Medicine and Health Sciences Commons^™

Role Of Trail-R In Primary And Secondary Genital And Respiratory Chlamydia Muridarum Infections In Mice, Sukumar Pal, Sydni Sheff, Mufadhal Al-Kuhlani, David M. Ojcius, Luis M. De La Maza

Pacific Faculty Work

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor (TRAIL-R) suppresses inflammation and could therefore affect the course of Chlamydia infections and their long-term sequelae. Wild-type (WT) and TRAIL-R^2/2 C57BL/6 mice were inoculated vaginally with Chlamydia muridarum; the course of the infection was followed with vaginal cultures and the presence of hydrosalpinx determined. To evaluate the role of TRAIL-R following a secondary infection, the mice were vaginally reinfected. WT and TRAIL-R^2/2 male mice were also infected and reinfected in the respiratory tract, and the course of the diseases and the infections were followed. Following the primary and secondary vaginal …

The Need For Queer Education In Graduate Psychotherapy Programs, Rachel Warner

Consensus

No abstract provided.

Capturing The Pool Dilution Effect In Group Testing Regression: A Bayesian Approach, Stella Self Ph.D., Ms, Christopher Mcmahan, Stefani Mokalled

Faculty Publications

Group (pooled) testing is becoming a popular strategy for screening large populations for infectious diseases. This popularity is owed to the cost savings that can be realized through implementing group testing methods. These methods involve physically combining biomaterial (eg, saliva, blood, urine) collected on individuals into pooled specimens which are tested for an infection of interest. Through testing these pooled specimens, group testing methods reduce the cost of diagnosing all individuals under study by reducing the number of tests performed. Even though group testing offers substantial cost reductions, some practitioners are hesitant to adopt group testing methods due to the …

Hima2: High-Dimensional Mediation Analysis And Its Application In Epigenome-Wide Dna Methylation Data, Chamila Perera, Haixiang Zhang, Yinan Zheng, Lifang Hou, Annie Qu, Cheng Zheng, Ke Xie, Lei Liu

2020-Current year OA Pubs

Mediation analysis plays a major role in identifying significant mediators in the pathway between environmental exposures and health outcomes. With advanced data collection technology for large-scale studies, there has been growing research interest in developing methodology for high-dimensional mediation analysis. In this paper we present HIMA2, an extension of the HIMA method (Zhang in Bioinformatics 32:3150-3154, 2016). First, the proposed HIMA2 reduces the dimension of mediators to a manageable level based on the sure independence screening (SIS) method (Fan in J R Stat Soc Ser B 70:849-911, 2008). Second, a de-biased Lasso procedure is implemented for estimating regression parameters. Third, …

Kstar: An Algorithm To Predict Patient-Specific Kinase Activities From Phosphoproteomic Data, Sam Crowl, Ben T Jordan, Hamza Ahmed, Cynthia X Ma, Kristen M Naegle

2020-Current year OA Pubs

Kinase inhibitors as targeted therapies have played an important role in improving cancer outcomes. However, there are still considerable challenges, such as resistance, non-response, patient stratification, polypharmacology, and identifying combination therapy where understanding a tumor kinase activity profile could be transformative. Here, we develop a graph- and statistics-based algorithm, called KSTAR, to convert phosphoproteomic measurements of cells and tissues into a kinase activity score that is generalizable and useful for clinical pipelines, requiring no quantification of the phosphorylation sites. In this work, we demonstrate that KSTAR reliably captures expected kinase activity differences across different tissues and stimulation contexts, allows for …

Hippocampal Threat Reactivity Interacts With Physiological Arousal To Predict Ptsd Symptoms, Büşra Tanriverdi, Stacey L House, Deanna M. Barch, Et Al.

