Medicine and Health Sciences Commons^™

Factors Influencing Sexuality, Gender And Norms Of Adolescent: A Cross-Sectional Study Among Adolescent In Indonesia, Tantut Susanto, Tirta Amerta Isworo, Dewi Rokhmah

Journal of Health Research

Background: The current study explored the factors related to the sexuality, gender, and norms among Indonesian adolescents via structural equation modelling.

Method: A cross-sectional design was performed among 394 adolescents from August to October 2020 in East Java of Indonesia. A self-administered questionnaire measured factors that influenced sexuality, gender, and norms of adolescents. We used smart PLS (Partial Least Squares) to analyze the data.

Results: Two correlations emerge among independent variables, namely sociodemographic of adolescent and knowledge of reproductive health (RH) and human immunodeficiency virus (HIV) (p< 0.001) and sociodemographic of parents and family structure and function of RH (p< 0.001). Sociodemographic of parents (p= 0.003), knowledge of RH and HIV (p= 0.012), and family structure and function of RH (p= 0.006) were directly related to sexuality, gender, and norms of adolescent. Sociodemographic of adolescents (p= 0.031) and parents (p= 0.024) were indirectly related to the sexuality, gender, and norms of adolescent through knowledge of RH and HIV. Our model explains 39.9% of the variance in sexuality, gender, and norms of adolescents.

Conclusion: Factors that influence sexuality, gender, and norms of the adolescent …

Depression And Related Factors Among Health Science Students In Da Nang, Vietnam: A Cross-Sectional Study, Ngoc Thi Nhu Hoang, Ann Jirapongsuwan, Sukhontha Siri

Journal of Health Research

Background: This paper aimed to investigate the prevalence of depression and related factors among health science students in Da Nang, Vietnam.

Method: A cross-sectional study was undertaken among 401 undergraduate students. Depression was measured using the Centre for Epidemiological Studies Short Depression Scale. Bivariate and multivariate logistic regression was applied to identify any associations.

Results: Findings indicated that the prevalence of depression among students was 41.6%. Factors associated with the depression were studying in second year (aOR=3.15, 95%CI: 1.24-7.99), studying in third year (aOR=2.60, 95%CI: 1.056-6.42), poor health status (aOR= 2.57, 95%CI: 1.54-4.29), low and moderate parents’ relationships (aOR=12.41, 95%CI: …

Delayed Pre-Hospital Time In Acute Coronary Syndrome Patients And Associated Factors In A Hospital In Southern Thailand, Thareerat Ananchaisarp, Siriwimon Tantarattanapong, Supakit Satayukun, Kamonluk Thepuatrakul, Nuteua Techapattanakorn, Noppawit Limwattanalert, Nitchada Mettraiyasakul, Siwa Rattanakitkoson, Abhisit Chuaboon

Journal of Health Research

Background: Acute coronary syndrome (ACS) is currently the leading cause of morbidity and mortality worldwide. The prognosis of ACS treatment outcome depends on the speed of reperfusion after a heart attack; wherein, one of the associated factors is pre-hospital time.

Method: A retrospective study was conducted in ACS patients, who visited the emergency room of a tertiary hospital; from 1^st January to 31^st December 2020. The primary outcome was pre-hospital time; and secondary outcome was factors associated with delayed pre-hospital time (≥ 2 hours) that were analyzed by using logistic regression.

Results: The Median age of …

Development Of Wefit Screening Tool For Assessing Pre-Exercise Fitness Level For Older Adults In Peninsular Malaysia, Divya Vanoh, Arimi Fitri Mat Ludin, Suzana Shahar, Shahrul Azman Mohd Noah, Zahara Abdul Manaf, Noorlaili Mohd Tohit

Journal of Health Research

Background: Pre-exercise screening is important to identify the fitness level of older adults prior to performing exercise. This study aimed to develop a screening tool for identifying older adults with poor physical fitness prior to exercising.

