Medicine and Health Sciences Commons^™

Pdxnet Portal: Patient-Derived Xenograft Model, Data, Workflow And Tool Discovery., Soner Koc, Michael W Lloyd, Jeffrey W Grover, Nan Xiao, Sara Seepo, Sai Lakshmi Subramanian, Manisha Ray, Christian Frech, John Digiovanna, Phillip Webster, Steven Neuhauser, Anuj Srivastava, Xing Yi Woo, Brian J Sanderson, Brian White, Paul Lott, Lacey E Dobrolecki, Heidi Dowst, Pdx Consortium, Yvonne A Evrard, Tiffany A Wallace, Jeffrey A Moscow, James H Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-Xian Pan, Moon S Chen, Luis Carvajal-Carmona, Alana L Welm, Bryan E Welm, Michael T Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A Davies, Jack Roth, Funda Meric-Bernstam, Peter N Robinson, Carol J Bult, Brandi Davis-Dusenbery, Dennis A Dean, Jeffrey H Chuang

Faculty Research 2022

We created the PDX Network (PDXNet) portal (https://portal.pdxnetwork.org/) to centralize access to the National Cancer Institute-funded PDXNet consortium resources, to facilitate collaboration among researchers and to make these data easily available for research. The portal includes sections for resources, analysis results, metrics for PDXNet activities, data processing protocols and training materials for processing PDX data. Currently, the portal contains PDXNet model information and data resources from 334 new models across 33 cancer types. Tissue samples of these models were deposited in the NCI's Patient-Derived Model Repository (PDMR) for public access. These models have 2134 associated sequencing files from 873 samples …

Prenatal Phenotyping: A Community Effort To Enhance The Human Phenotype Ontology., Ferdinand Dhombres, Patricia Morgan, Bimal P Chaudhari, Isabel Filges, Teresa N Sparks, Pablo Lapunzina, Tony Roscioli, Umber Agarwal, Shagun Aggarwal, Claire Beneteau, Pilar Cacheiro, Leigh Carmody, Sophie Collardeau-Frachon, Esther A Dempsey, Andreas Dufke, Michael Henri Duyzend, Mirna El Ghosh, Jessica L Giordano, Ragnhild Glad, Ieva Grinfelde, Dominic G Iliescu, Markus S Ladewig, Monica C Munoz-Torres, Marzia Pollazzon, Francesca Clementina Radio, Carlota Rodo, Raquel Gouveia Silva, Damian Smedley, Jagadish Chandrabose Sundaramurthi, Sabrina Toro, Irene Valenzuela, Nicole A Vasilevsky, Ronald J Wapner, Roni Zemet, Melissa A Haendel, Peter N Robinson

Faculty Research 2022

Technological advances in both genome sequencing and prenatal imaging are increasing our ability to accurately recognize and diagnose Mendelian conditions prenatally. Phenotype-driven early genetic diagnosis of fetal genetic disease can help to strategize treatment options and clinical preventive measures during the perinatal period, to plan in utero therapies, and to inform parental decision-making. Fetal phenotypes of genetic diseases are often unique and at present are not well understood; more comprehensive knowledge about prenatal phenotypes and computational resources have an enormous potential to improve diagnostics and translational research. The Human Phenotype Ontology (HPO) has been widely used to support diagnostics and …

Experiences Seeking Meaningful Employment For Individuals With Substance Use Disorder In York County Maine, Tyler Egeland Ba, Mark Richards Bs Bs, Evelyn Ali Bs, Mary Lindsey Smith Phd

Substance Use Research & Evaluation

Two focus groups and one interview conducted in November 2021 collected information from a total of six respondents regarding theiremployment experiences in York County as individuals receiving treatment for substance use disorder. The guided discussion coveredtopics related to resources and services for finding employment opportunities, experiences obtaining meaningful employment, andpotential barriers and facilitators to maintaining employment. The interview and focus groups were facilitated and analyzed byexperienced researchers from the Catherine Cutler Institute at the University of Southern Maine. For more information, please contact Lindsey Smith at [email protected]

