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Articles 1 - 23 of 23
Full-Text Articles in Virus Diseases
Beat-Bk: An Adaptive, Randomized Controlled Trial To Treat Polyomavirus Infections (Bkpyv) In Kidney And Kidney-Pancreas Transplantation Recipients (Beat-Bk) Study Protocol, Ryan Gately, Michael Dymock, Dharshana Sabanayagam, Scott B. Campbell, Jonathan C. Craig, Vikas Dharnidharka, Anna Francis, Jonathan M. Gleadle, Martin Hajek, Sana Hamilton, Martin Howell, Nicole Isbel, Allison Jaure, David W. Johnson, John Kanellis, Karen Keung, Siah Kim, Jen Kok, Dirk R. Kuypers, Nicholas Larkins, Wai H. Lim, Rahul Mainra, Julie A. Marsh, Gabor Mihala, Brian Nankivell, Samantha Ng
Beat-Bk: An Adaptive, Randomized Controlled Trial To Treat Polyomavirus Infections (Bkpyv) In Kidney And Kidney-Pancreas Transplantation Recipients (Beat-Bk) Study Protocol, Ryan Gately, Michael Dymock, Dharshana Sabanayagam, Scott B. Campbell, Jonathan C. Craig, Vikas Dharnidharka, Anna Francis, Jonathan M. Gleadle, Martin Hajek, Sana Hamilton, Martin Howell, Nicole Isbel, Allison Jaure, David W. Johnson, John Kanellis, Karen Keung, Siah Kim, Jen Kok, Dirk R. Kuypers, Nicholas Larkins, Wai H. Lim, Rahul Mainra, Julie A. Marsh, Gabor Mihala, Brian Nankivell, Samantha Ng
Research outputs 2022 to 2026
Background. – BK polyomavirus (BKPyV) is a common opportunistic infection in kidney transplant recipients, typically reactivating in the context of immunosuppression. Although asymptomatic in immunocompetent individuals, reactivation in transplant recipients can cause BKPyV-associated nephropathy (BKPyVAN), a leading cause of graft dysfunction and loss. BKPyV viremia affects approximately 10%–15% of transplant recipients, and once BKPyVAN is established, the risk of graft failure can exceed 50%. The current standard of care involves immunosuppression reduction to restore virus-specific immunity, but this approach increases the risk of acute and chronic rejection. Intravenous immunoglobulin (IVIg), which contains antiviral and immunomodulatory antibodies, has been proposed as …
The Association Between Sexually Transmitted Infections And Pregnancy Outcomes In The Northern Territory, Australia: A Population-Based Cohort Study, Jennifer Dunne, Gizachew A. Tessema, Matthew Legge, Sylvester Dodzi Nyadanu, Aditi Roy, Amanuel T. Gebremedhin, Jacqueline Hendriks, Tricia Reid-Moore, Gavin Pereira
The Association Between Sexually Transmitted Infections And Pregnancy Outcomes In The Northern Territory, Australia: A Population-Based Cohort Study, Jennifer Dunne, Gizachew A. Tessema, Matthew Legge, Sylvester Dodzi Nyadanu, Aditi Roy, Amanuel T. Gebremedhin, Jacqueline Hendriks, Tricia Reid-Moore, Gavin Pereira
Research outputs 2022 to 2026
Background: Often asymptomatic in nature, sexually transmitted infections (STIs) are highly prevalent in women of reproductive ages, leading to adverse perinatal outcomes. This study investigated the association between STIs during pregnancy and the risk of adverse perinatal outcomes using comprehensive population-linked data from the Northern Territory (NT), Australia. Methods: This population-based retrospective cohort study examined births (live births and stillbirths) from the NT Perinatal Data Collection and the NT Notifiable Diseases register from 2005 to 2020. All singleton births (N = 59,465) were included, along with infectious disease notifications of four STIs that occurred during pregnancy: chlamydia, gonorrhoea, trichomoniasis, and …
Clostridioides (Clostridium) Difficile In Hospitalised Children In Cambodia, Lengsea Eng, Kefyalew Addis Alene, Deirdre A. Collins, Su Chen Lim, Viso Srey, Choeung Chea, Sotera Yohn, Setha Leng, Archie C.A. Clements, Thomas V. Riley
Clostridioides (Clostridium) Difficile In Hospitalised Children In Cambodia, Lengsea Eng, Kefyalew Addis Alene, Deirdre A. Collins, Su Chen Lim, Viso Srey, Choeung Chea, Sotera Yohn, Setha Leng, Archie C.A. Clements, Thomas V. Riley
Research outputs 2022 to 2026