Method: Participants involved 2315 older adults from four states in Peninsular Malaysia. Several social and health parameters were investigated, and fitness level was assessed using hand grip strength. Receiver operating curve (ROC) analysis was chosen to determine the cut-off point, sensitivity, specificity, positive predictive value (PPV) and Youden`s Index of the screening tool.

Results: Age, sex, waist circumference, hypertension, diabetes mellitus and fasting blood …

Administrative Data Improves Quality Of Cervical Pre-Cancer Surveillance In Davidson County, Tennessee, United States, Sheelah Blankenship, Manideepthi Pemmaraju, Edward Mitchel, Tiffanie M. Markus, Marie R. Griffin, Jessica L. Castilho

Journal of Health Research

Background: Accurate data are critical for public health surveillance yet can be challenging to ensure. The Tennessee (TN) HPV Vaccine IMPACT Project aims to assess the effectiveness of the human papillomavirus (HPV) vaccine in prevention of cervical cancer and high-grade dysplasia through laboratory reporting of pathology results among Davidson County women. This project assessed feasibility and value of use of administrative sources for improved data quality and completeness of high-grade cervical events in TN HPV-IMPACT between 2013-2017.

Method: We queried three administrative data systems (Hospital Discharge Data System, Ambulatory Surgical Treatment Center, and Tennessee Medicaid [TennCare]) for eligible women with …

An Overlooked Problem: A Qualitative Meta-Synthesis From Experience Of Men With Diabetic Erectile Dysfunction, Junjira Seesawang, Pulawit Thongtaeng

Journal of Health Research

Background: ED is negatively associated with men’s sexual function capacity, emotional, intimate relationship and particularly psychological well-being. The purpose of this study was to synthesize qualitative findings which explain the experiences of men with diabetes who have erectile dysfunction.

Method: A meta-synthesis was performed. A search for qualitative studies published in English from 2010 to 2020 was conducted using PubMed, CINAHL, PsycInfo, and Science Direct databases. The main key words included: experience, men/male patient, erectile dysfunction, diabetes, diabetic erectile dysfunction, and qualitative research. Inductive and interpretative technique was used to analyze and synthesize findings from qualitative studies and reviewed by …

Acculturation Strategies Of The Recent Wave Of Indonesian Migrants In Thailand, Muhammad Zamal Nasution, Rosalia Sciortino, Sakkarin Niyomsilpa, Sureeporn Punpuing

Journal of Health Research

Background: The rapid increase of Indonesian migrants to Thailand in the last two decades due to greater regional integration, transport connectivity, and internationalization of education. Different religion, socio-culture, and other sociodemographic factors might affect their adaptation to the Thai society.

Method: A mixed-method design was employed for data collection. The quantitative data were derived from an online survey of 268 respondents, while the qualitative data came from literature review, in-depth interviews, focus group discussion, and direct observation.

Results: Indonesian migrants tended to opt for an integration strategy and to a lesser extent a separation strategy, with assimilation and marginalization ranking …

A Systematic Review Of The Use Of Simulated Client Method In Examining Medicine Price, Kah Seng Lee, Yaman Walid Kassab, Nur Akmar Taha, Zainol Akbar Zainal

Journal of Health Research

Background: Simulated patient method has been frequently utilised to explore the healthcare provider’s behaviour, services information, and its quality of services. This study was aimed to systematically identify and review studies conducted using simulated client/patients that examine medicine selling prices in various healthcare settings.

Method: We searched Pubmed, OVID, Scopus, Ebsco (Medline) and ProQuest for papers reporting on simulated patient studies, specifying drug or pharmaceutical pricings. Randomized controlled trials, non-randomized controlled trials, longitudinal studies, cohort or case–control studies, and descriptive studies were included.