Bringing People Back Into Public Health Data: Community Feedback On A Set Of Visualization Tools - Summary Report, Alejandro Cerón, Mia Glover, Quisi Rodriguez-Oregel, Dani Thompson, Tom Adams, Naomi Asakura, Kaela Belknap, Anna Block, Nicole Boehler, Hannah Boeve, Sarah Bomers, Sasha Borovok, Grace Bryan, Kate Buffington, Majesty Cain, Beth Carideo, Haley Chesno, Grace Connell, Jake Corbett, Camille Cruz, Chloe Dawkins, Anna Denniston, Lydia Dickens, Sophie Duplock, Samuel Dwinell, Avery Ess, Sam Ferman, Ellis Geis, Ethan Graupmann, Xander Hedrick, Angel Hernandez-Miramontes, Grant Huyghe, Sara Ibrahiem, Anna Jamieson, Ian Kang, Allie Kris, Erin Lawrence, Maddie Leake, Ryan Leary, Taylor Loh, Charlotte Monroe, Alexander Nguyen-Lopez, Henry O’Daffer, Cat Parish, Jaylee Recountre, Grace Rizzo, Noah Roseth, Grace Rothstein, Katie Sage, Marie Saltzmann, Stephen Shlain, Riley Shores, Mackenna Simson, Mark Teneza, Jack Weinmeister, Justin Weinzweig, Alison Wenman, Patch Whelan, Lea Zimmerman

Anthropology: Undergraduate Student Scholarship

This course-based study is a product of the University of Denver’s Spring 2022 The Social Determination of Health (ANTH 2424) class. The study aimed to understand how well a set of public health visualization tools tells the data stories about people in Colorado, and about important public health problems. For this, a team of almost sixty undergraduate students taking the class, coordinated by three graduate teaching assistants, and directed by the course instructor interviewed a total of fifty-six people from Colorado, qualitatively analyzed those interviews, and wrote reports that draw conclusions and recommendations.

Student Retention And Success In An Rn-Bsn Program: Determining Variables And Methods, Audrey C. Tolouian, Melissa Wholeben, Diane Rankin

Nursing Faculty Publications

Background

The Online Registered Nurse to Baccalaureate Science in Nursing (RN- BSN) Program has a retention rate of close to 97.5% (UTEP, 2020). Attrition rates in nursing programs are high. The National League for Nursing (NLN) last reported a 25 % attrition rate which may double for minority students in four-year nursing programs (NLN, 2014; Elkin, 2019). As online courses in colleges and universities are growing and are predicted to become mainstream by 2025, it is essential to identify factors contributing to our retention rates. American Association of Colleges of Nursing (AACN) has made it part of its 2021-2022 policy …

Comparing Indices Of Responsiveness For The Coma Near-Coma Scale With And Without Pain Items, Vera Pertsovskaya, Jennifer A. Weaver, Jasmine Tran, Allan J. Kozlowski, Trudy Mallinson

School of Medicine and Health Sciences Student Works

No abstract provided.

Rural-Urban Trends In Congenital Heart Disease-Related Mortality In The United States, 1999 To 2019, Abdul Mannan Khan Minhas, Rachel A. Wyand, Robert W. Ariss, Salik Nazir, Vardhmaan Jain, Sadeer G. Al-Kindi, Michael D. Shapiro, William Campbell, Laurence Sperling, Salim S. Virani

Office of the Provost

No abstract provided.