Background: Children may play an important role in disseminating Clostridioides (Clostridium) difficile within hospital and community settings. In many parts of the world, there has been a recent increase in interest in C. difficile infection (CDI) in paediatric populations. Objectives: This study aimed to investigate the prevalence of, risk factors for, and molecular types of C. difficile in hospitalised children in Cambodia. Methods: Stool samples were collected from children at the National Paediatric Hospital in Phnom Penh, Cambodia, between June 2022 and March 2023, for C. difficile culture. Toxin gene PCR and PCR ribotyping were performed on all isolates. Results: …
In Silico Evaluation Of Bisphosphonates Identifies Leading Candidates For Sars-Cov-2 Rdrp Inhibition, Mohammed Muzaffar-Ur-Rehman, Kishor Suryakant Chougule, Ala Chandu, Pranali Vijaykumar Kuthe, Mohit Garg, Murugesan Sankaranarayanan, Seshadri S. Vasan
In Silico Evaluation Of Bisphosphonates Identifies Leading Candidates For Sars-Cov-2 Rdrp Inhibition, Mohammed Muzaffar-Ur-Rehman, Kishor Suryakant Chougule, Ala Chandu, Pranali Vijaykumar Kuthe, Mohit Garg, Murugesan Sankaranarayanan, Seshadri S. Vasan
Research outputs 2022 to 2026
The novel coronavirus disease (COVID-19) pandemic has resulted in 777 million confirmed cases and over 7 million deaths worldwide, with insufficient treatment options. Innumerable efforts are being made around the world for faster identification of therapeutic agents to treat the deadly disease. Post Acute Sequelae of SARS-CoV-2 infection or COVID-19 (PASC), also called Long COVID, is still being understood and lacks treatment options as well. A growing list of drugs are being suggested by various in silico, in vitro and ex vivo models, however currently only two treatment options are widely used: the RNA-dependent RNA polymerase (RdRp) inhibitor remdesivir, and …
Risk Factors Associated With Helicobacter Pylori Infection In The Urban Population Of China: A Nationwide, Multi-Center, Cross-Sectional Study, Liang Wang, Zheng Kang Li, Jin Xin Lai, Yu Ting Si, Jie Chen, Eng Guan Chua, Ling Yan Dai, Qiong Dai, Xu Bo Dai, Zhao Hui Deng, Hong Du, Qi Fang, Cui Feng, Min He, Guo Chu Hu, Yi Zhong Hu, Hui Huang, Yan Jiang Huang, Fen Li, Jun Hong Li, Qi Xin Li, Zhi Fang Lin, Hai Tao Liu, Ming Bo Liu, Jin Hua Luo, Jian Hong Ma
Risk Factors Associated With Helicobacter Pylori Infection In The Urban Population Of China: A Nationwide, Multi-Center, Cross-Sectional Study, Liang Wang, Zheng Kang Li, Jin Xin Lai, Yu Ting Si, Jie Chen, Eng Guan Chua, Ling Yan Dai, Qiong Dai, Xu Bo Dai, Zhao Hui Deng, Hong Du, Qi Fang, Cui Feng, Min He, Guo Chu Hu, Yi Zhong Hu, Hui Huang, Yan Jiang Huang, Fen Li, Jun Hong Li, Qi Xin Li, Zhi Fang Lin, Hai Tao Liu, Ming Bo Liu, Jin Hua Luo, Jian Hong Ma
Research outputs 2022 to 2026
Objectives: To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population. Methods: The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioeconomic status, lifestyles, and public understanding. Univariate and multivariate logistic regression analysis was used to calculate corrected odds ratios (ORs) and 95% confidence intervals (CIs). Results: According to multivariate logistic regression, risk factors associated with significantly higher H. pylori infection rates included residency in developing (OR 1.27, 95% CI 1.13-1.43) and undeveloped cities (OR 1.15, …
Clostridioides (Clostridium) Difficile Infection In Hospitalized Adult Patients In Cambodia, Lengsea Eng, Deirdre A. Collins, Kefyalew Addis Alene, Sotharith Bory, Youdaline Theng, Pisey Vann, Sreyhuoch Meng, Setha Limsreng, Archie C.A. Clements, Thomas V. Riley
Clostridioides (Clostridium) Difficile Infection In Hospitalized Adult Patients In Cambodia, Lengsea Eng, Deirdre A. Collins, Kefyalew Addis Alene, Sotharith Bory, Youdaline Theng, Pisey Vann, Sreyhuoch Meng, Setha Limsreng, Archie C.A. Clements, Thomas V. Riley
Research outputs 2022 to 2026
