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Full-Text Articles in Psychiatry and Psychology

Toward A New Approach To Job-Related Distress: A Three-Sample Study Of The Occupational Depression Inventory, Renzo Bianchi, James Sowden, Jay Verkuilen, Irvin Sam Schonfeld Jan 2023

Toward A New Approach To Job-Related Distress: A Three-Sample Study Of The Occupational Depression Inventory, Renzo Bianchi, James Sowden, Jay Verkuilen, Irvin Sam Schonfeld

Publications and Research

The Occupational Depression Inventory (ODI) was recently developed to assess depressive symptoms that individuals specifically attribute to their work. One purpose of the ODI is to respond to limitations of current assessments of job-related distress, most notably, assessments relying on the burnout construct. In this study, we conducted a thorough examination of the psychometric and structural properties of the ODI using exploratory structural equation modelling bifactor analysis and Mokken scale analysis. The study involved three samples of employed individuals, recruited in France (N = 3454), Switzerland (N = 1971), and Australia (N = 1485). Results were consistent across the three …


The Effects Of Prolonged Exposure Therapy On The Symptoms Of Patients With Posttraumatic Stress Disorder, Hannah Belle Pontillas Jan 2023

The Effects Of Prolonged Exposure Therapy On The Symptoms Of Patients With Posttraumatic Stress Disorder, Hannah Belle Pontillas

Nursing | Senior Theses

The Diagnostic and Statistical Manual of Mental Disorders or DSM-5 defines posttraumatic stress disorder or PTSD as persistent psychophysiological reactions including intrusive memories of trauma, negative feelings towards such memories, and avoidance of related stimuli—all of which are a direct result of experiencing a traumatic event. The first line of treatment for this particular mental disorder is considered to be prolonged exposure therapy or PE therapy due to its high success rate in treating the symptoms of moderate to severe PTSD as it encourages patients to directly confront and overcome their trauma. However, PE therapy has garnered concern as it …


The Effects Of School-Based Art Therapy On Depressed Adolescents, Jasmine Nicolas Jan 2023

The Effects Of School-Based Art Therapy On Depressed Adolescents, Jasmine Nicolas

Nursing | Senior Theses

Depression in adolescents is associated with deficient behavioral and health outcomes (Fletcher, 2019). Art therapy has been shown to be effective in treating mental health condition such as depression. A student’s academic success heavily depends on treating their depression. Community health nurses can play a vital role in advocating for adequate mental health support to improve a student’s overall well-being and academic success. The literature review contains six articles on the prevalence and impact of depression among adolescents, art therapy as an intervention for improving psychological outcomes and resilience among adolescents, and experiences of adolescent clients in art therapy within …


Better Policy Interventions Through Intersectionality, Elizabeth R. Cole, Lauren E. Duncan Jan 2023

Better Policy Interventions Through Intersectionality, Elizabeth R. Cole, Lauren E. Duncan

Psychology: Faculty Publications

Deployment of intersectionality frameworks in policy design and implementation is a way to ensure that the means and goals of interventions are congruent with target populations’ understanding of their circumstances, their desired outcomes, and their empowerment. In this paper, we examine the ways concepts from psychology have been used to inform interventions and policies, and we use an intersectional lens to suggest improvements to these interventions to be more inclusive in their impact. We review three social policy interventions that were developed based on social psychological research: (1) sexual assault prevention programs based on bystander interventions; (2) so-called “wise schooling” …


Narratives Reflecting Theory Of Mind Among Bilingual Lyuli Children Of Uzbekistan, Hristo Kyuchukov, Jill De Villiers, Bahodir B. Mamurov, Gulbahor R. Akramova Jan 2023

Narratives Reflecting Theory Of Mind Among Bilingual Lyuli Children Of Uzbekistan, Hristo Kyuchukov, Jill De Villiers, Bahodir B. Mamurov, Gulbahor R. Akramova

Psychology: Faculty Publications

This is the first known study of the socio-cognitive development of Lyuli children, a Roma-type group living in Bukhara in Uzbekistan. The research was conducted in schools in Bukhara serving both Lyuli children and Uzbek children, both of whom are multi-lingual but whose sociolinguistic circumstances are somewhat different. There has been less cross-cultural work on later stages of Theory of Mind development, in which children have to make inferences about the mental states of characters in a complex narrative. The research here shows that the children from both groups do remarkably well on these tasks, and their multilingualism is hypothesized …