Results: A total of 19 papers from 13 countries from all regions of the world were included …

Effects Of Dietary Ω-3 Polyunsaturated Fatty Acids (N-3 Pufa) In Light Sensitivity Of Retinas Of Mice Models To Prevent Retinal Damage, Aaron Eugene Rice

Longitudinal Scholar's Project

Light-induced retinal degeneration (LIRD) causes photoreceptor cell death in albino mice after exposure to high intensity light for a set period of time (6-24 hours). This causes retinal photoreceptor cell death through apoptosis. From several previous studies, Dr. Mandal’s lab concluded that de novo biosynthesis of ceramide mediates photoreceptor cell death in a LIRD model. Previous studies in Dr. Mandal’s lab has shown that mouse models with higher endogenous ω-3 Polyunsaturated Fatty Acids (n-3 PUFA) generates less ceramide upon neuronal injury and prevent neurodegeneration (Mol Neurobio 2021). There are currently not many available effective therapies for retinal degeneration in humans …

Provider Attitude Towards Postpartum Sexual Health, Katie Shearer, Pallavi Khanna

Longitudinal Scholar's Project

Background: The prevalence of female sexual dysfunction (FSD) worldwide is estimated to be 41%. FSD is even more prevalent in postpartum patients. There are significant barriers to addressing FSD in a busy clinic, and the use of a standardized screening questionnaire could be used to improve outcomes during postpartum appointments.

Methodology: Providers that care for postpartum patients at Regional One Health in Memphis, TN, were asked to complete an anonymous survey online. General knowledge and practices of providers were assessed.

Results: 79% of respondents answered that they felt very comfortable assessing for postpartum sexual health, and 88% …

Medical School Watercooler Newsletter - August 4, 2022, Lindsey Lyle

Watercooler Newsletter

This is the August 4, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Register now: Opioid Awareness Summit set for Aug. 26
• Meet a Ph.D. Student: Takreem Aziz
• Alexeyev to present on mitochondrial DNA
• Williams named assistant dean for institutional and academic success
• Department of Urology established at Whiddon College of Medicine; interim chair appointed
• Lin awarded $2.3 million NIH grant to further study cognitive deficits in pneumonia patients

Relationship Between Preventive Health Behavior, Optimistic Bias, Hypochondria, And Mass Psychology In Relation To The Coronavirus Pandemic Among Young Adults In Korea, Dong-Suk Lee, Hyun-Ju Koo, Seung-Ok Choi, Ji-In Kim, Yeon Sook Kim

Nursing Faculty Publications

The great challenge to global public health caused by the coronavirus pandemic has lasted for two years in Korea. However, Korean young adults seem less compliant with preventive health behaviors than older adults. This study aims to explore the relationship between risk perception variables of optimistic bias, hypochondriasis, and mass psychology, and preventive health behavior in relation to the coronavirus pandemic through a cross-sectional online survey. The participants are 91 Korean young adults aged 19–30. The results show that mass psychology has a positive relationship with preventive health behavior, whereas optimistic bias and hypochondriasis do not. In detail, people with …

The Librarian’S Role In Evidence-Based Practice, Amanda Davis, Emily A. Brennan, Debra Trogdon-Livingston

MUSC Faculty Journal Articles

No abstract provided.

The 'Miracle Cure': How Do Primary Care Physicians Prescribe Physical Activity With The Aim Of Improving Clinical Outcomes Of Chronic Disease? A Scoping Review., Jane Thornton, Taniya Nagpal, Kristen Reilly, Moira Stewart, Robert Petrella

Family Medicine Publications

OBJECTIVES: To identify how primary care physicians (PCPs) prescribe physical activity for patients with chronic disease, and to determine characteristics of physical activity interventions with improved clinical outcomes of chronic disease.

DESIGN: A scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews 2018 was completed.

DATA SOURCES: Four bibliographic databases (Medline, EMBASE, SPORTDiscus, CINAHL) and four grey literature/unpublished databases (Proquest, National Institute for Health and Care Excellence, Canadian Health Research Collections, Clinical Trials) were searched from inception to 7 March 2022.

ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies involving PCP-delivered physical activity prescriptions or …

Developing Educational Resources For Hand Therapy Clinicians, Gabrielle M. Dannunzio

Department of Occupational Therapy Entry-Level Capstone Projects

My capstone project involved the development of a toolkit to implement evidence-based practice (EBP) for practitioners working in the outpatient hand therapy setting, while gaining experience working in this setting. This project was completed with the focus areas of education and clinical practice skills. The population served was occupational therapy practitioners who are working in the hand therapy setting and are seeking resources to maintain their EBP. The goals that were achieved included developing resources for clinicians specific to certain diagnoses and treatments to make EBP more accessible, and improving clinical practice skills for future certification in hand therapy.

Wellness And Longevity Program For Adults And Older Adults, Oliver D. Fay

Department of Occupational Therapy Entry-Level Capstone Projects

There are many areas of practice to choose from in the field of Occupational therapy (OT). OT has an incredibly diverse career path, with new opportunities being created every day. I completed my doctoral capstone experience at Iridium Enterprises with Dr. Aaron Green, who has a wealth of experience in business and entrepreneurship. My ACOTE focus areas were administration and program development. I wanted to learn how a business was properly developed and managed from the ground up.

Through this experience, I learned how to methodically approach market research and how to narrow in on a business idea. Our goal …

Clinical Practice Skills In Executive Function Within Acute Care, Jasmine Lake

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

The Sars-Cov-2 Differential Genomic Adaptation In Response To Varying Uvindex Reveals Potential Genomic Resources For Better Covid-19 Diagnosis And Prevention, Naveed Iqbal, Muhammad Rafiq, Masooma Ali, Sanaullah Tareen, Maqsood Ahmad, Faheem Nawaz, Sumair Khan, Rida Riaz, Ting Yang, Ambrin Fatima

Department of Biological & Biomedical Sciences

Coronavirus disease 2019 (COVID-19) has been a pandemic disease reported in almost every country and causes life-threatening, severe respiratory symptoms. Recent studies showed that various environmental selection pressures challenge the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infectivity and, in response, the virus engenders new mutations, leading to the emergence of more virulent strains of WHO concern. Advance prediction of the forthcoming virulent SARS-CoV-2 strains in response to the principal environmental selection pressures like temperature and solar UV radiation is indispensable to overcome COVID-19. To discover the UV-solar radiation-driven genomic adaption of SARS-CoV-2, a curated dataset of 2,500 full-grade genomes from …

Germline Thymidylate Synthase Deficiency Impacts Nucleotide Metabolism And Causes Dyskeratosis Congenita., Hemanth Tummala, Amanda Walne, Roberto Buccafusca, Jenna Alnajar, Anita Szabo, Peter N Robinson, Allyn Mcconkie-Rosell, Meredith Wilson, Suzanne Crowley, Veronica Kinsler, Anna-Maria Ewins, Pradeepa M Madapura, Manthan Patel, Nikolas Pontikos, Veryan Codd, Tom Vulliamy, Inderjeet Dokal

Faculty Research 2022

Dyskeratosis congenita (DC) is an inherited bone-marrow-failure disorder characterized by a triad of mucocutaneous features that include abnormal skin pigmentation, nail dystrophy, and oral leucoplakia. Despite the identification of several genetic variants that cause DC, a significant proportion of probands remain without a molecular diagnosis. In a cohort of eight independent DC-affected families, we have identified a remarkable series of heterozygous germline variants in the gene encoding thymidylate synthase (TYMS). Although the inheritance appeared to be autosomal recessive, one parent in each family had a wild-type TYMS coding sequence. Targeted genomic sequencing identified a specific haplotype and rare variants in …

2022-08-04_Michiganoverview_Misc, Michigan Department Of Health & Human Services

Michigan COVID-19 MIS-C Data

The MIS-C Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/mis-c-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by health care providers and local health departments. Data is updated on the first and third Thursdays of the month.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, …