Despite high levels of global concern, little is known about the epidemiology of Clostridioides (Clostridium) difficile infection (CDI) in Cambodia. This study aimed to identify the prevalence and risk factors for CDI, and molecular types of C. difficile in hospitalized adults at Calmette Hospital, Phnom Penh, Cambodia. Stool samples were collected from 263 hospitalized adults between June and September 2022 and tested for C. difficile using direct and enrichment cultures. PCR toxin genes tcdA, tcdB, cdtA, and cdtB, and amplification of the 16s–23s rRNA intergenic spacer region for ribotyping, were performed on all C. difficile isolates. C. difficile was isolated …
Immunoglobulin G N-Glycome As A Biomarker Of Mortality Risk In Escherichia Coli Induced Sepsis, Huachen Wang, Houqiang Li, Zheng Guo, Hongda Hou, Haifeng Hou, Bing Chen
Immunoglobulin G N-Glycome As A Biomarker Of Mortality Risk In Escherichia Coli Induced Sepsis, Huachen Wang, Houqiang Li, Zheng Guo, Hongda Hou, Haifeng Hou, Bing Chen
Research outputs 2022 to 2026
Background: Sepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis. The role of immunoglobulin G N-glycome in estimating the mortality in patients with sepsis remains unknown. This study aims to reveal the clinical application of immunoglobulin G N-glycome as a potentially novel biomarker to predict mortality risk in Escherichia coli-induced sepsis. Methods: The serum immunoglobulin G N-glycome levels in 100 adult septic patient serum samples on the day of intensive care unit (ICU) admission, and 100 …
Rapid Profiling Of Carcinogenic Types Of Helicobacter Pylori Infection Via Deep Learning Analysis Of Label-Free Sers Spectra Of Human Serum, Fen Li, Yu Ting Si, Jia Wei Tang, Zeeshan Umar, Xue Song Xiong, Jin Ting Wang, Quan Yuan, Alfred Chin Yen Tay, Eng Guan Chua, Li Zhang, Barry J. Marshall, Wei Xuan Yang, Bing Gu, Liang Wang
Rapid Profiling Of Carcinogenic Types Of Helicobacter Pylori Infection Via Deep Learning Analysis Of Label-Free Sers Spectra Of Human Serum, Fen Li, Yu Ting Si, Jia Wei Tang, Zeeshan Umar, Xue Song Xiong, Jin Ting Wang, Quan Yuan, Alfred Chin Yen Tay, Eng Guan Chua, Li Zhang, Barry J. Marshall, Wei Xuan Yang, Bing Gu, Liang Wang
Research outputs 2022 to 2026
WHO classified Helicobacter pylori as a Group I carcinogen for gastric cancer as early as 1994. However, despite the high prevalence of H. pylori infection, only about 3 % of infected individuals eventually develop gastric cancer, with the highly virulent H. pylori strains expressing cytotoxin-associated protein (CagA) and vacuolating cytotoxin (VacA) being critical factors in gastric carcinogenesis. It is well known that H. pylori infection is divided into two types in terms of the presence and absence of CagA and VacA toxins in serum, that is, carcinogenic Type I infection (CagA+/VacA+, CagA+/VacA-, CagA-/VacA+) and non-carcinogenic Type II infection (CagA-/VacA-). Currently, …
Coordinated Nasal Mucosa-Mediated Immunity Accelerates Recovery From Covid-19, Steven P. Cass, Dan V. Nicolau, Jonathan R. Baker, Christine Mwasuku, Sanjay Ramakrishnan, Mahdi Mahdi, Peter J. Barnes, Louise E. Donnelly, Rocio T. Martinez-Nunez, Richard E.K. Russell, Mona Bafadhel
Coordinated Nasal Mucosa-Mediated Immunity Accelerates Recovery From Covid-19, Steven P. Cass, Dan V. Nicolau, Jonathan R. Baker, Christine Mwasuku, Sanjay Ramakrishnan, Mahdi Mahdi, Peter J. Barnes, Louise E. Donnelly, Rocio T. Martinez-Nunez, Richard E.K. Russell, Mona Bafadhel
Research outputs 2022 to 2026
Introduction Understanding the interplay of immune mediators in relation to clinical outcomes during acute infection has the potential to highlight immune networks critical to symptom recovery. The objective of the present study was to elucidate the immune networks critical to early symptom resolution following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods In a community-based randomised clinical trial comparing inhaled budesonide against usual care in 139 participants with early onset SARS-CoV-2 (the STOIC study; clinicaltrials.gov identifier NCT04416399), significant clinical deterioration (reported need for urgent care, emergency department visit, hospitalisation: the primary outcome), self-reported symptom severity (Influenza Patient-Reported Outcome questionnaire) …
