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Articles 241 - 270 of 9590
Full-Text Articles in Psychiatry and Psychology
Requesting Less, Winning More: A Plaintiff Strategy To Eliminate Low-Value Anchors, Emily V. Shaw, Jade E. Larson
Requesting Less, Winning More: A Plaintiff Strategy To Eliminate Low-Value Anchors, Emily V. Shaw, Jade E. Larson
Mercer Law Review
Picture this: You are a plaintiffs’ lawyer representing a permanently injured client in a high-stakes lawsuit. You think you can earn millions of dollars for your client based on their injuries—but something is holding you back: your client’s past medical bills. To date, she has only had to pay around $20,000. You worry that this fact might make your request for several million dollars in non-economic damages seem excessive to a jury. So, you make a plan: on the eve of trial, you withdraw your request for economic damages and stick to only requesting non-economic damages in the millions. There …
Addressing Health Inequities For People With Intellectual And Developmental Disabilities In The Hospital Through Partnerships In Nurse Training, Suzannah Iadarola, Amanda Laprime, Samantha Hochheimer, Tabby Anvari, Carrie Baker, Jacqueline Goodman
Addressing Health Inequities For People With Intellectual And Developmental Disabilities In The Hospital Through Partnerships In Nurse Training, Suzannah Iadarola, Amanda Laprime, Samantha Hochheimer, Tabby Anvari, Carrie Baker, Jacqueline Goodman
Developmental Disabilities Network Journal
People with intellectual/developmental disabilities (IDD) deserve the same access to quality healthcare yet are at increased risk of medical and/or psychiatric conditions as compared to the general population. Patients with IDD have less health satisfaction, shorter life expectancy, less access to preventative care, higher chronic health conditions, overuse of certain medications, and increased mortality. This population and their caregivers report high levels of dissatisfaction with emergency/inpatient care. Nurses also express frustration with lack of training, limited resources, and competing priorities.
We developed the Advancing Supportive Care through Education for Nurses on Disability (ASCEND) Program, to build the capacity of inpatient/Emergency …
Sociodemographic Influences On Student-Athlete Eating Disorder Risk And Treatment-Seeking Behavior In The National College Health Assessment, Savannah Hughbanks, Andrew W. Froehle, Brian A. Edwards
Sociodemographic Influences On Student-Athlete Eating Disorder Risk And Treatment-Seeking Behavior In The National College Health Assessment, Savannah Hughbanks, Andrew W. Froehle, Brian A. Edwards
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Objective: The present study was developed to explicate attributes associated with increased likelihood of disordered eating behaviors and treatment avoidance and help practitioners better-identify and assist high-risk individuals.
Participants: Varsity athletes (n=51,882) who completed the National College Health Assessment (NCHA) between 2011 and 2019.
Methods: Data was collected from survey responses to questions related to disordered eating behaviors. Disorders were cross-sectioned into eight predictors: year in school, gender, sexual-orientation, race/ethnicity, school-type, international-student, history of mental health illness, and anxiety of impending academic performance.
