Other Medicine and Health Sciences Commons^™

Potential Cellular Mechanisms Of Estrogen's Effects On Maintaining Sperm Production In Aging Rats, Matthew Pate

Honors Theses

Testosterone production by Leydig cells declines during aging in both men and rodent models. Previous results from our lab demonstrated that daily sperm production also declines in aging rats and alterations in the estrogen environment of the testis contribute to this decline. Importantly, estrogen treatment during aging was able to attenuate the age-associated decline in sperm production. However, the cellular and molecular mechanisms by which estrogen maintains sperm production remain unclear. These experiments were designed to further investigate the effects of estrogen on sperm production in an attempt to further define the cellular mechanisms regulated by estrogen within the testis. …

Street Drug Markets Beyond Favelas In Belo Horizonte, Brazil, Elenice De Souza Oliveira, Braulio Figueiredo Alves Silva, Marcos Oliveira Prates

Department of Justice Studies Faculty Scholarship and Creative Works

This study examines whether social disorganization mechanisms that explain clusters of street drug markets in socially disorganized neighborhoods in developed countries can also help explain geographical patterns of drug dealing across neighborhoods in Belo Horizonte, Brazil. Data for this study includes drug arrests from 2007 to 2011 and socio demographic data from the 2010 Census. To examine the influence of exploratory variables on drug market locations, the Negative Binominal regression model was used at two levels of analysis—the Belo Horizonte city center and other neighborhoods including favelas. The findings show that a high hot spot of street drug markets located …

Muscle Cramping During A 161-Km Ultramarathon: Comparison Of Characteristics Of Those With And Without Cramping, Martin D. Hoffman, Kristin J. Stuempfle

Health Sciences Faculty Publications

Background: This work sought to identify characteristics differing between those with and without muscle cramping during a 161-km ultramarathon.

Methods: In this observational study, race participants underwent body weight measurements before, during, and after the race; completed a post-race questionnaire about muscle cramping and “near” cramping (controllable, not reaching full-blown cramping), drinking strategies, and use of sodium supplementation during four race segments; and underwent a post-race blood draw for determination of serum sodium and blood creatine kinase (CK) concentrations.

Results: The post-race questionnaire was completed by 280 (74.5 %) of the 376 starters. A post-race blood sample was provided by …

Today - December 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Terrorist bullets shatter the peace of the holidays in San Bernardino and neighboring communities
-- Loma Linda University Health family remembers victims
-- Advancement team Christmas gathering reflects tragedy and hope
-- Media relations ream inundated with inquiries
-- Faculty and students profess solidarity with victims of San Bernardino terrorist attack
-- Flag of Hope promotes unity, peace, and healing
-- Second graders make Christmas cards for LLUMC emergency department
-- Food distribution event at Highland Springs Medical Plaze provides food supplies for local area families in need
-- Charity Navigator gives LLU coveted 4-star rating …

Mechanisms By Which Dietary Ellagic Acid Attenuates Obesity And Obesity-Mediated Metabolic Complications, Inhae Kang

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Ellagic acid (EA) is a polyphenol found in various fruits and plants, such as berries, pomegranates, muscadine grapes, nuts and bark of oak tree. EA has been known to exhibit anti-inflammatory and anti-proliferative effects in various types of cancer. However, little is known about the effects of EA on obesity. Herein, 1) the lipid-lowering role of EA was identified in primary human adipose stem cells (hASCs) and human hepatoma Huh7 cells; 2) the molecular mechanisms by which EA attenuates adipogenesis by epigenetic modification were identified; 3) the effects of EA on high fat and high sucrose-mediated obesity was …

Alumni Journal - Volume 86, Number 3, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
10 | A Call for Medical Missionaries
12 | They Helped to Establish This Noble Legacy
14 | The Evolution of Graduation
22 | Graduation 2015

Departments
2 | From the Editor
3 | This and That
4 | From the President
5 | From the Dean
6 | The Student Fund
8 | School of Medicine News
38 | AIMS Report
40 | Book Review
42 | Alumni News
43 | In Memoriam
49 | What's Up Doc?