Corrigendum: Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar
Corrigendum: Evolution, Ecology, And Zoonotic Transmission Of Betacoronaviruses: A Review, Herbert F. Jelinek, Mira Mousa, Eman Alefishat, Wael Osman, Ian Spence, Dengpan Bu, Samuel F. Feng, Jason Byrd, Paola A. Magni, Shafi Sahibzada, Guan K. Tay, Habiba S. Alsafar
Research outputs 2022 to 2026
In the published article, there was an error in the legend for Figure 1 as published. The figure legend did not indicate that it has been adapted from Plowright et al. (2017). Copyright permission was obtained from Springer Nature to adapt Figure 1 from Plowright et al. (2017). The corrected legend appears below. Figure 1. Zoonotic risk distribution, pathway to spillover, and the multimodal role of the determinants of spillover. The zoonotic risk is demonstrated by the accumulated distribution of reservoir hosts and vectors that play a role in the pathway to spillover. The risk of spillover is determined by …
Covid-19 In Western Australia: ‘The Last Straw’ And Hopes For A ‘New Normal’ For Parents Of Children With Long-Term Conditions, Stephanie Smith, Mary Tallon, James Smith, Lauren Jones, Evalotte Mörelius
Covid-19 In Western Australia: ‘The Last Straw’ And Hopes For A ‘New Normal’ For Parents Of Children With Long-Term Conditions, Stephanie Smith, Mary Tallon, James Smith, Lauren Jones, Evalotte Mörelius
Research outputs 2022 to 2026
Background: Children with long-term conditions are vulnerable due to the treatments required for their conditions. Since the start of the coronavirus disease 2019 (COVID-19) pandemic, Western Australians experienced restrictions that changed daily life activities but were able to return to some of their previous routines due to the restrictions. Aim: The study explored the stress experiences of parents caring for children with long-term conditions during COVID-19 in Western Australia. Design and Participants: The study was codesigned with a parent representative caring for children with long-term conditions to ensure essential questions were targeted. Twelve parents of children with various long-term conditions …
Physical Education And Covid-19: What Have We Learned?, Valeria Varea, Ana Riccetti, Gustavo González-Calvo, Marcela Siracusa, Alfonso García-Monge
Physical Education And Covid-19: What Have We Learned?, Valeria Varea, Ana Riccetti, Gustavo González-Calvo, Marcela Siracusa, Alfonso García-Monge
Research outputs 2022 to 2026
The aim of this paper is to explore what we have learned during the COVID-19 pandemic in the field of Physical Education in three different countries: Argentina, Spain and Sweden. Data were generated through semi-structured interviews, and the concept of field agency is used to make sense of the data. Differences were found among the three countries, regarding the content of the classes, the use of resources, the emotions of teachers, and the use of physical contact. This was also a result of the regulations and resources in place. The COVID-19 pandemic has demonstrated that the nature of the field …
Analysis Of Sars-Cov-2 Viral Loads In Stool Samples And Nasopharyngeal Swabs From Covid-19 Patients In The United Arab Emirates, Mariane Daou, Hussein Kannout, Mariam Khalili, Mohamed Almarei, Mohamed Alhashami, Zainab Alhalwachi, Fatima Alshamsi, Mohammad Tahseen Al Bataineh, Mohd Azzam Kayasseh, Abdulmajeed Al Khajeh, Shadi W. Hasan, Guan Kwang Tay, Samuel F. Feng, Dymitr Ruta, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership
Analysis Of Sars-Cov-2 Viral Loads In Stool Samples And Nasopharyngeal Swabs From Covid-19 Patients In The United Arab Emirates, Mariane Daou, Hussein Kannout, Mariam Khalili, Mohamed Almarei, Mohamed Alhashami, Zainab Alhalwachi, Fatima Alshamsi, Mohammad Tahseen Al Bataineh, Mohd Azzam Kayasseh, Abdulmajeed Al Khajeh, Shadi W. Hasan, Guan Kwang Tay, Samuel F. Feng, Dymitr Ruta, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership
Research outputs 2022 to 2026
Coronavirus disease 2019 (COVID-19) was first identified in respiratory samples and was found to commonly cause cough and pneumonia. However, non-respiratory symptoms including gastrointestinal disorders are also present and a big proportion of patients test positive for the virus in stools for a prolonged period. In this cross-sectional study, we investigated viral load trends in stools and nasopharyngeal swabs and their correlation with multiple demographic and clinical factors. The study included 211 laboratory-confirmed cases suffering from a mild form of the disease and completing their isolation period at a non-hospital center in the United Arab Emirates. Demographic and clinical information …
Dependence On A Variable Residue Limits The Breadth Of An Hiv Mper Neutralizing Antibody, Despite Convergent Evolution With Broadly Neutralizing Antibodies, Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S. Gray, Thandeka Moyo-Gwete, Bronwen E. Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J. Garrett, Salim S.Abdool Karim, Lynn Morris, Penny L. Moore
Dependence On A Variable Residue Limits The Breadth Of An Hiv Mper Neutralizing Antibody, Despite Convergent Evolution With Broadly Neutralizing Antibodies, Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S. Gray, Thandeka Moyo-Gwete, Bronwen E. Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J. Garrett, Salim S.Abdool Karim, Lynn Morris, Penny L. Moore
Research outputs 2022 to 2026
Broadly neutralizing antibodies (bNAbs) that target the membrane-proximal external region (MPER) of HIV gp41 envelope, such as 4E10, VRC42.01 and PGZL1, can neutralize > 80 % of viruses. These three MPER-directed monoclonal antibodies share germline antibody genes (IGHV1 - 69 and IGKV3 - 20) and form a bNAb epitope class. Furthermore, convergent evolution within these two lineages towards a 111.2GW111.3 motif in the CDRH3 is known to enhance neutralization potency. We have previously isolated an MPER neutralizing antibody, CAP206 - CH12, that uses these same germline heavy and light chain genes but lacks breadth (neutralizing only 6 % of …
Causal Associations Between Covid-19 And Atrial Fibrillation: A Bidirectional Mendelian Randomization Study, Xiaoyu Zhang, Biyan Wang, Tao Geng, Di Liu, Qiuyue Tian, Xiaoni Meng, Qiaoyun Zhang, Mengyang Jiang, Yiqiang Zhang, Manshu Song, Wei Wang, Youxin Wang, Baoguo Wang
Causal Associations Between Covid-19 And Atrial Fibrillation: A Bidirectional Mendelian Randomization Study, Xiaoyu Zhang, Biyan Wang, Tao Geng, Di Liu, Qiuyue Tian, Xiaoni Meng, Qiaoyun Zhang, Mengyang Jiang, Yiqiang Zhang, Manshu Song, Wei Wang, Youxin Wang, Baoguo Wang
Research outputs 2022 to 2026
Background and aims: Observational studies showed that coronavirus disease (2019) (COVID-19) attacks universally and its most menacing progression uniquely endangers the elderly with cardiovascular disease (CVD). The causal association between COVID-19 infection or its severity and susceptibility of atrial fibrillation (AF) remains unknown. Methods and results: The bidirectional causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with not hospitalized COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and AF are determined by using two-sample Mendelian randomization (MR) analysis. Genetically predicted severe COVID-19 was not significantly associated with the risk of AF [odds ratio (OR), 1.037; 95% …
Impact Of You Only Live Once: A Resilience-Based Hiv Prevention Intervention To Reduce Risky Sexual Behaviour Among Youth In South Africa, Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana, Ebenezer Afrifa-Yamoah, Maggie Zgambo
