Immune System Diseases Commons^™

Reproductive Autonomy In Immunological Intervention: Ethical Boundaries In Maternal-Fetal Immune Therapy, Marium Z. Rizvi

Journal of Health Ethics

Recent advances in immunology have broken barriers in reproductive medicine through immune-modulating therapies that support fertility and pregnancy. Treatments such as intravenous immunoglobulin (IVIG) and intralipid infusions are increasingly offered to patients with Recurrent Implantation Failure (RIF) or Recurrent Pregnancy Loss (RPL), conditions that result in miscarriages and failed IVF treatments (Pillarysetti et al., 2023). Maternal-fetal immunology reveals a delicate interplay between immune tolerance and defense: the maternal system must accept a genetically foreign fetus while preserving immunological protection. Disruptions in this balance are implicated in implantation disorders and pregnancy failure. As a result, immune-based therapies have emerged as promising …

Warm Autoimmune Hemolytic Anemia Camouflaged As Persistent Anemia Post-Embolization For Abnormal Uterine Bleeding: A Case Report, Nischal Pokhrel, Sathish Karmegam

North Texas Research Forum 2025

This case report presents a 42-year-old female with heavy menstrual bleeding and syncope, initially diagnosed with AUB due to fibroids. The patient's hemoglobin (Hb) dropped from 11.8 g/dl to 7.3 g/dl within three days, despite multiple PRBC transfusions. Uterine artery embolization (UAE) was performed, but Hb levels continued to decline, prompting further investigation. Additional testing revealed normal iron studies, vitamin B12, and folic acid levels. The peripheral blood smear showed mild anisocytosis, and the ANA screen was negative. However, elevated lactate dehydrogenase (LDH) at 571 U/L, a positive DAT for IgG, and a reticulocyte count of 6.37 were observed. These …

A Case Of Leukocytoclastic Vasculitis In The Setting Of Adalimumab Therapy For Treatment Of Crohn's Disease, Ferris Ghosh, Kinsey Lano, Dina Zamil

Gulf Coast Division GME Research Day 2025

No abstract provided.

Sle And Aps Synergy: Aortic Dissection, Neil Maithel, Ali Asghar, Rabia Mahfooz, Ibrahim Musa, Hasnan Ijaz, Thomas Alexander

Gulf Coast Division GME Research Day 2025

No abstract provided.

Hydralazine Induced Anca Vasculitis, Justin Huang, Yasasvi Sabbineni, Sumanth Reddy, Hani Khair

North Texas Research Forum 2025

Hydralazine is a vasodilator commonly used for hypertension. Hydrazine is commonly used in patients who can not tolerate ACEs and ARBs, resistant hypertension, and during pregnancy. Hydralazine has also been implicated in ANCA-associated vasculitis and drug-induced lupus erythematosus. Vasculitis is the presence of inflammatory leukocytes in vessel walls, inflammation can cause loss of vessel integrity which can lead to bleeding and downstream tissue ischemia and necrosis. Antineutrophil cytoplasmic antibody (AΝCΑ)-associated vаsсulitiѕ (ΑΑV) is a necrotizing vаsсսlitis that does not substantially involve the deposition of immune complexes. AΑV predominantly affects small vessels and is associated with ANСΑ specific for myeloperoxidase (MPO-ΑNCΑ) …

Atypical Presentation Of Cd4+ Small/Medium T-Cell Lymphoproliferative Disorder, Rafael Do Valle, Reem Ayoub, Marshall Hall, Henry Lim, Christian Scheufele, Garrett Furth, Michael Carletti, Stepehen E. Weis

North Texas Research Forum 2025

Introduction: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PCSM-LPD) is a rare cutaneous disorder that until 2016, was classified as a primary cutaneous lymphoma. PCSM-LPD histopathologically consists of a localized proliferation of small to medium-sized T lymphocytes. Clinically there is minimal to no systemic involvement. It typically presents as an asymptomatic, solitary red-purple nodule, papule, or plaque on the face. PCSM-LPD has an indolent course and an excellent prognosis. It is important to recognize PCSM-LPD as a distinct entity from primary cutaneous lymphoma to avoid treatments with side effects. Case Presentation: A 68-year-old female with a history of insulin-dependent type …

Distinguishing Dress From Morbilliform Drug Reactions: A Challenge In An Underserved Community Hospital, Ivan Mogollon, Francisco Arias, Catherine Matos, Luis Salcedo, Michelle Lopez

Gulf Coast Division GME Research Day 2025

No abstract provided.