2020-Current year OA Pubs

Hippocampal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat-sensitivity may interact with arousal responses to alter hippocampal reactivity, and further how these interactions relate to the sequelae of trauma-related symptoms. In a sample of individuals recently exposed to trauma (N=116, 76 Female), we found that PTSD symptoms at 2-weeks were associated with decreased hippocampal responses to threat as assessed with functional magnetic resonance imaging (fMRI). Further, the relationship between hippocampal threat sensitivity and PTSD symptomology only emerged in individuals who showed transient, high threat-related arousal, as assayed by an independently collected …

Adapting And Developing An Academic And Community Practice Collaborative Care Model For Metastatic Breast Cancer Care (Project Adapt): Protocol For An Implementation Science-Based Study, Ashley J Housten, Uzoma Charles Okere, Graham A Colditz, Cynthia Ma, Jingxia Liu, Courtney Harriss, Nancy U Lin, Melissa Rooney, Jennifer Dill, Muhammad Popalzai, Jennifer Badiu, Kan Huang, Casey Burton, Lindsay Peterson

2020-Current year OA Pubs

BACKGROUND: Metastatic breast cancer (MBC) remains incurable despite significant treatment advances. Coordinating care for patients with MBC can be challenging given the various treatment options, available clinical trials, and frequent need for ancillary services. To optimize MBC care, we designed a project for adapting and developing an academic and community practice collaborative care model for MBC care (Project ADAPT), based on the Ending Metastatic Breast Cancer for Everyone (EMBRACE) program developed at Dana Farber Cancer Institute.

OBJECTIVE: We aim to describe the implementation science-based study design and innovative components of Project ADAPT.

METHODS: Project ADAPT uses the Dynamic Adaptation Process …

Examining Demographic And Environmental Factors In Predicting The Perceived Impact Of Cancer On Childhood And Adolescent Cancer Survivors, Nazan Cetin

Dissertations and Theses

Cancer survivors' perceptions on how cancer has impacted their lives has been identified as a "critical predictor" of psychosocial well-being and quality of life outcomes. Given the dramatic increase in survival rates and the long-term health and psychosocial challenges, as well as survivorship care barriers, this study focuses special attention on childhood and adolescent cancer survivors and is guided by Tedeschi and Calhoun's theory of posttraumatic growth and Hammond's theory of distinctiveness. This study aims to examine the influence of demographic (i.e., age at diagnosis, biological sex, race/ethnicity, type of cancer) and environmental factors (i.e., geographical location and insurance type), …

Comparing Substance Use Outcomes By Sexual Identity Among Women: Differences Using Propensity Score Methods, Katherine J. Karriker-Jaffe, Laurie Drabble, Libo Li, Cat Munroe, Amy A. Mericle, Karen F. Trocki, Tonda L. Hughes

Faculty Research, Scholarly, and Creative Activity

Background: Differences in alcohol, tobacco, and other drug (ATOD) use by sexual identity vary across samples of women recruited using different sampling methods. We used propensity score (PS) weighting methods to address two methodological questions: (1) Do disparities between sexual minority women (SMW) and heterosexual women persist when differences in risk and protective factors are similarly distributed between groups, and (2) Does accounting for SMW-specific resiliency factors impact differences between non-probability samples of SMW? Methods: Four samples included SMW from a longitudinal study with a nonprobability sample (n = 373), a national general population panel sample (n = 373), …

Intouch Week Of July 25, 2022, New York Medical College

InTouch

• Student Clinician Ceremony Marks Start of Clinical Years for SOM Class of 2024
• NYMC and TU Host 20th COVID-19 Symposium
• Student Housing Superintendent Visar Zeka Brings More Than 15 Years of Experience to NYMC

