Other Medicine and Health Sciences Commons^™

Cold-Inducible Rna Binding Protein Impedes Breast Tumor Growth In The Pymt Murine Model For Breast Cancer, Daniel A. Lujan, Joey L. Ochoa, Ellen J. Beswick, Tamara A. Howard, Helen J. Hathaway, Nora I. Perrone-Bizzozero, Rebecca S. Hartley

Markey Cancer Center Faculty Publications

RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by associating with regulatory sequences in the untranslated regions of mRNAs. Cold-inducible RBP (CIRP) is a stress-induced RBP that was recently shown to modulate inflammation in response to cellular stress, where it increases or decreases pro-tumorigenic (proinflammatory) cytokines in different contexts. CIRP expression is altered in several cancers, including breast cancer, but the effects of CIRP on inflammation in breast cancer is not known. Here, we investigate if CIRP alters growth and the inflammatory profile of breast tumors. Transgenic mice overexpressing CIRP in the mammary epithelium were crossed with the PyMT mouse …

Effectiveness Of Antibiotic Stewardship For Healthcare Providers At Urgent Care Clinics, Helen T. Adewole

Electronic Theses and Dissertations

Antibiotics have revolutionized modern medicine; however, the overuse in urgent care and primary care significantly contributes to the global burden of infections resistant to available antimicrobial medicines. Approximately 30% of the antimicrobials prescribed in acute care settings are unnecessary. Patient demand for antibiotics has seemingly skyrocketed following the recent COVID-19 pandemic. Practitioners must be knowledgeable about antibiotic stewardship initiatives, such as the wait-and-see approach, to reduce antibiotic overuse and improve the trajectory of antibiotic resistance and patient health outcomes. The gap in practice was the limited awareness of scientific evidence-based tools to partner with patients and improve antibiotic prescription patterns. …

Bioethics Of Human Cloning: Are We Playing God?, Caleb Smith, Mary Katherine Flage

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

Global Perspective: Comparison Of Prehospital Use Of Pas In The United States And The Netherlands, Brendan K. Lucas, Lindsay Gietzen

Pacific Journal of Health

The prehospital use of advanced clinicians, including physician assistants (PAs), can potentially improve clinical outcomes and reduce unnecessary burdens on emergency departments. This literature review offers a global perspective by comparing the use of PAs in the prehospital setting in the United States and the Netherlands. While there is limited research on clinical outcomes and the clinical utility of advanced clinicians in alternative transport models, the domestic and international examples evaluated in this review have the potential to impact the American healthcare system significantly. The Dutch healthcare system, which utilizes PAs in the prehospital setting, is known for being accessible, …

“Everything Seems To Be The Right Eye In Our Family”: Intergenerational Family Living With Facial Eye Disfigurement: An Interpretative Phenomenological Analysis, Zali M. O'Dea Ms, Jane Southcott

The Qualitative Report

This paper presents the lived experience of an intergenerational family, spanning three generations living with Facial Eye Disfigurement (FED). Living with vision loss and FED is estimated to affect nearly 8 billion people worldwide. Inadequate attention is paid to the impact of Living with FED (LwFED) on the lives of individuals. This research offers a deep dive into the lived experiences of one family LwFED. This family comprises a grandfather (deceased), son, wife, and child, all of whom have lived or live with FED. In this Interpretive Phenomenological Analysis (IPA) study three interviewees are deemed the experts. Data were collected …

Meta-Narrative Synthesis: The Effectiveness Of Diagnosing And Treating Melanoma With Micrographically Oriented Histograph Surgery Mohs Technique, Gabriella Casas Ms, Nida Mubeen Ms, Nicole Rivera Ms, Tan Thien Tang Mr., Mark A. Bailey Mr, Mary Coolbaugh-Murphy, Denise M. Juroske Short Mrs

Research Methods Poster Session 2024

This meta-narrative synthesis highlights the effectiveness of diagnosing and treating melanoma with Micrographically Oriented Histography Surgery (MOHS) technique. Initiating the questions: What techniques does MOHS surgery involve when diagnosing and treating non-metastasized Melanoma? How will it provide positive outcomes for the patient? The significance of using MOHS excision technique and diagnosis of localized facial melanoma compared to traditional cancer excision techniques is designed to remove affected tissue while preserving anatomical facial structure in an aesthetic fashion. Providing an overview of the technique’s diagnostic professional capabilities as well as its strengths, limitations, improvement for upcoming studies, and potential prognosis. Melanoma, a …

