Comparison Between Two Different Attachment Caps Used In Locator Attachments Of Implant Supported Overdentures (In-Vitro Study), Hossam Eldein Faisal Haridy, Hebatalla Mahmoud El Afandy, Mohammed Farouk Abdalla, Ahmed Mohammed Osama

Future Dental Journal

Purpose: To compare different retentive cap material used in LOCATOR attachments, namely the nylon retentive cap versus PEEK retentive caps, and measure the loss of retention over a period of two years, through 2880 cycles of insertion and removal. Materials and methods: Two implants 3.8mm x 10.5mm were inserted into a clear epoxy resin cast, through a surgical guide, with the implants being 23mm apart. Two LOCATOR attachments with 5 mm gingival height were screwed to the implants, custom made nylon caps were fabricated as an exact replica of the PEEK retentive caps, then two dentures were constructed …

Effect Of Two Different Forms Of Smoking On Periodontium : A Retrospective Study, Mohammed Wagdy Bissar

Future Dental Journal

Aim of the study: Is to compare the effects of smoking T-cigs and vaping E-cigs on clinical periodontal parameters in patients.Materials and Methods: It consisted of a clinical examination of a total of 60 individuals aged between 29 and 39 years. They responded to a questionnaire about their smoking history, and they were divided into 2 groups as E-cig vapers and T-cig smokers. Full-mouth plaque index (PI),bleeding on probing (BOP),clinical attachment loss (AL),and probing depth (PD) were measured at six sites per tooth on all maxillary and mandibular teeth except third molars. Results: T-cigarette had significantly higher probing depth, …

Assessment Of Knowledge, Attitude And Practice Of Molar-Incisor Hypomineralisation Among A Group Of Egyptian Dentists (Observational Cross-Sectional Study), Mohamed Salah Shalaby, Osama Ibrahim El-Shahawy Professor Dr, Eman Alaa, Manal Ahmed Mofied El-Shiekh

Future Dental Journal

Abstract:

Introduction: Molar Incisor Hypomineralisation (MIH) is one of qualitative DED. MIH is increasing dramatically in the new generations, which is considered to be challenging for the majority of dentists. MIH was found to be prevalent in 14.2% of the world's population, with the high incidence 18% in South America and the least (10.9%) in Africa. This study was carried out to assess the knowledge, attitude, and practice of graduated Egyptian dentists' group regarding MIH condition and compare the outcome information among different dental specialists.

Material and methods: A google based questionnaire based on previously validated published papers distributed electronically …

Evaluation Of Anchorage Loss Following Anterior Segment Retraction Using Friction Versus Frictionless Mechanics: A Randomized Clinical Trial, Dorra Izzat Bakhit, Heba Mohamed Dehis, Yehia A. Moustafa, Fouad A. El Sharaby

Future Dental Journal

Objective: Evaluation of anchorage loss following anterior segment retraction (ASR) using friction versus frictionless mechanics when mini-screws are directly and indirectly loaded using Cone beam computed tomography (CBCT). Material and methods: Thirty females with bimaxillary protrusion were randomly allocated into two groups, friction and frictionless. In friction group, a hook was crimped on 0.017- by 0.025-inch stainless steel wire distal to the lateral incisor and elastomeric chain rendering 160 g/side extending between the hook and mini-screw implant to complete the ASR. In the frictionless group, canines were ligated to the mini-screws for indirect anchorage then ASR was done using closing …

Canine Retraction Rate And Angulation With 0.017”X0.025” Versus 0.016”X0.022” Stainless Steel Arch Wire With A Power Arm, Amr R. El-Beialy, Fouad A. El Sharaby, Hend S. Elsayed

Future Dental Journal

Background: The dimensions of the arch wire affect its stiffness and the play between the wire and bracket. Canine retraction over stiffer arch wires limits the degree of canine tipping. However, the greater the wire dimensions, the greater the resistance to sliding. Frictional resistance is known to delay tooth movement. Aim: The aim of this controlled clinical trial was to compare canine retraction rate and angulation with 0.017”X0.025” versus 0.016”X0.022” stainless steel arch wire with a power arm. Materials and Methods: Twenty-four Class II malocclusion patients (age 13.8± 2.6 years) participated in this study. The teeth were leveled and aligned. …