Altered Genome-Wide Hippocampal Gene Expression Profiles Following Early Life Lead Exposure And Their Potential For Reversal By Environmental Enrichment, Garima Singh, V Singh, T Kim, A Ertel, W Fu, J S Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Early life lead (Pb) exposure is detrimental to neurobehavioral development. The quality of the environment can modify negative influences from Pb exposure, impacting the developmental trajectory following Pb exposure. Little is known about the molecular underpinnings in the brain of the interaction between Pb and the quality of the environment. We examined relationships between early life Pb exposure and living in an enriched versus a non-enriched postnatal environment on genome-wide transcription profiles in hippocampus CA1. RNA-seq identified differences in the transcriptome of enriched vs. non-enriched Pb-exposed animals. Most of the gene expression changes associated with Pb exposure were reversed by …

Joint Models For Repeated Measured, Non-Normally Distributed Multilevel Data, Weiwei He

USF Tampa Graduate Theses and Dissertations

Clinical trials have tended to collect both survival information and longitudinal biomarkers, as well as other covariates. In order to better assess the severity of diverse diseases, we need to collect various longitudinal outcomes. Furthermore, longitudinal data could consist of a number of different measurements of varying types. The multilevel item response theory (MLIRT) model has been widely used in several fields such as public health and health sciences for multivariate longitudinal outcomes. Joint models combining the longitudinal and survival processes, as well as the relation between them, have been developed to minimize bias and improve the efficiency of estimates. …

Holarctic Species In The Pluteus Romellii Clade Five New Species Described And Old Names Reassessed, Hana Ševčíková, Ekaterina Malysheva, Giuliano Ferisin, Francesco Dovana, Egon Horak, Jacob Kalichman, Oğuzhan Kaygusuz, Renée Lebeuf, Guillermo Muñoz González, Andrew M Minnis, Stephen D Russell, Michal Sochor, Bálint Dima, Vladimír Antonín, Alfredo Justo

Faculty, Staff and Students Publications

We studied the taxonomy of Pluteus romellii, and morphologically similar Holarctic species in the/romellii clade of section Celluloderma, using morphological and molecular data (nrITS, TEF1-α). Pluteus romellii is lectotypified and epitypified and accepted as an exclusively Eurasian species. Pluteus lutescens and P. pallescens are considered synonyms of P. romellii. Pluteus fulvibadius is accepted as a related, but separate, North American species. Five species in the/romellii clade are described as new to science: two from North America (P. austrofulvus and P. parvisporus), one from Asia (P. parvicarpus), one from Europe (P. siccus …

Masthead 2022, Dujpew Editorial Board

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

No abstract provided.

Letter From The Editor 2022, Dujpew Editorial Board

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

No abstract provided.

Volume I | Issue Iv | 2022, Dujpew Editorial Board

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

No abstract provided.

Triple (Identity) Threat: Multi-Layered National Identity Appeals In Republican Political Narratives During The 2016 And 2020 Presidential Elections, Brita Mackey

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

National identity, as a broadly constituted social identity category, has been shown to hold power both as a source of political mobilization and as an enforcer of democratic stability. In recent years, Republican voters have reported stronger national attachments than Democrats, perhaps due to national identity’s longstanding implicit associations with white racial identity – and the rising prominence of multiculturalist and globalist ideologies in recent decades. In light of such findings, I propose that the rhetoric of Republican political elites may function to further exacerbate a stronger sense of national identity among their base by appealing to conjoined national and …

Econometric Analysis Of The Relationship Between Domestic Economic Growth And Levels Of Inflow Of Remittances In Developing Countries, Mihail Naskovski

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

The international global migration has produced an exponential growth of remittances, which can be defined as the transfer of funds from one country to another. This study will inspect the macroeconomic impact of remittance inflow on economic growth using panel regression, covering the period from 1981 to 2020 and focusing on a sample of 152 countries, then filtered by 4 geographical regions for additional analysis. Like many studies before, a consensus about an overall effect of the flows on global level could not be reached from his study following the analysis of the general sample. However, on a more specific …

Identifying Potential Pork-Barrel Legislation Using Machine Learning: A Preliminary Analysis, Sunil Green

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

Pork-barrel legislation has been criticized by some as an excessive and potentially corrupt use of Congressional appropriations. The task of finding the specific parts of legislation that have been “pork-barreled”, however, requires many hours of labor by policy researchers. Using data from government watchdogs and machine learning algorithms, the research explores the idea of creating a model to flag specific line items of appropriations bills for policy researchers to further explore as potential pork-barrel legislation. The model constructed uses data from the Earmark Database by Taxpayers for Common Sense, and the Congressional Pig Book by Citizens Against Government Waste to …

Conservatism, Collaboration, And Capacity: Political Explanations For Canada’S Shift In Immigrant Admissions Logic, Jaidyn Appel

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

Canada is often regarded as the United States’ friendlier neighbor to the north, but how welcoming is it really? A critical analysis of immigration and citizenship policy throughout Canadian history reveals that Canada may not be the inclusive member of the world community it is often conceptualized as. This paper examines some of the recent key changes in Canadian immigration policy and their broader contexts, while benchmarking the policies against two leading scholars' thoughts on how the relative presence of certain political ideologies in a country drives its immigration policies to the left or right of the political spectrum. As …

Studying The Economic Impact Of The Demonetization Across Indian Districts, Arnav Joshi

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

This thesis studies the economic impact of the Indian demonetization which was a unique monetary event that made 86.9 percent of the total currency in circulation illegal tender overnight. The decision to demonetize high-value currency notes was taken by the Indian government on November 8th, 2016, leading to a severe shortage of cash. This thesis tries to analyze how the impact of the demonetization differed across districts in India and how the characteristics of those districts pertaining to education, electricity and tap water access, employment, and technology access can help explain these differences. The thesis uses satellite data on human-generated …

Bias In The Jury Box: The Sociological Determinants Of Jury Selection For Capital Cases In North Carolina, Alessandra Quattrocchi

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

An evaluation of four Wake County capital cases from 2014-2018 reveals the disparate effects that the jury selection process had on Black and female potential jurors and especially on Black female potential jurors. The requirement that capital jurors be willing and able to sentence death systematically excluded Blacks and females, with Black females excused for this reason at a rate over three times higher than White males. Black potential jurors not struck for death qualification were disproportionately excluded by prosecutorial peremptory strikes at a rate nearly two times greater than Whites. Final analyses conclude that Black females had significantly lower …

Early Childhood Intervention And Income Inequality: An Analysis On The Intergenerational Mobility Of Head Start Participants, Paul Hinton

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

The Head Start program is an early childhood intervention program funded by the federal government. Designed for low-income families, it promotes school readiness among its participants. In my research, I examine the effects of Head Start on the intergenerational mobility of its participants. Using data from the National Longitudinal Survey of Youth (NLSY79) and the NLSY Child and Young Adult Supplement (CNLSY), I measure the degree of earnings persistence between parents and their children for students in preschool and Head Start. I find that participation in Head Start is associated with an increase in mobility, which remains true after controlling …

“Pure People” And “Corrupt Elites:” Corruption Talk In The 2020 Election, Milan Loewer

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

The word “corruption” has two separate but interrelated meanings. The first kind of corruption refers specifically to an abuse of public office for private gain; the second is broader and indicates a disjunction between a political reality and the ideal to which that reality ought to conform. This paper explores the role of various forms of “corruption talk” in the 2020 presidential election. The first part of the paper examines the “supply side,” looking at the kinds of “corruption narratives” that politicians offered in 2020. Using natural language processing, I analyze how Joe Biden, Donald Trump, and Bernie Sanders spoke …

The Religious Seculars: How Does Yom Kippur Impact Electoral Turnout?, Gall Sigler

Dartmouth Undergraduate Journal of Politics, Economics and World Affairs

Does Yom Kippur impact electoral turnout in religious and secular Jewish communities in Israel? By collecting data on electoral behavior in elections to local councils from 1983 to 2018 in Jewish-secular, Jewish-religious and non-Jewish municipalities, this research attempts to elucidate the relationship between the communal Yom Kippur experience and electoral turnout. This research finds that the Yom Kippur experience appears to decrease turnout in secular municipalities, while no statistically significant impact was observed in religious municipalities. Research on the psychological significance of novelty and religious events, as well as ethnographic analysis of Israel, suggests that the Yom Kippur experience undermines …

Remote Work: Job Satisfaction And Healthy Work Boundaries, Carlee Thesier

University Honors Program

This paper addresses mass remote work as a growing organizational structure. COVID-19 initiated the movement for organizations to have employees work from home, and as workplaces are beginning to reopen, remote work is continuing to grow. The remote work presents many challenges that organizations were not prepared to address when initially moving online. While these challenges are being addressed and evaluated, organizations are not standardized in the structure of remote work and are continuing to perfect the method. This paper analyzes how mental health, job satisfaction, and long-term effects of continued mass remote work. The process of mass remote work …

Men’S Stories: An Account Of Translating Vaccine Decision Narratives From Young Men In The U.S. Into A Targeted Public Health Intervention, Michelle Miller-Day, Erin S. Craw, Diana Harris, Michael L. Hecht

Communication Faculty Articles and Research

Effective interventions to promote human papillomavirus (HPV) vaccination are needed for all young adults across the globe. Yet, most public health efforts focus on HPV-related risks for females. Unfortunately, HPV-related cancers in men are also a concern, as is the potential for men to spread HPV to their partners. The HPV vaccine is highly effective in reducing risks related to these cancers. Yet, vaccination rates among young males are low and their vaccination concerns are not well understood. This project conducted 15 in-depth qualitative interviews with U.S. males aged 18–22 to hear their vaccine decision stories. Themes of HPV vaccination …

Optimising Response To An Introduction Of African Swine Fever In Wild Pigs, Kim M. Pepin, Vienna R. Brown, Anni Yang, James C. Beasley, Raoul Boughton, Kurt C. Vercauteren, Ryan S. Miller, Sarah N. Bevins

United States Department of Agriculture Wildlife Services: Staff Publications

African swine fever virus (ASFv) is a virulent pathogen that threatens domestic swine industries globally and persists in wild boar populations in some countries. Persistence in wild boar can challenge elimination and prevent disease-free status, making it necessary to address wild swine in proactive response plans. In the United States, invasive wild pigs are abundant and found across a wide range of ecological conditions that could drive different epidemiological dynamics among populations. Information on the size of the control areas required to rapidly eliminate the ASFv in wild pigs and how this area should change with management constraints and local …

Professional Development In Nursing Starting At The Bedside: An Evidence-Based Study, Annette Joyce Carlisle-Spotts

Graduate Theses, Dissertations, and Capstones

Frontline nurses are faced with a host of responsibilities requiring clinical skills to care for complex, and often, chronically ill patients. Nurses need leadership skills to communicate effectively with the interdisciplinary and multidisciplinary teams they are increasingly required to work alongside. The Institute of Medicine’s recommendation is to prepare bedside nurses with the advanced skills needed to collaborate with others to revolutionize healthcare (Institute of Medicine, 2010). With more than four million nurses in the United States serving a variety of patients and families and levels of need; the urgency for gaining advanced skills has never been greater. We also …

Reducing Falls Related To Toileting, Brian Locastro

Student Scholarly Projects

Practice Problem: The practice problem for the medical-surgical unit is a high rate of falls associated with toileting activities, despite universal fall precautions for all patients. The current fall rate is an average rate of 4 falls per 1,000 patient days.

PICOT: The PICOT question that guided this project was: Among adult patients in the inpatient medical-surgical unit (P), what is the effect of adding a toileting care plan (I) to the current practice of universal fall precautions (C) to reduce the severity and incidence of falls (O) within an 8-week period (T)?

Evidence: Nine high-quality articles supported a toileting …