Exploratory And Confirmatory Factor Analysis Of The Acs-Response Index In Adults Without Diagnosed Heart Disease, John R. Blakeman, Myoungjin Kim, Marilyn Prasun

Faculty Publications - Mennonite College of Nursing

Background & Purpose: To report on the psychometric properties of the Acute Coronary Syndrome Response Index in adults without heart disease. Methods: Participants were enrolled online, using social media platforms and an email listserv. The sample of 1,040 was randomly split into two sub-samples for exploratory and confirmatory factor analysis. Results: Exploratory factor analysis yielded a four-factor solution for the knowledge subscale, a one-factor solution for the attitudes subscale, and a two-factor solution for the belief subscale. Subsequent confirmatory factor analysis demonstrated an excellent fit for the attitudes and beliefs subscales and an acceptable fit for the knowledge subscale. Conclusions: …

Midwives’ Associations’ Dual Role In Supporting Members And Driving The Profession Forward: A Qualitative Interview Study From Bangladesh, Mosammat Ratna Mon, Most Nargis Parvin, Joy Kemp, Sharmin Shobnum Joya, Christina Pedersen, Ulrika Byrskog, Kerstin Erlandsson

Journal of Asian Midwives (JAM)

Background: Professional midwives are being introduced as a long-term solution to improve maternal and newborn health in Bangladesh and to contribute to Universal Health Coverage. Professional midwives’ associations are a core element of a strong midwifery profession according to the International Confederation of Midwives (ICM). The Bangladesh Midwifery Society (BMS) was formed in 2010 to advocate for the introduction of professional midwifery in Bangladesh. Since 2017 BMS has benefitted from an international twinning partnership with the Royal College of Midwives (RCM) UK and has undergone significant organizational development.

Objective: The study aimed to describe the experiences, knowledge and attitudes of …

Prevalence & Factors Associated With Acute Kidney Injury In Patients Undergoing Percutaneous Coronary Intervention At A Tertiary Healthcare Facility In Tanzania, Faisal Hooda

Master of Medicine in Internal Medicine

Background: Acute kidney injury is a potentially fatal but preventable outcome of percutaneous coronary intervention: the most plausible cause being radiocontrast-induced nephropathy; others include: pre-existing renal insufficiency from underlying illnesses and also acute renal insult caused by hypoperfusion from cardiac causes. The prevalence, associated risk factors and outcomes of AKI post-PCI are unclear and unexplored in our setting. Objectives: The study sought to determine the prevalence of acute kidney injury post-percutaneous coronary intervention at The Aga Khan Hospital, Dar es Salaam, Tanzania. Secondary objectives included: factors associated, with and outcomes of acute kidney injury (AKI) post percutaneous coronary intervention (PCI). …

Churg Strauss Syndrome With Neuropathy: A Case Report, Zaid Waqar

Pakistan Journal of Neurological Sciences (PJNS)

A 24 years old man with known history of asthma came with acute presentation of ascending weakness for four days following flu like symptoms and worsening of asthma. His complete blood counts showed elevated eosinophil count. Nerve conduction showed neuropathy. He was diagnosed as Churg Strauss syndrome due to presence of asthma, eosinophilia, neuropathy and pulmonary infiltrates. Churg Strauss is a systemic eosinophilic vasculitis involving multiple organ systems that may present with neuropathy, as in this case.

Post Covid-19 Vaccine (Sinovac) Cerebral Venous Sinus Thrombosis, Soban Khan, Maryam Khalil, Zaid Waqar

Pakistan Journal of Neurological Sciences (PJNS)

SINOVAC is an inactivated virus COVID 19 vaccine given emergency authorization for COVID-19 Pandemic. Different adverse reactions have been seen in after-marketing of COVID-19 vaccines. Here we present a case of patient who developed cerebral venous sinus thrombosis two weeks after the first dose of SINOVAC vaccine.