Assessment Of Maximal Incisal Opening Using Autogenous Inlay Eminoplasty Technique For Treatment Of Chronic Recurrent Temporo Mandibular Joint Dislocation, Mustafa Abdelkawy, Youssef Elmansi, Ahmed Shehab, Mohamed Mounir, Ragia Mounir

Future Dental Journal

Purpose: Different surgical protocols have been introduced for eminence augmentation for treatment of recurrent temporomandibular joint dislocation, The aim of this study is to assess maximal incisal opening (MIO) using inlay (sandwich osteotomy) autogenous block augmentation harvested from patient’s symphesis for more stable condylar movements . Methods: five patients were treated in this study (10 joints) with bilateral autogenous inlay block bone grafting technique, each autogenous cortico-cancellous bone block was harvested from chin and wedged at the created defect of the eminence through a green stick fracture to increase its height . Results: The follow up period …

Clinical Assessment Of Arthroscopic Temporomandibular Joint Discopexy Using Wire Fixation Technique, Abanoub Sliem, Ahmed Barakat, Sameh Mekhemer, Reem Hossameldin

Future Dental Journal

Introduction Anterior disc displacement is one of the most frequent temporomandibular joint (TMJ) disorders, which often results in clicking, joint pain, a limited range of motion and masticatory difficulties.Methodology Four subjects (with a total number of six joints) who had significant pain and dysfunction that did not respond to non-surgical therapy, went into arthroscopic disc repositioning using wire fixation for 3 weeks then it was removed, and the patient continued on occlusal splints.Results After six months postoperatively, there was a significant increase in the MIO (Maximum incisal opening) and an insignificant decrease in the pain perception in the …

2022-06-08_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/stats.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted once a week on Wednesdays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) …

Deep Learning Features Encode Interpretable Morphologies Within Histological Images., Ali Foroughi Pour, Brian S White, Jonghanne Park, Todd B Sheridan, Jeffrey H Chuang

Faculty Research 2022

Convolutional neural networks (CNNs) are revolutionizing digital pathology by enabling machine learning-based classification of a variety of phenotypes from hematoxylin and eosin (H&E) whole slide images (WSIs), but the interpretation of CNNs remains difficult. Most studies have considered interpretability in a post hoc fashion, e.g. by presenting example regions with strongly predicted class labels. However, such an approach does not explain the biological features that contribute to correct predictions. To address this problem, here we investigate the interpretability of H&E-derived CNN features (the feature weights in the final layer of a transfer-learning-based architecture). While many studies have incorporated CNN features …

Identification Of Arhgef12 And Prkci As Genetic Modifiers Of Retinal Dysplasia In The Crb1rd8 Mouse Model., Sonia M Weatherly, Gayle B. Collin, Jeremy R. Charette, Lisa Stone, Nattaya Damkham, Lillian F Hyde, James G Peterson, Wanda L. Hicks, Gregory W. Carter, Juergen K. Naggert, Mark P. Krebs, Patsy M. Nishina

Faculty Research 2022

Mutations in the apicobasal polarity gene CRB1 lead to diverse retinal diseases, such as Leber congenital amaurosis, cone-rod dystrophy, retinitis pigmentosa (with and without Coats-like vasculopathy), foveal retinoschisis, macular dystrophy, and pigmented paravenous chorioretinal atrophy. Limited correlation between disease phenotypes and CRB1 alleles, and evidence that patients sharing the same alleles often present with different disease features, suggest that genetic modifiers contribute to clinical variation. Similarly, the retinal phenotype of mice bearing the Crb1 retinal degeneration 8 (rd8) allele varies with genetic background. Here, we initiated a sensitized chemical mutagenesis screen in B6.Cg-Crb1rd8/Pjn, a strain with a mild clinical presentation, …

