Immune System Diseases Commons^™

Trends. The Attack On Mbeki: Praising Through Damning, Ibpp Editor

International Bulletin of Political Psychology

This article discusses the controversial contention by President Thabo Mbeki of the Republic of South Africa that poverty and lack of health infrastructures are the causes of AIDS and HIV in Africa instead of limiting his analysis to the biological line of virus inducing disease.

The Import Of Political Psychology For Global Health And Security: The Case Of Aids, Ibpp Editor

International Bulletin of Political Psychology

This article describes a number of applied research areas that political psychologists can explore to help manage the threat to global health and security from acquired immune deficiency syndrome (AIDS).

Orthognathic Surgery In The Juvenile Rheumatoid Arthritic Patient, David H. Gilbert

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis attempts to use a retrospective evidenced base review of a series of five patients afflicted with juvenile rheumatoid arthritis and its inherent dento-facial deformity as a basis for establishing a proposal for a surgical protocol.

A review of pertinent and current literature is performed in describing the disease process as it relates to epidemiology, histopathophysiology, immunology, and clinical presentation. General treatment options are reviewed for the acutely and chronically afflicted patients as well as specific approaches to dento-facial reconstruction.

The studies reviews a series of five female patients who were evaluated and treated by the same surgeon at …

Trends. Controlling Aids Through Control, Ibpp Editor

International Bulletin of Political Psychology

This article discusses the concept of political control and public health in the context of the HIV/AIDS epidemic.

Anti-Gag Cytolytic T Lymphocytes Specific For An Alternative Translational Reading Frame-Derived Epitope And Resistance Versus Susceptibility To Retrovirus-Induced Murine Aids In F1 Mice, Shawn-Marie Mayrand, Patricia A. Healy, Bruce E. Torbett, William R. Green

Dartmouth Scholarship

Murine AIDS (MAIDS) develops in susceptible mouse strains after infection with the LP-BM5 murine leukemia virus complex that contains causative defective, and ecotropic helper, retroviruses. We previously demonstrated that the MAIDSresistant H-2d strains BALB/cByJ and C57BL/KsJ generate MHC class I (Kd ) restricted virus-specific CD81 cytolytic T lymphocytes (CTLs) that lyse cells expressing either defective or ecotropic gag proteins. In contrast, the congenic BALB.B and closely related C57BL/6J MAIDS-susceptible H-2b strains were unable to serve as a source of gag-specific CTLs (Schwarz and Green, 1994), suggesting that anti-gag CTLs might provide a basis for resistance to MAIDS. Although its susceptibility …

Quantitative Image Analysis Of Simian Immunodeficiency Virus Replication In Macrophages Coinfected With Mycobacterium Avium Complex, Qingsheng Li, Keith G. Mansfield, Andrew Lackner, Ashley T. Haase

Qingsheng Li Publications

Mycobacterium avium is the most frequent cause of disseminated bacterial infection in patients with human immunodeficiency virus type 1 infection and in rhesus macaques with simian immunodeficiency virus (SIV) infection. This animal model of AIDS was used to test the hypothesis that this frequent association is the result of reciprocal enhancement of replication of both microorganisms. The replication of M. avium and SIV was analyzed in lymphatic tissues obtained from rhesus macaques experimentally inoculated with SIVmac who developed or remained free of overt M. avium infection. In situ hybridization, quantitative image analysis, and staining of M. avium and of macrophages …

Novel Approaches For Designing 5'-O-Ester Prodrugs Of 3'-Azido-2'3'-Dideoxythymidine (Azt), Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus

Pharmacy Faculty Articles and Research

3'-Azido-2'3'-dideoxythymidine (AZT, 1, zidovudine, RetrovirTM) is used to treat patients with human immunodeficiency virus (HIV) infection. AZT, after conversion to AZT-5'-triphosphate (AZT-TP) by cellular enzymes, inhibits HIV-reverse transcriptase (HIV-RT). The major clinical limitations of AZT are due to clinical toxicities that include bone marrow suppression, hepatic abnormalities and myopathy, absolute dependence on host cell kinase-mediated activation which leads to low activity, limited brain uptake, a sort half-life of about one hour in plasma that dictates frequent administration to maintain therapeutic drug levels, low potential for metabolic activation and/or high susceptibility to catabolism, and the rapid development of resistance by HIV-1. …