Molecular Analyses Of Phenylketonuria In The Intellectually Disabled Children From Faisalabad, Punjab, Pakistan, Habiba Hussain, Muhammad Wasim, Haq Nawaz Khan, Hina Ayesha, Fazli Rabbi Awan

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT Background and Objective: Phenylketonuria (PKU) is a rare inherited metabolic disorder, caused by mutations in the phenylalanine hydroxylase (PAH). It is a treatable disorder if diagnosed earlier in life. The objective was to identify PKU patient(s) amongst the intellectually disabled children. Methods: Blood samples (n=100) were collected from intellectually disabled children from Faisalabad, Pakistan. Screening was performed on plasma samples through High Performance Liquid Chromatography (HPLC), and DNA samples were examined for mutation analysis of PAH through direct PCR and SSCP analyses. Results: In the current study, 85% consanguinity rate was observed, with the average BMI (16.15 kg/m2) and …

Prevalence Of Depression In Caregivers Of Stroke Patients In Karachi, Pakistan, Marium Mansoor, Shahina Pirani, Rabeeka Aftab, Tania Nadeem

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT Background and Objective: Caregivers of patients with chronic debilitating illnesses are at risk of developing mental health problems. The objective of this study is to determine the frequency of depression in caregivers of stroke patients at a tertiary care teaching hospital in Karachi, Pakistan. Methods: A cross-sectional study was conducted among caregivers of stroke, who were recruited from the Aga Khan University Hospital between January 2018 to October 2018. Data was collected through the Urdu Hamilton rating scale for depression (HAM-D-U) and it was analyzed using descriptive and inferential statistics. Results: A total of 136 caregivers participated in the …

Practical Measures For Disabled’S Empowerment-Time For Economic Growth!, Mahnoor Hafeez

Pakistan Journal of Neurological Sciences (PJNS)

The objective of this article is to advocate for persons with disabilities’ (PWD) rights, to discuss issues solutions, social awareness and to promote diversity and inclusion. The word ‘Disability’ covers a wide range of irreversible permanent impairments including physical and mobility difficulties, hearing, visual impairment, specific learning disabilities including dyslexia, medical conditions and mental health problems that may hinder their full and effective participation in society on an equal basis with others.1 Handicap is the condition of being unable to perform due to physical or mental unfitness.

Correlates Of Rem Sleep Without Atonia In Dream Enactment Behavior Associated With Parkinson’S Disease, Medication Use And Obstructive Sleep Apnea, Abigail Quintos, Rohin Saroya, Nisha Bagchi, Ritu G. Grewal

Student Papers, Posters & Projects

METHODS: We did a retrospective review of medical records and polysomnographic (PSG) data of patients with dream enactment behavior (DEB) from 2015 to 2020. REM sleep without atonia (RSWA) was scored according to the AASM rules, and %RSWA was calculated.

RESULTS: Thirty-six patients with DEB were analyzed. Recursive partitioning algorithm was used to determine the %RSWA that correlated with the presence or absence of Parkinson’s disease (PD). RSWA >=20% was present in 11 patients, and had the highest correlation with PD (9/11). RSWA of 2.1% to 19.9% was present in 10 patients, and had modest correlation with PD (3/10). RSWA= …

Assessing Public Health Benefits Of Replacing Freight Trucks With Cargo Cycles In Last Leg Delivery Trips In Urban Centers, Jennifer C. Hartle, Ossama (Sam) A. Elrahman, Cara Wang, Daniel A. Rodriguez, Yue Ding, Matt Mcgahan

Mineta Transportation Institute

Increased urbanization, population growth, and demand for time-sensitive deliveries means increased freight movement in cities, which contributes to emissions, noise, and safety concerns. One innovative mode gaining widespread attention for urban deliveries is cargo cycles—bicycles adapted for freight delivery. Despite the recognized potential and possible success of transporting at least 25% of freight via cycle, research remains limited. This research investigates the potential of cargo cycle delivery for last mile freight in Oakland, California, with a focus on the West Oakland neighborhood. The data collection included interviews, focus groups, vehicle field observation and counts, and traffic simulation modeling. The traffic …

An Evaluation Of The Effects Of Sub-Chronic Ketamine Exposure On Rodent Memory As Assessed By The Odor Span Task In Female Rats, Angela Marie Thomas