Copper-67-Labeled Bombesin Peptide For Targeted Radionuclide Therapy Of Prostate Cancer, Truc T Huynh, Ellen M Van Dam, Sreeja Sreekumar, Cedric Mpoy, Benjamin J Blyth, Fenella Muntz, Matthew J Harris, Buck E Rogers

2010-2019 OA Pubs

The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging and therapy of prostate cancer using bombesin peptides that bind to the receptor with high affinity. Targeted copper theranostics (TCTs) using copper radionuclides,

Analyzing Factors Impacting Time To Full Approval Of Innovative Drugs Via An Accelerated Approval Pathway In The United States, Eleanor Panico

Seton Hall University Dissertations and Theses (ETDs)

Background and purpose of study: Pharmaceutical drugs are commonly used to treat various ailments and the pharmaceutical industry is increasingly leveraging expedited pathways to market, like the FDA’s accelerated approval pathway. Thus, these pathways are becoming more prevalent and thus more scrutinized for reliability. A consequence from this increased utilization is observed variability in time to reach full approval from the point accelerated approval was received. Variables that may impact time and ability to reach full approval should be further investigated. The purpose of this study was to explore, identify and predict variables that may influence time from accelerated approval …

2022-06-08_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …

2022-06-08_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

2022-06-08 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-06-08_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was downloaded as an Excel spreadsheet which appeared in the Public Use Datasets section under the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173---,00.html.

Cases are aggregated by the date of onset of COVID-19 symptoms, if known, otherwise by laboratory specimen date if known, otherwise by case referral date. Deaths are aggregated by the date of death if known, otherwise by the last date of a change to the case status.

Implementing Service-Learning Projects For The First Time During The Pandemic: Two Instructors’ Inspiration, Motivation And Goals, Lesley Sylvan, Robyn Becker

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

While much has been written about student experiences with service-learning and factors that sustain university instructors’ experiences in service-learning over time, less is understood about the contexts that prompt instructors to embark on their first experiences of incorporating service-learning into their teaching. The focus of this article is the experiences of two instructors, one tenure track faculty member and one adjunct faculty member, who incorporated service-learning projects into their classes for the first time during the 2020-2021 academic year. Both professors teach within a speech-language pathology graduate program. The timing and context of their first service-learning experiences are important because …

The Urobiomes Of Adult Women With Various Lower Urinary Tract Symptoms Status Differ: A Re-Analysis, Cara Joyce, Thomas Halverson, Caroline Gonzalez, Linda Brubaker, Alan J. Wolfe

Biostatistics Collaborative Core: Faculty Publications and Other Works

The discovery of the urinary microbiome (urobiome) has created opportunities for urinary health researchers who study a wide variety of human health conditions. This manuscript describes an analysis of catheterized urine samples obtained from 1,004 urobiome study participants with the goal of identifying the most abundant and/or prevalent (common) taxa in five clinically relevant cohorts: unaffected adult women (n=346, 34.6%), urgency urinary incontinence (UUI) (n=255, 25.5%), stress urinary incontinence (SUI) (n=50, 5.0%), urinary tract infection (UTI) (n=304, 30.4%), and interstitial cystitis/painful bladder syndrome (IC/PBS) (n=49, 4.9%). Urine was collected via transurethral catheter and assessed for microbes with the Expanded Quantitative …

A Peptide Blocking The Adora1-Neurabin Interaction Is Anticonvulsant And Inhibits Epilepsy In An Alzheimer's Model, Shalini Saggu, Yunjia Chen, Liping Chen, Diana Pizarro, Sandipan Pati, Wen Jing Law, Lori Mcmahon, Kai Jiao, Qin Wang

