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Full-Text Articles in Other Medicine and Health Sciences
Tgfβ3 Inhibits E-Cadherin Gene Expression In Palate Medial-Edge Epithelial Cells Through A Smad2-Smad4- Lef1 Transcription Complex, Ali Nawshad, Damian Medici, Chang-Chih Liu, Elizabeth D. Hay
Tgfβ3 Inhibits E-Cadherin Gene Expression In Palate Medial-Edge Epithelial Cells Through A Smad2-Smad4- Lef1 Transcription Complex, Ali Nawshad, Damian Medici, Chang-Chih Liu, Elizabeth D. Hay
College of Dentistry: Faculty Publications
Dissociation of medial-edge epithelium (MEE) during palate development is essential for mediating correct craniofacial morphogenesis. This phenomenon is initiated by TGFβ3 upon adherence of opposing palatal shelves, because loss of E-cadherin causes the MEE seam to break into small epithelial islands. To investigate the molecular mechanisms that cause this E-cadherin loss, we isolated and cultured murine embryonic primary MEE cells from adhered or non-adhered palates. Here, we provide the first evidence that lymphoid enhancer factor 1 (LEF1), when functionally activated by phosphorylated Smad2 (Smad2- P) and Smad4 (rather than β-catenin), binds with the promoter of the E-cadherin gene to repress …
Dental Hygiene Participation In Managing Incipient And Hidden Caries, Caren M. Barnes
Dental Hygiene Participation In Managing Incipient And Hidden Caries, Caren M. Barnes
College of Dentistry: Faculty Publications
The essence of dental hygiene practice includes the use of preventive and therapeutic methods for the promotion of good health and to prevent and control oral diseases. Dental hygienists actively promote the prevention of oral diseases through patient education that encourages self-care prevention of dental caries, supplemented by needs-related professional preventive services. Equally significant in the scope of dental hygiene practice are thorough oral examinations for disease detection. Although dental hygienists do not legally or definitively diagnose dental caries, they are responsible for detecting caries at all stages of the disease, recognizing caries risk factors, and planning management strategies. Because …
The Effects Of A Commercial Aluminum Airpolishing Powder On Dental Restorative Materials, William W. Johnson, Caren M. Barnes, David A. Covey, Mary P. Walker, Judith A. Ross
The Effects Of A Commercial Aluminum Airpolishing Powder On Dental Restorative Materials, William W. Johnson, Caren M. Barnes, David A. Covey, Mary P. Walker, Judith A. Ross
College of Dentistry: Faculty Publications
Introduction: JET-Fresh™ (Dentsply International, York, PA), a new airpolishing powder that contains aluminum trihydroxide as the abrasive agent, has been introduced for use with Prophy-Jet™ (Dentsply International).
Purpose: The aim of this study was to investigate the surface effects of aluminum trihydroxide airpolishing powder on a series of restorative materials.
Materials and Methods: A total of 6 Class V preparations with enamel margins were created on the buccal surface of extracted human molars. The preparations were restored with Type III gold, a high copper spherical alloy amalgam, porcelain, a lightactivated hybrid composite material, a light-activated microfilled composite material, and a …
The Formin-Homology-Domain-Containing Protein Fhod1 Enhances Cell Migration, Sreenivas Koka, Cheryl L. Neudauer, Xiaodong Li, Robert E. Lewis, James B. Mccarthy, Jennifer J. Westendorf
The Formin-Homology-Domain-Containing Protein Fhod1 Enhances Cell Migration, Sreenivas Koka, Cheryl L. Neudauer, Xiaodong Li, Robert E. Lewis, James B. Mccarthy, Jennifer J. Westendorf
College of Dentistry: Faculty Publications
Formin-homology-domain-containing proteins interact with Rho-family GTPases and regulate actin cytoskeleton organization and gene transcription. FHOD1 is a member of this family, interacts with Rac1 and induces transcription from the serum response element. In this study, we examined the effects of FHOD1 expression on cytoskeletal organization and function in mammalian cells. FHOD1 proteins were stably expressed in WM35 melanoma cells and NIH-3T3 fibroblasts. Cells expressing full-length FHOD1 demonstrated an elongated phenotype compared with vector-transfected cells and cells expressing a truncated FHOD1 (1-421) that lacks the conserved FH1 and FH2 domains. Full-length FHOD1 co-localized with filamentous actin at cell peripheries. Cells transiently …
Effects Of An Air-Powder Polishing System On Orthodontically Bracketed And Banded Teeth, Caren M. Barnes, Carl M. Russell, Laurence R. Gerbo, Bobby R. Wells, David Barnes
Effects Of An Air-Powder Polishing System On Orthodontically Bracketed And Banded Teeth, Caren M. Barnes, Carl M. Russell, Laurence R. Gerbo, Bobby R. Wells, David Barnes
College of Dentistry: Faculty Publications
Since the introduction of air-powder polishing systems in 1977, air-powder polishing has been shown to be an efficient and effective method for removal of stain and plaque. Air-powder polishing systems use air, water, and sodium bicarbonate to deliver a controlled stream that propels specially processed sodium bicarbonate particles to the tooth surface. It has been demonstrated that this increasingly popular technique requires less time and less physical exertion by the operator than polishing with a rubber cup and prophylaxis paste. In addition, no heat is generated with this type of system.
Studies of the air-powder polishing method have examined its …
Magnitude And Pattern Of Compensatory Growth In Rats After Cold Exposure, Marjorie Lee, P. C. Chu, H. C. Chan
Magnitude And Pattern Of Compensatory Growth In Rats After Cold Exposure, Marjorie Lee, P. C. Chu, H. C. Chan
College of Dentistry: Faculty Publications
It is a common observation that normal growth is affected or suppressed in young individuals by environmental adversities and physical disturbances. On the other hand, when health or favorable conditions are restored, the tempo of growth promptly accelerates as if the individual is trying to make up for the growth debt incurred. Tanner has referred to this increased growth rate after diseases or starvation as compensatory or 'catch-up' growth, a topic on which he has written eloquently and fully in a number of articles (1963a, b). He considers this compensatory growth as a 'self-stabilizing' or 'target-seeking' phenomenon in the regulatory …
The Development In Vitro And In Vivo Of Fusion Of The Palatal Processes Of Rat Embryos, Thomas Moriarty, Sam Weinstein, R. D. Gibson
The Development In Vitro And In Vivo Of Fusion Of The Palatal Processes Of Rat Embryos, Thomas Moriarty, Sam Weinstein, R. D. Gibson
College of Dentistry: Faculty Publications
The congenital anomaly of cleft palate can now be reproduced by a variety of teratogenetic agents in a number of laboratory animals (Kalter & Warkany, 1959). Through the use of the induced cleft palate numerous studies have been directed toward detecting the developmental mishaps which create this defect. The work of Fraser et al. (1957) suggested that various positional factors of the developing palatal and facial structures may be the underlying cause for failure of palatal closure in mouse embryos. Walker & Fraser (1956) observed elastic fibers among the palatal processes of mouse embryos which they suggested might impart a …