Musculoskeletal Diseases Commons^™

Heterotopic Ossification: Cellular Basis, Symptoms, And Treatment, Brian Wolfe

Senior Honors Theses

Heterotopic ossification (HO) is the process by which calcified bone develops in soft tissues. Because of the abnormal calcification, complications such as bone deformation, loss of range of motion, and joint immobility adversely affect patients. There are many genetic types of heterotopic ossification, namely fibrodysplasia ossificans progressiva, progressive osseous heteroplasia, and Albright hereditary osteodystrophy. However, this condition can also arise from surgery, burns, or traumatic injuries, so it is seen as an important area for research in the future. There are various treatments available such as non-steroidal anti-inflammatory drugs and radiation therapy, as well as combinations of the two. The …

Decorin Expression, Straw-Like Structure, And Differentiation Of Human Costal Cartilage, Michael W. Stacey, Janna Grubb, Anthony Asmar, Julie Pryor, Hani Elsayed-Ali, Ali Beskok, Diganta Dutta, Annie Fecteau, Alice Werner, Dennis A. Darby, Robert Kelly

Bioelectrics Publications

Costal cartilage is much understudied compared with the load-bearing cartilages. Abnormally grown costal cartilages are associated with the inherited chest wall deformities pectus excavatum and pectus carinatum resulting in sunken and pigeon chests, respectively. A lack of understanding of the ultrastructural and molecular biology of costal cartilage is a major confounder in predicting causes and outcomes of these disorders. This study analyzed the structure of marginal human costal cartilage (ribs 6-10) through scanning electron and atomic force microscopes and identified the presence of straw-like structures running longitudinally. We also demonstrated that chondrocytes tend to occur singly or as doublets and …

Is Radial Extracorporeal Shock Wave Therapy An Effective Treatment For Chronic Plantar Fasciitis In Adults?, Lauren H. Rucker

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not radial extracorporeal shock wave therapy (ESWT) is an effective treatment in adults with chronic plantar fasciitis.

STUDY DESIGN: Review of three English language primary studies published between 2008 and 2010.

DATA SOURCES: Two randomized control trials and one cohort study analyzing the effects of radial extracorporeal shock wave therapy on chronic plantar fasciitis were found using the OVID, Medline and Cochrane Databases.

OUTCOMES MEASURED: Each of the three studies measured improvement in pain from baseline after patients were treated with ESWT. Pain levels were quantified using …

Decision Quality Instrument For Treatment Of Hip And Knee Osteoarthritis: A Psychometric Evaluation, Karen R. Sepucha, Dawn Stacey, Catharine F. Clay, Yuchiao Chang

Dartmouth Scholarship

A high quality decision requires that patients who meet clinical criteria for surgery are informed about the options (including non-surgical alternatives) and receive treatments that match their goals. The aim of this study was to evaluate the psychometric properties and clinical sensibility of a patient self report instrument, to measure the quality of decisions about total joint replacement for knee or hip osteoarthritis.

Femoroacetabular Impingement: Saving The Joint, Ronald Huang, Javad Parvizi

Department of Orthopaedic Surgery Faculty Papers

Many factors have been linked to the development of osteoarthritis (OA) of the hip, but often, cases are still considered “idiopathic.” Femoroacetabular impingement (FAI) has been suggested as a possible etiologic factor for the otherwise “idiopathic” cases. It is theorized that the subtle morphologic abnormalities seen at the head-neck junction and acetabulum in FAI may lead to labral tears, chondral damage, and subsequent progression of OA. Prevalence of FAI has been suggested to be as high as 14% in the general population. It often presents in young active patients that subject their hip joint to repetitive micro trauma associated with …

Natural History Study Of Arthrogryposis Multiplex Congenita, Amyoplasia Type, Trisha Nichols

Dissertations and Theses (Open Access)

Arthrogryposis or Arthrogrypsosis Multiplex Congenita (AMC) are terms used to describe the clinical finding of multiple congenital contractures. There are more than 300 distinct disorders associated with arthrogryposis. Amyoplasia is the most common type of arthrogryposis and is often referred to as the “classic” type. There is no known cause of amyoplasia and no risk factors have been identified. Moreover, there is no established diagnostic criteria, which has led to inconsistency and confusion in the medical literature. The purpose of this study was to describe the natural history of amyoplasia, to determine if there are any identifiable risk factors and …

Effect Of Calcium Supplements On Risk Of Myocardial Infarction And Cardiovascular Events: Meta-Analysis, Mark J. Bolland, Allison Avenell, John A. Baron, A. Grey

Dartmouth Scholarship

Objective: To investigate whether calcium supplements increase the risk of cardiovascular events.