Results: Two percent of the student-athletes self-reported an ED diagnosis, and within those two percent 65.9% reported …
Association Between Children’S Secondhand Co-Exposure To Tobacco And Cannabis Smoke And Elevated Urinary Cotinine Levels: A Cross-Sectional Analysis, Bradley N. Collins, Stephen J. Lepore, Vincent Berardi, Renee D. Goodwin, Karen Wilson, Mona Baishya
Association Between Children’S Secondhand Co-Exposure To Tobacco And Cannabis Smoke And Elevated Urinary Cotinine Levels: A Cross-Sectional Analysis, Bradley N. Collins, Stephen J. Lepore, Vincent Berardi, Renee D. Goodwin, Karen Wilson, Mona Baishya
Psychology Faculty Articles and Research
Background Cannabis use is far more common among adults who smoke tobacco than adults who do not, and its use is increasing among people who smoke tobacco with children living in the home. Given the well-established evidence that caregiver smoking is the primary source of children’s secondhand exposures to these products, the increasing trend in caregiver co-use is raising public health concerns about children’s co-exposure. Emerging data indicates that adult co-use is linked to additive health consequences, such as elevated nicotine and other tobacco-related toxicant blood levels, relative to use of only tobacco. It is unknown whether children’s co-exposure leads …
Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons
Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons
Journal of Counselor Preparation and Supervision
Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …
Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook
Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook
Journal of Counselor Preparation and Supervision
No person is without biases, even the most culturally adept among us. Managing biases is critical to counselors’ continued journey of understanding clients contextually and holistically. In this article, we describe two novel bias management concepts: A specific type of bias called saintly corrections and the more clinically fruitful approach of realistic corrections. We define and illustrate saintly and realistic corrections, outline a multifold approach (i.e., cognitive complexity, cultural identity development, and the multicultural orientation model) for remediating saintly corrections, and offer recommendations counselor educators can use during planned and contextual learning opportunities, including an example of a contextual …
Teaching Multicultural Counseling: A Phenomenological Exploration Of Counselor Educators’ Voices, Cameka Hazel, Paul Leheste, Raymond Blanchard
Teaching Multicultural Counseling: A Phenomenological Exploration Of Counselor Educators’ Voices, Cameka Hazel, Paul Leheste, Raymond Blanchard
Journal of Counselor Preparation and Supervision
This study explored the perceptions of counselor educators who taught the graduate level multicultural counseling course. Six participants shared experiences, leading to four themes: personal and professional rewards, who is fit to teach? dealing with resistance and difficult conversations and limited time and class size. Implications for counselor education are discussed.
Competencies And Preparation For Addressing Poverty In Counselor Education: A Q Methodological Study, Seneka Rachel Gainer
Competencies And Preparation For Addressing Poverty In Counselor Education: A Q Methodological Study, Seneka Rachel Gainer
Journal of Counselor Preparation and Supervision
This study explored the competencies needed to prepare counselors to address the systemic and relational impacts of poverty within counselor education. Using Q methodology, expert participants identified critical knowledge, skills, and awareness factors required for effective practice. Two distinct factors emerged: (1) the centrality of relational competencies such as empathy, cultural humility, and trust-building, and (2) the necessity for curriculum-wide integration of poverty-specific training and systemic advocacy. Findings highlight the need for counselor education programs to embed poverty-related competencies across curricula, foster interdisciplinary collaboration, and develop experiential and advocacy-based training models. Implications for counselor education, accreditation standards, and professional development …
Dismantling Racism In The Classroom: Recommendations For White Male Counselor Educators, Jason L. Vannest, Rebecca J. Vannest, Lorise D. Grey
Dismantling Racism In The Classroom: Recommendations For White Male Counselor Educators, Jason L. Vannest, Rebecca J. Vannest, Lorise D. Grey
Journal of Counselor Preparation and Supervision
In response to the historical tradition of Eurocentrism and Whiteness in counseling programs in the United States, the American Counseling Association (ACA) and the Association for Counselor Education and Supervision (ACES) have challenged their members to confront implicit bias, become allies with Black Indigenous People of Color (BIPOC), and commit to challenging racism and implicit bias. Despite these robust calls to disrupt racism and implicit bias, counselor educators - specifically White male counselor educators (WMCEs) - may wonder how to effectively take action due to their own racial identity. Several factors may contribute to WMCEs' reticence to deconstruct racism and …
Artificial Intelligence Literacy In Counselor Education: The Developmental Ai Literacy Framework, Leo Gonzalez Jr.
Artificial Intelligence Literacy In Counselor Education: The Developmental Ai Literacy Framework, Leo Gonzalez Jr.