Extras
24 | Note from the Class of 2015 President
48 | 1 Corinthians 13 - Revised Medicalized Version

Fair Weight Loss After Gastric Rebanding For Slippage, Ahmed Dalmar, Maharaj Singh, Sara K. Roloff, Thomas Y. Chua

Journal of Patient-Centered Research and Reviews

Background: Laparoscopic adjustable gastric banding (LAGB) is one of the most common bariatric surgery procedures performed in the United States. LAGB results in safe and satisfactory weight loss, but it is often complicated with slippage, a complication requiring rebanding (reoperation). There is a paucity of studies and no uniform consensus regarding weight loss after rebanding.

Purpose: This study assessed the effect of rebanding for slippage after LAGB on weight loss up to five years.

Methods: This is a historical cohort study of 865 patients who underwent LAGB from 2001 to 2011. Rebanding was performed in 103 (11.9%) patients. Primary outcome …

Today - November 2015, Loma Linda University Health

TODAY

In this issue:

-- First hospital-based proton center hosts celebratory events with reunion of hundreds of former patients and families
-- SAC Health Systems celebrates 20 years of health care to San Bernardino residents
-- New global initiative brings dermatological telemedicine to rural communities on the African continent
-- Loma Linda University Health employees enjoy excellent health care benefits and low premiums
-- The Children's Hospital and Proton Treatment and Research Center: a rare combination
-- Team-building program at Drayson Center brings people together through play
-- More than 2,000 people attend Family Health Fair and 5k run
-- Dishes …

Current Opinion In The Role Of Testosterone In The Development Of Prostate Cancer: A Dynamic Model, Xiaohui Xu, Xinguang Chen, Hui Hu, Amy B. Dailey, Brandie D. Taylor

Health Sciences Faculty Publications

Background: Since the landmark study conducted by Huggins and Hodges in 1941, a failure to distinguish between the role of testosterone in prostate cancer development and progression has led to the prevailing opinion that high levels of testosterone increase the risk of prostate cancer. To date, this claim remains unproven.

Presentation of the Hypothesis: We present a novel dynamic mode of the relationship between testosterone and prostate cancer by hypothesizing that the magnitude of age-related declines in testosterone, rather than a static level of testosterone measured at a single point, may trigger and promote the development of prostate cancer.

Testing …

Loma Linda University Health - San Bernardino Groundbreaking, Loma Linda University Health

Scope

Table of Contents

Features

2 | New facility in San Bernardino to enhance opportunities
4 | Loma Linda shares its story with world church

Campus news

8 | Historic step taken toward unified governance
9 | Quarter-century milestones celebrated
10 | School of Public Health conferences lead the way

Clinical care

11 | Children’s Hospital receives separate license
11 | Pediatric ICU celebrates 25 years of service
12 | Clinicians train with FEMA for disasters
14 | Woman regains her life through bariatric surgery

Research

15 | Grant enables purchase of next-generation DNA sequencer
16 | Potholes and primordial mysteries: …

Today - October 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Pro surfer and shark attack survivor Bethany Hamilton speaks at PossAbilities luncheon and fundraiser
-- Murry Brandstater honored by donor through special gift
-- Perryman named administrator for Loma Linda University Children's Hospital
-- Chinnock appointed Children's Hospital chief medical officer
-- Becker named director of Loma Linda University Health office of public relations
-- ENT professors teach vocal and choral students to protect their voices
-- Internal medicine residency program celebrates 50 years
-- Loma Linda University Health awarded $1.4 million grant for San Bernardino Campus
-- Corky's Cookies raises $10,000 for pediatric cancer treatment …

Today - September 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Anonymous donor honors three long-time Loma Linda physicians
-- LLUMC - Murrieta accredited as chest pain center
-- SAC Health System granted new status by federal government
-- Nursing dean attends executive training at Wharton School
-- Congressman tours Children's Hospital and research facilities
-- Leadership team from Naval Hospital Twentynine Palms visits Medical Center
-- LLUMC - Murrieta to hold Family Health Fair on Sept. 27
-- School of Public Health presents 'Asthma Theatre' program at Riverside County Office of Education Head Start training
-- End-of-life issues explored and discussed during screening of the PBS …

Development Of Soft-Matter Delivery Systems: Coupling Ph Responsive Polymers To Porous Silica Particles, Andrew Gomez

