status, anxiety sensitivity, and the interplay between these individual difference factors in terms of cannabis-related problems, perceived barriers for cannabis cessation, and self-efficacy for quitting cannabis use. The sample consisted of 132 adult cannabis users who met …


Comparison Of Postoperative Outcomes Of Laparoscopic Vs Open Inguinal Hernia Repair, Jennie Meier, Audrey Stevens, Miles Berger, Konstantinos I Makris, Athanasios Bramos, Joan Reisch, C Munro Cullum, Simon C Lee, Celette Sugg Skinner, Herbert Zeh, Cynthia J Brown, Courtney J Balentine Feb 2023

Comparison Of Postoperative Outcomes Of Laparoscopic Vs Open Inguinal Hernia Repair, Jennie Meier, Audrey Stevens, Miles Berger, Konstantinos I Makris, Athanasios Bramos, Joan Reisch, C Munro Cullum, Simon C Lee, Celette Sugg Skinner, Herbert Zeh, Cynthia J Brown, Courtney J Balentine

Faculty, Staff and Students Publications

Importance: Advocates of laparoscopic surgery argue that all inguinal hernias, including initial and unilateral ones, should be repaired laparoscopically. Prior work suggests outcomes of open repair are improved by using local rather than general anesthesia, but no prior studies have compared laparoscopic surgery with open repair under local anesthesia.

Objective: To evaluate postoperative outcomes of open inguinal hernia repair under general or local anesthesia compared with laparoscopic repair.

Design, setting, and participants: This retrospective cohort study identified 107 073 patients in the Veterans Affairs Surgical Quality Improvement Program database who underwent unilateral initial inguinal hernia repair from 1998 to 2019. …


Pediatric Eosinophilia: A Review And Multiyear Investigation Into Etiologies, Tara E Ness, Timothy A Erickson, Veronica Diaz, Amanda B Grimes, Ryan Rochat, Sara Anvari, Joud Hajjar, Jill Weatherhead Feb 2023

Pediatric Eosinophilia: A Review And Multiyear Investigation Into Etiologies, Tara E Ness, Timothy A Erickson, Veronica Diaz, Amanda B Grimes, Ryan Rochat, Sara Anvari, Joud Hajjar, Jill Weatherhead

Faculty, Staff and Students Publications

Objectives: To identify the etiology of peripheral eosinophilia in a large pediatric population and to develop a diagnostic algorithm to help guide diagnosis and management of peripheral eosinophilia in the outpatient pediatric population.

Study design: We performed a retrospective chart review of children presenting to Texas Children's Hospital in Houston with peripheral eosinophilia between January 1, 2011 and December 31, 2019. Eosinophilia was classified as mild (absolute eosinophil count [AEC] >500 and < 1500 cells/μL), moderate (AEC >1500 and < 4500 cells/μL), or severe (AEC >4500 cells/μL). Demographic information and diagnostic workup data were collected.

Results: A total of 771 patients aged < 18 years were evaluated. The most common cause of eosinophilia was allergy (n = 357; 46%), with atopy (n = 296) and drug reaction (n = 54) the most common subcauses. This was followed by unknown etiology (n = 274; 36%), infectious causes (n = 72; 9%), and eosinophilic disorders (n = 47; 6%). Many patients with an unknown cause (n = 202; 74%) had limited or no follow-up testing.

Conclusions: More information on the etiology of pediatric eosinophilia …


The Nlrp3 Inflammasome Fires Up Heme-Induced Inflammation In Hemolytic Conditions, Suruchi Salgar, Beatriz E Bolívar, Jonathan M Flanagan, Shaniqua J Anum, Lisa Bouchier-Hayes Feb 2023

The Nlrp3 Inflammasome Fires Up Heme-Induced Inflammation In Hemolytic Conditions, Suruchi Salgar, Beatriz E Bolívar, Jonathan M Flanagan, Shaniqua J Anum, Lisa Bouchier-Hayes

Faculty, Staff and Students Publications

Overactive inflammatory responses are central to the pathophysiology of many hemolytic conditions including sickle cell disease. Excessive hemolysis leads to elevated serum levels of heme due to saturation of heme scavenging mechanisms. Extracellular heme has been shown to activate the NLRP3 inflammasome, leading to activation of caspase-1 and release of pro-inflammatory cytokines IL-1β and IL-18. Heme also activates the non-canonical inflammasome pathway, which may contribute to NLRP3 inflammasome formation and leads to pyroptosis, a type of inflammatory cell death. Some clinical studies indicate there is a benefit to blocking the NLRP3 inflammasome pathway in patients with sickle cell disease and …


Sumoylation Regulates Functional Properties Of The Oocyte Transcription Factors Sohlh1 And Nobox, Bethany K Patton, Surabhi Madadi, Shawn M Briley, Avery A Ahmed, Stephanie A Pangas Feb 2023

Sumoylation Regulates Functional Properties Of The Oocyte Transcription Factors Sohlh1 And Nobox, Bethany K Patton, Surabhi Madadi, Shawn M Briley, Avery A Ahmed, Stephanie A Pangas

Faculty, Staff and Students Publications

SOHLH1 and NOBOX are oocyte-expressed transcription factors with critical roles in ovary development and fertility. In mice, Sohlh1 and Nobox are essential for fertility through their regulation of the oocyte transcriptional network and cross-talk to somatic cells. Sumoylation is a posttranslational modification that regulates transcription factor function, and we previously showed that mouse oocytes deficient for sumoylation had an altered transcriptional landscape that included significant changes in NOBOX target genes. Here, we show that mouse SOHLH1 is modified by SUMO2/3 at lysine 345 and mutation of this residue alters SOHLH1 nuclear to cytoplasmic localization. In NOBOX, we identify a non-consensus …


A Synthesis Of Evidence For Cancer-Specific Screening Interventions: A Preventive Medicine Golden Jubilee Review, Suvi Rintala, Kristina R Dahlstrom, Eduardo L Franco, Karolina Louvanto Feb 2023

A Synthesis Of Evidence For Cancer-Specific Screening Interventions: A Preventive Medicine Golden Jubilee Review, Suvi Rintala, Kristina R Dahlstrom, Eduardo L Franco, Karolina Louvanto

Faculty, Staff and Students Publications

The goal of cancer screening guidelines is to inform health practitioners to practice evidence-based cancer prevention. Cancer screening aims to detect treatable precancerous lesions or early-stage disease to enable actions aimed at decreasing morbidity and mortality. Continuous assessment of the available evidence for or against screening interventions by various organizations often results in conflicting recommendations and create challenges for providers and policymakers. Here we have summarized the current cancer screening recommendations by five leading organizations in North America and Europe: the National Cancer Institute's Physician Data Query (PDQ), the U.S. Preventive Services Task Force (USPSTF), the Canadian Task Force on …


Stanford Type A Aortic Dissection In A Patient With Primary Antiphospholipid Syndrome And Coronavirus Disease 2019, Sarah A Ahmad, Nauman Khalid, Lovely Chhabra, Waleed T Kayani, Tarek Helmy Feb 2023

Stanford Type A Aortic Dissection In A Patient With Primary Antiphospholipid Syndrome And Coronavirus Disease 2019, Sarah A Ahmad, Nauman Khalid, Lovely Chhabra, Waleed T Kayani, Tarek Helmy

Faculty, Staff and Students Publications

Acute aortic dissection is one of the most lethal diseases, affecting the lining of the aortic wall. We describe a case of Stanford Type A aortic dissection in a patient with underlying primary antiphospholipid syndrome (APS) complicated by coronavirus disease 2019 (COVID-19). APS is characterized by recurrent venous and/or arterial thrombosis, thrombocytopenia, and rarely vascular aneurysms. The hypercoagulable milieu attributable to APS and the prothrombotic state from COVID-19 posed a challenge in achieving optimal postoperative anticoagulation in our patient.