Impact Of You Only Live Once: A Resilience-Based Hiv Prevention Intervention To Reduce Risky Sexual Behaviour Among Youth In South Africa, Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana, Ebenezer Afrifa-Yamoah, Maggie Zgambo
Research outputs 2022 to 2026
Purpose: Interventions focused on promoting resilience or protective factors of youth have been proposed as a strategy for reducing risky behaviours associated with HIV infection among youth; however few studies have explored their effectiveness. This study assessed the impact of a resilience-based HIV prevention intervention (You Only Live Once) on risky sexual behaviours, resilience and protective factors of youth. Methods: A one-group pretest-posttest design was used. One hundred and ninety-seven youth aged 15 – 24 years were conveniently recruited from a non-profit organisation in Maluti-a-Phofung Local Municipality, South Africa and participated in a 12-session, resilience-based HIV intervention delivered over a …
Ancestral Sars-Cov-2, But Not Omicron, Replicates Less Efficiently In Primary Pediatric Nasal Epithelial Cells, Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina Mccallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short
Ancestral Sars-Cov-2, But Not Omicron, Replicates Less Efficiently In Primary Pediatric Nasal Epithelial Cells, Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina Mccallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short
Research outputs 2022 to 2026
Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. However, the emergence of SARS-CoV-2 variants of concern (VOCs) has been associated with an increased number of pediatric infections. Whether this is the result of widespread adult vaccination or fundamental changes in the biology of SARS-CoV-2 remain to be determined. Here, we use primary nasal epithelial cells (NECs) from children and adults, differentiated at an air-liquid interface to …
Evaluation Of Individual And Combined Markers Of Urine Dipstick Parameters And Total Lymphocyte Count As A Substitute For Cd4 Count In Low-Resource Communities In Ghana, Enoch Odame Anto, Christian Obirikorang, Emmanuel Acheampong, Bright Amankwaa, Bright Oppong Afranie, Sampson Donkor, Isaac Hope, Juliana Jommo, Esther Osaah
Evaluation Of Individual And Combined Markers Of Urine Dipstick Parameters And Total Lymphocyte Count As A Substitute For Cd4 Count In Low-Resource Communities In Ghana, Enoch Odame Anto, Christian Obirikorang, Emmanuel Acheampong, Bright Amankwaa, Bright Oppong Afranie, Sampson Donkor, Isaac Hope, Juliana Jommo, Esther Osaah
Research outputs 2014 to 2021
We evaluated the individual and combined levels of urine dipstick and total lymphocyte count (TLC) as surrogate markers for CD4 count in a low-resource community in Ghana. This cross-sectional study recruited 200 HIV-infected patients from the Saint Francis Xavier Hospital, Assin Fosu, Ghana. Complete blood count, CD4 count, and urine dipstick analysis were measured for participants. The threshold values were determined as/
Prevalence And Factors Associated With Hepatitis B Immunization And Infection Among Men Who Have Sex With Men In Beijing, China, Chao Wang, You Xin Wang, Xiao Jie Huang, Xia Li, Tong Zhang, Manshu Song, Li Juan Wu, Juan Du, Xiao Qin Lu, Shuang Shao, Fei Fei Zhao, Michele Ball, Hao Wu, Wei Wang
Prevalence And Factors Associated With Hepatitis B Immunization And Infection Among Men Who Have Sex With Men In Beijing, China, Chao Wang, You Xin Wang, Xiao Jie Huang, Xia Li, Tong Zhang, Manshu Song, Li Juan Wu, Juan Du, Xiao Qin Lu, Shuang Shao, Fei Fei Zhao, Michele Ball, Hao Wu, Wei Wang
Research outputs 2012