Biomedical Engineering ETDs

This work investigates polymeric coating of evaporated induced self-assembly (EISA) mesoprous silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for dynamic response to environmental stimuli. In addition to coupling commercially available diblock polymers we synthesized and characterized a unique dual hydrophilic pH responsive diblock copolymer, PEO-PAA. This hybrid polymeric-nanoparticle system drastically improves targeting and release capabilities through the modular ability to couple multiple different polymers. Furthermore, this work is supported by an improved method to form and study giant polymer vesicles (pGVs)

Alumni Journal - Volume 86, Number 2, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
8 | Interview: To Know the Truth
12 | Rec Hall No More
16 | APC 2015 in Review
30 | Law and Medicine

Departments
2 | From the Editor
3 | This and That
4 | From the President
5 | From the Dean
6 | School of Medicine News
42 | AIMS Report
44 | Alumni News
45 | In Memoriam
48 | Historical Snapshot
49 | What's Up Doc?

Extras
14 | 2014 Class Giving Report
19 | Dr. Bob's Programs
31 | The Good Samaritan (a poem)
40 | Leaving a Mark on Dr. Shryrook

Today - August 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Final beam is placed for Loma Linda University Health - San Bernardino in topping-off ceremony
-- Loma Linda University Transplantation Institute leads all of Southern California in liver transplant survival
-- Cancer Center receives UniHealth Foundation grant
-- Innerweave The Wholeness Story
-- Center for Health Disparities holds annual research symposium
-- Off to work . . . one woman's story of retirement
-- Cheng Family Foundation presents $75,000 gift to Loma Linda University Eye Institute for children's intervention program
-- IndyCar racer visits Children's Hospital outpatient clinic
-- Loma Linda University Health reaches out to …

Negative Skeletal Effects Of Locally Produced Adiponectin, Marcia J. Abbott, Theresa M. Roth, Linh Ho, Liping Wang, Dylan O'Carroll, Robert A. Nissenson

Health Sciences and Kinesiology Faculty Articles

Epidemiological studies show that high circulating levels of adiponectin are associated with low bone mineral density. The effect of adiponectin on skeletal homeostasis, on osteoblasts in particular, remains controversial. We investigated this issue using mice with adipocyte-specific over-expression of adiponectin (AdTg). MicroCT and histomorphometric analysis revealed decreases (15%) in fractional bone volume in AdTg mice at the proximal tibia with no changes at the distal femur. Cortical bone thickness at mid-shafts of the tibia and at the tibiofibular junction was reduced (3–4%) in AdTg mice. Dynamic histomorphometry at the proximal tibia in AdTg mice revealed inhibition of bone formation. AdTg …

Paramedicine And Social Work: Case Studies In Authentic Student Recruitment, Nathalie Collins, Lynelle Watts, Renee Strauss, David Hodgson

eCULTURE

Selling the course experience to future students has been corporatised across the Higher Education sector. At many universities marketing and sales specialists, such as ECU’s Student Recruitment Team, rather than academic staff, field prospective student enquiries. Representing courses authentically is crucial to matching future students with an appropriate course experience and career, as well is managing future students’ expectations. A challenge for academics is communicating the course/career experience to university sales agents (recruiters). A challenge for recruiters is conveying an authentic course experience to future students when they have not taken a course themselves. This paper selects two ECU courses, …

Statement Of The Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015, Tamara Hew-Butler, Mitchell H. Rosner, Sandra Fowkes-Godek, Jonathan P. Dugas, Martin D. Hoffman, Douglas P. Lewis, Ronald J. Maughan, Kevin C. Miller, Scott J. Montain, Nancy J. Rehrer, William O. Roberts, Ian R. Rogers, Arthur J. Siegel, Kristin J. Stuempfle, James Winger, Joseph G. Verbalis

Health Sciences Faculty Publications

The third International Exercise-Associated Hyponatremia (EAH) Consensus Development Conference convened in Carlsbad, California in February 2015 with a panel of 17 international experts. The delegates represented 4 countries and 9 medical and scientific sub-specialties pertaining to athletic training, exercise physiology, sports medicine, water/sodium metabolism, and body fluid homeostasis. The primary goal of the panel was to review the existing data on EAH and update the 2008 Consensus Statement.¹ This document serves to replace the second International EAH Consensus Development Conference Statement and launch an educational campaign designed to address the morbidity and mortality associated with a preventable and treatable …