Faculty, Staff and Student Publications

Epileptic seizures are common sequelae of stroke, acute brain injury, and chronic neurodegenerative diseases, including Alzheimer's disease (AD), and cannot be effectively controlled in approximately 40% of patients, necessitating the development of novel therapeutic agents. Activation of the A1 receptor (A1R) by endogenous adenosine is an intrinsic mechanism to self-terminate seizures and protect neurons from excitotoxicity. However, targeting A1R for neurological disorders has been hindered by side effects associated with its broad expression outside the nervous system. Here we aim to target the neural-specific A1R/neurabin/regulator of G protein signaling 4 (A1R/neurabin/RGS4) complex that dictates A1R signaling strength and response outcome …

College Of Public Heath News, Georgia Southern University

College of Public Health: News & Publications

• JPHCOPH Student Recognized for Registering 300 Bone Marrow Donors

Response To "Further Insight On Aoa Ophthalmology Residency Program Closure Data"., Harris Ahmed, Kim Vo, Wayne Robbins

Medical Education Articles

No abstract provided.

The Maternal Oral Microbiome Throughout Pregnancy, Rebecca Koerner

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation was to longitudinally examine the salivary microbiome during the second and third trimesters of pregnancy and explore its associations amongst adverse pregnancy outcomes (preterm birth, gestational diabetes mellitus, and hypertensive disorders of pregnancy), perceived stress and depression, and hair/salivary cortisol levels. The specific aims were to (1) explore the literature for studies longitudinally examining the oral microbiome during pregnancy using a scoping review guided by the Arskey and O’Malley framework; (2) to examine the salivary microbiome for changes in diversity and abundance during the second and third trimesters during pregnancy and its association with adverse …

Decoding The Pitx2-Controlled Genetic Network In Atrial Fibrillation, Jeffrey D Steimle, Francisco J Grisanti Canozo, Minjun Park, Zachary A Kadow, Md Abul Hassan Samee, James F Martin

Faculty, Staff and Students Publications

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia and a major risk factor for stroke, often arises through ectopic electrical impulses derived from the pulmonary veins (PVs). Sequence variants in enhancers controlling expression of the transcription factor PITX2, which is expressed in the cardiomyocytes (CMs) of the PV and left atrium (LA), have been implicated in AF predisposition. Single nuclei multiomic profiling of RNA and analysis of chromatin accessibility combined with spectral clustering uncovered distinct PV- and LA-enriched CM cell states. Pitx2-mutant PV and LA CMs exhibited gene expression changes consistent with cardiac dysfunction through cell type-distinct, PITX2-directed, cis-regulatory …

Social Determinants Of Health And Cancer Screening Implementation And Outcomes In The Usa: A Systematic Review Protocol, Ariella R Korn, Callie Walsh-Bailey, Meagan Pilar, Brittney Sandler, Prema Bhattacharjee, W Todd Moore, Ross C Brownson, Karen M Emmons, April Y Oh

2020-Current year OA Pubs

BACKGROUND: Improving the delivery, uptake, and implementation of cancer screening to meet evidence-based recommendations is needed to reduce persistent cancer health disparities in the USA. Current national public health targets emphasize the role of social determinants of health (SDOH) on cancer screening. However, there remains a need to explicate these linkages, toward the goal of identifying and implementing effective interventions that target and address SDOH to reduce inequities in cancer screening.

METHODS: We will conduct a systematic review of English language peer-reviewed original research articles published between 2010 and 2021 that describe observational (qualitative and quantitative) and intervention studies conducted …

Signal Detection Of Adverse Events Associated With Trastuzumab In A Cohort Of Elderly Patients With Breast Cancer, Efstathia Polychronopoulou, Sharon H Giordano, Lin-Na Chou, Xiaoying Yu, Yong-Fang Kuo

Faculty, Staff and Student Publications

AIM: Utilization of signal detection methods in longitudinal claims data can improve post-marketing drug surveillance, but to date there has been limited application. The aim of this study is to use 3 approaches, the proportional reporting ratio, Gamma Poisson Shrinker, and tree-based scan statistic in detecting adverse drug events (ADEs) attributed to trastuzumab using an administrative claims dataset.

