Oral Biology and Oral Pathology Commons^™

Double Immunohistochemical Analysis Of Pcna And Fak Expression In Selected Odontogenic Lesions, Safaa Baz, Sally Ibrahim

Dentistry

Background: Odontogenic neoplasms and cysts have diverse biological behaviors, ranging from indolence to aggression along a spectrum. The proliferating cell nuclear antigen (PCNA) is an antigen involved in DNA synthesis and proliferation. Focal adhesion kinase (FAK) is a cytoplasmic molecule associated with cellular signaling, growth, and invasion. PCNA and FAK markers have been shown to be involved in neoplastic proliferation, invasion, and migration. Hence, an immunohistochemical assay of PCNA and FAK can be used as a predictive tool for the level of aggressive behavior of odontogenic lesions. Methods: The current study was conducted to evaluate the expressions of PCNA and …