Immune System Diseases Commons^™

Coexisting Systemic Lupus Erythematosus And Acquired Thrombotic Thrombocytopenic Purpura In A Clinically Stable Patient With Class V Lupus Nephritis, Anabel Al Abdallah, Nimmy Joy, Rodrigo Alfaro

Central & West Texas and San Antonio GME Research Day 2026

No abstract provided.

Lupus, Children's Health School Services

School Guides

Educator guide about how to support students with lupus.

The Face-Off Between Two Mimics: Lupus And Tuberculosis, Fnu Swatisikta, Nang Kham, Ali Chaudhry

East Florida Division GME Research Day 2025

INTRODUCTION Both lupus and Mycobacterium tuberculosis can affect any organ and can present with non-specific multi-organ involvement. In a patient with lupus, it may be difficult to distinguish between a lupus flare and a mycobacterial infection.

CASE A 28-year-old female with a history of systemic lupus erythematosus (SLE), (anti-Smith and ds-DNA positive), presented with knee swelling, chest and abdominal pain. She had elevated inflammatory markers, hyperkalemia with AKI. CT chest showed bilateral lung micronodules and patchy opacity. The patient had been on long-term steroids, mycophenolate, and hydroxychloroquine. Belimumab and voclosporin were initiated after a recent kidney biopsy revealed class 4 …

Drug-Induced Leukocytoclastic Vasculitis From An Unreported Source: Daptomycin, Jennifer K. Priessnitz, Timothy Kuzel, Lindsay Ackerman, Nelson Nicolasora

Department of Medicine Faculty Publications

Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis caused by immune-complex-mediated deposition on endothelial cells of dermal capillaries. Common triggers include medications, infections, autoimmune disorders, and malignancies. We present a case of a 58-year-old male who developed daptomycin-induced LCV after being treated for Methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. The patient experienced painful palpable purpura on his lower extremities, which was diagnosed as LCV by skin biopsy. At the time of the biopsy, warfarin and daptomycin were discontinued, and the patient was transitioned to heparin and ceftaroline. MRSA-induced LCV was ruled out, due to negative blood cultures and adequate source control …

Investigating The Link Between Vitamin D Levels And Glucocorticoid Usage In Systemic Lupus Erythematosus, Ellen Yos, Jayden Navarro, Mohamed Faris

South Atlantic Division GME Research Day 2024

No abstract provided.

Severe Case Of Systemic Lupus Erythematosus In A 36-Year-Old Male, Aleeza Ali, Max Kaito, Stanley Dennison, Hanan Zisling, Esam Khalifa, John Romano

East Florida Division GME Research Day 2023

Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease that is capable of involving almost any organ in the body, leading to significant morbidity and mortality in affected patients. SLE is characterized by pathogenic autoantibodies that react with antigens and form immune complexes, resulting in tissue damage and a potential wide array of manifestations, including arthralgias, lupus nephritis, pleuritis, and delirium. Experts cite the effect of estrogens or factors related to the X chromosome as possible explanations regarding the increased prevalence of SLE in women over men, with ratios of up to 15:1. Here, we discuss the case of a …

Can Viruses Cause Lupus?, Stephen I. Reeder

Selected Honors Theses

Like so many autoimmune diseases, the exact cause of systemic lupus erythematosus (SLE) remains unknown. Evidence points to both genetics and environment playing roles in the onset of the disease, but neither acts independent of the other. Genetics are the easier of the two to study with recent advances in the field making it easier to isolate genes shared by individuals with the disease. However, genetic studies reveal that there is almost certainly an environmental component to the development of SLE. The underlying pathology and existing research on environmental contributors to the development of SLE suggest that viruses could potentially …

The Severity And Lack Of Awareness Of Dermatomyositis, Alexander Lorenzo Perez Herrera