Examining The Impact Of Firearm Recoil During A Round Of Trap Shooting On Neurometabolic Changes Associated With Traumatic Brain Injury, Lakota Jones

Theses, Dissertations and Capstones

The CDC identifies concussion as a blunt, blow, or jolt to the head resulting in brain injury. Shooting sports do not impose a direct blow to the head but instead inflict rapid acceleration to the brain via recoil transfer. Exposure to rapid, repetitive recoil may cause physiological disturbances in the brain, therefore resulting in mild traumatic brain injury (TBI). Chronic recoil transfer and overpressure exposure influencing neurometabolic changes of TBI have yet to be measured. The objective of this study was to examine kinetic energy experienced in trap and skeet shooters following one round of shooting in comparison to neurometabolic …

Outpatient Medications Deimplemented By The Aap Bronchiolitis Guidelines: An Umbrella Review Of Meta-Analyses, Larry Mellick, Paul Walsh, Clista Clanton, Sarathi Kalra, Shane Mckinney

University Research Data and Datasets

OBJECTIVE: To systematically perform an umbrella review all meta-analyses that included outpatient sub-analyses or network meta-analyses with medication treatment comparisons to study the clinical benefits of these deimplemented medications in the outpatient setting.

Microbial Profile And Antimicrobial Resistance Patterns Of Surgical Intra-Abdominal Infections At A Tertiary Hospital In Tanzania A Retrospective Cross-Sectional Study, Abduel Julius Kitua

Master of Surgery

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Among infections of surgical importance, intra-abdominal infections prevail among the most common in surgical patients with considerable morbidity and mortality. The ever-rising microbial resistance to commonly available antibiotics and geographical variations in microbial profile and resistance patterns poses a challenge to the management of these surgical infections of abdominal origin. The aim of this study was to evaluate microbiological characteristics and antibiotic susceptibility of isolates from intra-abdominal infections at a tertiary hospital in Tanzania and how these influence early treatment outcomes.

Outpatient Fall Prevention In Ambulatory Adults 65 Years Old And Over, Dorothy L. Osborne-White

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Background: In the United States (U.S.), falls are the leading cause of injury among adults 65 and over, resulting in 36 million falls yearly (Moreland et al., 2020). According to the Centers for Disease Control and Prevention (CDC, 2023), one in four older adults experiences a fall each year. Falls are the world's second most prominent cause of accidental deaths (World Health Organization [WHO], 2021). Falls are the leading cause of both fatal and non-fatal injuries among older adults (Moreland et al., 2020).

Methods: A quality improvement project that included a fall bundle was implemented in a primary clinic. A …

Sex Differences In The Effects Of Cortisol On Muscle Characteristics: A Meta-Analysis, Natalie Bitetti

CMC Senior Theses

Background: Cortisol plays a central role in both muscle breakdown and growth. These effects are highly dependent on dose and interactions with other hormones. It is known that men and women show considerable differences in their muscle structure and physiology, which are largely driven by hormonal differences. Cortisol release patterns may also vary between the sexes, with current research showing considerable disagreement. The interplay between cortisol and muscle, two highly variable and sexually dimorphic factors, may prove to have different effects in males versus females.

Objective: This meta-analysis integrates existing research on sex differences in cortisol-muscle physiology with existing research …

The Effects Of Alcohol Consumption On Cognitive Decline, Ashley Highland

Graduate Research Papers

The purpose of this study was to examine the relationship between alcohol use and cognitive decline among young adults. This study is a quantitative study in which secondary data was used as a means to gather information from the 2022 Behavioral Risk Factor Surveillance System (BRFSS) database. In this study, the researcher analyzed the data using descriptive statistics and inferential statistics, such as independent sample t-test, correlations analysis, ANOVA, and Chi-Square test. The findings in this research revealed that there is a significant relationship between cognitive decline and binge drinking in young adults. Meaning, young adults who binge drink are …

N(Alpha)-Acetyltransferase 40-Mediated Histone Acetylation Plays An Important Role In Ecdysone Regulation Of Metamorphosis In The Red Flour Beetle, Tribolium Castaneum, Sharath Chandra Gaddelapati, Smitha George, Anilkumar Moola, Karthi Sengodan, Subba Reddy Palli

