Effect Of Remineralization And Resin Infiltration On Microhardness, Mineral Content And Cervical Leakage Of Restored Demineralized Enamel., Caroline Maged Massieh, Sarah Adel Botros

Dentistry

Purpose: To evaluate the effect of remineralization and resin infiltration on microhardness, mineral content and microleakage in artificially-induced cervical enamel lesions. Materials and Methods: 50 human central incisors were assigned to 5 study groups (n=10) according to different surface intervention: Group 1: Positive Control (sound teeth not subjected to demineralization); Group 2: Negative Control (teeth subjected to demineralization); Group 3: CPP-ACP paste (remineralization of demineralized lesions with CPP-ACP, Tooth Mousse, GC); Group 4: HAp toothpaste (remineralization of demineralized lesions subjected with HAp, Herbadent Remin); Group 5: Resin infiltration (resin infiltration of demineralized lesions with ICON, DMG). Microhardness (MH) was evaluated …

Dual Regulation Of Osteogenesis And Inflammation By Pomegranate (Punica Granatum L.) Extract In Periodontal Ligament-Derived Stem Cells: Implications For Regenerative Medicine, Mai Hafez

Dentistry

Objectives

This article aims to compare the osteogenic along with anti-inflammatory activity of different concentrations of pomegranate extract (PG) on human periodontal ligament-derived stem cells (hPDLSCs) in vitro.

Materials and Methods

hPDLSCs were acquired from the root surface of removed molars, cultured, and then distinguished by flow cytometry analysis and several lineage differentiation potentials. To identify the effect of PG on hPDLSCs' viability, an MTT assay was performed. hPDLSCs were maintained in osteogenic induction medium with varying concentrations of PG. At the end of the induction period, osteogenesis was assessed using Alizarin Red staining, ALP assay, and qRT-PCR to determine …

Remineralization Effect On Enamel Physicochemical Properties After Chlorine-Induced Erosion, Sara Adel Botros, Mohamed Samy Salama, Mahmoud Al Ankily, Nora Ahmed Alzayyat

Dentistry

No abstract provided.

Assessment Of Incisive Canal Morphology And Position In A Sample Of Egyptian Population: A Cone Beam Computed Tomography Study, Sherif Shafik

Dentistry

ABSTRACT Several studies have highlighted the diversity in the anatomy of the incisive canal. Evaluation of incisive canal as well as its approximation to the maxillary incisor root is crucial before orthodontic treatment, implant placement and other surgical procedures in the anterior maxillary area. Cone beam computed tomography (CBCT) provides detailed three-dimensional information and have been used to evaluate the nasopalatine region with high accuracy along with relative safety due to low radiation exposure. Aim: The study aimed to provide analysis of the nasopalatine canal anatomy using cone-beam computed tomography (CBCT) in a sample of the Egyptian population. Materials & …

Epidemiology Of Recurrent Herpes Labialis Among Dentistry Students: A Cross-Sectional Survey In Egypt, Sara Abdelwahed, Dalia Ghalwash, Al Hassan Diab

Dentistry

Aim: Recurrent herpes labialis (RHL) is a common viral infection with significant psychosocial and clinical implications. Dental students are particularly vulnerable due to stress and frequent patient contact, yet data on their epidemiology in Egyptian cohorts are scarce. The study aimed to determine the prevalence, recurrence patterns, and associated risk factors of RHL among dentistry students in Egypt. Materials and Methods: A cross-sectional survey was conducted among 559 dentistry students at the British University in Egypt. A structured, self-administered questionnaire captured sociodemographic data, history of RHL episodes, frequency, severity, and triggering factors. Data were analyzed using descriptive statistics and Chi-square …

Effect Of Green Synthesized Silver Nanoparticles Using Pisum Sativum Peel Aqueous Extract On Oral Squamous Cell Carcinoma, Oral Epithelial Cells And Fibroblasts Cell Lines, Mai Hafez

Dentistry

No abstract provided.

Double Immunohistochemical Analysis Of Pcna And Fak Expression In Selected Odontogenic Lesions, Safaa Baz, Sally Ibrahim

Dentistry

Background: Odontogenic neoplasms and cysts have diverse biological behaviors, ranging from indolence to aggression along a spectrum. The proliferating cell nuclear antigen (PCNA) is an antigen involved in DNA synthesis and proliferation. Focal adhesion kinase (FAK) is a cytoplasmic molecule associated with cellular signaling, growth, and invasion. PCNA and FAK markers have been shown to be involved in neoplastic proliferation, invasion, and migration. Hence, an immunohistochemical assay of PCNA and FAK can be used as a predictive tool for the level of aggressive behavior of odontogenic lesions. Methods: The current study was conducted to evaluate the expressions of PCNA and …

Comorbidity Of Hypertension And Chronic Renal Failure And Their Impact On Oral Complications: A Cross-Sectional Study., Dalia Ghalwash, Sara Abdelwahed, Asmaa Abobakr

Dentistry

The present study aimed to investigate the influence of both end-stage renal diseases (ESRD) and hypertension (HTN) on the various oral manifestations and periodontal condition, to evaluate and compare the oral manifestations and periodontal health status in hypertensive patients with ESRD versus control, and to explore any possible correlation of the oral findings with systemic disease status. This was a cross-sectional study which included two equal groups of patients, Group I were hypertensive patients with ESRD and Group II were hypertensive patients only. All patients were hypertensive and were on antihypertensive medications. Regarding the incidence of oral lesions in both …

Orofacial Pigmentation In Hemodialysis Patients: A Case Control Study, Asmaa Ras, Eman Khalil, Radwa Hussein, Nevine Kheir El Din

Dentistry

ABSTRACT Introduction: Orofacial pigmented lesions are one of the most significant changes that present in patients with end-stage renal disease (ESRD), reflecting a wide range of clinical entities ranging from physiologic changes to signs of systemic disorders and even cancers. The research on oral pigmentations is limited, so it is important to pay close attention to this topic. The majority of original publications is either focused on a single lesion or are narrative reports with limited demographic information. As a result, the current study’s goal was to determine the incidence of orofacial pigmentation in ESRD patients on hemodialysis in a …

A Rat Experimental Model For Investigation Of The Effect Of Diabetes On Submandibular Salivary Glands Treated With Epidermal Growth Factor, Mahmoud Bakr, Mohamed Shamel, Sara Abdelwahed, Mahmoud Al Ankily

Dentistry

BACKGROUND: Despite the plethora of research around the negative effects of diabetes on different body organs, this topic still attracts a lot of attention to find potential remedies that could counteract or reverse the damaging effect of diabetes.AIM: In this study, we developed a reliable experimental rat model that can be used for the investigation of the ability of epidermal growth factor (EFG) in restoring the normal architecture of oral tissues after being damaged by diabetes.METHODS: Eighty adult male albino rats (average weight ±220 gm) were used in the current study. Twenty rats served as control and received no treatment. …

The Frequency Of Periodontitis In End-Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi-Center Clinical Cross-Sectional Study, Asmaa Ras, Enji A. Ahmed, Radwa Hussein, Eman Khalil

Dentistry

Abstract Background: There is a general assumption that periodontal disease is highly prevalent among patients with chronic renal failure undergoing hemodialysis. The aim of the study to estimate the frequency of periodontitis in patients on hemodialysis among a sample of the Egyptian population, as well as the correlation between different clinical parameters of periodontal status with serum creatinine and blood urea. This may rule out the bidirectional relation‑ ship between periodontitis and renal failure in patients on hemodialysis. Methods: The study was conducted on 263 hemodialysis patients (165 males and 98 females) at three dialysis cent‑ ers in Benha Governorate, …

In Vitro Comparative Sem Analysis Of Nano-Hydroxyapatite Toothpaste And Diode Laser: Evaluation Of Efficacy Of Dentinal Tubular Occlusion, Mohamed Shamel, Sara Elbanna

Dentistry

Introduction Dentin hypersensitivity (DH) is a very common problem that faces many patients and maintaining treatments with a long term effectiveness remains a challenge. Based on hydrodynamic theory, the main approach of overcoming DH are tubular occlusion.

Objectives The aim of this study was to discover the efficacy of diode laser alone and in combination with a desensitizing toothpaste containing nano-hydroxyapatite (nHap) to evaluate dentinal tubule occlusion after acid challenge under scanning electron microscope (SEM).

Material and methods Forty dentin discs were divided into 4 groups: group 1, control; group 2, dentin disc treated with nHap toothpaste for one week; …

Attenuating Effect Of Vitamin E Against Silver Nano Particles Toxicity In Submandibular Salivary Glands, Mahmoud Bakr, Mahmoud Al Ankily, Sara M. Shogaa, Mohamed Shamel

Dentistry

Open AccessArticle

Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands

Cytokeratin Overexpression In Submandibular Salivary Glands Of Rats Treated With Botulinum Toxin And Epidermal Growth Factor, Mahmoud Bakr, Mahmoud Al Ankily, Mohamed Shamel

Dentistry

Botulinum toxin (BTX) is used in different cosmetic and therapeutic procedures. In dentistry, BTX has been used successfully for management of drooling. BTX injection into salivary glands has damaging adverse effects on all components of the gland. Epidermal Growth Factor (EGF) is well known for its regenerative properties. The aim of this study was to investigate the effect of BTX injections on the submandibular salivary glands of adult female Albino rats, when administered solely or in conjunction with EGF through measuring the expression of cytokeratin in the parenchyma of the gland. Sixty rats were used in this study and were …

Histological And Ultrastructural Study Of Silver Nanoparticles Toxicity And The Possible Protective Effect Of Vitamin C On Submandibular Salivary Glands Of Albino Rats, Mohamed Shamel, Dalia Riad, Mahmoud Al Ankily

Dentistry

Introduction: Despite silver nanoparticles (AgNPs) beneficial effect in many fields, it has been shown that AgNPs can induce toxic effects. Cytotoxic effect of AgNPs is related to the increased release of reactive oxygen species (ROS) which may lead to cell death. Natural antioxidant scavengers like vitamin C have the capacity to bind and neutralize ROS thus having a vital role in cellular defense against oxidative stress. Objective: The objective of the current study was to assess the cytotoxic impact of AgNPs on the submandibular salivary glands of Albino rats and to reveal the potential antioxidant influence of vitamin C to …

Histological And Ultrastructural Study Of Silver Nanoparticles Toxicity And The Possible Protective Effect Of Vitamin C On Submandibular Salivary Glands Of Albino Rats, Mohamed Shamel, Mahmoud Ankily

Dentistry

Introduction: Despite silver nanoparticles (AgNPs) beneficial effect in many fields, it has been shown that AgNPs can induce toxic effects. Cytotoxic effect of AgNPs is related to the increased release of reactive oxygen species (ROS) which may lead to cell death. Natural antioxidant scavengers like vitamin C have the capacity to bind and neutralize ROS thus having a vital role in cellular defense against oxidative stress. Objective: The objective of the current study was to assess the cytotoxic impact of AgNPs on the submandibular salivary glands of Albino rats and to reveal the potential antioxidant influence of vitamin C to …

The Effect Of Egf On Vegf Expression On Submandibular Salivary Gland Of Albino Rats Receiving Doxorubicin, Mohamed Shamel, Mohamed Mansy, Rabab Mubarak

Dentistry

Background: Vascular endothelial growth factor (VEGF) has two prominent biological effects of inducing mitogenesis and migration of vascular endothelial cells and to produce permeability on the microvasculature. Epidermal growth factor (EGF), known by its mitogenic activity on different types of cells, could induce the proliferation and differentiation of the epithelial cells and stimulate its regeneration. Doxorubicin (DXR) is a widely used anticancer drug and is one of most commonly used chemotherapeutic drugs, however it may cause some serious complications such as toxicity in various tissues in the body. Aims: The present study aims to investigate the effect of EGF on …

Evaluation Of Anti-Cancer Effect Of Different Concentrations Of Black Raspberries Extract On Oral Squamous Cell Carcinoma Cell Line (In Vitro Study), Sara Abdelwahed

Dentistry

Background: Black Raspberry has a wide range of pharmacological and therapeutic aspects including anti-inflammatory and antioxidant activities. Moreover, the effect of Black Raspberry has been studied in many cancers such as human cervical, esophageal and colorectal cancer and showed cytotoxic and anti-proliferative effects against these types of cancer. Aim: To identify the possible anti-cancer effect of Black Raspberry on Oral Squamous Cell Carcinoma cell line. Material and methods: Human tongue squamous cell carcinoma cell line was divided into 3 groups: one control group, second group treated with Black Raspberry, and the third group treated with Doxorubicin, each of the two …

Systemic Versus Local Injection Of Bone Marrow Mesenchymal Stem Cells On 5-Fluorouracil Treated Parotid Glands Of Albino Rats, Caroline Maged Massieh, Medhat El Zainy, Reham Magdy Amin, Iman Fathy

Dentistry

ABSTRACT Objective: Head and neck cancer is the sixth leading cancer by incidence worldwide and eighth by death. Recent reports revealed that, not only radiotherapy but also chemotherapy may induce xerostomia. The aim of this study was to compare the possible regenerative effect of BMSCs through systemic and local injections. Material and Methods: 52 male Albino rats were randomly divided into 4 groups: Group 1: 10 rats received 0.5 ml of PBS by injection. Group 2: 14 rats received an intraperitoneal injection of 5-FU drug. Group 3: 14 rats were injected the same dose of 5-FU then received an intraglandular …

Oral Mucormycosis In Post-Covid- 19 Patients: A Case Series, Enji Ahmed Mahmoud, Asmaa Abobakr, Radwa Raghib, Ayman El-Gawish, Dalia Galwash

Dentistry

No abstract provided.

The Possible Protective Role Of Vitamin E On The Induced Silver Nanoparticles Toxicity On Filiform And Circumvallate Tongue Papillae Of Albino Rats Histological And Immunohistochemical Study, Nada Tarek Zaki, Mahmoud Al Ankily, Reham Magdy Amin, Ahmed Mahmoud Halawa

Dentistry

Recently Silver nanoparticles (AgNPs) are widely used as in manufacturing of filters to purify drinking water, as a part of surgical prosthesis, splints, dental alloys and most importantly in the medical field as a bactericidal, fungicidal and as a therapeutic agent. Although these widely usage of AgNPs, can induce toxicity. to evaluate the protective role of vitamin Eon the induced silver nanoparticles toxicity on filiform and circumvallate tongue papillae of albino rats. twenty-eight male albino rats weighing 200-250 grams were divided into; the control and the experimental groups, which is subdivided into, subgroup I receiving AgNPs and subgroup II receiving …

Relation Of Oral Ulcers To Quality Of Life: A Cross-Sectional Study, Enji Ahmed, Ayat Gaml Abdelnasser, Mai Zakaria, Soheir Gafar

Dentistry

Oral ulcers affect many dental patients; impairing their lives physically, psychologically, and socially. Due to the absence of information about oral ulcers in our population, the authors undertook a pilot study to obtain a more complete picture of prevalence of oral ulcers, its probable risk factors and its burden on the quality of life. Materials and methods The authors performed a cross‑sectional study with 605 adult dental patients. All patients filled a questionnaire inquiring about the risk factors. An oral examination was performed to each participant to determine presence or absence of oral ulcers; and the type of the oral …

The Effect Of Egf On The Ultrastructure Of Submandibular Salivary Glands Of Albino Rats Receiving Doxorubicin, Mohamed Shamel, Mohamed Mansy, Rabab Mubarak

Dentistry

Objectives: The present study was designed to detect the outcome of EGF injection on the cytotoxic effect of DXR induced in submandibular SG of rats regarding its ultrastructure. Methods: 30 male Albino rats, two months old and 200gm body weight were divided into three groups. Group I assisted as a control group. Group II (DXRgp), 20 mg/kg body weight DXR was injected intraperitoneally into the rats. Whereas group III (DXR+ EGF) the rats received the same dose of DXR and on the next day, they were injected intraperitoneally with EGF in a daily dose of 10µg/kg bodyweight for 7 consecutive …

Effect Of Different Scaling Methods And Materials On The Enamel Surface Topography: An In Vitro Sem Study, Mahmoud Al Ankily, Fatma Makkeyah, Mohamed Shamel, Mahmoud Bakr

Dentistry

Aims and Objectives: Scaling is important for maintenance of gingival and periodontal conditions. These procedures have a harmful effect on the dental hard tissues. The aim of this study was to investigate the effects of hand and ultrasonic instruments made of stainless and titanium on the surface properties of enamel. Materials and Methods: Forty extracted premolars were used in this in vitro study and were randomly divided into four groups (n = 10). Group I received ultrasonic scaling with stainless steel tip, group II received ultrasonic scaling with titanium tip, group III hand scaling with stainless steel tip, and group …

Effects Of Aflatoxin B1 On The Submandibular Salivary Gland Of Albino Rats And Possible Therapeutic Potential Of Rosmarinus Officinalis: A Light And Electron Microscopic Study, Mohamed Shamel, Bassant Ashraf

Dentistry

Background: Aflatoxin B1 (AFB1), a highly toxic mycotoxin, is one of the contaminants of food items such as corn, rice, nuts, and flour. This study aimed to evaluate the effect of AFB1 on the histology and ultrastructure of the submandibular salivary glands (SMSG) of albino rats and examine the possible therapeutic effect of Rosmarinus officinalis extract. Methods: This study used 21 adult male albino rats equally divided into three groups as follows: Group C (saline-treated control group); Group A (AFB1 treated group) subjected to intraperitoneal injection of AFB1 (2 mg/kg) once daily for four weeks; Group R …

Effect Of Different Scaling Methods And Materials On The Enamel Surface Topography: An In Vitro Sem Study, Mohamed Shamel, Mahmoud Bakr, Mahmoud Ankily, Fatma Makkeyah

Dentistry

Aims and Objectives: Scaling is important for maintenance of gingival and periodontal conditions. These procedures have a harmful effect on the dental hard tissues. The aim of this study was to investigate the effects of hand and ultrasonic instruments made of stainless and titanium on the surface properties of enamel. Materials and Methods: Forty extracted premolars were used in this in vitro study and were randomly divided into four groups (n= 10). Group I received ultrasonic scaling with stainless steel tip, group II received ultrasonic scaling with titanium tip, group III hand scaling with stainless steel tip, and group IV …

The Effect Of Smoking On Clinical Presentation And Expression Of Tlr-2 And Cd34 In Oral Lichen Planus Patients: Clinical And Immunohistochemical Study, Enji Ahmed Mahmoud, Nermin Yousif, Nermin Raouf

Dentistry

Background: Oral lichen planus is a chronic inflammatory disease which is considered as a potential precancerous condition. Numerous studies have confirmed that inflammation is a strong risk factor for cancer development. Smoking is associated with potentially malignant disorders of the oral and oropharyngeal mucosa. The adverse consequences of smoking in various pathologies are mediated by its effects on the immune-inflammatory system. Little is known about the influence of cigarette smoke content on the course of OLP and inflammatory response. Methods: Twenty oral lichen planus smoker patients, 20 oral lichen planus non-smoker patients and 20 control patients were included in this …

Immunohistochemical Assessment Of Cytokeratin 17 And Epcam Expression In Different Grades Of Oral Squamous Cell Carcinoma, Safaa El-Baz, Iman Helmy, Mohamed Hosam El Mallahy

Dentistry

Oral squamous cell carcinoma (OSCC), one of the most common malignancies in the head and neck region, is graded based on Broder’s classification into well-differentiated, moderately, and poorly differentiated. Cytokeratin 17 (K17, CK17) is an acid-type I cytokeratin with a low-molecular weight of 48.1 kDa. Epithelial cell adhesion molecule (EpCAM) is a hemophilic Ca2+ independent adhesion molecule. This study used an immunohistochemical technique (IHC) to examine the expression of CK17 and EpCAM in thirty-two specimens of OSCC (comprising 13 well-, 9 moderately, and 10 poorly differentiated cases), and 2 specimens of normal oral mucosa, used as control. It was found …