Background: Among the Chinese population of 1.3 billion, there are an estimated 93 million carriers of hepatitis B virus (HBV). Men who have sex with men (MSM) are at increased risk for HBV infection; however, the prevalence of HBV immunization and infection among Chinese MSM remains undetermined. Methods: A cross-sectional survey of 1,114 eligible participants was conducted in Beijing, China. Multiple methods were used to recruit study participants. Demographic information and potential correlated factors were collected by questionnaire. Additionally, blood specimens were collected and tested for sexually transmitted infections and serologic markers of hepatitis B immunization and infection. Results: Laboratory …
Health Communication Theories: Implications For Hiv Reporting In Asia And The Pacific, Trevor Cullen
Health Communication Theories: Implications For Hiv Reporting In Asia And The Pacific, Trevor Cullen
Research outputs pre 2011
This paper focuses on the expanding HIV (Human Immunodeficiency Virus) epidemic in parts of Asia and the Pacific region and recommends the adoption of insights from particular health communication theories. The author argues that these paradigms can assist in broadening the current scope and content of HIV reporting. One theory in particular - Social Change Communication (SCC) - challenges the media to extend the framing of HIV from primarily a health story to one that is linked to more macro socio-economic, cultural and political factors. Asian and Pacific countries that have an emerging or expanding HIV epidemic need to realise …
Hepatitis C, Quality Of Life And Cognitive Function : An Exploratory Study, John Caithness
Hepatitis C, Quality Of Life And Cognitive Function : An Exploratory Study, John Caithness
Theses : Honours
Active chronic hepatitis C (CHC) is a viral infection that affects approximately 150,000 Austra1ians. It has various quality of life impacts and the literature suggests some cognitive ramifications. In this Western Australian exploratory study, 13 healthy students from Edith Cowan University made up a control group. One experimental group consisted of 11 people with CHC and mild liver damage, and a second experimental group consisted of 8 people with CHC and at least moderate liver damage. The participants were assessed with a health-related quality of life questionnaire, the Short Form 36 Health Survey (SF-36); a test of cognitive functioning, the …
Living With Hepatitis C : A Literature Review, & The Physical, Psychological And Social Impacts Of Hepatitis C And The Effects On Quality Of Life, Narelle Cockman
Living With Hepatitis C : A Literature Review, & The Physical, Psychological And Social Impacts Of Hepatitis C And The Effects On Quality Of Life, Narelle Cockman
Theses : Honours
Hepatitis C (HCV) is a blood borne virus that affects the liver. It has become one of the most widespread blood borne viruses in Australia, now reaching epidemic proportions within the population. Given that HCV is a chronic long-term illness, with long term effects, a positive diagnosis potentially impacts on various aspects of' a person's life. The aim of this paper was to review HCV related research to examine what it is like for people living with the virus and the possible personal and social impacts of a positive diagnosis. The nature of HCV, including current incidence and prevalence rates, …
Fear, Frustration And The Will To Overcome: A Social History Of Poliomyelitis In Western Australia, John H. Smith
Fear, Frustration And The Will To Overcome: A Social History Of Poliomyelitis In Western Australia, John H. Smith
Theses: Doctorates and Masters
This thesis investigates community responses to Poliomyelitis, and the Impact of the disease on those who experienced It, particularly during the epidemics that occurred In Western Australia between 1938 and 1956. The research sources an.: W.A. Health Department records, held mostly at the Battye Library, records held by Australian Archives and Royal Perth Hospital, newspaper reports, comparative studies from several states in Australia and overseas, oral history interviews, biographies and personal records. The history of polio has several layers and the presence or the disease In the community evoked varied and ambiguous reactions, summarised here as fear, frustration and the …