Entomology Faculty Publications

Histone acetylation, a crucial epigenetic modification, is governed by histone acetyltransferases (HATs), that regulate many biological processes. Functions of HATs in insects are not well understood. We identified 27 HATs and determined their functions using RNA interference (RNAi) in the model insect, Tribolium castaneum. Among HATs studied, N-alpha-acetyltransferase 40 (NAA40) knockdown caused a severe phenotype of arrested larval development. The steroid hormone, ecdysone induced NAA40 expression through its receptor, EcR (ecdysone receptor). Interestingly, ecdysone-induced NAA40 regulates EcR expression. NAA40 acetylates histone H4 protein, associated with the promoters of ecdysone response genes: EcR, E74, E75, and HR3, and causes an increase …

Hamstring Tendons Don’T Lie #Eccentricsdontexist, Alec Espinoza, Chris Garcia, Enoch Ho, Ian Rousseau, Joel Centeno, Robin Dorociak, Tyler Cuddeford

Student-Faculty Research - College of Physical Therapy

Research done on the plantarflexor MTU have shown the degree of achilles tendon and muscle fascicle shortening/stretching is specific to demands of the activity. To expand on this principle, we wanted to explore if a similar relationship exists with the Biceps Femoris MTU. We predict that the biceps femoris (long head) muscle tendon unit (MTU) will behave similarly to the Achilles tendon complex exhibiting the 80/20 principle during dynamic activities (jogging, walking) and the muscle fascicle will lengthen more than the MTU during stationary exercise (Nordic hamstring curls, Romanian deadlifts).

The Oral-Microbiome-Brain Axis: A Thorough Review On The Relationship Between Periodontitis And Alzheimer’S Disease And A Proposed Innovative Application Of Biomagnetism As A Means Of Alternative Therapy., Taha Al Hassan, Noah Al-Hassan, Maria Quiñones-Peña, Juan Lopez-Alvarenga, Seratna Guadarrama-Beltran

MEDI 9331 Scholarly Activities Clinical Years

The relationship between periodontitis and Alzheimer's disease (AD) has garnered significant attention due to the potential influence of chronic oral inflammation on neurodegenerative processes. Our hypothesis is supported by the oral-microbiome-brain axis and highlights the possibility that chronic periodontitis contributes to cognitive decline by promoting systemic inflammation and neuroinflammation, mediated by specific pathogenic microorganisms within the oral microbiome. Our findings reveal a strong association between elevated levels of Porphyromonas gingivalis and Treponema denticola, red complex bacteria, and markers of systemic inflammation, such as C-reactive protein (CRP) and pro-inflammatory cytokines. Additionally studies have demonstrated that beta amyloid plaque in rat …

Cycle Synced Fitness: The Impact Of Menstrual Cycle Phases On Women's Exercise Performance And Health, Sabrina Galindo

Graduate Research Projects

No abstract provided.

Fast-Track To The Frontline: Evaluating A Surgical Technology Program’S Response To A Workforce Shortage, Jill Theresa Davis

Graduate Student Theses, Dissertations, & Professional Papers

As the demand for Certified Surgical Technologists (CSTs) continues to grow, traditional educational pathways struggle to meet the urgent workforce needs within the healthcare sector. This paper presents a comprehensive evaluation of a pilot fast-track surgical technology program implemented at Missoula College, designed to expedite the training of surgical technologists while maintaining high educational standards. Employing a mixed-methods research approach, this study assesses both the quantitative outcomes and qualitative experiences of participants in the fast-track program compared to traditional pathways. Key findings indicate that the fast-track program not only reduces the time required for training but also adequately prepares students …

Project-Based Learning And Student Outcomes In Health Professions Education: A Literature Review, Melanie Aley, Regina Lee, Jordana Wang, Joy Wang, Sophia Zheng

Health Professions Education

Purpose. Project-based learning (PjBL) is an instructional method designed to help students cultivate skills transferable beyond traditional education systems focused on didactic learning. This literature review aims to critically summarise existing literature on PjBL and its value in tertiary health professions curricula, especially with regards to cognitive, affective and behavioral student outcomes. In doing so, this study seeks to inform teaching and learning approaches that nurture skills desirable in professional settings.

Method. An electronic search for relevant English journal articles was conducted using four databases; EBSCOhost, Medline, Web of Science and Scopus. Studies which pre-date 2012, fail to …

Traumatic Brain Injury And Public Stigma: The Effect Of Perceived Responsibility, Mackenzie Grenko

Dissertations and Theses @ UNI

No abstract provided.