Today - July 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Thousands experience Loma Linda University Health at 60th General Conference Session
-- Empowering teachers: EXSEED trains K-12 educators in the art of teaching STEM
-- LLUMC Murrieta named 'Most Wired' by American Hospital Association for second consecutive year
-- Twins overcome insurmountable odds to celebrate first berthday
-- Worldwide delegates from General Conference session tour Loma Linda University Health campus
-- The importance of child health care spans across continents
-- Memory of Cancer Center patients lives on
-- Why go on a mission trip?
-- President's Award recipients represent that University's best
-- Ralph Lee …

Attitudes Toward Death Anxiety And Dying Among Respiratory Therapy Students: A Pilot Study, Kevin Collins, S. Gregory Marshall, Philip Vaughan

Internet Journal of Allied Health Sciences and Practice

Objective: To evaluate relative and absolute reliability and repeatability in assessing median nerve mobility at the level of the wrist and distal upper arm of the right upper extremity during wrist extension. Methods: Six healthy participants participated in the study. Median nerve mobility was captured three times at both sites using Sonocyte Turbo by two sonologists for a total of 72 video clips (36 for each site and 18 by each sonologist). Longitudinal movement was measured using Motion Tracking Analysis Program (MTAP) by the two assessors who were rehabilitation medicine residents. After one month, the assessors remeasured the longitudinal excursion …

Today - June 29, 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Loma Linda University celebrates 1,480 newest alumni
-- University celebrates honorees during ceremonies
-- Safe Kids and Children's Hospital host media event for water safety awareness
-- Zipcar, which brought car sharing to Loma Linda University Health, may expand
-- Kids learn to trust care providers during teddy bear clinic
-- Annual Celebration of Life provides heartfelt laughter, inspiration and hope
-- Food and family are important to LLUMC - Murrieta chef
-- Official negotiations begin for affiliation with San Gorgonio Memorial Hospital
-- Study finds increasing respiratory risks for children living near major rail yards …

Commencement Program 2015, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2015 Events of Commencement

5 | The Academic Procession

7 | Significance of Academic Regalia

9 | The Good Samaritan

10 | University History Highlights

12 | Loma Linda University Song - "Healing Love"

13 | The Speakers

23 | The University Honorees

45 | The School Honorees

72 | The Programs

• School of Medicine, 73
• School of Pharmacy, 95
• School of Dentistry, 103
• School of Allied Health Professions, 122
• School of Allied Health Professions - Physical Therapy, 143
• School of Public Health, 154
• School of Behavioral Health and School of …

Designing An Effective User Interface For A Mobile Application, Cynthia N. Kim

Graphic Communication

The purpose of this study was to determine the best user interface design practices for an iOS mobile application created for Pre-R, a local start-up company that offers physician house calls and telemedicine services throughout San Luis Obispo. The study included initial background research on best user interface design practices, mapping out and implementing the entire process of designing for mobile applications, conducting usability tests on potential users, and making changes according to the test results. Usability tests allowed for a greater understanding of the effectiveness of Pre-R’s mobile interface design prototype. Results from the usability tests have indicated a …

Diagnoses, Intervention Strategies, And Rates Of Functional Improvement In Integrated Behavioral Health Care Patients, Ana J. Bridges, Samantha J. Gregus, Juventino Hernandez Rodriguez, Arthur R. Andrews Iii, Bianca T. Villalobos, Freddie A. Pastrana, Timothy A. Cavell

Psychological Science Faculty Publications

Objective—Compared with more traditional mental health care, integrated behavioral health care (IBHC) offers greater access to services and earlier identification and intervention of behavioral and mental health difficulties. The current study examined demographic, diagnostic, and intervention factors that predict positive changes for IBHC patients.

Method—Participants were 1,150 consecutive patients (mean age = 30.10 years, 66.6% female, 60.1% Hispanic, 47.9% uninsured) seen for IBHC services at 2 primary care clinics over a 34-month period. Patients presented with depressive (23.2%), anxiety (18.6%), adjustment (11.3%), and childhood externalizing (7.6%) disorders, with 25.7% of patients receiving no diagnosis.