A Rare Case Of Pulmonary Amyloidosis Causing Cystic Lung Disease In Sjogren's Syndrome, Suhas Kandimalla, Jordan Torres, Ramesh Kesavan, Siva T. Sarva

Gulf Coast Division GME Research Day 2025

No abstract provided.

Prevelence Odds Of Melanoma In Patients With Inflammatory Bowel Disease: An Observational Cross-Sectional Study, Nilay Bhatt, Kumail Rizvi

Gulf Coast Division GME Research Day 2025

No abstract provided.

Fatal Streptococcal Pneumonia Bacteremia Complicated By Purpura Fulminans In An Asplenic Patient, Farigol Hakem Zadeh, Nikita Shah, Vidya S. Kollu

North Florida Division GME Research Day 2025

No abstract provided.

A Novel Triad: Ulcerative Colitis, Granulomatosis With Polyangiitis, And Antiphospholipid Syndrome In A Single Patient, Neil Maithel, Rabia Mahfooz, Sean Alloju

Gulf Coast Division GME Research Day 2025

No abstract provided.

Avatrombopag-Induced Thrombocytosis Leading To Pulmonary Embolism In A Patient With Refractory Itp, Rohit Jaishankar, Kristine Peligrino, Alejandra Rinaldi, Racquel Fournet

East Florida Division GME Research Day 2025

No abstract provided.

The Face-Off Between Two Mimics: Lupus And Tuberculosis, Fnu Swatisikta, Nang Kham, Ali Chaudhry

East Florida Division GME Research Day 2025

INTRODUCTION Both lupus and Mycobacterium tuberculosis can affect any organ and can present with non-specific multi-organ involvement. In a patient with lupus, it may be difficult to distinguish between a lupus flare and a mycobacterial infection.

CASE A 28-year-old female with a history of systemic lupus erythematosus (SLE), (anti-Smith and ds-DNA positive), presented with knee swelling, chest and abdominal pain. She had elevated inflammatory markers, hyperkalemia with AKI. CT chest showed bilateral lung micronodules and patchy opacity. The patient had been on long-term steroids, mycophenolate, and hydroxychloroquine. Belimumab and voclosporin were initiated after a recent kidney biopsy revealed class 4 …

Unmasking Multicentric Reticulonodular Histiocytoma: A Rare Impostor Of Rheumatoid Arthritis, Rabia S. Mahfooz, Neil Maithel, Annmary Behanan, Naser Elkhalili

Gulf Coast Division GME Research Day 2025

No abstract provided.

A Swelling Mystery: Hereditary Angioedema In Pregnancy, Karen Valadez-Cuen, Andrea Francis, Alison Rossduetscher, Micheline Tantchou

Central & West Texas and San Antonio GME Research Day 2025

No abstract provided.

Not So Sle-Ghtly Bloody, A Nguyen, Napat Rangsipat, Shai Ring, Suhas Tatapudi, Cassie Robertson, Achi Chary, Damon Cao

Gulf Coast Division GME Research Day 2025

No abstract provided.

Bleeding Lungs: A Case Of Hydralazine Induced Systemic Lupus Erythematosus With Diffuse Alveolar Hemorrhage, Damara Miller, Munanchu Poudel, Neil Maithel, Deekshita Valiveti, Arjun Kamath, Rahul Dadhwal, Ali Mohammed, Rene Franco Jr., Abhay Vakil, Zuhair Ali

Gulf Coast Division GME Research Day 2025

No abstract provided.

Immune Related Cardiac Cardiac Tamponade Triggered By Pd-L1 Blockade In Breast Cancer: A Case Report, Luis Salcedo, Ivan Mogollon, Francisco Arias, Jose Donis, Michelle Lopez

Gulf Coast Division GME Research Day 2025

No abstract provided.

A Case Of Dress Syndrome Following Recurrent Hardware-Related Knee Infection: Diagnosis, Management, And Recovery, Cooper Alden Josephs, Himani Patel, James Everhart

South Atlantic Division GME Research Day 2025

No abstract provided.

Granulomatosis With Polyangitis Presenting As Cavernous Sinus Thrombosis And Oculomotor Nerve Palsy: A Case Report, Kempes Chan, Nanda Gopalan

Central & West Texas and San Antonio GME Research Day 2025

No abstract provided.