Behavioral Markers And Endophenotypes Underlying Individual Differences In Ethanol Use, Haily R. Knapp Jan 2023

Behavioral Markers And Endophenotypes Underlying Individual Differences In Ethanol Use, Haily R. Knapp

Honors Theses and Capstones

The main concern of this study is to evaluate the neurobiology of ethanol self-administration and cue-induced reinstatement in rats and its implications for Alcohol Use Disorder (AUD) prevention and treatment. The purpose of this study is to use a pre-clinical model of ethanol use to understand the individual effects at the neurobiological level. The study utilized economic demand and negative consequence testing to evaluate the rats' motivation to consume ethanol and their ability to relapse after periods of abstinence. The results showed individual and sex differences in ethanol consumption, with rats who placed a higher value on ethanol being more …


The Influence Of Early Childhood Parental Feeding Behaviors On Self-Regulation & Food Decision-Making In Young Adults, Natasha Singareddy Jan 2023

The Influence Of Early Childhood Parental Feeding Behaviors On Self-Regulation & Food Decision-Making In Young Adults, Natasha Singareddy

CMC Senior Theses

This study used data from a diverse set of undergraduates from the Claremont Colleges to examine the relationship between cognitive control (impulsivity and response inhibition) and self-regulatory ability as an indicator of sustained early childhood parental feeding behaviors in adulthood. In addition, the current study explored if early childhood parental feeding behaviors predicted food decision-making in adulthood as a result of perceived taste and nutritional value of food items. It was hypothesized that heightened impulsivity and impaired response inhibition as measures of cognitive control would correlate to poorer self-regulation, in turn reflecting a particular mode of early childhood parental feeding …


Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini Jan 2023

Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini

CMC Senior Theses

Dance/movement therapy (D/MT) is the psychotherapeutic use of expressive, creative movement to support holistic well-being. D/MT views the human being as a single body-mind unit and movement as a manifestation of life experiences. While typically practiced as a mental health intervention, D/MT can be adapted for a variety of populations. This thesis evaluates scientific data for the non-traditional use of D/MT for three conditions: autism, Parkinson’s disease, and cancer. For individuals on the autism spectrum, D/MT can strengthen attunement skills, provide creative communication outlets, and relieve harmful physical manifestations of autism. For individuals with Parkinson’s disease, D/MT can simultaneously ease …


Developing Ecologically Valid Clinical Tools For Persons With Tbi: Understanding The Role And Impact Of Distractions, Deanna Pinnow Jan 2023

Developing Ecologically Valid Clinical Tools For Persons With Tbi: Understanding The Role And Impact Of Distractions, Deanna Pinnow

Theses and Dissertations--Rehabilitation Sciences

There is a critical need for the development of ecologically valid clinical tools to assess real-life cognitive functioning in persons impacted by traumatic brain injury (TBI). Chronic cognitive impairments that are exacerbated by distractions are one of the core factors contributing to poor home and community re-integration post injury. Simulation-based digital platforms (i.e., virtual reality, augmented reality, and mixed reality) have become potential solutions for eliciting real-world cognitive performance in clinical settings. Yet, there is a paucity of research investigating the role and impact of distractions on cognition. As a result, there is no clear framework of measuring distractions to …


Internalized Homonegativity And The Mental Health Of Lesbian, Gay, And Bisexual Individuals: An Integrative Treatment Approach, David Kearby Jan 2023

Internalized Homonegativity And The Mental Health Of Lesbian, Gay, And Bisexual Individuals: An Integrative Treatment Approach, David Kearby

DSW Capstone Projects

Lesbian, gay, and bisexual individuals (LGBI) have a higher rate of mental health disorders than the general population. The mental health disparities experienced by LGBI are positively correlated with higher internalized homonegativity (IH) levels, which impacts their functioning at the unconscious, cognitive, and interpersonal levels. Thus, effective interventions targeting the mental health of LGBI must consider IH's intrapsychic, cognitive, and interpersonal nature. An integrative psychotherapy approach addressing the mental health and IH of LGBI is needed to address the intrapsychic, cognitive, and interpersonal factors at play.

Product one of this capstone is a systematic literature review that identified psychotherapeutic interventions …


Physiological Responses Regarding Stress And Trauma: The Freeze Response, Emma Arie Von Holten Jan 2023

Physiological Responses Regarding Stress And Trauma: The Freeze Response, Emma Arie Von Holten

UNF Graduate Theses and Dissertations

Fight-or-flight is a commonly known response to threatening situations, but the freeze response is another defensive mechanism that might arise in such situations. There is also evidence that exposure to trauma can impact physiological reactions when defensive mechanisms are not required, such as freezing in response to non-threatening situations. The current study aimed to replicate and expand upon a limited number of previous studies on the human freeze response by implementing measurements of postural sway, heart rate, and infrared thermography while valenced images were shown to participants. Ninety-two participants were recruited from the University of North Florida and participants were …


Illness Stigma, Social Connectedness, And Health In People Living With Chronic Illness: A Structural Equation Model, Abigail Brooke Crawford Jan 2023

Illness Stigma, Social Connectedness, And Health In People Living With Chronic Illness: A Structural Equation Model, Abigail Brooke Crawford

UNF Graduate Theses and Dissertations

The complexity of chronic or unexplained conditions may lead to potential stigma for those suffering long-term symptoms as they do not follow the expected pattern of recovery following diagnosis and treatment. Experiencing such illness-related stigma has potential for leading to a belongingness identity of detachment with implications for health across physical, social, and psychological dimensions. This study aimed to examine the relationship between stigma, social connection, mental health, physical health, and social functioning in a group of 231 participants with ongoing symptoms of chronic illness through structural equation modeling. The fit indices all suggest that the model reasonably fits the …


Theory Of Mind And Clausal Embedding, Jill De Villiers, Tom Roeper Jan 2023

Theory Of Mind And Clausal Embedding, Jill De Villiers, Tom Roeper

Psychology: Faculty Publications

No abstract provided.


Autism For The Professions: One University, Three Colleges And One Undergraduate Course, Mary E. Carlson, Wendy Krueger, Amy V. Van Hecke Jan 2023

Autism For The Professions: One University, Three Colleges And One Undergraduate Course, Mary E. Carlson, Wendy Krueger, Amy V. Van Hecke

College of Education Faculty Research and Publications

Purpose

This paper discusses the elements of successful university-level, cross-disciplinary course development using best practices to foster richer relational networks and to meet the complex demands of education and treatment for children with autism spectrum disorder (ASD).

Design/methodology/approach

The three authors created and taught a class on best practices in autism nine times. The authors assessed the knowledge base and attitudinal changes of undergraduates (most in psychology, speech pathology and audiology, and education) for two of the nine cohorts who were being prepared to work with individuals with ASD.

Findings

Pre- and postmeasures indicated significant improvement in knowledge and a …


Childhood Trauma And The Faith Maturity Of Seventh-Day Adventist Pastors And Seminarians, Pete A. Palmer Jan 2023

Childhood Trauma And The Faith Maturity Of Seventh-Day Adventist Pastors And Seminarians, Pete A. Palmer

Dissertations

Problem

Unfortunately, Childhood Trauma is a fact of life. For instance, children lose parents/guardians through death or divorce. Children grow up in impoverished situations. Children have parents who suffer from mental illness and/or commit suicide. In addition, more unfortunately, some children are mistreated, neglected, and/or abused. The long-lasting impact of Childhood Trauma includes increased morbidity and mortality, and decreased opportunities for prosperity. This research sought to establish a statistical relationship between Childhood Trauma and Faith Maturity. Childhood Trauma has been demonstrated to affect attachment processes in children and, since religion is an attachment process and God is an attachment figure, …


Neurobiology Of Ptsd In Adults And Children: The Impact Of Stress-Induced Brain Abnormalities Across The Lifespan, Catherine Clover Jan 2023

Neurobiology Of Ptsd In Adults And Children: The Impact Of Stress-Induced Brain Abnormalities Across The Lifespan, Catherine Clover

Undergraduate Honors Theses

In the scholarly community, there is disagreement about the effects of PTSD or chronic stress on the brain of adults and children. Though PTSD or chronic stress are known to negatively affect neurobiological structures, specifically due to prolonged glucocorticoid excess, volumetric discrepancies between traumatized and control groups are not unanimously confirmed. This review sought to address the common understandings in academia of the effects of PTSD on the brains of adults and children. Literature on this topic indicated that, in adults, the hippocampus, cingulate gyrus, and prefrontal cortex bilaterally appeared to decrease in gray matter volume and the corpus callosum …


Cumulative Risk For Children’S Behavior Problems And Child Abuse Potential Among Mothers Receiving Substance Use Treatment: The Unique Role Of Parenting Stress, Stephanie Gusler, Angela Moreland Jan 2023

Cumulative Risk For Children’S Behavior Problems And Child Abuse Potential Among Mothers Receiving Substance Use Treatment: The Unique Role Of Parenting Stress, Stephanie Gusler, Angela Moreland

Psychiatry Faculty Publications

There is a high prevalence of children whose parents suffer with a substance use disorder (SUD), which is associated with negative outcomes for children such as behavior problems and parents’ child abuse potential. To understand negative consequences for children, it is important to consider a cumulative risk model, examining the impact of multiple co-occurring risks, as well as examine unique singular risk factors, such as parenting stress, which may have a direct effect on outcomes as well as mediate an association between cumulative risk and outcomes. Data came from 99 mothers with SUD, engaged in a substance treatment program. Results …


Cannabidiol And Delta-9-Tetrahydrocannabinol Interactions In Male And Female Rats With Persistent Inflammatory Pain, Stevie C. Britch, Rebecca M. Craft Jan 2023

Cannabidiol And Delta-9-Tetrahydrocannabinol Interactions In Male And Female Rats With Persistent Inflammatory Pain, Stevie C. Britch, Rebecca M. Craft

Behavioral Science Faculty Publications

Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), 2 of the primary constituents of cannabis, are used by some individuals to self-treat chronic pain. It is unclear whether the painrelieving effects of CBD alone and in combination with THC are consistent across genders and among types of pain. The present study compared the effects of CBD and THC given alone and in combination in male and female rats with Complete Freund’s adjuvant-induced inflammatory pain. After induction of hindpaw inflammation, vehicle, CBD (0.05−2.5 mg/kg), THC (0.05−2.0 mg/kg), or a CBD: THC combination (3:1, 1:1, or 1:3 dose ratio) was administered i.p. twice daily for …


The Endowment Effect And Temporal Discounting Of Drug And Non-Drug Commodities, Sean D. Regnier, Mark J. Rzeszutek, Justin C. Strickland, Thomas Shellenberg, William W. Stoops Jan 2023

The Endowment Effect And Temporal Discounting Of Drug And Non-Drug Commodities, Sean D. Regnier, Mark J. Rzeszutek, Justin C. Strickland, Thomas Shellenberg, William W. Stoops

Behavioral Science Faculty Publications

Objectives: Despite a rich history of behavioral economic research on substance use there remains a need for further exploration of behavioral mechanisms that may underlie the etiology or persistence of substance use disorder. The purpose of this study was to measure the association between delay discounting and the endowment effect in people who smoke cigarettes, use cocaine, and controls, using online crowdsourcing. Methods: Participants were categorized to a cocaine group (n = 36), cigarette group (n = 48), or control group (n = 47) based on recent reported drug use. Based on group, participants completed up to three delay discounting …


The Moderating Effect Of Physical Activity On The Relationship Between Bullying And Mental Health Among Sexual And Gender Minority Youth, Sally J. Kirklewski, Ryan J. Watson, Carolyn Lauckner Jan 2023

The Moderating Effect Of Physical Activity On The Relationship Between Bullying And Mental Health Among Sexual And Gender Minority Youth, Sally J. Kirklewski, Ryan J. Watson, Carolyn Lauckner

Behavioral Science Faculty Publications

Background: Sexual and gender minority youth frequently experience bullying, which often contributes to higher depressive symptoms and lower self-esteem. Given that physical activity (PA) can mitigate depressive symptoms and improve self-esteem, we examined the moderating effect of PA on the relationship between bullying and mental health among sexual and gender minority youth.

Methods: Data from the Lesbian, Gay, Bisexual, Transgender, and Queer National Teen Survey (n = 9890) were analyzed. Hierarchical regression analyses examined the influence of history and frequency of being bullied, PA, and the interaction of these variables on depressive symptoms and self-esteem. Simple slopes analyses were used …


Effect Of Positive Emotion Intervention During Late Pregnancy On Improving Colostrum Secretion: A Randomised Control Trial Protocol, Kechen Xu, Ying Xie, Xiujun Han, Ying Yu, Suqing Liu, Suliu Wu, Qian Yang, Qi Zhang Jan 2023

Effect Of Positive Emotion Intervention During Late Pregnancy On Improving Colostrum Secretion: A Randomised Control Trial Protocol, Kechen Xu, Ying Xie, Xiujun Han, Ying Yu, Suqing Liu, Suliu Wu, Qian Yang, Qi Zhang

Community & Environmental Health Faculty Publications

Introduction Though evidence has revealed the beneficial effects of cognitive improvement interventions on breastfeeding, the effect of psychological interventions has rarely been studied. This study aims to test whether promoting a positive emotion intervention, 'Three Good Things' intervention, during the last trimester of pregnancy can enhance early colostrum secretion and breastfeeding behaviours by modulating the hormones associated with lactation (prolactin and insulin-like growth factor I). We will attempt to promote exclusive breastfeeding by using physiological behavioural measures.

Methods and analysis This study is designed as a randomised controlled trial conducted in the Women's Hospital School of Medicine at Zhejiang University …


Integrating Feminist Approaches In Counseling Work With Adult Women, Kristen M. Toole Jan 2023

Integrating Feminist Approaches In Counseling Work With Adult Women, Kristen M. Toole

Adultspan Journal

The scope of ‘women’s issues’ in counseling is an ever-evolving landscape. Recent events such as the reversal of Roe v. Wade and the disproportionate impact of COVID-19 on women serve as powerful reminders of the necessity of this focus while underscoring a deep-rooted history of oppressive patriarchal structures. Therefore, counselors must remain informed of the unique considerations surrounding adult women in counseling and acquire proficiency in versatile techniques to meet this population’s nuanced needs. This article examines the complexity of contemporary womanhood and explores the fundamentals of Feminist Counseling Theory (FCT), a holistic, multiculturally conscious, social justice theory in counseling. …


Human Service Student's Preparedness For Assessing Suicidality: Recommendations For Human Services Education, Narketta Sparkman-Key, Jeffrey Moe, Bianca Augustine, T'Airra Belcher Jan 2023

Human Service Student's Preparedness For Assessing Suicidality: Recommendations For Human Services Education, Narketta Sparkman-Key, Jeffrey Moe, Bianca Augustine, T'Airra Belcher

Counseling & Human Services Faculty Publications

Suicide continues to be a public health concern, with suicide rates increasing. Human service professionals are among the helping professions tasked with assessing and addressing suicidality. Despite the well-documented benefits of suicide assessment and training for those within the helping professions, there remains a dearth of literature specific to suicide prevention in the preparation of human services students. To address this gap, the current study used the SIRI-2 to assess the preparedness of human services students (n = 98) to assess and address client suicidality. Findings indicated that participants’ responses were less competent than area experts. Furthermore, student participants’ responses …


Interprofessional Team Collaboration For Routine And Emergent Mental Health Concerns Among Collegiate Student-Athletes: A Case Series From The Association For Athletic Training Education Research Network, Lindsey E. Eberman, Tara A. Armstrong, Elizabeth R. Neil, Jessica L. Kirby, Korrin M. Vanderhoof, Stacy E. Walker Jan 2023

Interprofessional Team Collaboration For Routine And Emergent Mental Health Concerns Among Collegiate Student-Athletes: A Case Series From The Association For Athletic Training Education Research Network, Lindsey E. Eberman, Tara A. Armstrong, Elizabeth R. Neil, Jessica L. Kirby, Korrin M. Vanderhoof, Stacy E. Walker

Rehabilitation Sciences Faculty Publications

Collegiate student-athletes experience an increasing number of mental health concerns. To help address these concerns and provide high-quality health care for student-athletes, institutions of higher education are being encouraged to create interprofessional health care teams that are specifically dedicated to managing mental health. We interviewed 3 interprofessional health care teams who collaborate to manage routine and emergency mental health conditions in collegiate student-athletes. Teams represented all 3 National Collegiate Athletics Association (NCAA) divisions and included athletic trainers, clinical psychologists, psychiatrists, dietitians and nutritionists, social workers, nurses, and physician assistants (associates). The interprofessional teams indicated that the existing NCAA recommendations helped …


The Psychological Impact Of An Intensive Care Admission On Survivors Of Acute Respiratory Distress Syndrome And Covid-19 Ards, Leah K. Shinn Jan 2023

The Psychological Impact Of An Intensive Care Admission On Survivors Of Acute Respiratory Distress Syndrome And Covid-19 Ards, Leah K. Shinn

Honors Undergraduate Theses

Background:

With the COVID-19 pandemic, there has been an influx of patients with acute respiratory distress syndrome (ARDS), an inflammatory lung condition. ARDS survivors are at high risk for developing post-traumatic stress disorder (PTSD) due to intensive care unit (ICU) medical treatments/procedures. They are known to have traumatic memories triggered by their sensorium months to years after being discharged from the ICU. One study found that 23% of ARDS survivors experienced long-term PTSD symptoms 2-3 years after hospital discharge (Bienvenu et al., 2018). Unknown is whether there are similarities in the memories and sensory triggers of PTSD amongst ARDS and …


Utilizing Outpatient Telehealth As A Treatment Approach For Patients With Substance Use Disorder: A Quality Improvement Project, Veronica Kwegyir-Afful Jan 2023

Utilizing Outpatient Telehealth As A Treatment Approach For Patients With Substance Use Disorder: A Quality Improvement Project, Veronica Kwegyir-Afful

DNP Scholarly Projects

Background: The issue of substance use disorder (SUD) has demonstrated a growing prevalence both in the United States (U.S.) and globally. Effective treatment modalities have been devised for individuals afflicted by SUD, thereby enabling their post-treatment prognosis to be parallel to that of patients with other chronic diseases, such as diabetes. However, several factors or barriers impede individuals with SUD from assessing treatment. These barriers encompass financial constraints stemming from inadequate insurance coverage and high cost, the stigma surrounding SUD, which results in patient's hesitancy to seek treatment treat, adverse societal attitudes, collateral social percussions like work hour losses and …


Sensory Marketing For Consumer Wellbeing, Josh Lundberg Jan 2023

Sensory Marketing For Consumer Wellbeing, Josh Lundberg

Theses and Dissertations--Marketing and Supply Chain

Chapter 1. Many consumer decisions – from trying a new brand to trying a new recipe – involve some risk. However, although consumers’ appetite for risk has received over fifty years of investigation, the impact of situational variables (e.g., atmospherics) on consumer decision making involving risk remains relatively unexplored. To address this gap, the current work examines the influence of temperature, a ubiquitous situational influence, on consumers’ inclination toward risk. Across four studies, we find evidence for a positive relationship between temperature and risk taking, using multiple manipulations of temperature and measurements of risk. Evidence suggests that this effect is …


Assessing 4-H And Its Circle Of Courage In A Psychiatric Residential Treatment Facility: A Case Study, Elizabeth Steering Jan 2023

Assessing 4-H And Its Circle Of Courage In A Psychiatric Residential Treatment Facility: A Case Study, Elizabeth Steering

Theses and Dissertations--Family Sciences

This 4-H case study takes place in a psychiatric residential treatment facility (PRTF) in Kentucky. The PRTF provides clinical services to youth that are not able to be safely maintained in their homes due to having demonstrated unsafe or harmful behaviors. Youth admitted to the PRTF stay for an average of three to six months while they receive intensive therapeutic and psychiatric care as well as medical treatment and public schooling. The current case study incorporates programming from 4-H, which is the youth development program of the Cooperative Extension System (CES) and the National Institute of Food and Agriculture (NIFA), …


Alternative Pharmacology: Exploring Ketamine Use For Treatment Resistant Mental Health Disorders, Kiersten L. Ash Jan 2023

Alternative Pharmacology: Exploring Ketamine Use For Treatment Resistant Mental Health Disorders, Kiersten L. Ash

Soaring: A Journal of Undergraduate Research

No abstract provided.


The Kynurenine Pathway In Alzheimer’S Disease: A Meta-Analysis Of Central And Peripheral Levels, Brisa S Fernandes, Mehmet Enes Inam, Nitesh Enduru, Joao Quevedo, Zhongming Zhao Jan 2023

The Kynurenine Pathway In Alzheimer’S Disease: A Meta-Analysis Of Central And Peripheral Levels, Brisa S Fernandes, Mehmet Enes Inam, Nitesh Enduru, Joao Quevedo, Zhongming Zhao

Faculty, Staff and Student Publications

OBJECTIVE: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer's disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine pathway metabolites are altered in AD.

METHODS: We performed a systematic review and random-effects meta-analyses. Inclusion criteria were studies that compared AD and cognitively normal (CN) groups and assessed tryptophan or kynurenine pathway metabolites in cerebrospinal fluid or peripheral blood.

RESULTS: Twenty-two studies with a total of 1,356 participants (664 with AD and 692 CN individuals) were included. Tryptophan was decreased only in peripheral …