Development Of The Centrifugal Blood Pump For A Hybrid Continuous Flow Pediatric Total Artificial Heart: Model, Make, Measure, Carson S Fox, Thomas Palazzolo, Matthew Hirschhorn, Randy M Stevens, Joseph Rossano, Steven W Day, Vakhtang Tchantchaleishvili, Amy L Throckmorton

Department of Medicine Faculty Papers

Clinically-available blood pumps and total artificial hearts for pediatric patients continue to lag well behind those developed for adults. We are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). The hybrid TAH design integrates both an axial and centrifugal blood pump within a single, compact housing. The centrifugal pump rotates around the separate axial pump domain, and both impellers rotate around a common central axis. Here, we concentrate our development effort on the centrifugal blood pump by performing computational fluid dynamics (CFD) analysis of the blood flow through the pump. We also conducted transient CFD analyses (quasi-steady …

Group B Streptococcus In The Urine In Nonpregnant Adults: Disease Or Distraction?, Nicole Mongilardi, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

In this large, retrospective cohort study, we used administrative data to evaluate nonpregnant adults with group B Streptococcus (GBS) bacteriuria. We found greater all-cause mortality in those with urinary tract infections compared to asymptomatic bacteriuria. Differences in patients' baseline characteristics and the 1-year mortality rate raise the possibility that provider practices contribute to differences observed.

The Role Of Medical Image Modalities And Ai In The Early Detection, Diagnosis And Grading Of Retinal Diseases: A Survey., Gehad A Saleh, Nihal M Batouty, Sayed Haggag, Ahmed Elnakib, Fahmi Khalifa, Fatma Taher, Mohamed Abdelazim Mohamed, Rania Farag, Harpal Sandhu, Ashraf Sewelam, Ayman El-Baz

All Works

Traditional dilated ophthalmoscopy can reveal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), diabetic macular edema (DME), retinal tear, epiretinal membrane, macular hole, retinal detachment, retinitis pigmentosa, retinal vein occlusion (RVO), and retinal artery occlusion (RAO). Among these diseases, AMD and DR are the major causes of progressive vision loss, while the latter is recognized as a world-wide epidemic. Advances in retinal imaging have improved the diagnosis and management of DR and AMD. In this review article, we focus on the variable imaging modalities for accurate diagnosis, early detection, and staging of both AMD and DR. In addition, …

A Systematic Review Of Reproductive Counseling In Cases Of Parental Constitutional Reciprocal Translocation (9;22) Mimicking Bcr-Abl1, Zimeng Gao, Stephanie M Rice, Sascha Wodoslawsky, Sara C Long, Zi-Xuan Wang, Mehnoosh Torkzaban, Ana Milena Angarita Africano, Jinglan Liu, Huda B Al-Kouatly

Department of Obstetrics and Gynecology Faculty Papers

We aim to determine the spectrum of cytogenetic abnormalities and outcomes in unbalanced offspring of asymptomatic constitutional balanced t(9;22) carriers through a systematic literature review. We also include a case of a constitutional balanced t(9;22) carrier from our institution. Among the 16 balanced t(9;22) carriers in our review, 13 were maternal and 3 were paternal. Of the 15 unbalanced translocation cases identified, 13 were live births, one was a missed abortion, and one resulted in pregnancy termination. The spectrum of established syndromes reported among the live births was the following: trisomy 9p syndrome (6/13), dual trisomy 9p and DiGeorge syndrome …

Impact Of The Time To Surgery On Visual Outcomes For Rhegmatogenous Retinal Detachment Repair: A Meta-Analysis, Amirthan Sothivannan, Arshia Eshtiaghi, Arjan S. Dhoot, Marko M. Popovic, Sunir J. Garg, Peter J. Kertes, Rajeev H. Muni

Wills Eye Hospital Papers

PURPOSE: To determine the relationship between time from symptom onset or presentation to repair and visual outcomes for macula-on and macula-off rhegmatogenous retinal detachment (RRD).

DESIGN: Meta-analysis.