An Atypical Presentation Of Anti-Caspr2 Autoimmune Encephalomyelitis, Aaron De La Cruz, Sarita Thanedar, Shao-Ting Min, Prabhdeep Singh, Hitesh Gidwani

Central & West Texas and San Antonio GME Research Day 2025

No abstract provided.

A Rare Case Of Pseudo-Pseudo Meigs Syndrome With Systemic Lupus Erythematosus, Rabia Mahfooz, Grant Patterson, Neil Maithel, Daniel Kim

Gulf Coast Division GME Research Day 2025

No abstract provided.

Two Is Not Always Better Than One: An Intersting Case Of Inflammatory Myositis With Dual Myositis Specific Antibodies, Neil Maithel, Rabia Mahfooz, Ali Asghar, Paul S. Bongat

Gulf Coast Division GME Research Day 2025

No abstract provided.

Too Rash To Rule Out The Rash, Fnu Swatisikta, Chinar Singh

East Florida Division GME Research Day 2025

No abstract provided.

Severe Hypersensitivity Reaction After Unsupervised Hyaluronic Acid Filler Injection, Kevin Posner, Julia Fashner

East Florida Division GME Research Day 2025

No abstract provided.

Phentermine Induced Thrombocytopenia, Claudia Thornton, Jack Demirjian, Jason Pereira, Juan Nunez Rodriguez

Central & West Texas and San Antonio GME Research Day 2025

No abstract provided.

Microbial Remodeling Of Gut Tryptophan Metabolism And Indole-3-Lactate Production Regulate Epithelial Barrier Repair And Viral Suppression In Human And Simian Immunodeficiency Virus Infections, Clarissa Santos Rocha, Katie L. Alexander, Carolina Herrera, Mariana G. Weber, Irina Grishina, Lauren A. Hirao, Dylan J. Kramer, Juan Arredondo, Abigail Mende, Katti R. Crakes, Anne N. Fenton, Maria L. Marco, David A. Mills, John C. Kappes, Lesley E. Smythies, Paul Ziprin, Sumathi Sankaran-Walters, Phillip D. Smith, Satya Dandekar

Department of Obstetrics & Gynecology Faculty Publications

Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability and mechanisms of gut microbes to restore epithelial barriers and mucosal immunity in virally inflamed gut by using a multipronged approach: an in vivo simian immunodeficiency virus (SIV)-infected nonhuman primate model of HIV/AIDS, ex vivo HIV-exposed human colorectal explants and primary human intestinal epithelial cells. SIV infection reprogrammed tryptophan (TRP) metabolism, increasing kynurenine catabolite levels that are …

Impact Of Hiv-2 Rod9 Vpx Mutations On Samhd1 Degradation And Vpx Nuclear Trafficking, Tolulope R. Oladimeji

All Graduate Theses, Dissertations, and Other Capstone Projects

Human Immunodeficiency Virus (HIV) is a leading cause of death in many parts of the world. HIV-2, endemic to West Africa, has infected over 2 million people globally. A key difference between HIV-2 and the more widespread HIV-1 is the HIV-2 protein Vpx, which facilitates infection in non-dividing cells by targeting SAMHD1, a host innate immune protein, for proteasomal degradation. This research aims to identify specific amino acid residues in HIV-2 ROD9 Vpx that are essential for mediating SAMHD1 degradation by the proteosome. I hypothesize that amino acid residues located in the C-terminal region of Vpx play a critical role …

Therapeutic Roles For Alkaline Phosphatases To Target Intestinal Dysfunction In Mouse Models Of Experimental Sepsis And Ischemic Stroke, Rhiannon V. Macom

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Therapeutic Roles for Alkaline Phosphatases to Target Intestinal Dysfunction in Mouse Models of Experimental Sepsis and Ischemic Stroke

Rhiannon V. Macom

Stroke is a disease that primarily affects the brain; however, ongoing research continues to show that stroke has far reaching systemic effects that can affect both short- and long-term recovery. The gastrointestinal tract has been shown to be affected post-stroke, and these effects are likely due to the bidirectional communication between the gut and the brain via the gut-brain-axis. Alkaline phosphatases (APs) are common membrane bound enzymes that are known to have a role in mitigating inflammation. The …

Hemoptysis In A Previously Healthy Hispanic Male: A Case Of Anca Vasculitis Diagnosis, Muhammad Anzar Ullah, Angel Pacheco-Rueda, Marwa Hegagi

West Florida Division GME Research Day 2025

No abstract provided.