Pd-L1 Translocation To The Plasma Membrane Enables Tumor Immune Evasion Through Mib2 Ubiquitination, Xinfang Yu, Wei Li, Haidan Liu, Xu Wang, Cristian Coarfa, Chao Cheng, Xinlian Yu, Zhaoyang Zeng, Ya Cao, Ken H Young, Yong Li Feb 2023

Pd-L1 Translocation To The Plasma Membrane Enables Tumor Immune Evasion Through Mib2 Ubiquitination, Xinfang Yu, Wei Li, Haidan Liu, Xu Wang, Cristian Coarfa, Chao Cheng, Xinlian Yu, Zhaoyang Zeng, Ya Cao, Ken H Young, Yong Li

Faculty, Staff and Students Publications

Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T cell surface. This interaction delivers coinhibitory signals to T cells, thereby suppressing their function and allowing evasion of antitumor immunity. Most companion or complementary diagnostic devices for assessing PD-L1 expression levels in tumor cells used in the clinic or in clinical trials require membranous staining. However, the mechanism driving PD-L1 translocation to the plasma membrane after de novo synthesis is poorly understood. Herein, …


Remote Care Adoption In Underserved Congenital Heart Disease Patients During The Covid-19 Era, Ruth M Vaughan, Judson A Moore, Jasmine S Moreno, Karla J Dyer, Abiodun O Oluyomi, Keila N Lopez Feb 2023

Remote Care Adoption In Underserved Congenital Heart Disease Patients During The Covid-19 Era, Ruth M Vaughan, Judson A Moore, Jasmine S Moreno, Karla J Dyer, Abiodun O Oluyomi, Keila N Lopez

Faculty, Staff and Students Publications

The COVID-19 pandemic restricted in-person appointments and prompted an increase in remote healthcare delivery. Our goal was to assess access to remote care for complex pediatric cardiology patients. We performed a retrospective chart review of Texas Children's Hospital (TCH) pediatric cardiology outpatient appointments from March 2020 to December 2020 for established congenital heart disease (CHD) patients 1 to 17 yo. Primary outcome variables were remote care use of telemedicine and patient portal activation. Primary predictor variables were age, sex, insurance, race/ethnicity, language, and location. Descriptive statistics were used to analyze patient demographics. Multivariate logistic regression determined associations with remote care …


How Much Did It Cost To Develop And Implement An Ehealth Intervention For A Minority Children Population That Overlapped With The Covid-19 Pandemic?, Alexandra Monashefsky, Dar Alon, Tom Baranowski, Tiago V Barreira, Kelly A Chiu, Amy Fleischman, Melanie C Green, Shirley Huang, Ronald C Samuels, Caio Victor Sousa, Debbe Thompson, Amy S Lu Feb 2023

How Much Did It Cost To Develop And Implement An Ehealth Intervention For A Minority Children Population That Overlapped With The Covid-19 Pandemic?, Alexandra Monashefsky, Dar Alon, Tom Baranowski, Tiago V Barreira, Kelly A Chiu, Amy Fleischman, Melanie C Green, Shirley Huang, Ronald C Samuels, Caio Victor Sousa, Debbe Thompson, Amy S Lu

Children’s Nutrition Research Center Staff Publications

Background: eHealth interventions using active video games (AVGs) offer an alternative method to help children exercise, especially during a pandemic where options are limited. There is limited data on costs associated with developing and implementing such interventions.

Objectives: We quantified the costs of delivering an eHealth RCT intervention among minority children during COVID-19.

Methods: We categorized the total trial cost into five subcategories: intervention material development, advertising and recruitment, intervention delivery, personnel salaries, and COVID-19-related equipment costs.

Results: The total RCT cost was $1,927,807 (Direct: $1,227,903; Indirect: $699,904) with three visits required for each participant. The average cost per participant …