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Full-Text Articles in Oral Biology and Oral Pathology
Immunohistochemical Assessment Of Cytokeratin 17 And Epcam Expression In Different Grades Of Oral Squamous Cell Carcinoma, Safaa El-Baz, Iman Helmy, Mohamed Hosam El Mallahy
Immunohistochemical Assessment Of Cytokeratin 17 And Epcam Expression In Different Grades Of Oral Squamous Cell Carcinoma, Safaa El-Baz, Iman Helmy, Mohamed Hosam El Mallahy
Dentistry
Oral squamous cell carcinoma (OSCC), one of the most common malignancies in the head and neck region, is graded based on Broder’s classification into well-differentiated, moderately, and poorly differentiated. Cytokeratin 17 (K17, CK17) is an acid-type I cytokeratin with a low-molecular weight of 48.1 kDa. Epithelial cell adhesion molecule (EpCAM) is a hemophilic Ca2+ independent adhesion molecule. This study used an immunohistochemical technique (IHC) to examine the expression of CK17 and EpCAM in thirty-two specimens of OSCC (comprising 13 well-, 9 moderately, and 10 poorly differentiated cases), and 2 specimens of normal oral mucosa, used as control. It was found …