Immune System Diseases Commons^™

Asymmetric Deactivation Of Hiv-1 Gp41 Following Fusion Inhibitor Binding., Kristen M Kahle, H Kirby Steger, Michael J Root

Department of Biochemistry and Molecular Biology Faculty Papers

Both equilibrium and nonequilibrium factors influence the efficacy of pharmaceutical agents that target intermediate states of biochemical reactions. We explored the intermediate state inhibition of gp41, part of the HIV-1 envelope glycoprotein complex (Env) that promotes viral entry through membrane fusion. This process involves a series of gp41 conformational changes coordinated by Env interactions with cellular CD4 and a chemokine receptor. In a kinetic window between CD4 binding and membrane fusion, the N- and C-terminal regions of the gp41 ectodomain become transiently susceptible to inhibitors that disrupt Env structural transitions. In this study, we sought to identify kinetic parameters that …

Primary Iga And Igg Subclass Deficiency In A 17-Year-Old Pakistani Girl: A Case Report., Taimur Saleem, Madiha Rabbani, Bushra Jamil

Department of Medicine

Primary immunodeficiency disorders pose a diagnostic dilemma for physicians in the developing countries such as Pakistan because of lack of adequate diagnostic facilities. We present here the case of a 17-year-old girl who had a history of recurrent respiratory tract infections since childhood and had been treated with anti-tuberculous medications thrice, for a total of 24 months. She had also received multiple courses of antibiotics. Her initial presentation to our hospital was with acute bronchopneumonia. Her past medical history of recurrent infections also alerted the treating physician to the possibility of bronchiectasis secondary to a variety of underlying potential pathologies …

Stigma Cities: Dystopian Urban Identities In The United States West And South In The Twentieth Century, Jonathan Lavon Foster

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation examines how historical events and representation of those events relative to the wider historical context have allowed the media, opinion setters, and the ordinary public to use the names of San Francisco, California, Birmingham, Alabama and Las Vegas, Nevada as denigrating adjectives and the effect of this usage on those cities. Exploration of Birmingham’s image as a racist city, San Francisco’s as a gay Mecca, and Las Vegas, Nevada’s as an adult playground or sinful city serves this purpose. These case studies support a central argument that the nature of place-based stigmatization’s influence depends upon ever-shifting cultural values …

Sero-Negative Celiac Disease With Dermatitis Herpetiformes: A Case Report., Mehreen Adhi, Asma Farooq, Syed Ali Hamid, Rabia Hasan, Salman Mamji, Akhtar Ali Baloch

Department of Surgery Docs

Introduction:We report a case of sero-negative celiac disease in Pakistan. Case Presentation: A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms.

Conclusions:

Negative serology should not rule out celiac disease, …

The Role Of Interferon Gamma In The Regulation Of Il-18 Binding Protein And The Development Of Autoimmune Arthritis In A Genetically Non-Susceptible Mouse Strain, Timothy Daniel Kayes

Theses and Dissertations (ETD)

The etiology of the autoimmune disease rheumatoid arthritis (RA) is unknown, but the role of cytokines, including IFN-g, as effectors of immune cell function has been established by the examination of cytokine production in RA patients and through the use of animal models. C57BL/6 (B6) mice that express MHC class II molecules of the b haplotype (I-A^b) are not typically susceptible to collagen-induced arthritis (CIA), the most widely studied animal model of RA. When the gene encoding IFN-g is removed by genetic deletion, however, susceptibility to CIA is conferred. In addition, T cell responses against the immunogen that …

Women's Health And Fitness Magazines: An Accurate Portrayal?, Jennifer M. Shymansky

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study is a content analysis examining the representation of health information, particularly the leading causes of death, in cover story headlines of one year of the top women's health and fitness magazines: Prevention , Shape , Fitness , Self , Health and Women's Health. The study is grounded in social responsibility theory, a normative media theory. The findings show that women's health and fitness magazines' cover story headlines predominately discuss diet and exercise for weight loss, rather than the leading causes of death facing women. This under representation of actual societal health concerns can limit the vast readerships' health …

The Curse Of A Generation: Evaluating The Effects Of Gender Roles And Marriage On Hiv/Aids In Sub-Saharan Africa And Developing An Efficient Prevention Plan, Mark B. Krom

Senior Honors Theses

HIV/AIDS research in sub-Saharan Africa shows an important relationship between gender roles, marriage, and HIV prevalence. Research is collected and analyzed, and cultural issues are addressed in order to develop a prevention plan. The African church seems to be an efficient venue through which to reach sub-Saharan Africa, and the most efficient prevention plan to curb HIV/AIDS is abstinence.

Prevention Of Mother-To-Child Transmission (Pmtct) Of Hiv In The Sub-Saharan Africa Region With A Focus On Uganda, Emily K. Franks

Senior Honors Theses

With the rise of the HIV/AIDS epidemic in the past thirty years, people of all ages, infants to elderly alike, all over the world, suffer from its adverse effects. Even an unborn baby in-utero can contract this virulent infection by means of mother-to-child transmission (MTCT) (Sweeney, 2005). Infants and children diseased in this way comprise 90% of the estimated 800,000 new cases of HIV in children seen each year, but the region hit hardest, however, is Sub-Saharan Africa, with the country of Uganda historically having the highest incident rate for a time (Stringer, E.M., et al. 2008). Therefore, the purpose …

Evaluation Of Hiv Counseling And Testing In Anc Settings And Adherence To Short Course Antiretroviral Prophylaxis For Pmtct In Francistown, Botswana, Carolyn Baek, Tracy Creek, Lee Ann Jones, Louis Apicella, Jennifer Redner, Naomi Rutenberg

HIV and AIDS

The vast majority of children infected with HIV are the result of mother-to-child transmission (MTCT) of the virus during pregnancy, labor, or breastfeeding. Botswana is one of the first countries in the developing world with a national prevention program (PMTCT) to reduce vertical transmission. The Horizons Program of the Population Council, in collaboration with the Centers for Disease Control and Prevention (CDC) and Premiere Personnel in Botswana, conducted an evaluation to describe the adherence of pregnant women to the current PMTCT regimen. The report recommends standardizing post-test counseling content through the use of job aids and adapting existing WHO materials, …

Commercial Sex Workers In Five Ethiopian Cities: A Baseline Survey For Usaid Targeted Hiv Prevention Program For Most-At-Risk Populations, Woldemariam Girma, Annabel Erulkar

HIV and AIDS

This report presents findings from a baseline survey of commercial sex workers (CSWs) that was undertaken in five Ethiopian cities. 2,050 CSWs were interviewed for the survey. CSW were disproportionally young and came from extremely disadvantaged backgrounds. Most respondents also cited negative working standards from another profession, or family responsibilities as reasons leading to sex work. Condom use was very high but use may be inconsistent or over-reported and should be studied further. Findings also propose additional advocacy for positive peer support groups, more HIV testing for at-risk populations, and addressing violence among CSWs and other Ethiopian women.

Global Trends In Aids Mortality, John Bongaarts, Francois Pelletier, Patrick Gerland

Poverty, Gender, and Youth

This working paper reviews the evolution of the HIV/AIDS epidemic and provides estimates of past trends and future projections of AIDS mortality indicators, including numbers of AIDS deaths, the proportion of all deaths that are due to AIDS, and life expectancy. A cumulative total of 24 million people have died from AIDS between 1980 and 2007, and by 2030 this total is projected to reach 75 million. Despite the rapid spread of this new disease during the 1980s and 1990s, the epidemic has reached a major turning point in recent years as the rate of new infections peaked and began …

A Narrative Analysis Of The Experiences Of Living With Hiv For Heterosexual Men, Tanya Millard

Theses : Honours

The number of heterosexual men presenting with Human Immunodeficiency Virus (HIV) is steadily increasing in Australia. A paucity of literature currently exists surrounding the experience of living with HIV for heterosexual men, with most information targeted towards gay men, injecting drug users (IDUs) and women. This narrative literature review examines the body of knowledge concerning the experiences of heterosexual men living with HIV. The findings of this review indicate that for heterosexual men, HIV significantly impacts on their physical, psychological and social well being. In particular, they struggle with social and intimate relationships, negotiating disclosure, managing their stigmatised identity, and …

African American Women And Hiv Prevention, Nicole Monique Samuel

Master's Theses and Doctoral Dissertations

For many health conditions, non-Hispanic Blacks bear a disproportionate burden of disease, injury, death, and disability. The purpose of this study was to examine African American females and their HIV prevention methods, as well as to identify factors that may lead to the non-use of condoms. Seventy-one participants were recruited from Planned Parenthood in Detroit. The instrumentation used for this research was the Sexual Health and Beliefs Survey. Results indicated that 69 percent of the respondents had five or more sexual partners in the lifetime. Ninety-four percent of the participants knew where to purchase condoms, and 89 percent stated that …

Combined Effects Of Hyperglycemic Conditions And Hiv-1 Nef: A Potential Model For Induced Hiv Neuropathogenesis., Edward A Acheampong, Cassandra Roschel, Muhammad Mukhtar, Alagarsamy Srinivasan, Mohammad Rafi, Roger J Pomerantz, Zahida Parveen

Department of Neurology Faculty Papers

Hyperglycemic conditions associated with diabetes mellitus (DM) or with the use of antiretroviral therapy may increase the risk of central nervous system (CNS) disorders in HIV-1 infected patients. In support of this hypothesis, we investigated the combined effects of hyperglycemic conditions and HIV-1 accessory protein Nef on the CNS using both in vitro and in vivo models. Astrocytes, the most abundant glial cell type required for normal synaptic transmission and other functions were selected for our in vitro study. The results show that in vitro hyperglycemic conditions enhance the expression of proinflammatory cytokines including caspase-3, complement factor 3 (C3), and …

2009- 2010 Unlv Mcnair Journal, Kathleen Bell, Danetta Bradley, Vacheral M. Carter, Nydia Diaz, Kathryn E. English, Sarah Harrison, Michelle Israel, Christina Macke, Erica Orozco, Pilar Palos, Sandra Ramos, Soraya A. Silverman, Susan Taylor, Sajar Camara, William Mccurdy, Yvonne C. Morris, Maxym V. Myroshnychenko, Ricardo Rios, Monique Sulls, Bremen Vance, Barbara Wallen

McNair Journal

Journal articles based on research conducted by undergraduate students in the McNair Scholars Program

Table of Contents

Biography of Dr. Ronald E. McNair

Statements:

Dr. Neal J. Smatresk, UNLV President

Dr. Juanita P. Fain, Vice President of Student Affairs

Dr. William W. Sullivan, Associate Vice President for Retention and Outreach

Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach

McNair Scholars Institute Staff

Taking Be Proud! Be Responsible! To The Suburbs: A Replication Study, Elaine A. Borawski, Erika S. Trapl, Kimberly Adams-Tufts, Laura L. Hayman, Merdith A. Goodwin, Loren D. Lovegreen

Ellmer School of Nursing Faculty Publications

CONTEXT: An important phase of HIV prevention research is replicating successful interventions with different groups and in different settings.

METHODS: Be Proud! Be Responsible!, a successful intervention originally targeting black urban males and carried out in nonschool settings, was presented in health classes at urban and suburban schools with diverse student bodies. A group-randomized intervention study, which included 1,357 ninth and 10th graders from 10 paired schools in a Midwestern metropolitan area, was conducted in 2000-2002. Half the schools received the intervention, and half received a general health promotion program. Students' reports of their sexual behavior and selected cognitive mediators …

The Effectiveness And Adoption Of Market-Based State Health Care Expansion Programs, Nathan Gregory Myers

UNLV Theses, Dissertations, Professional Papers, and Capstones

Market-based state health expansion programs are alternatives to government programs like Medicaid and SCHIP which also seek to expand access to health insurance for uninsured populations. These programs either utilize the private health insurance market or function according to market principles. The market-based policies at issue in this research are state high-risk health insurance pools, limited benefit plans, group purchasing arrangements, reinsurance programs, and Health Insurance Flexibility and Accountability waivers. This research addresses two separate but related research questions: (1) Do these market-based programs provide general economic and social benefits for the citizens of a state? (2) What role does …