Senior Theses

Dermatomyositis is a rare autoimmune disease that affects a very small percentage of the population, close to 10 cases per million, according to the National Organization of Rare Disorders (NORD). The amount of men that are diagnosed with this disease are even smaller. However, hardly anyone knows what Dermatomyositis is, let alone what its side effects are. The purpose of this research paper is to exploit the severity of Dermatomyositis for those who are unaware of its existence, characteristics and significance within the health community. In doing so, I hope to create awareness throughout society by also telling my father’s …

Role Of B Cell And Hematopoietic Cell Intrinsic Actions Of Erα In Lupus Pathogenesis, Dana E. Tabor

Theses & Dissertations

Lupus is a chronic autoimmune disease characterized by the presence of autoimmune B and T cells and the production of pathogenic antibodies against nuclear antigens. Lupus predominately affects women between menarche and menopause. There are both genetic and environmental risk factors which affect an individuals’ risk of developing lupus. Estrogens are a risk factor for developing lupus and are thought to contribute significantly to the initiation and progression of disease. In lupus-prone mice, genetic knockout of a receptor for estrogen, estrogen receptor alpha (ERα), causes significant attenuation of lupus. Previous studies have not identified the cell type or …

Initial Benchmarking Of The Quality Of Medical Care In Childhood-Onset Systemic Lupus Erythematosus., Rina Mina, Julia G. Harris, Marisa S. Klein-Gitelman, Simone Appenzeller, Maraisa Centeville, Diane Eskra, Jennifer L. Huggins, Anne L. Johnson, Raju Khubchandani, Prachi Khandekar, Jiha Lee, Hai Mei Liu, Joshua D. Pendl, Clovis A. Silva, Marco F. Silva, Ahmad I. Zaal, Esi Morgan Dewitt, Stacy P. Ardoin, Hermine I. Brunner

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To assess the quality of medical care in childhood-onset systemic lupus erythematosus (SLE) at tertiary pediatric rheumatology centers as measured by observance of SLE quality indicators (SLE-QIs).

METHODS: International consensus has been achieved for childhood-onset SLE-QIs capturing medical care provision in 9 domains: diagnostic testing, education of cardiovascular (CV) risk and lifestyles, lupus nephritis (LN), medication management, bone health, ophthalmologic surveillance, transition, pregnancy, and vaccination. Using medical record information, the level of performance of these childhood-onset SLE-QIs was assessed in childhood-onset SLE populations treated at 4 tertiary pediatric rheumatology centers in the US, 2 in Brazil, and 1 center …

Caspase-12 And Lupus: The Curious Case Of The Dog That Didn’T Bark, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

CASPASE-12 (CASP12) has an anti-inflammatory function during infection, and is a risk factor for sepsis in African-Americans (AA). To determine if CASP12 could be protective for systemic lupus erythematosus (SLE) in AA, we genotyped AA SLE patients and controls. We found that, at best, there was a weak association between CASP12 genotype with the absence of anti-dsDNA autoantibodies in SLE patients. No effect was seen upon serum interleukin-1 beta levels, nor was any other protective effect noted for the CASP12 genotype, whether upon association with SLE, or any of the 11 American College of Rheumatology classification criteria. We concluded that …

The Anti-Inflammatory Caspase-12 Gene Does Not Influence Sle Phenotype In African-Americans, Trista Fuchs, Jennifer A. Kelly, Emily Simon, Kathy L. Sivils, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

No abstract provided.

Aberrant Expression Of Light And Its Associated Receptors In Systemic Lupus Erythematosus And Coeliac Disease, Eugene Dempsey

Doctoral

Members of the TNF superfamily play important roles in the development and maintenance of an effective immune response. One such member of this superfamily, LIGHT, can act as a ligand for three receptors, HVEM, LT-R and DcR3. The engagement of LIGHT and HVEM, an important secondary signal for the full activation of T cells, results in a strong Th1 type response with increased production of cytokines such as INF--. The LIGHT-LT-R pathway plays a role in the recruitment of immune cells to sites of inflammation and can induce apoptosis in certain cells. DcR3, a soluble receptor, is speculated to function …