Osteoporosis is a major cause of morbidity and mortality in older people. Calcium supplements margin- ally reduce the risk of fracture, and most guidelines recommend adequate calcium intake as an integral part of the prevention or treatment of osteoporosis. Consequently, calcium supplements are commonly used by people over the age of 50. Observational stu- dies suggest that high calcium intake might protect against vascular disease, and the findings are consis- tent with those of interventional studies of calcium sup- plements thatshow improvementin some vascular risk factors. In contrast, …

Variable Number Of Tandem Repeat Polymorphisms (Vntrs) In The Acan Gene Associated With Pectus Excavatum, Michael W. Stacey, Serina Neumann, Ashley Dooley, Kara Segna, Robert Kelly, Donald Nuss, Anne Kuhn, Michael Goretsky, Annie Fecteau, Aimee Pastor, Virginia Proud

Bioelectrics Publications

No abstract provided.

Determination Of Sphk1 In The Development Of A Murine Model Of Inflammatory Arthritis, Deanna Andrea Baker

MUSC Theses and Dissertations

Patients with rheumatoid arthritis (RA) have an over production of pro-inflammatory cytokines, especially TNFα, causing joint erosions and disability in untreated patients. Targeted therapies have had some success but are not without side effects and limitations; additionally, patients become refractory to treatment, and are obligated to use a combination of therapies. Therefore, new therapeutics are necessary. One novel target is sphingolipids, specifically sphingosine kinase 1 (SphK1). Previous research has demonstrated that knockdown/knockout of SphK1 influences the production of inflammatory mediators (i.e. COX-2 and PGE2) in vitro and in vivo. Since sphingosine 1 phosphate (S1P) receptors are upregulated in RA synovium, …

Development And Validation Of An Index Of Musculoskeletal Functional Limitations, Jeffrey N. Katz, Elizabeth A. Wright, John A. Baron, Elena Losina

Dartmouth Scholarship

While musculoskeletal problems are leading sources of disability, there has been little research on measuring the number of functionally limiting musculoskeletal problems for use as predictor of outcome in studies of chronic disease. This paper reports on the development and preliminary validation of a self administered musculoskeletal functional limitations index.

Effects Of 5 Different Finger Rest Positions On Arm Muscle Activity During Scaling By Dental Hygiene Students, Mary E. Cosaboom-Fitzsimons, Susan Lynn Tolle, Michele L. Darby, Martha L. Walker

Dental Hygiene Faculty Publications

Purpose. This study was conducted to determine the effects of 5 different finger rest positions: opposite arch, standard intraoral, basic extraoral, cross arch, and finger on finger on the muscle activity of 4 forearm muscles (extensor carpi radialis longus, flexor carpi ulnaris, biceps brachii, and pronator teres) during a simulated periodontal scaling experience.

Methods. A convenience sample of 32 consenting senior dental hygiene students who met inclusion criteria participated. Using a 4 x 5 counter-balanced research design, each participant used a Gracey 11/12 curet to scale one cc of artificial calculus from first permanent molar typodont teeth (#3,14,19,30). Five different …

The Effects Of A Short Course Of Muscle Energy Technique On Sacral Dysfunction In Patients With Acute Lumbosacral Pain, Regina O'Hara

Human Movement Studies & Special Education Theses & Dissertations

The purposes of this research study were to examine the effects of treating patients with suspected acute iliosacral rotational dysfunction with muscle energy techniques (MET) on (1) disability, (2) perceived pain during lumbar motion in neutral, flexion, and extension, (3) lumbar range of motion in flexion and extension, and (4) sagittal innominate rotation. Subjects were randomly assigned to the experimental and placebo groups. Experimental subjects received MET treatments, and placebo subjects received a stretching placebo treatinent. Subjects were treated four times over the course of one week. The initial examination and treatment occurred within 72 hours of the onset of …

Does Verbal Communication Impairment Affect Quality Of Life In Amyotrophic Lateral Sclerosis Patients?, Jason Michael Duff

PCOM Psychology Dissertations

The purpose of this study was to examine the self-perceived QOL in ALS patients. Literature will be presented on the incidence, prevalence, prognosis, diagnosis and management of ALS, QOL studies for ALS, the role of the multidisciplinary team, the impairments and dysfunction that ALS patients experience, communication issues, and the development of ALS specific instruments to measure QOL. The "bulbar dysfunction" that ALS patients experience in salivation management, speech, and swallowing were examined in detail. The objectives of this research study were to investigate the following hypotheses: 1. QOL will differ among ALS patients with varying levels of speech, swallowing, …

Pulmonary Langerhans Cell Histiocytosis, Muhammad Irfan, Javed Hussain, Riaz Lakdawala, Fayyaz Hussain, Javaid Khan

Section of Pulmonary & Critical Care

No abstract provided.

Results Of A "Stages Of Change" Pilot Survey From An Osteoporosis Prevention Outreach Program, Amy S. Gray

Inquiry: The University of Arkansas Undergraduate Research Journal

Osteoporosis is a serious health problem and crippling condition that often results in premature mortality and significant morbidity that may be manifested in the form of fractures, bone deformity, and pain. Osteoporosis affects almost 44 million people in the United States, 80% of whom are women. The purpose of this project was to test a pilot survey using the Stages of Change Model for health behaviors that may affect the risk of osteoporosis. Current research is lacking in use of the Stages of Change model for studying behaviors related to the prevention and reducing the risk of osteoporosis. Three surveys …

Job Accommodation In The Automobile Industry : Addressing The Problem Of Lateral Epicondylitis, Thanigaivel Ashwin Raj

Theses and Dissertations (ETD)

Cumulative trauma disorders are musculoskeletal problems such as carpal tunnel syndrome, rotator cuff tendinitis, and epicondylitis which can affect assembly line workers. The injuries are thought to result from repetitive motions performed under excessive loads in anomalous postures. The project aimed to design, build, install, and evaluate worksite accommodation at the Saturn plant for a worker with right lateral epicondylitis. The goal was to make her fully functional in her original team which required addressing the injurious aspects of the task that caused or aggravated her injury.

A process of observation, interview, and analysis identified “the door mount” operation on …

Accidents Types Des Monteurs De Lignes Du Secteur De La Construction (Annexe), Évelyne Kedl, Lucie Laflamme, Lyne Marinacci

Rapports de recherche scientifique

La première phase du projet dont il est ici question vise à résumer, en un nombre limité d’accidents types, les circonstances dans lesquelles les monteurs de lignes se blessent le plus souvent et les caractéristiques les plus courantes de leurs lésions. À cette fin, les fichiers "pairés" d’accidents des trois entrepreneurs participants et de la CESST ont servi à décrire 236 accidents en utilisant un total de 15 variables. Le traitement de ces données, rétrospectives, a conduit à la reconstruction de six classes d’accidents différentes les unes des autres.

Ces classes se distinguent d’abord par le genre de l’accident. Nos …

Accidents Types Des Monteurs De Lignes Du Secteur De La Construction, Évelyne Kedl, Lucie Laflamme, Lyne Marinacci

Rapports de recherche scientifique

La première phase du projet dont il est ici question vise à résumer, en un nombre limité d’accidents types, les circonstances dans lesquelles les monteurs de lignes se blessent le plus souvent et les caractéristiques les plus courantes de leurs lésions. À cette fin, les fichiers "pairés" d’accidents des trois entrepreneurs participants et de la CESST ont servi à décrire 236 accidents en utilisant un total de 15 variables. Le traitement de ces données, rétrospectives, a conduit à la reconstruction de six classes d’accidents différentes les unes des autres.

Ces classes se distinguent d’abord par le genre de l’accident. Nos …

Selenium And Sheep Health, B J. Gabbedy, A. J. Hadlow

Journal of the Department of Agriculture, Western Australia, Series 4

For many years selenium was known to the livestock industries only because of its toxic properties. Some soils, particularly in the United States of America, were so high in selenium that many animals died after grazing plants on these soils.

In 1957 it was discovered that selenium supplements could prevent a number of diseases and, from that time, selenium has been regarded as an essential trace element.

White muscle disease (WMD) was first recognised in sheep in Western Australia in 1960 and has occurred each year since.