Virus Diseases Commons^™

Factors In The Probability Of Covid-19 Transmission In University Classrooms, Charles Connor

Numeracy

University students and faculty members need an effective strategy to evaluate and reduce the probability that an individual will become infected with COVID-19 as a result of classroom interactions. Models are developed here that consider the probability an individual will become infected as a function of: prevalence of the disease in the university community, number of students in class, number of class meetings, and transmission rate in the classroom given the presence of an infected individual. Absolute probabilities that an individual will become infected in a classroom environment cannot be calculated because some of these factors have unknown values. Nevertheless, …

Coverage Of The 2019 Eastern Equine Encephalitis Virus Outbreak On News Media, Corey H. Basch, Joseph Fera, Christie Jaime, Nasia Quininoes

Publications and Research

Background: The media plays as an important role in delivering information about emergent issues, such as the Eastern equine encephalitis virus (EEEV) outbreak of 2019. As such, there has been an increase in news coverage of vector-borne disease coverage due to a rise in emerging or re-emerging arboviruses.

Methods: The purpose of this study was to describe the content of news clips related to the recent (2019) EEEV outbreak in the United States.

Results: Only 3 of the important topics identified were mentioned in a majority of the 110 videos analyzed. These topics were, mosquito mentioned as transmitter, prevention by …

Endocrine Significance Of Sars-Cov-2'S Reliance On Ace2, Eric Lazartigues, Mirza Muhammad Fahd Qadir, Franck Mauvais-Jarvis

School of Medicine Faculty Publications

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and …

Foundational Research And Nih Funding Enabling Emergency Use Authorization Of Remdesivir For Covid-19, Ekaterina Galkina Cleary, Matthew J. Jackson, Zoë Folchman-Wagner, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

Emergency Use Authorization for remdesivir months after discovery of COVID-19 is unprecedented. Typically, decades of research and public-sector funding are required to establish the mature body of foundational research requisite for efficient, targeted drug discovery and development. This work quantifies the body of research related to remdesivir’s biological target, RNA-dependent RNA polymerase (RdRp), or parent chemical structure, nucleoside analogs (NcAn), through 2019, as well as NIH funding for this research 2000–2019. There were 6,567 RdRp-related publications in PubMed, including 1,263 with NIH support, and 11,073 NcAn-related publications, including 2,319 with NIH support. NIH support for RdRp research comprised 2,203 Project …

Convalescent Plasma In Covid-19, Ranjit S. Banwait, Joshua K. Salabei, Troy J. Fishman, Uma G. Iyer

HCA Healthcare Journal of Medicine

The recent pandemic of SARS-CoV-2, which causes novel coronavirus disease 2019 (Covid-19), has had devastating impact on a global and national scale. In order to overcome this outbreak it is imperative we find treatments that are safe and effective. To date, no definitive treatment is available that can curtail the spread of this viral syndrome. Convalescent plasma (CP) is one such option that has repeatedly served as an important tool in treatment of various bacterial and viral infections, especially in the setting of no specific antimicrobial or vaccination against an infectious disease. Herein, we review the history of CP, prior …

Return To Work Guidelines, The Coronavirus Planning Team

University Briefings & Virtual Events

"Return to Work" employee transition timeline, guidelines and requirements.

Initial And Repeated Point Prevalence Surveys To Inform Sars-Cov-2 Infection Prevention In 26 Skilled Nursing Facilities - Detroit, Michigan, March-May 2020, Guillermo V. Sanchez, Caitlin Bierdon, Lauren R. Fink, Kelly M. Hatfield, Jordan Micah F. Polistico, Monica P. Meyers, Rebecca S. Noe, Casey E. Copen, Amanda K. Lyons, Gonzalo Gonzalez, Keith Kiama, Mark Lebednick, Bonnie K. Caander, Amen Agbonze, Aimee R. Surma, Avnish Sandhu, Valerie H. Mika, Tyler Prentiss, John Zervos, Donia A. Dalal, Amber M. Vasquez, Sujan C. Reddy, John Jernigan, Paul E. Kilgore, Marcus J. Zervos, Teena Chopra, Carla P. Bezold, Najibah K. Rehman

Department of Pharmacy Practice

No abstract provided.

Resolving Tensions Between Disability Rights Law And Covid-19 Mask Policies, Elizabeth Pendo, Robert Gatter, Seema Mohapatra

All Faculty Scholarship

As states reopen, an increasing number of state and local officials are requiring people to wear face masks while out of the home. Grocery stores, retail outlets, restaurants and other businesses are also announcing their own mask policies, which may differ from public policies. Public health measures to stop the spread of the coronavirus such as wearing masks have the potential to greatly benefit millions of Americans with disabilities, who are particularly vulnerable to the impact of COVID-19. But certain disabilities may make it difficult or inadvisable to wear a mask.
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/="/">Mask-wearing has become a political flashpoint, putting …

Viral Membrane Fusion And The Transmembrane Domain, Chelsea T. Barrett, Rebecca Ellis Dutch

Molecular and Cellular Biochemistry Faculty Publications

Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target. Viral fusion proteins have been studied for decades, and numerous critical insights into their function have been elucidated. However, the transmembrane region remains one of the most poorly understood facets of these proteins. In the past ten years, the field has made significant advances in understanding the role of the membrane-spanning region of viral fusion proteins. We summarize developments made in the past …

Towards Effective Management Protocols: A Transnational Review Of The State-Of-The-Art Of Coronavirus Disease 2019 (Covid-19) In Pakistan And The United Arab Emirates, Maryam Ehtesham, Talal Almas, Absam Akbar, Muhammad Ali Niaz, Noreen Zia

Medical College Documents

Coronavirus disease 2019 (COVID-19) has proliferated rapidly in Pakistan, adversely affecting every province. The grave repercussions that the pandemic has elicited in Pakistan have evoked a dire need for drastic measures to be employed at both the governmental and provincial levels. Due to the inequitable appropriation of healthcare resources with respect to the various provinces, however, a stark contrast in terms of morbidity and mortality persists. Furthermore, considering that Pakistani citizens constitute a noteworthy proportion of expatriates residing in the United Arab Emirates (UAE) and the close proximity of the two countries, due consideration of the situation in the UAE …

Emergency Department Admissions During Covid-19: Implications From The 2002-2004 Sars Epidemic, Muhammad Musaab Munir, Russell S. Martins, Asad Mian

Medical College Documents

No abstract provided.