METHODS: We searched MEDLINE, EMBASE, and Cochrane Library for randomized controlled trials and observational studies comparing best-corrected visual acuity (BCVA) based on time to RRD repair. Study identifiers, baseline characteristics, intervention characteristics, and visual outcomes were extracted. We conducted a random effects meta-analysis. Sensitivity analyses included leave-1-out and influence analyses. Primary outcomes included mean difference (MD) in final BCVA, MD between preoperative and final BCVA (∆BCVA), and relative risk of final BCVA24 hours. …

The Impact Of The Covid-19 Pandemic On Mental Health And Stressors Among Asian American And Pacific Islanders, Ava Lu Kupperman

University Honors Theses

The Asian American and Pacific Islander (AAPI) community, along with the rest of the population globally, has been facing disruptions emerging from the COVID-19 pandemic in all parts of life. However, with the significant rise in racism, the AAPI community has had to confront a set of new challenges in their lives. Utilizing studies and literature written over the course of the pandemic, the purpose of this literature review is to examine the impacts observed on mental health outcomes among AAPIs as a result of the COVID-19 pandemic. This paper aims to collect and present information surrounding the impact on …

Glycan Shield Of The Ebolavirus Envelope Glycoprotein Gp, Weiwei Peng, Vamseedhar Rayaprolu, Amar D Parvate, Matti F Pronker, Sean Hui, Diptiben Parekh, Kelly Shaffer, Xiaoying Yu, Erica O Saphire, Joost Snijder

2020-Current year OA Pubs

The envelope glycoprotein GP of the ebolaviruses is essential for host cell entry and the primary target of the host antibody response. GP is heavily glycosylated with up to 17 N-linked sites, numerous O-linked glycans in its disordered mucin-like domain (MLD), and three predicted C-linked mannosylation sites. Glycosylation is important for host cell attachment, GP stability and fusion activity, and shielding from neutralization by serum antibodies. Here, we use glycoproteomics to profile the site-specific glycosylation patterns of ebolavirus GP. We detect up to 16 unique O-linked glycosylation sites in the MLD, and two O-linked sites in the receptor-binding GP1 subunit. …

Genetic Variants In Aldh1l1 And Gldc Influence The Serine-To-Glycine Ratio In Hispanic Children, Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti

Children’s Nutrition Research Center Staff Publications

Background: Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the 10-formyltetrahydrofolate dehydrogenase enzyme in serine-to-glycine conversion.

Objectives: We sought to determine the genomic influence on the serine-glycine ratio in 803 Hispanic children from 319 families of the Viva La Familia cohort.

Methods: We performed a genome-wide association analysis for plasma serine, glycine, and the serine-glycine ratio …

Quantification Of Obstetric Hemorrhage, Alma Garcia

Student Scholarly Projects

Practice Problem: The practice problem identified involved the inconsistent measurement of blood loss during the postpartum period due to the standard practice of estimating blood loss. Estimates are subjective measures that can have variable results based on interpretation and thus provide minimal meaningful data.

PICOT: The question that guided this project was structured in the following PICOT format. In postpartum women (P), how does the implementation of quantitative blood loss measurements (I), compared to estimated blood loss measurement (C), affect the early identification of severe hemorrhage (O), during the recovery period (T)?

Evidence: Obstetric hemorrhage is a preventable event that …

Influence Of Cultural Competency Program On Bias In A Community Volunteer Program, Melodie L. Anderson

Student Scholarly Projects

Practice Problem: Individuals may express hesitancy in volunteering in community health programs that directly interface with persons experiencing poverty due to poverty biases. Failure to understand the issues and needs of those experiencing poverty may factor into disparities and inequities along the social determinants of health, leading to poorer population health, well-being, and quality of life.

PICOT: The PICOT question that guided this project was in volunteers (mentors) of community health programs (P) how does a cultural competency program (I) compare to the standardized training program(C) influence bias (0) over 8 weeks (T)?

Evidence: An evidence review indicated …