METHODS: Using data from the Texas Cancer Registry and SEER linked to Medicare from 2010 to 2013, we conducted 1:2 propensity score matching. Breast cancer HER2+ patients treated with trastuzumab in addition to standard chemotherapy were matched to HER2- patients treated with …

Targeting Il-1Β As An Immunopreventive And Therapeutic Modality For K-Ras-Mutant Lung Cancer, Bo Yuan, Michael J Clowers, Walter V Velasco, Stephen Peng, Qian Peng, Yewen Shi, Marco Ramos-Castaneda, Melody Zarghooni, Shuanying Yang, Rachel L Babcock, Seon Hee Chang, John V Heymach, Jianjun Zhang, Edwin J Ostrin, Stephanie S Watowich, Humam Kadara, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

K-ras-mutant lung adenocarcinoma (KM-LUAD) is associated with abysmal prognosis and is tightly linked to tumor-promoting inflammation. A human mAb, canakinumab, targeting the proinflammatory cytokine IL-1β, significantly decreased the risk of lung cancer in the Canakinumab Anti-inflammatory Thrombosis Outcomes Study. Interestingly, we found high levels of IL-1β in the lungs of mice with K-rasG12D-mutant tumors (CC-LR mice). Here, we blocked IL-1β using an anti-IL-1β mAb in cohorts of 6- or 14-week-old CC-LR mice to explore its preventive and therapeutic effect, respectively. IL-1β blockade significantly reduced lung tumor burden, which was associated with reprogramming of the lung microenvironment toward an antitumor phenotype …

Prostate Cancer Therapy Personalization Via Multi-Modal Deep Learning On Randomized Phase Iii Clinical Trials, Andre Esteva, Jeff M Michalski, Et Al

2020-Current year OA Pubs

Prostate cancer is the most frequent cancer in men and a leading cause of cancer death. Determining a patient's optimal therapy is a challenge, where oncologists must select a therapy with the highest likelihood of success and the lowest likelihood of toxicity. International standards for prognostication rely on non-specific and semi-quantitative tools, commonly leading to over- and under-treatment. Tissue-based molecular biomarkers have attempted to address this, but most have limited validation in prospective randomized trials and expensive processing costs, posing substantial barriers to widespread adoption. There remains a significant need for accurate and scalable tools to support therapy personalization. Here …

Individual Differences In The Criminogenic Effects Of Discrimination: An Exploration Of The Role Of Impulse Control And Callous-Unemotional Traits, Toni Walker

LSU Doctoral Dissertations

The association between perceived discrimination and engagement in criminal offending has been well studied, especially in samples of minority (predominantly Black, Hispanic, and Latinx) adolescents. Several theories have been developed (Social Schematic Theory) and adapted (General Strain Theory) in an attempt to explain how harmful, discriminatory experiences may have an effect on an individual’s behavior. There may be variability in how an individual responds to perceived discrimination, however, but the moderating role of personality characteristics has not been explored. Impulse control and callous-unemotional (CU) traits are both established predictors of offending and may also relate to the mechanisms that theories …

Doctor Of Physical Therapy Students’ Clinical Reasoning Readiness And Confidence Treating With Telehealth: A United States Survey, Derrick F. Campbell, Jean-Michel Brismée, Brad Allen, Troy L. Hooper, Manuel A. Domenech, Kathleen Manella

Education Collection

Purpose: Telehealth has an emerging footprint on entry-level physical therapy programs. Students’ readiness for clinical reasoning with virtual versus traditional face-to-face treatment remains unknown. The purpose of this study was to evaluate Doctor of Physical Therapy (DPT) students’ preparedness for clinical experiences with and without telehealth.

Methods: A descriptive and exploratory cross-sectional survey was employed, with a voluntary convenience sample of 211 second- and third-year university DPT students during Fall 2020 clinical experiences. Descriptive and inferential statistics evaluated differences in DPT students’ (1) Physical Therapist Self-Efficacy (PTSE) scale scores, (2) confidence with treating initial and subsequent same-patient visits, …

2022-06-07_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …