Medicine and Health Sciences Commons^™

Novel App Knock-In Mouse Model Shows Key Features Of Amyloid Pathology And Reveals Profound Metabolic Dysregulation Of Microglia., Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H Suh, Elliot Thomsen, Jason Dugas, Michelle E Pizzo, Sarah L Devos, Timothy K Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T Masoud, Chun-Chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G Thorne, Kevin Shen, Stephanie Miller, Jorge J Palop, Dylan Garceau, Michael Sasner, Jennifer D Whitesell, Julie A Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S Zimmer, Anna G Orr, Kimberly Scearce-Levie, Joseph W Lewcock, Gilbert Di Paolo, Pascal E Sanchez

Faculty Research 2022

BACKGROUND: Genetic mutations underlying familial Alzheimer's disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transgenes have yielded key insights in mechanisms of disease, those models are subject to artifacts, including random genetic integration of the transgene, ectopic expression and non-physiological protein levels. The genetic engineering of novel mouse models using knock-in approaches addresses some of those limitations. With mounting evidence of the role played by microglia in AD, high-dimensional approaches to phenotype microglia in those models are critical to refine our understanding …

Inari Large-Bore Mechanical Thrombectomy In Intermediate-High Risk Submassive Pe Patients: Case Series And Literature Review, Mohammad F. Mathbout, Hussam Al Hennawi, Anwar Khedr, Medical University Of South Carolina, Thomas M. Todoran

Abington Jefferson Health Papers

Pulmonary embolism (PE) is one of the most common causes of cardiovascular (CV) mortality worldwide. Owing to the associated morbidity and mortality with other treatment modalities, including systemic thrombolysis, a discernible change in the era of acute pulmonary embolism management has been reported. Catheter-directed thrombectomy using the FlowTriever system (Inari Medical; Irvine, CA, USA) was shown to reduce endpoints of interest in patients with acute intermediate-high risk PE and was associated with rapid hemodynamic improvement. In this report, we describe our experience with three cases of patients presenting with submassive PE, whereby immediate pulmonary artery pressure improvement was evident in …

Ciliogenesis Mechanisms Mediated By Pak2-Arl13b Signaling In Brain Endothelial Cells Is Responsible For Vascular Stability, Karthikeyan Thirugnanam, Shubhangi Prabhudesai, Emma Van Why, Amy Pan, Ankan Gupta, Koji Foreman, Rahima Zennadi, Kevin R. Rarick, Surya M. Nauli, Sean P. Palacek, Ramani Ramchandran

Pharmacy Faculty Articles and Research

In the developing vasculature, cilia, microtubule-based organelles that project from the apical surface of endothelial cells (ECs), have been identified to function cell autonomously to promote vascular integrity and prevent hemorrhage. To date, the underlying mechanisms of endothelial cilia formation (ciliogenesis) are not fully understood. Understanding these mechanisms is likely to open new avenues for targeting EC-cilia to promote vascular stability. Here, we hypothesized that brain ECs ciliogenesis and the underlying mechanisms that control this process are critical for brain vascular stability. To investigate this hypothesis, we utilized multiple approaches including developmental zebrafish model system and primary cell culture systems. …

Gibbon Surgical Review, Volume 5, Issue 1, 2022

Gibbon Surgical Review

In this Issue:

6 - A History of ECMO and its Use During the COVID-19 Pandemic

8 - The First Pig-to-Human Heart Xenotransplantation

9 - Residency Interviewing in the Zoom Era

10 - An Interview with Dr. Andrew Newman

12 - Lung Transplantation for Patients with Severe COVID-19 Pulmonary Disease

14 - Risk Factors for Five-year Mortality after Carotid Endarterectomy

18 - An Interview with Dr. Scott Cowan

18 - General Surgery 101: The J-Pouch

20 - The Business of Surgery: Recognizing Barriers to Gender Equity

Gibbon Surgical Review, Volume 4, Issue 1, 2021

Gibbon Surgical Review

Contents:

The Evolution of Surgical Practice During the Ongoing COVID-19 Pandemic, 4

Socially responsible surgical care: a movement committed to surgical equity, 6

The MS4 Perspective on the Path to Surgery, 8

The Role of Empathy in Surgery: A Commentary and Conversation with Dr. Harish Lavu, 10

Interview with Dr. Olugbenga Okusanya, 12

The Ultimate Test in Medicine: Adapting Patient Care, Procedures, and Training During a Pandemic, 14

Robotic Surgery: Development, Applications, and Future Directions,16

Editorial Board and Reviewers, 19

Gibbon Surgical Society, 20

John H. Gibbon Jr., MD, 21

Also in this Issue:

The Jefferson Legacy: Where are they …

Medical School Watercooler Newsletter - June 10, 2022, Lindsey Lyle

Watercooler Newsletter

This is the June 10, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Meet a Med Student: Jazmyne Tabb
• Resident and Fellow Scholarship Exposition set for June 16
• FBI and U.S. Attorney’s Office to present on healthcare fraud
• Medical students present at M3 Case Report Symposium
• Phung to present at Precision Medicine World Conference
• College of Medicine to be named after university’s first president

A Cost-Effectiveness Study Comparing Ready-Toadminister And Traditional Vial-And-Syringe Method For Opioids, Prachi Arora, Maria Muehrcke, John Hertig

Scholarship and Professional Work – COPHS

No abstract provided.

Book Review – Lean Impact: How To Innovate For Radically Greater Social Good Review & Implications For Engaged Programming, M.C. "Molly" Immendorf

Journal of Human Sciences and Extension

The book “Lean Impact: How to Innovate for Radically Greater Social Good” outlines ways to infuse innovation techniques learned from the private start-up sector into sectors traditionally working to make a societal change that may be funded through governmental agencies and grants. These techniques are also applicable to the Land-Grant Cooperative Extension System (CES) through combining them with engaged programming practices and CES best practices and the tools and methods of the Extension Foundation’s Impact Collaborative in urban programs and beyond.

Translation And Validation Of The Caprini Risk Assessment Score For Urdu Speakers, Khairunisa Lalani

College of Science and Health Theses and Dissertations

Background: Venous Thromboembolism (VTE) is a potentially fatal condition and determination of risk level and identification of risk factors for VTE should be performed during the post-operative period. The Caprini Risk Assessment Score (CRS), is a validated risk assessment instrument tool used widely to predict postoperative VTE in the Western world, but it has limited utility among resource-poor and developing countries due to the limited English language proficiency of potential instrument users.

Aims: We aimed to translate the CRS tool to Urdu and validate its use in the Urdu speaking population through a correlation of self-administered and healthcare professional-administered scores. …

2022-06-10 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Accessibility And Inclusion As An Approach To Enhancing Local Extension Programs, S. Dee Jepsen, Laura Akgerman, Karen Funkenbusch, Jessie Calero, Heather Kelejian

Journal of Human Sciences and Extension

Providing accessible learning opportunities and inclusive programs are critical to Extension’s mission. Creating inclusive environments is more than consideration for individuals’ personal identity. Using principles of Inclusion, Diversity, Equity, and Accessibility (IDEA) is an approach to intentionally build community and create new opportunities for education and growth. The Americans with Disabilities Act is a federal law requiring businesses and events to be accessible to individuals with disabilities. The Rehabilitation Act of 1973 states, “no qualified individual with a disability may be discriminated against in any program or activity receiving federal financial assistance.” The legislation applies to Extension buildings, programs, and …

Full Issue, Volume 10, Number 1, Donna J. Peterson, Scott Cummings

Journal of Human Sciences and Extension

No abstract provided.

“I’M Going To Live My Life Freely”: Authenticity As An Indicator Of Belonging Among Urban Latinx Lgbtq+ Youth, Maru Gonzalez, Bianka M. Reese, Tania Connaughton-Espino

Journal of Human Sciences and Extension

While there is a growing body of scholarship on the experiences of LGBTQ+ youth in school and community settings, less is known about Latinx LGBTQ+ youth specifically. In response, this phenomenological study examined the experiences of eight Latinx LGBTQ+ youth relative to school and community belonging, with a specific focus on urban environments, using intersectionality and minority stress frameworks, and Lee and Robbins’ operational definition of belongingness. Three overarching themes emerged from the data: (a) navigating challenges, (b) the importance of an inclusive climate, and (c) thriving through adversity. Further, authenticity was identified as an additional indicator of belonging among …

Documentary Review – Two Roles In Urban Community Revitalization: Julian Price The Philanthropist And Cooperative Extension, Susan A. Kelly

Journal of Human Sciences and Extension

Julian Price used his inherited wealth to revitalize downtown Asheville, North Carolina. This documentary review reflects on his passion for community, and the concepts he believed would bring the city back from decay. Some of those same community development practices are successfully used across the country by Extension professionals to assist urban communities in revitalization. Examples of Extension programs and techniques are provided throughout this review about an inspiring documentary about a man looking for purpose and finding it by transforming a troubled downtown with his generosity.

Impact Of The Covid-19 Pandemic On The Care Continuum Of Youth Living With Hiv: Qualitative Study Of The Scale It Up Program Clinical Sites, Tyra Dark, Sitaji Gurung, Mary Dooley, Kit N. Simpson, Seyram A. Butame, Sylvie Naar

Publications and Research

The study objective was to explore the impact of COVID-19 pandemic restrictions on the clinics’ ability to provide continuous healthcare services to youth (15–24 years) living with HIV (YLWH). One focused semi-structured interview was conducted with each HIV clinic site—resulting in ten interviews. Data were analyzed using thematic analysis techniques assisted by NVIVO coding software and themes indicating barriers and facilitators to providing uninterrupted healthcare were elicited. Six themes were identified that affected the care continuum of YLWH: Timeframe of clinic preparation to address COVID-19 restrictions; impact on treatment cascade monitoring data; impact on patient care; impact on staff and …

Examining The Effects Of Passenger Conversation On Older Adult Driving, Allison Green, Meg Tedder, Amanda J. Mohler, Amanda M. Carpenter

Student Journal of Occupational Therapy

Older adults have impaired driving performance compared to other age groups, and auditory stimuli has adverse effects on driving performance (Karthaus & Falkenstein, 2016). Therefore, the purpose of this study was to expand knowledge of driving and passenger conversation within the older adult population. Participants (n = 17) completed a drive of 7.8 miles on a driving simulator twice; once without conversation and again with conversation. Both drives used the same simulated driving tasks to examine driving performance with and without conversation. Participants exhibited poorer driving performance from the first drive without conversation to the second drive with conversation, …

Atr-Mediated Cd47 And Pd-L1 Up-Regulation Restricts Radiotherapy-Induced Immune Priming And Abscopal Responses In Colorectal Cancer, Rodney Cheng-En Hsieh, Sunil Krishnan, Ren-Chin Wu, Akash R Boda, Arthur Liu, Michelle Winkler, Wen-Hao Hsu, Steven Hsesheng Lin, Mien-Chie Hung, Li-Chuan Chan, Krithikaa Rajkumar Bhanu, Anupallavi Srinivasamani, Ricardo Alexandre De Azevedo, Yung-Chih Chou, Ronald A Depinho, Matthew Gubin, Eduardo Vilar, Chao Hsien Chen, Ravaen Slay, Priyamvada Jayaprakash, Shweta Mahendra Hegde, Genevieve Hartley, Spencer T Lea, Rishika Prasad, Brittany Morrow, Coline Agnes Couillault, Madeline Steiner, Chun-Chieh Wang, Bhanu Prasad Venkatesulu, Cullen Taniguchi, Yon Son Betty Kim, Junjie Chen, Nils-Petter Rudqvist, Michael A Curran

Faculty, Staff and Student Publications

Radiotherapy (RT) of colorectal cancer (CRC) can prime adaptive immunity against tumor-associated antigen (TAA)-expressing CRC cells systemically. However, abscopal tumor remissions are extremely rare, and the postirradiation immune escape mechanisms in CRC remain elusive. Here, we found that irradiated CRC cells used ATR-mediated DNA repair signaling pathway to up-regulate both CD47 and PD-L1, which through engagement of SIRPα and PD-1, respectively, prevented phagocytosis by antigen-presenting cells and thereby limited TAA cross-presentation and innate immune activation. This postirradiation CD47 and PD-L1 up-regulation was observed across various human solid tumor cells. Concordantly, rectal cancer patients with poor responses to neoadjuvant RT exhibited …

Overexpression Of Foxf2 In Prostate Cancer Cells Causes An Increase In Cancer Cell Apoptosis And A Decrease In Proliferation, Vaughn Poon

Honors Projects

FOXF2 is a transcription factor that plays a crucial role in organ development, and recent studies have shown that it suppresses tumor growth and progression in mouse prostate models by attenuating the cancer-associated fibroblasts (CAF) phenotype and transcriptionally downregulating Cxcl5. However, the effects of FOXF2 overexpression in prostate cancer cells have not been extensively studied. Here, we investigate the impact of FOXF2 overexpression in prostate cancer cells and demonstrate that it leads to a significant increase in cell apoptosis and a decrease in proliferation. These findings suggest that FOXF2 may have potential as an immunotherapy drug target for prostate …

Prison Or Paradise? Perceptions Of Communication Between Cohabitating Couples During Covid-19 Restrictions, Caroline Fenker, Olivia Fisher, Amy Hodel, Clayton Lange, Jory Swider, Jena Thompson

Student Journal of Occupational Therapy

Purpose: Due to the immediacy of the COVID-19 phenomenon, researchers recognized a need to examine the effects of restrictions on communication patterns between committed, cohabiting partners. Prior literature investigated factors contributing to communication satisfaction; however, a substantial gap remains within the occupational therapy (OT) literature. The study explored perceived satisfaction of quantity and quality of communication before and during COVID-19 restrictions between cohabitating, committed partners and its relation to occupation.

Methods: A questionnaire sent via e-mail recruited subjects from an occupational therapy doctorate (OTD) program who self-identified as having quarantined with a committed partner during COVID-19 restrictions. A mixed-methods …

Avian Assisted Intervention During Covid-19 Pandemic Restrictions, Sandia Wood, Mary Thelander Hill

Student Journal of Occupational Therapy

Occupational Deprivation has been a present risk [ER1] for people in inpatient hospital settings such as Skilled Nursing Facilities (SNF) during the Coronavirus Disease 2019 (COVID-19) pandemic restrictions. Clients have described their days as “boring” and “unfulfilling.” Clients experiencing extended in-patient hospitalization, who already might experience great interruptions to their treasured roles, routines, and occupations, were further restricted from recreational and social opportunities usually present in those settings. This work describes the translation of the animal assisted intervention evidence base to an occupational therapy student-developed program at a SNF to address this deficit. A vibrant avian therapy partner gave moments …

Transitioning From Face-To-Face To Telehealth Speech And Language Services Due To The Covid-19 Pandemic: Perceptions Of Persons With Aphasia And Their Ehelpers, Emma Logan

USF Tampa Graduate Theses and Dissertations

The purpose of this research study was to investigate the perceptions of the aphasia community, as well as their caregivers, that are provided speech and language services and how their services were affected due to transitions because of the COVID-19 pandemic. The recency and novelty of the pandemic warrants research of many areas related to health care, including that of speech language pathology.

An online survey was completed by nine persons with aphasia and three eHelpers. Participants were recruited through a university clinic and by informational fliers through social media. Participants with aphasia qualified by having experiences with speech and …

Understanding The Efficacy Of Telehealth In Pediatric Occupational Therapy, Katheren Bettermann

University Honors Theses

In response to the COVID-19 pandemic, the American Occupational Therapy Association (AOTA) expanded telehealth, an electronic health care service, to virtually treat patients. Many occupational therapy and public health scholars are researching the effectiveness of telehealth for all age groups or for adults only. The purpose of this study is to understand the efficacy of telehealth as a pediatric occupational therapy modality and expose variables effecting treatment quality.

I created a survey in Qualtrics, a web-based software. The target population was pediatric occupational therapists (OTs) licensed in Oregon. Qualitative and quantitative questions addressed respondent qualifications, telehealth and pediatric occupational therapy …

Genomic Tools Reveal Complex Social Organization Of An Invasive Large Mammal (Sus Scrofa), Chelsea L. Titus, Courtney F. Bowden, Timothy J. Smyser, Stephen L. Webb, James C. Beasley

United States Department of Agriculture Wildlife Services: Staff Publications

A comprehensive understanding of sociality in wildlife is vital to optimizing conservation and management efforts. However, sociality is complicated, especially for widely distributed species that exhibit substantive behavioral plasticity. Invasive wild pigs (Sus scrofa), often representing hybrids of European wild boar and domestic pigs, are among the most adaptable and widely distributed large mammals. The social structure of wild pigs is believed to be similar to European wild boar, consisting of matriarchal groups (sounders) and solitary males. However, wild pig social structure is understudied and largely limited to visual observations. Using a hierarchical approach, we incorporated genomic tools …

Electronic Health Record-Based Recruitment And Retention And Mobile Health App Usage: Multisite Cohort Study., Janelle W Coughlin, Lindsay M Martin, Di Zhao, Attia Goheer, Thomas B Woolf, Katherine Holzhauer, Harold P Lehmann, Michelle R. Lent, Kathleen M Mctigue, Jeanne M Clark, Wendy L Bennett

PCOM Scholarly Works

BACKGROUND: To address the obesity epidemic, there is a need for novel paradigms, including those that address the timing of eating and sleep in relation to circadian rhythms. Electronic health records (EHRs) are an efficient way to identify potentially eligible participants for health research studies. Mobile health (mHealth) apps offer available and convenient data collection of health behaviors, such as timing of eating and sleep.

OBJECTIVE: The aim of this descriptive analysis was to report on recruitment, retention, and app use from a 6-month cohort study using a mobile app called Daily24.

METHODS: Using an EHR query, adult patients from …

Cis- And Trans-Resveratrol Have Opposite Effects On Histone Serine-Adp-Ribosylation And Tyrosine Induced Neurodegeneration, Megha Jhanji, Chintada Nageswara Rao, Jacob C. Massey, Marion C. Hope Iii, Xueyan Zhou, C. Dirk Keene, Tao Ma, Michael D. Wyatt, Jason A. Stewart, Sajish Mathew

Faculty Publications

Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We previously showed that tyrosine inhibits tyrosyl-tRNA synthetase (TyrRS)-mediated activation of poly-ADP-ribose polymerase 1 (PARP1). Here, we show that histone serine-ADP-ribosylation is decreased in Alzheimer’s Disease (AD) brains, and increased tyrosine levels deplete TyrRS and cause neuronal DNA damage. However, dopamine and brain-derived neurotrophic factor (BDNF) increase TyrRS and histone serine-ADP-ribosylation. Furthermore, cis-resveratrol (cis-RSV) that binds to TyrRS mimicking a ‘tyrosine-free’ conformation increases TyrRS, facilitates histone serine-ADP-ribosylation-dependent DNA repair, and provides neuroprotection in a TyrRS-dependent manner. …

Multilevel Determinants Of Racial/Ethnic Disparities In Severe Maternal Morbidity And Mortality In The Context Of The Covid-19 Pandemic In The Usa: Protocol For A Concurrent Triangulation, Mixed-Methods Study, Jihong Liu, Peiyin Hung Ph.D, Chen Liang Ph.D., Jiajia Zhang Ph.D., Shan Qiao Ph.D., Berry A. Campbell, Bankole Olatosi Ph.D., Myriam E. Torres Ph. D., Neset Hikmet, Xiaoming Li Ph.D.

Faculty Publications

Introduction The COVID-19 pandemic has affected communities of colour the hardest. Non-Hispanic black and Hispanic pregnant women appear to have disproportionate SARS-CoV-2 infection and death rates.

Methods and analysis We will use the socioecological framework and employ a concurrent triangulation, mixed-methods study design to achieve three specific aims: (1) examine the impacts of the COVID-19 pandemic on racial/ethnic disparities in severe maternal morbidity and mortality (SMMM); (2) explore how social contexts (eg, racial/ethnic residential segregation) have contributed to the widening of racial/ethnic disparities in SMMM during the pandemic and identify distinct mediating pathways through maternity care and mental health; and …

Foreword, Mary A. Ruemenapp, Katherine Williams

Journal of Human Sciences and Extension

No abstract provided.

Extension Engagement With Urban Communities: Editors’ Introduction To The Urban-Themed Issue Of Jhse, Julie Fox, Donna J. Peterson, Scott R. Cummings

Journal of Human Sciences and Extension

This introductory article for the special issue of the Journal of Human Sciences and Extension (JHSE) highlights respectful Extension research and engagement with dynamic urban communities. Like the 2017 urban-themed issue of JHSE, the intent is not to diminish the importance of rural and suburban Extension engagement but to better understand unique experiences of Extension in urban communities. The 35 contributing authors represent a range of geographic and programmatic viewpoints. Insights shared

• demonstrate that diversity in our cities is multidimensional;
• reinforce the importance of culturally relevant engagement;
• address issues of access, equity, inclusion, and a sense of belonging;
• highlight the …

Visualizing Diversity: Spatial Data As A Resource Enabling Extension To Better Engage Communities, Justin Krohn, Jacqueline Davis-Manigaulte, Christopher Fulcher, Jennifer Sarah Tiffany

Journal of Human Sciences and Extension

Effective Extension programming relies on engaging people of all races, ethnicities, and cultures. Extension educators sometimes struggle with how best to engage communities that are not “traditional” program audiences. Centering data visualization on the strength of Black, Latino/Hispanic, Asian, Native American, and other potentially marginalized communities can assist Extension’s work to engage diverse staff, program participants, and advisory board members. For example, using maps to understand what languages people speak at home strengthens the connections between Extension programs and community participants and can inform staff recruitment and advisory board composition. However, maps of aggregated areas like counties can mask socioeconomic …

Strengthening Urban Food Systems Through Extension Programming And Community Engagement: A Case Study Of New Brunswick, New Jersey, Cara L. Cuite, Lauren B. Errickson

Journal of Human Sciences and Extension

Cooperative Extension (Extension) can, and in many cases already does, engage in well-rooted partnerships with urban audiences. Yet, it is important to recognize that there are many layers to the diversity that exists within urban audiences– there is no single “urban community.” This article presents a case study of food security programming in New Brunswick, New Jersey, including collaborations between Rutgers Cooperative Extension and multiple community organizations to illustrate important considerations for engaging in urban Extension initiatives. Specifically, challenges exist in identifying urban audiences, including those who are hidden, especially as the demographics of city residents can vary greatly within …