Penyakit Sel Sabit Pada Pasien Laki-Laki Berusia 27 Tahun Yang Sebelumnya Didiagnosis Sebagai Talasemia: Sebuah Laporan Kasus, Rahmat Cahyanur, Andree Kurniawan, Ratuafni Sharfina, Nadia Ayu Mulansari

Jurnal Penyakit Dalam Indonesia

Sickle cell disease (SCD) is a hemoglobinopathy inherited in an autosomal recessive pattern arising from a mutation causing substitution of valine for glutamic acid in the sixth amino acid of the β-globin chain. The clinical manifestation of SCD varies from acute pain, chronic anemia, to multi-organ infarct and failure. SCD is known to be rare in Indonesia. However, we recently encountered a SCD patient presenting with recurrent pain and hypesthesia since a year ago. The diagnosis of SCD in this patient was established based on the results of peripheral blood smear and hemoglobin electrophoresis. The patient had previously been diagnosed …

Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen

Purdue Journal of Service-Learning and International Engagement

Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …

Describing The Evidence Linking Interprofessional Education Interventions To Improving The Delivery Of Safe And Effective Patient Care: A Scoping Review, Tamara Cadet, Joseph Cusimano, Shelley Mckearney, Julie Honaker, Cynthia O'Neal, Reza Taheri, Virginia Uhley, Yingting Zhang, Margaret Dreker, Judith S. Cohn

Pharmacy Faculty Articles and Research

Empirical evidence indicates that collaborative interprofessional practice leads to positive health outcomes. Further, there is an abundance of evidence examining student and/or faculty perceptions of learning or satisfaction about the interprofessional education (IPE) learning experience. However, there is a dearth of research linking IPE interventions to patient outcomes. The objective of this scoping review was to describe and summarize the evidence linking IPE interventions to the delivery of effective patient care. A three-step search strategy was utilized for this review with articles that met the following criteria: publications dated 2015–2020 using qualitative, quantitative or mixed methods; the inclusion of healthcare …

Non-Clinical Perspectives On Sepsis: A Project For Enhanced Awareness, Anjali Kumari Singh

Master's Projects and Capstones

Problem: This project aimed to enhance non-clinical staff knowledge of sepsis through a targeted awareness campaign, while also seeking to uphold or enhance the organization's sepsis-related performance.

Context: Clinical Nurse Leader students conducted a microsystem assessment in five crucial non-clinical departments of an urban Bay Area hospital, each playing a vital role in the organization's efficiency at different levels.

Intervention: During Sepsis Awareness Month, a sepsis awareness campaign was implemented. This involved a concise presentation on sepsis, its consequences, and the significance of awareness in each department. Additionally, informational fliers detailing sepsis signs and symptoms were distributed.

Measures: A pre-and …

Secondary Electrons And Compton X-Ray Generation In Solid And Heated Biological Sample In The Presence Of Radiologic Contrast Media, Vanessa Robinson, Daler Djuraev, Fatima Ahmed

Publications and Research

Our goal is identification of secondary electrons and Compton photons when externally infused radiological contrast from iodine and gadolinium interferes with calcium and iron in tissues. This could help develop next generation of x-ray methods as well as mechanistic understanding of toxic effects of radiology contrast materials on living tissue and agriculture. Changes in tissue minerals over time, aging and heat stress are manipulated in our experiments by infusing imaging contrast agents that consist of large atoms like Gadolinium and Iodine. These have chelation properties to alter electron distribution of proteins and carbohydrates of biological matrix. Our experiments try to …

“Be Sustainable”: Eosc-Life Recommendations For Implementation Of Fair Principles In Life Science Data Handling, Romain David, Arina Rybina, Jean-Marie Burel, Jean-Karim Heriche, Pauline Audergon, Jan-Willem Boiten, Frederik Coppens, Sara Crockett, Katrina Exter, Sven Fahrner, Maddalena Fratelli, Carole Goble, Philipp Gormanns, Tobias Grantner, Björn Grüning, Kim Tamara Gurwitz, John M Hancock, Henriette Harmse, Petr Holub, Nick Juty, Geoffrey Karnbach, Emma Karoune, Antje Keppler, Jessica Klemeier, Carla Lancelotti, Jean-Luc Legras, Allyson L Lister, Dario Livio Longo, Rebecca Ludwig, Bénédicte Madon, Marzia Massimi, Vera Matser, Rafaele Matteoni, Michaela Th Mayrhofer, Christian Ohmann, Maria Panagiotopoulou, Helen Parkinson, Isabelle Perseil, Claudia Pfander, Roland Pieruschka, Michael Raess, Andreas Rauber, Audrey S Richard, Paolo Romano, Antonio Rosato, Alex Sánchez-Pla, Susanna-Assunta Sansone, Ugis Sarkans, Beatriz Serrano-Solano, Jing Tang, Ziaurrehman Tanoli, Jonathan Tedds, Harald Wagener, Martin Weise, Hans V Westerhoff, Rudolf Wittner, Jonathan Ewbank, Niklas Blomberg, Philip Gribbon