Ua37/2 Corona Paper, Ellen Micheletti

Faculty/Staff Personal Papers

Paper written regarding Ellen Micheletti's experiences during the 2020 Coronavirus pandemic.

The Clinical Features Of Co-Circulating Dengue Viruses And The Absence Of Dengue Hemorrhagic Fever In Pakistan, Erum Khan, Dhani Prakoso, Kehkashan Imtiaz, Faisal Malik, Joveria Farooqi, Maureen T. Long, Kelli L. Barr

Department of Pathology and Laboratory Medicine

Dengue virus (DENV) is the most common and widespread arboviral infection worldwide. Though all four DENV serotypes cocirculate in nature, the clinicopathological framework of these serotypes is undefined in Pakistan. A cross-sectional, observational study was performed to document the circulation of various arboviruses in the Sindh region of Pakistan. Here we describe a population of patients diagnosed with DENV spanning a 2-year period. This study used an orthogonal system of NS1 antigen ELISA followed by RT-PCR for DENV detection and subtyping. A total of 168 NS1 positive patients were evaluated of which 91 patients were serotyped via RT-PCR. There was …

We Are Not Alone In Trying To Be Alone, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Certain diseases, like colds, tend not to stop us. A paracetamol here, an ibuprofen there, and we are on the go. That is, until we, as a species, are faced with a virus that not only spreads through social contact, but has an estimated reproductive number of 2 to 2.5 and potentially kills 3–4% of those infected (WHO, 2020). To reduce transmission probability of COVID-19, governmental agencies around the world have recommended or enforced measures to decrease social contact; early evidence suggests these measures produce the intended effect (Kucharski et al., 2020).

Considerations For Events And Gatherings, Centers For Disease Control And Prevention

Pandemic Response and Religion in the USA: Law and Public Policy

No abstract provided.

Investigation Of Japanese Encephalitis Virus As A Cause Of Acute Encephalitis In Southern Pakistan, April 2015-January 2018, Tazeen Fatima, Abida Rais, Erum Khan, Susan L. Hills, Trudy V. Chambers, Aneeta Hotwani, Shahida Qureshi, Saad Shafqat, Saima Malik, Farah Qamar, Fatima Mir, Anthony A. Marfin, Anita K. M. Zaidi, Asif Raza Khowaja, Sadia Shakoor

Department of Pathology and Laboratory Medicine

Background: Japanese encephalitis (JE) occurs in fewer than 1% of JE virus (JEV) infections, often with catastrophic sequelae including death and neuropsychiatric disability. JEV transmission in Pakistan was documented in 1980s and 1990s, but recent evidence is lacking. Our objective was to investigate JEV as a cause of acute encephalitis in Pakistan.
Methods: Persons aged ≥1 month with possible JE admitted to two acute care hospitals in Karachi, Pakistan from April 2015 to January 2018 were enrolled. Cerebrospinal fluid (CSF) or serum samples were tested for JEV immunoglobulin M (IgM) using the InBios JE DetectTM assay. Positive or equivocal samples …

Ua94/6/1 Clinic Covid-19 Reflections - Jones, C. Jones

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student C. Jones.

Ua94/6/1 Clinic Covid-19 Reflections - Hall, G. Hall

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student G. Hall.

Checklist For Communities Of Faith, Centers For Disease Control And Prevention

Pandemic Response and Religion in the USA: Health

This PDF from the Centers for Disease Control and Prevention provides a checklist for places of worship to use in order to prevent the spread of COVID-19 among their congregations. The checklist includes hygiene practices, disinfecting practices, social distancing, the use of masks, isolation, and support for those facing discrimination.

Ua94/6/1 Clinic Covid-19 Reflections - Mccurry, L. Mccurry

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student L. McCurry.

Ua94/6/1 Clinic Covid-19 Reflections - Lackey, B. Lackey

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student B. Lackey.

Ua94/6/1 Clinic Covid-19 Reflections - Perdew, H. Perdew

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders graduate student H. Perdew.

Ua94/6/1 Clinic Covid-19 Reflections - Decker, A. Decker

Student/Alumni Personal Papers

Reflections on the Covid-19 by WKU Communication Sciences & Disorders graduate student A. Decker.

Ua94/6/1 Clinic Covid-19 Reflections - Davis, H. Davis

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student H. Davis.

Ua94/6/1 Clinic Covid-19 Reflections - Hoyer, J. Hoyer

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student J. Hoyer.

Ua94/6/1 Clinic Covid-19 Reflections - Walton, E. Walton

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student E. Walton.

Ua94/6/1 Clinic Covid-19 Reflections - Gunderson, H. Gunderson

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders graduate student H. Gunderson.

Ua94/6/1 Clinic Covid-19 Reflections - Dyer, N. Dyer

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student N. Dyer.

Ua94/6/1 Clinic Covid-19 Reflections - Page, A. Page

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders undergraduate student A. Page.

Ua94/6/1/ Clinic Covid-19 Reflections - Holloman, K. Holloman

Student/Alumni Personal Papers

Reflections of Covid-19 pandemic by WKU Communication Sciences & Disorders graduate student K. Holloman