Journal of Counselor Preparation and Supervision
Artificial intelligence (AI) is transforming counselor education, yet frameworks for preparing counselors-in-training (CITs) to use AI remain limited. This article introduces the developmental AI literacy framework (DALF), a conceptual model integrating developmental theory, professional identity formation, and AI literacy. The DALF reframes AI literacy as a developmental competency comprising intentional AI use, critical evaluation, ethical engagement, and awareness of professional identity. The framework outlines three stages, including foundational awareness, reflective application, and integrated professionalization, that parallel CITs’ growth from dependence to autonomy. Pedagogical, developmental, and research implications are provided to guide ethical and reflective AI integration in counselor education.
The State Of Mental Health In The Mountain West, 2025, Cason Noll, Anirudh Polagani, Taylor Volk, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.
The State Of Mental Health In The Mountain West, 2025, Cason Noll, Anirudh Polagani, Taylor Volk, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.
Health
This fact sheet presents data on the mental health of youth and adults, as well as the availability of mental health care, across the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah in 2025. The data are derived from "The State of Mental Health in America 2025,” originally published by Mental Health America (MHA).
Trends In The Psychedelic Renaissance: Applying Artificial Intelligence To Measure Media Portrayal Of Psychedelic Drugs In The 21st Century, David A. Bender, Harrison M. Dunn, Amanda Pekau, Arushi D. Mohite, Akila Anandarajah, Brendan D. Ross, Jacob Steinle, Suraj Shankar, Brandon Kiley, Umer Jalil
Trends In The Psychedelic Renaissance: Applying Artificial Intelligence To Measure Media Portrayal Of Psychedelic Drugs In The 21st Century, David A. Bender, Harrison M. Dunn, Amanda Pekau, Arushi D. Mohite, Akila Anandarajah, Brendan D. Ross, Jacob Steinle, Suraj Shankar, Brandon Kiley, Umer Jalil
School of Medicine Publications
Background: The relationship between media portrayal of psychedelic drugs, scientific research and drug policy is an area of debate.
Aims: To apply artificial intelligence technology to measure trends in media sentiment towards the therapeutic potential of psychedelic drugs.
Method: Up to 300 of the most relevant articles from Google News searches for the term 'psychedelics' were sampled for each year from 2000 to 2025. A large language model, ChatGPT, evaluated subject matter and sentiment.
Results: In total, 88.3% of screened URLs (3308 of 3747) were included in the analysis. The proportion of articles focusing on the therapeutic potential of psychedelics …
Post-Traumatic Stress And Post-Traumatic Growth: A Literary Lens On Trauma, Meaning, And Survival, Audrey Gruben
Post-Traumatic Stress And Post-Traumatic Growth: A Literary Lens On Trauma, Meaning, And Survival, Audrey Gruben
CAFE Symposium 2026
This project examines how literature provides insight into these differing trauma responses by comparing Man’s Search for Meaning by Viktor Frankl and Slaughterhouse-Five by Kurt Vonnegut. Drawing on contemporary psychological frameworks of PTSD and PTG, this analysis argues that psychological distress and growth are not mutually exclusive responses to trauma. Instead, they can coexist along a spectrum shaped by meaning-making, responsibility, avoidance, and engagement with suffering.
Comparing Sociological Suicide Studies In The 1800s To Psychological Suicide Studies Now, Amanda Mic
Comparing Sociological Suicide Studies In The 1800s To Psychological Suicide Studies Now, Amanda Mic
CAFE Symposium 2026
Sociology can look at the numbers and explain to us the physical, concrete facts about when, where, and how suicides happen, but psychology gives us an explanation as to why it happens. This project looks into the ways that 19th century societal stigmas around suicide caused inaccuracies in the statistics that sociologists studied, and therefore their findings, as well as the abundance of discoveries on suicide and mental conditions by psychologists in more recent times.