Results—The most commonly …

Today - May 15, 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Commencement ceremonies in May and June will celebrate Loma Linda University class of 2015
-- Dexter Emoto honored by grateful patient with Healing Hands recognition
-- First-ever Family Fitness Fun 5K & Expo may not be the last
-- Physicians leads the way with robotic surgery
-- LLUMC-Murrieta brings robotic surgery to the Murrieta/Temecula Community
-- 25th Annual Proton Charity Golf Tournament reaches $3.5 million total raised
-- Annual Children's Day, presented by Farmer Boys, marks 30 years of health education and interactive fun
-- PossAbilities Triathlon Draws 1,150 participants
-- Debbie Chisholm Memorial Foundation representatives …

Knowledge, Attitudes, And Behaviors Related To Emergency Contraception Among College Students, Sarah Donohue

Senior Honors Projects, 2010-2019

More than 50% of pregnancies in the United States are unplanned. Though recent regulations have expanded access to EC, the numerous policy changes, lack of knowledge, and unreliable sources of information regarding EC prevent women from utilizing the benefits that EC can offer.

The purpose of this study was to assess students’ knowledge and attitudes about emergency contraception (EC) and to determine if there is a relationship between sexual behaviors and the use of EC. Two hundred and twelve undergraduate students from James Madison University completed an anonymous 29-question survey regarding EC.

Results indicated that students were reasonably knowledgeable regarding …

Teaching Behaviors In Athletic Training Education And Student Perceptions Of Instructional Effectiveness, Elizabeth J. Walters

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

No abstract provided.

Effect Of Novel Dietary Supplement On Metabolism In Vitro And In Vivo, Robert A. Vaughan, Ailish C. White, Jason R. Beam, Nicholas P. Gannon, Randi Garcia-Smith, Roy M. Salgado, Marco Bisoffi, Kristina A. Trujillo, Carole A. Conn, Christine M. Mermier

Health Sciences and Kinesiology Faculty Articles

Obesity is an increasingly prevalent and preventable morbidity with multiple behavioral, surgical and pharmacological interventions currently available. Commercial dietary supplements are often advertised to stimulate metabolism and cause rapid weight and/or fat loss, although few well-controlled studies have demonstrated such effects. We describe a commercially available dietary supplement (purportedly containing caffeine, catechins, and other metabolic stimulators) on resting metabolic rate in humans, and on metabolism, mitochondrial content, and related gene expression in vitro. Human males ingested either a placebo or commercially available supplement (RF) in a randomized double-blind placebo-controlled cross-over fashion. Metabolic rate, respiratory exchange ratio, and blood pressure were …

Bridging The Location Gap: Physician Perspectives Of Physician-Pharmacist Collaboration In Patient Care (Bridge Phase Ii), Keri D. Hager, Donald Uden, Daniel M. Tomaszewski

Pharmacy Faculty Articles and Research

Background: To optimize patient outcomes, the patient-centred medical home model emphasizes comprehensive team-based care. Pharmacists are qualified to enhance appropriate medication use and help improve patient outcomes through provision of medication therapy management (MTM) services. To optimally provide MTM, pharmacists must effectively collaborate with physicians. This study explored factors that influence pharmacist-physician collaboration.

Methods and Findings: A convenience sample of five physicians participated in semi-structured interviews and the resulting data were analyzed using qualitative methods. Transcripts of the interviews were independently coded for themes by two researchers. Five themes emerged: trustworthiness, role specification, relationship initiation, effects on practice, …

Radiography Faculty Perceptions Of The Effectiveness Of Asynchronous Online Courses, Shirley J. Cherry

Electronic Theses and Dissertations

The purpose of this study was to assess radiography faculty perceptions of the effectiveness of asynchronous online courses. Learning effectiveness in a web-based virtual learning environment (VLE) was the conceptual framework for this project (Piccoli, Ahmad, & Ives, 2001). For the purposes of this study, learning effectiveness was defined as the quality of learning being comparable between online and traditional courses (Moore, 2011).

Ten research questions were used to guide this study, and statistical tests were conducted to evaluate 17 null hypotheses. The statistical tests included use of one-way analysis of variance (ANOVA), Pearson correlations, and single-sample t-tests. Ten of …