Dissertations

Though numerous studies have been undertaken to explore the mechanisms of action of antidepressant medications, little is known about the origins of the disorders they treat. Recently, the therapeutic value of ketamine as a treatment for depression was recognized by the Food and Drug Administration. Historically, ketamine has been used in the laboratory setting to induce ‘schizophrenia-like’ symptomology in humans and animals to allow for further study of those symptoms in a controlled environment; a correlation between ketamine use and deficits in memory and cognitive function has been suggested. This study evaluated the impact of sub-chronic sub-anesthetic ketamine on performance …

Epilepsy Research In Africa: A Scoping Review By The Ilae Pediatric Commission Research Advocacy Task Force, Pauline Samia, Jane Hassell, Jessica Hudson, Azim Ahmed, Jasmit Shah, Charles Hammond, Edward Kija, Stéphane Auvin, Jo Wilmshurst

Paediatrics and Child Health, East Africa

Objective: Despite the high prevalence of epilepsy in Africa, evaluation of epi- lepsy research trends on the continent is lacking. Without establishing effective research, improvement in care for people with epilepsy cannot be effectively strategized or targeted.

Methods: A scoping review of the peer-reviewed literature on epilepsy from Africa (1989–2019) was conducted. The aim was to understand from this what areas are well researched versus underresearched based on published epilepsy topics.

Results: A total of 1227 publications were identified and assessed. A significant increase in publications occurred over the 30 years assessed. African author lead- ership was …

The Impact Of Training On Self-Reported Performance In Reproductive, Maternal, And Newborn Health Service Delivery Among Healthcare Workers In Tanzania: A Baseline- And Endline-Survey, Tumbwene Mwansisya, Columba Mbekenga, Kahabi Isangula, Loveluck Mwasha, Stewart Mbelwa, Mary Lyimo, Lucy Kisaka, Victor Mathias, Eunice Pallangyo, Grace Edwards, Michaela Mantel, Sisawo Konteh, Thomas Rutachunzibwa, Marleen Temmerman

School of Nursing & Midwifery, East Africa

Background: Delivery of quality reproductive health services has been documented to depend on the availability of healthcare workers who are adequately supported with appropriate training. However, unmet training needs among healthcare workers in reproductive, maternal, and newborn health (RMNH) in low-income countries remain disproportionately high. This study investigated the effectiveness of training with onsite clinical mentorship towards self-reported performance in RMNH among healthcare workers in Mwanza Region, Tanzania.

Methods: The study used a quasi-experimental design with pre-and post-intervention evaluation strategy. The baseline was compared with two endline groups: those with intervention (training and onsite mentorship) and those without. The differences …

A Pilot Study Comparing Pre-Analytic Tissue Processes Before And After Implementation Of A Quality Improvement Program For Handling Breast Cancer Specimens, Joseph Gatheru Macharia

Master of Medicine in Anatomic Pathology

Background: Breast cancer as the most frequently occurring cancer in women is highly heterogeneous in its pathological characteristics. Assessment of tumor biologic characteristics including hormone receptor profile and growth factor receptor activity is important in characterizing the pathologic nature of such cancers. Tumor biomarker activity plays a big role in diagnosis and management of invasive breast cancer (IBC). Biological specimens are the primary sources of this molecular information. Optimal handling of the specimen through the various analytic phases assures of the validity of the final pathologic diagnosis. Objective: To assess the feasibility of implementing an intervention plan to improve specific …

Nursing News & Views - June 2022, Joanne Miller Rn

Nursing Newsletters

No abstract provided.

Weakly-Supervised Tumor Purity Prediction From Frozen H&E Stained Slides, Matthew Brendel, Vanesa Getseva, Majd Al Assaad, Michael Sigouros, Alexandros Sigaras, Troy Kane, Pegah Khosravi, Juan Miguel Mosquera, Olivier Elemento, Iman Hajirasouliha

Publications and Research

Background

Estimating tumor purity is especially important in the age of precision medicine. Purity estimates have been shown to be critical for correction of tumor sequencing results, and higher purity samples allow for more accurate interpretations from next-generation sequencing results. Molecular-based purity estimates using computational approaches require sequencing of tumors, which is both time-consuming and expensive.