Emotional Intelligence : The Road To Professionalism Development, Wuttipat Iammeechai, Tanapat Prakairungtong
Emotional Intelligence : The Road To Professionalism Development, Wuttipat Iammeechai, Tanapat Prakairungtong
Chulalongkorn Medical Journal
Abstract
Medical professionalism development is a significant challenge of medical education, even though it is essential for medical practitioners. The Dynamics and ambiguity of medical professionalism cause difficulty in setting specific learning objectives, creating validated assessment methods, and designing effective teaching methodologies. Meanwhile, emotional intelligence is a growing area of study in medical education. There is a significant connection between medical professionalism and emotional intelligence. Certain attributes of emotional intelligence contribute to developing professionalism. Numerous pieces of literature illustrated emotional intelligence development and assessment in health professions education. Emotional intelligence is potentially the path to developing medical professionalism.
Psychological Correlates Of Audiological And Self-Report Indicators Of Hyperacusis In Adults With Misophonia, Mercedes G. Woolley, Karen F. Muñoz, Guadalupe G. San Miguel, Anderson Clements, Julie M. Petersen, Michael P. Twohig
Psychological Correlates Of Audiological And Self-Report Indicators Of Hyperacusis In Adults With Misophonia, Mercedes G. Woolley, Karen F. Muñoz, Guadalupe G. San Miguel, Anderson Clements, Julie M. Petersen, Michael P. Twohig
Psychology Student Research
Purpose:
Misophonia and hyperacusis are distinct sound sensitivity conditions that can co-occur and are linked to heightened emotional distress and impaired functioning. This study investigated the convergence between audiometric-based and self-reported indicators of hyperacusis and examined how each related to misophonia severity and psychological outcomes in adults with misophonia.
Method:
Participants (N = 60) completed self-report measures and underwent loudness discomfort level (LDL) testing.
Results:
Analyses revealed discrepancies between self-reported and LDL-defined hyperacusis, with no significant associations between LDL-based classifications and psychological or misophonia-related outcomes. In contrast, hyperacusis identified via a standardized self-report measure was significantly …
Information Distortion As A Source Of Overconfidence In Managerial Decisions, Peter Boyle, Pete Nye
Information Distortion As A Source Of Overconfidence In Managerial Decisions, Peter Boyle, Pete Nye
All Faculty Scholarship for the College of the Sciences
Managers confronting important strategic decisions often receive diagnostic information sequentially over time. As new information becomes available, they may need to update their understanding of the situation and possibly revise their preferences. During a decision, as a preference develops for one alternative course of action, a nonconscious goal of maintaining consistency between that preference, however tentative, and the new information can lead to an interpretation of that information so as to support the current preference. This tendency to bias or distort information to support the currently preferred option can in turn lead to even greater confidence in that leading option, …
Human Papillomavirus Vaccine Perceptions Among Noncollege Young Adults And Tiktok Influencers: Qualitative Study, Amelia Burke-Garcia, Dasha Afanaseva, Erin Cutroneo, Kayla Madden, Angela Sustaita-Ruiz, Estefany Rivera Sanchez, Amy Leader
Human Papillomavirus Vaccine Perceptions Among Noncollege Young Adults And Tiktok Influencers: Qualitative Study, Amelia Burke-Garcia, Dasha Afanaseva, Erin Cutroneo, Kayla Madden, Angela Sustaita-Ruiz, Estefany Rivera Sanchez, Amy Leader
Department of Medical Oncology Faculty Papers
BACKGROUND: Human papillomavirus (HPV) vaccination is a proven and effective tool for preventing several types of cancers, yet vaccination rates among young adults remain suboptimal, particularly among those not enrolled in 4-year colleges. This population can be more difficult to reach due to fewer established institutional touchpoints, limited engagement with campus-based health services, and greater variability in access to preventive care. At the same time, social media has become a dominant source of information for young adults, with TikTok (ByteDance) emerging as one of the most widely used platforms. Approximately 41% of TikTok's users are between the ages of 16 …
Predicting The Prognosis Of Primary And Substance-Associated Psychoses Using Urine Drug Screens: A 5-Year Retrospective Longitudinal Study Using Medical Records, Erich J. Aschenbrenner, Andrew C. Voluse
Predicting The Prognosis Of Primary And Substance-Associated Psychoses Using Urine Drug Screens: A 5-Year Retrospective Longitudinal Study Using Medical Records, Erich J. Aschenbrenner, Andrew C. Voluse
Psychiatry Publications
Substance use is frequently implicated in psychosis. However, the prognostic assumptions guiding differential treatment decisions between substance-induced and primary/affective psychoses have received inconsistent support. Substance-induced psychosis research has often been limited by aggregating substances or using diagnosis as both a grouping variable and an outcome (i.e., diagnostic conversion). The current study examined medical records for 1379 patients for 5 years following their first presentation with psychosis after January 2013 to a regional medical center. Clinically relevant outcomes were compared across groups defined by the substances detected in patients' urine at their initial presentation. Initial drug screen results predicted the initial …
Mom Is Developing Too: Preliminary Evidence For The Reciprocal Effects Of Infant Sensory Reactivity And Maternal Behavior, Emily C. Sweiss, Vincent Berardi, Elysia Poggi Davis, Curt A. Sandman, Laura M. Glynn
Mom Is Developing Too: Preliminary Evidence For The Reciprocal Effects Of Infant Sensory Reactivity And Maternal Behavior, Emily C. Sweiss, Vincent Berardi, Elysia Poggi Davis, Curt A. Sandman, Laura M. Glynn
Psychology Faculty Articles and Research
Caregiver sensitivity to infant cues is well-established as a predictor of child development. Infants also actively influence their social environment, especially their caregivers, even from their earliest days. Sensory reactivity, characterized as hypo- (under) and hyper- (over) responding to environmental stimuli, is one domain of development that is likely to influence caregiver-infant interaction, due to its role in regulating emotions and responses to both physical and social stimuli. Although sensory reactivity could be an important target for improving caregiver-child interaction, the longitudinal, reciprocal relations between infant sensory reactivity and caregiver behaviors are currently unknown. In the present proof-of-concept study, we …
Neuroinflammation And Its Role In Depression– A Review Of Emerging Biomarkers And Therapeutic Targets, Sophia M. Valerino
Neuroinflammation And Its Role In Depression– A Review Of Emerging Biomarkers And Therapeutic Targets, Sophia M. Valerino
Advances in Clinical Medical Research and Healthcare Delivery
Major depressive disorder (MDD) is a prevalent and debilitating mental illness that affects millions globally. Traditionally, the pathophysiology of MDD was thought to be due primarily neurotransmitter imbalances. However, emerging research highlights the role of neuroinflammation in MDD pathogenesis. Elevated levels of pro-inflammatory cytokines, microglial activation, and blood-brain barrier dysfunction have been implicated in the etiology of MDD. Additionally, biomarkers such as C-reactive protein and neuroimaging findings further support the neuroinflammatory hypothesis. This growing body of evidence has led to increased interest in novel treatment approaches, including anti-inflammatory medications and lifestyle interventions, as potential therapeutic strategies. While selective serotonin reuptake …
Mindfulness Approach Used To Reduce The Impact Of Internalized Psychopathology: Anxiety And Depression, Taniyah Drayton
Mindfulness Approach Used To Reduce The Impact Of Internalized Psychopathology: Anxiety And Depression, Taniyah Drayton
The Kean Review: Journal in Student Research
The emergence of mindfulness practices has increased in medical spaces throughout recent years. Mindfulness was once seen strictly for its spiritual origins, yet beginning in the late 20th century it began being assessed for its reliability in treating individuals who experienced extreme levels of pain and stress. Its origin “is often spoken of as ‘the heart of Buddhist meditation,’” as Kabat-Zinn discusses (Kabat-Zinn, 2011). Kabat-Zinn, founder of the Stress Reduction Clinic at the University of Massachusetts Medical School, introduced a new translation for mindfulness in 1979 through highlighting the skills individuals can learn and apply throughout their daily life. Kabat-Zinn …
Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson
Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson
Psychology Faculty Publication Series
Humanity is evolving its consciousness at individual and collective levels. Given these seemingly tumultuous times, as of this writing (January 2026), to make such a statement may sound like a strange thing to say. However, I suggest that if you are alive today and if you are reading these words, these are the very times for which you were born—to assist Humanity as it evolves its consciousness with your unique gifts, whatever they may be. That is, this period of our individual and collective human being-ness may be characterized as an unfolding period of weeding out and alignment with the …
Association, Affect, And Material Reading Practices Of Anna Laetitia Barbauld, Renee Harris
Association, Affect, And Material Reading Practices Of Anna Laetitia Barbauld, Renee Harris
ABO: Interactive Journal for Women in the Arts, 1640–1830
At the end of the eighteenth century, reading practice was shifting from an embodied, affective exercise to a detached cognitive one. This essay examines how debates about truth and knowledge diverged along disciplinary and gender lines during this critical transition. The essay traces the influence of association psychology—particularly the theories of David Hartley and Joseph Priestley—on Romantic-era poets including Anna Laetitia Barbauld and Samuel Taylor Coleridge. Through Feminist Formalist Analysis attuned to affect and cognition, this essay demonstrates how Barbauld's poetic montages challenge the period's scientific discourse. Her "Inventory of the Furniture in Dr. Priestley's Study" and two "Hill of …
Unlocking Hope: Mirtazapine's Promise In Obsessive-Compulsive Disorder Treatment, Rebecca K. Hicks, Iram Kingson, Jordan Gaal, Suzanne Holroyd
Unlocking Hope: Mirtazapine's Promise In Obsessive-Compulsive Disorder Treatment, Rebecca K. Hicks, Iram Kingson, Jordan Gaal, Suzanne Holroyd
Marshall Journal of Medicine
Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric condition characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions). While selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) are first-line treatments for OCD, a significant proportion of patients remain refractory to these interventions. Mirtazapine, an atypical antidepressant with unique pharmacological properties, has emerged as a potential adjunctive therapy for treatment-resistant OCD. This review synthesizes existing evidence regarding the efficacy and safety profile of mirtazapine in OCD management. We analyze clinical trials, observational studies, and case reports, distinguishing high- vs. low-quality evidence, and discuss mechanisms underlying mirtazapine's therapeutic effects. Additionally, …
Mental Health First Aid Training In K-12 Schools, Jenna L. Workman, Brianna L. Schierberg, Grace H. Sullivan, Erin Robinson
Mental Health First Aid Training In K-12 Schools, Jenna L. Workman, Brianna L. Schierberg, Grace H. Sullivan, Erin Robinson
Posters-at-the-Capitol
The increasing prevalence of mental health challenges among school-aged children has become a rising public health concern. Recent data indicates that nearly 70% of schools report heightened mental health problems among students, with anxiety and depression being most common (National Center for Education Statistics, 2024). The purpose of this capstone project is to raise awareness of mental health issues in K–12 public schools and to increase faculty and staff confidence in recognizing and assisting students experiencing mental health difficulties through nurse-led Mental Health First Aid (MHFA) training. Using Peplau’s Interpersonal Relations Theory as a guiding framework, this project emphasizes the …
Increasing Participation Through Online Focus Groups With Adults With Intellectual Disabilities, Emily L. Cary, Chris A. Taylor, Susan Havercamp, Andrea Witwer
Increasing Participation Through Online Focus Groups With Adults With Intellectual Disabilities, Emily L. Cary, Chris A. Taylor, Susan Havercamp, Andrea Witwer
Developmental Disabilities Network Journal
The aim of this study was to develop and describe methods on how to conduct virtual focus groups with adults with intellectual disability. Using a community-engaged research approach, adults with intellectual and developmental disabilities helped develop virtual focus group methods. We report on the implementation of these methods through an illustrative application of applying these adaptations to virtual focus groups with 13 adults with intellectual disability in a study assessing their perspectives on mental health therapy.
This work resulted in several adaptations that can enhance inclusivity of focus group research to individuals with intellectual disability. Adaptions broadly included: involving guardians …
Clinical, Imaging And Blood Biomarker Outcomes In A Phase 3 Clinical Trial Of Tau Aggregation Inhibitor Hydromethylthionine Mesylate In Mild Cognitive Impairment And Mild To Moderate Dementia Due To Alzheimer’S Disease, Claude Wischik, Richard G. Stefanacci, Peter Bentham, Serge Gauthier, Henrik Zetterberg, Gordon Wilcock, Lutz Froelich, Alistair Burns, Emer Macsweeney, Clive Ballard, Jin-Tai Yu, Tay Siew Choon, Vahe Asvatourian, Natalia Muehlemann, Jan Priel, Karin Kook, Tenecia Sullivan, Diane Downie, Sonya Miller, Carol Pringle, John Storey, Tom Baddeley, Charles R Harrington, Lewis Penny, Mohammad Arastoo, Roger Staff, Anca-Larisa Sandu, Helen Shiells, Serena Lo, Nafeesa Nazlee, Emily Evans, Claire Hull, Bjoern Schelter
Clinical, Imaging And Blood Biomarker Outcomes In A Phase 3 Clinical Trial Of Tau Aggregation Inhibitor Hydromethylthionine Mesylate In Mild Cognitive Impairment And Mild To Moderate Dementia Due To Alzheimer’S Disease, Claude Wischik, Richard G. Stefanacci, Peter Bentham, Serge Gauthier, Henrik Zetterberg, Gordon Wilcock, Lutz Froelich, Alistair Burns, Emer Macsweeney, Clive Ballard, Jin-Tai Yu, Tay Siew Choon, Vahe Asvatourian, Natalia Muehlemann, Jan Priel, Karin Kook, Tenecia Sullivan, Diane Downie, Sonya Miller, Carol Pringle, John Storey, Tom Baddeley, Charles R Harrington, Lewis Penny, Mohammad Arastoo, Roger Staff, Anca-Larisa Sandu, Helen Shiells, Serena Lo, Nafeesa Nazlee, Emily Evans, Claire Hull, Bjoern Schelter
College of Population Health Faculty Papers
BACKGROUND: Hydromethylthionine mesylate (HMTM) targets tau pathology and has tau-independent symptomatic activity.
OBJECTIVES: To evaluate the safety and efficacy of HMTM in participants with mild cognitive impairment (MCI) and mild to moderate dementia due to Alzheimer's disease (AD).
SETTING: 82 centres in Canada, European Union, United Kingdom and United States of America.
PARTICIPANTS: A total of 598 amyloid β-PET positive participants were included; 44% (263) met clinical criteria for MCI due to Alzheimer's disease and 56% (335) were diagnosed with mild to moderate dementia due to AD.
INTERVENTION: HMTM 16 mg/day and 8 mg/day were compared with methylthioninium chloride (MTC) …
Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy
Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy
Psychology Faculty Articles and Research
Background and aim
Higher dietary flavonoid intake has been associated with lower risks of mortality and major chronic disease, yet its relationship with psychological well-being (PWB), a key contributor to health and quality of life, remains unclear. This study aimed to investigate bidirectional associations between dietary flavonoid intake and two PWB facets: happiness (positive emotional state) and optimism (generalized expectation of positive outcomes). Specifically, we examined whether (1) overall flavonoid-rich dietary patterns (flavodiet score), (2) intake of specific flavonoid-rich foods, and (3) total flavonoid and subclass intakes were each associated with happiness and optimism over time.Methods
Data were drawn …Elevated Trna Halves In Olfactory Epithelial Cells Of Patients With Schizophrenia, Justin T. Gumas, Megumi Shigematsu, Karin E. Borgmann-Winter, C. G. Hahn, Yohei Kirino
Elevated Trna Halves In Olfactory Epithelial Cells Of Patients With Schizophrenia, Justin T. Gumas, Megumi Shigematsu, Karin E. Borgmann-Winter, C. G. Hahn, Yohei Kirino
Computational Medicine Center Faculty Papers
Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.