Faculty, Staff and Student Publications

The main goals and challenges for the life science communities in the Open Science framework are to increase reuse and sustainability of data resources, software tools, and workflows, especially in large-scale data-driven research and computational analyses. Here, we present key findings, procedures, effective measures and recommendations for generating and establishing sustainable life science resources based on the collaborative, cross-disciplinary work done within the EOSC-Life (European Open Science Cloud for Life Sciences) consortium. Bringing together 13 European life science research infrastructures, it has laid the foundation for an open, digital space to support biological and medical research. Using lessons learned from …

National Emergency Department Sample In Geriatric Subsequent Mild Traumatic Brain Injury Visits And Associations With Sex, Falls, Payor, And Discharge Outcomes, Carrie Ann Barrett

Dissertations

The purpose of this study was to explore the variables of sex (male, female), fall mechanism of injury, payor source, and emergency department (ED) discharge outcomes in patients aged >65 who presented with mild traumatic brain injury (mTBI) subsequent ED visits.

A secondary data analysis was performed to assess the relationship among the independent and dependent variables listed above. The independent variables were dichotomous for age (>65, < 65), sex (male, female), and fall mechanism of injury (yes, no), and categorical for payor source (Medicare, Medicaid, Private, Other). The ED discharge dependent variables were categorical [home; healthcare services (including skilled nursing facility, home care, and intermediary care)]. Logistic regression analyses were performed to evaluate specific variables that increase the probability of affecting ED discharge outcomes. The software, SPSS v. 28 was used in the statistical calculations. The study was approved by the Western Michigan University Human Subjects Internal Review Board.

A Case Study Of The Political Determinant Of Health On The Public Health Crisis Of Malaria In Nigeria, Bisola M. Olumegbon

Electronic Theses and Dissertations

Abstract

Globally, there were about 229 million cases of malaria in 2022. The sub-Saharan African region accounted for 92% of the reported cases and 94% of deaths. Nigeria had the highest number of malaria cases and deaths, representing 27% of global cases. This scholarly project was a case study guided by the political determinants of health. Triangulation of data using thematic analysis was used to identify the political determinants of malaria in Nigeria and to understand how the concept of interaction contributes to the persistence of the disease. The analysis involved a deductive and inductive approach based on the literature …

Conference Proceedings: Select Abstracts Presented At 2023 Advocate Aurora Scientific Day

Journal of Patient-Centered Research and Reviews

This abstract supplement includes findings presented at the 49th annual Advocate Aurora Scientific Day on May 24, 2023. The Scientific Day symposium provides a virtual forum for the sharing of preliminary results from research and case studies conducted by faculty, fellows, residents, and other health professionals associated with Illinois-based Advocate Health Care and Wisconsin-based Aurora Health Care.

Prevalence Of Risk Factors For Human Immunodeficiency Virus Among Sexually Active Women In Rwanda: A Nationwide Survey, Joseph Kawuki, Lilian Nuwabaine, Angella Namulema, John Baptist Asiimwe, Quraish Sserwanja, Ghislaine Gatasi, Elorm Donkor

School of Nursing & Midwifery, East Africa

No abstract provided.

Idiopathic Intracranial Hypertension: A Case Report, Christopher Bugajski Od

Optometric Clinical Practice

Background: Optic nerve head edema is a serious finding for which multiple etiologies need to be considered. When optic nerve head edema is observed bilaterally, among the top differentials is idiopathic intracranial hypertension (IIH), also known as primary pseudotumor cerebri. An emergent magnetic resonance image with and without contrast as well as venography and lumbar puncture with opening pressure measurement must be performed to diagnose and determine management. Case Report: This case specifically features a 30-year-old Caucasian female with bilateral optic disc edema secondary to IIH. In addition to discussing the details regarding this patient’s case, this report …