Methods

Here we propose an approach, weakly-supervised purity (wsPurity), which can accurately quantify tumor purity within a digitally captured hematoxylin and eosin (H&E) stained histological slide, using several types of cancer from The Cancer Genome Atlas (TCGA) as a proof-of-concept.

Findings

Our model predicts …

Nh Delivery System Reform Incentive Payment Program (Dsrip): Key Findings From The Summative Evaluation Report, Mary Lindsey Smith Phd, Deborah Thayer Mba, Katie Rosingana Ba, Rachel M. Gallo Mph, Catherine Mcguire Bs, Evelyn Ali Mph, Katharine Knight Mph, Chinonye Anumaka, Tyler Egeland Ba, Mark Richards Bs, Karen Pearson Mlis

Substance Use Research & Evaluation

Delivery System Reform Incentive Payment (DSRIP) programs are part of the broader Center for Medicare & Medicaid Services (CMS) Section 1115 Waiver programs and provide states with significant funding to support system transformation efforts. CMS approved New Hampshire’s five-year Building Capacity for Transformation Section 1115(a) Medicaid Demonstration Waiver in 2015. The overall goal of the DSRIP Demonstration is to improve the care for New Hampshire’s Medicaid Beneficiaries with behavioral health disorders by addressing workforce and infrastructure shortages, improving care transitions, and integrating physical and behavioral health. This condensed report highlights key findings from the NH DSRIP summative evaluation report. For …

Summative Evaluation Report By The Independent Evaluator For The New Hampshire Delivery System Reform Incentive Payment (Dsrip) Program, Mary Lindsey Smith Phd, Deborah Thayer Mba, Katie Rosingano Ba, Rachel M. Gallo Mph, Catherine Mcguire Bs, Evelyn Ali Mph, Katharine Knight Mph, Chinonye Anumaka Od, Mph, Tyler Egelund Ba, Mark Richards Bs, Karen Pearson Mlis, Ma

Substance Use Research & Evaluation

Delivery System Reform Incentive Payment (DSRIP) programs are part of the broader Center for Medicare & Medicaid Services (CMS) Section 1115 Waiver programs and provide states with significant funding to support system transformation efforts. CMS approved New Hampshire’s five-year Building Capacity for Transformation Section 1115(a) Medicaid Demonstration Waiver in 2015. The overall goal of the DSRIP Demonstration is to improve the care for New Hampshire’s Medicaid Beneficiaries with behavioral health disorders by addressing workforce and infrastructure shortages, improving care transitions, and integrating physical and behavioral health. This report is the final summative evaluation report on New Hampshire's DSRIP program. For …

Role Of Alendronate Gel Versus Chlorohexidine Gel As Adjunct To Mechanical Therapy In Treatment Of Chronic Periodontitis (Clinical And Microbiological Study), Ahmed M. El-Hadidy, Bassant H. Mowafy, Medhat El-Daker, Una M. El-Shinnawi

Mansoura Journal of Dentistry

Objective: Background: This study evaluated the clinical and microbiological efficacy of Alendronate (ALN) gel versus Chlorohexidine (CHX) gel as an adjunct to mechanical therapy in the treatment of chronic periodontitis and compared this effect with Scaling and Root Planning (SRP) only. Materials and Methods: Forty patients with chronic periodontitis were randomly allocated into two groups. Each group of twenty patients was split into a study group and a control group, group 1 was treated on one side with ALN gel after (SRP) and the other side was treated with (SRP) only. group 2 was treated on one side with CHX …

Microtensile Bond Strength Of Resin Modified Glass Ionomer Restoration In Carious Primary Molars Pretreated With Silver Diamine Fluoride, Weaam I. El-Tantawy, Noha A. El-Wassefy, Abeer M. Abdellatif

Mansoura Journal of Dentistry

Objective: To evaluate microtensile bond strength of resin modified glass ionomer restoration in carious primary molars pretreated with silver diamine fluoride. Materials and Methods: forty carious primary molars were collected and divided into two equal groups (n=20) as the following: (Group I) the microtensile bond strength testing group and (Group II) the control group. Each main group subdivided into two subgroups (n=10): (Group I a) the microtensile testing comprised group of no caries excavation and (Group I b) group with caries excavation. (Group II a) the control comprised group of no caries excavation and(Group II b) group of caries excavation.The …

Is The Phq-9 A Unidimensional Measure Of Depression? A 58,272-Participant Study, Renzo Bianchi, Jay Verkuilen, Sharon Toker, Irvin Sam Schonfeld, Markus Gerber, Elmar Brähler, Kurt Kroenke

Publications and Research

The PHQ-9 has become a measure of reference in depression research and clinical practice. However, the issue of the PHQ-9’s unidimensionality has not been fully elucidated, and the usability of the PHQ-9’s total score requires clarification. In this study, we examined the dimensionality, scalability, and monotonicity properties of the PHQ-9 as well as the scale’s total-score reliability. We did so based on exploratory structural equation modeling (ESEM) bifactor analysis and Mokken scale analysis (MSA). We relied on a total of 58,272 participants (63% female; Mage = 43, SDage = 13) from 29 samples involving seven different countries (e.g., Germany, the …

Identifying Genetic Determinants Of Inflammatory Pain In Mice Using A Large-Scale Gene-Targeted Screen., Janine M Wotton, Emma Peterson, Ann M Flenniken, Rasneer S Bains, Surabi Veeraragavan, Lynette R Bower, Jason A. Bubier, Marc Parisien, Alexandr Bezginov, Hamed Haselimashhadi, Jeremy Mason, Michayla A Moore, Michelle E Stewart, Dave A Clary, Daniel J Delbarre, Laura C. Anderson, Abigail D'Souza, Leslie Goodwin, Mark E Harrison, Ziyue Huang, Matthew Mckay, Dawei Qu, Luis Santos, Subhiksha Srinivasan, Rachel Urban, Igor Vukobradovic, Christopher S Ward, Amelia M Willett, Robert E Braun, Steve D M Brown, Mary E Dickinson, Jason D Heaney, Vivek Kumar, K C Kent Lloyd, Ann-Marie Mallon, Colin Mckerlie, Stephen A Murray, Lauryl M J Nutter, Helen Parkinson, John R Seavitt, Sara Wells, Rodney C Samaco, Elissa J Chesler, Damian Smedley, Luda Diatchenko, Kyle M Baumbauer, Erin E Young, Robert P Bonin, Silvia Mandillo, Jacqueline K White

Faculty Research 2022

ABSTRACT: Identifying the genetic determinants of pain is a scientific imperative given the magnitude of the global health burden that pain causes. Here, we report a genetic screen for nociception, performed under the auspices of the International Mouse Phenotyping Consortium. A biased set of 110 single-gene knockout mouse strains was screened for 1 or more nociception and hypersensitivity assays, including chemical nociception (formalin) and mechanical and thermal nociception (von Frey filaments and Hargreaves tests, respectively), with or without an inflammatory agent (complete Freund's adjuvant). We identified 13 single-gene knockout strains with altered nocifensive behavior in 1 or more assays. All …

Use Of Cgm In Monitoring Neonatal Diabetes, Emily Metzinger, Kelsee Halpin

Posters

Introduction Although continuous glucose monitoring (CGM) has increased in patients with Type 1 diabetes, its use in the neonatal population has remained limited. Neonates, particularly preterm infants, are at risk of impaired glucose control. Several studies have looked at the use of these devices in improving care for premature infants without diabetes. We describe a case of a very low birth infant with neonatal diabetes secondary to a GATA-6 mutation. Clinical Case This is a late preterm infant with IUGR, truncus arteriosus, and neonatal diabetes. Exome genetic panel showed a mutation in GATA-6. Her neonatal diabetes was challenging to control …