Medicine and Health Sciences Commons^™

Advancing Psychiatric Curricula Through A Diverse Lens, Rahn K. Bailey, Ronja R. Bodola, Ayush Arora

School of Medicine Faculty Publications

No abstract provided.

Adaptation And Dosimetric Commissioning Of A Synchrotron-Based Proton Beamline For Flash Experiments, Ming Yang, Xiaochun Wang, Fada Guan, Uwe Titt, Kiminori Iga, Dadi Jiang, Takeshi Takaoka, Satoshi Tootake, Tadashi Katayose, Masumi Umezawa, Emil Schüler, Steven Frank, Steven H Lin, Narayan Sahoo, Albert C Koong, Radhe Mohan, X Ronald Zhu

Faculty, Staff and Student Publications

Objective. Irradiation with ultra-high dose rates (>40 Gy s^-1), also known as FLASH irradiation, has the potential to shift the paradigm of radiation therapy because of its reduced toxicity to normal tissues compared to that of conventional irradiations. The goal of this study was to (1) achieve FLASH irradiation conditions suitable for pre-clinicalin vitroandin vivobiology experiments using our synchrotron-based proton beamline and (2) commission the FLASH irradiation conditions achieved.

Approach. To achieve these suitable FLASH conditions, we made a series of adaptations to our proton beamline, including modifying the spill length …

Prevalence Of Human Papillomavirus Infection Among Women Born In The 1990s Vs The 1980s And Association With Hpv Vaccination In The Us, Zahed Shahmoradi, Haluk Damgacioglu, Jane Montealegre, Elizabeth Y Chiao, Keith Sigel, Kalyani Sonawane, Ashish A Deshmukh

Center for Medical Ethics and Health Policy Staff Publications

This cross-sectional study examines rates of human papillomavirus infections among a cohort of vaccinated and unvaccinated women born in the 1990s.

Identification Of The Nrf2 Transcriptional Network As A Therapeutic Target For Trigeminal Neuropathic Pain, Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S Dhindsa, Evan R Semenza, Bindu D Paul, Dustin P Green, Mark F Sabbagh, Joseph Y Shin, Wuyang Yang, Adele M Snowman, Lauren K Albacarys, Abhay Moghekar, Carlos A Pardo-Villamizar, Mark Luciano, Judy Huang, Chetan Bettegowda, Shawn G Kwatra, Xinzhong Dong, Michael Lim, Solomon H Snyder

Duncan NRI Faculty and Staff Publications

Trigeminal neuralgia, historically dubbed the "suicide disease," is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)-approved medication for trigeminal neuralgia carries substantial side effects, with many patients requiring surgery. Here, we identify the NRF2 transcriptional network as a potential therapeutic target. We report that cerebrospinal fluid from patients with trigeminal neuralgia accumulates reactive oxygen species, several of which directly activate the pain-transducing channel TRPA1. Similar to our patient cohort, a mouse model of trigeminal neuropathic pain also exhibits notable oxidative stress. We discover that stimulating the …

Safety And Tolerability Of Carboplatin And Paclitaxel In Cancer Patients With Hiv (Amc-078), An Aids Malignancy Consortium (Amc) Study, Missak Haigentz, Page Moore, Milan Bimali, Timothy Cooley, Joseph Sparano, Michelle Rudek, Lee Ratner, David Henry, Juan Ramos, John Deeken, Paul Rubinstein, Elizabeth Chiao

Center for Medical Ethics and Health Policy Staff Publications

Background: Persons living with human immunodeficiency virus are an underserved population for evidence-based cancer treatment. Paclitaxel and carboplatin (PCb) is an active regimen against a variety of solid tumors, including several seen in excess in patients with HIV infection. We performed a pilot trial to evaluate the safety of full-dose PCb in people living with human immunodeficiency virus and cancer.

Methods: Eligible patients, stratified by concurrent antiretroviral therapy (ART) that included CYP3A4 inhibitors or not, received paclitaxel (175 mg/m2) in combination with carboplatin (target AUC 6) intravenously every 3 weeks for up to 6 cycles.

Results: Sixteen evaluable patients received …

Neurologic Complications Of Cancer, David Green

Conference Presentation Abstracts

No abstract provided.

The Value Of In Vivo Reflectance Confocal Microscopy As An Assessment Tool In Chemotherapy-Induced Peripheral Neuropathy: A Pilot Study, Sabrina R Ramnarine, Patrick M Dougherty, Roman Rolke, Linda J Williams, Christi Alessi-Fox, Andrew J Coleman, Caterina Longo, Lesley A Colvin, Marie T Fallon

Faculty, Staff and Student Publications

Background: There is a lack of standardized objective and reliable assessment tools for chemotherapy-induced peripheral neuropathy (CIPN). In vivo reflectance confocal microscopy (RCM) imaging offers a non-invasive method to identify peripheral neuropathy markers, namely Meissner's corpuscles (MC). This study investigated the feasibility and value of RCM in CIPN.

Patients and methods: Reflectance confocal microscopy was performed on the fingertip to evaluate MC density in 45 healthy controls and 9 patients with cancer (prior, during, and post-chemotherapy). Quantification was completed by 2 reviewers (one blinded), with maximum MC count/3 × 3 mm image reported. Quantitative Sensory Testing (QST; thermal and mechanical …

Developmental Trajectories Of Cortical Thickness By Functional Brain Network: The Roles Of Pubertal Timing And Socioeconomic Status, Ashley F. P. Sanders, Graham L. Baum, Michael P. Harms, Sridhar Kandala, Susan Y. Bookheimer, Mirella Dapretto, Leah H. Somerville, Kathleen M. Thomas, David C. Van Essen, Essa Yacoub, Deanna M Barch

2020-Current year OA Pubs

The human cerebral cortex undergoes considerable changes during development, with cortical maturation patterns reflecting regional heterogeneity that generally progresses in a posterior-to-anterior fashion. However, the organizing principles that govern cortical development remain unclear. In the current study, we characterized age-related differences in cortical thickness (CT) as a function of sex, pubertal timing, and two dissociable indices of socioeconomic status (i.e., income-to-needs and maternal education) in the context of functional brain network organization, using a cross-sectional sample (n = 789) diverse in race, ethnicity, and socioeconomic status from the Lifespan Human Connectome Project in Development (HCP-D). We found that CT generally …

Asymmetric Synthesis Of Nortropanes Via Rh-Catalyzed Allylic Arylation, Yan Zhang, F Wieland Goetzke, Kirsten E Christensen, Stephen P Fletcher

Faculty, Staff and Student Publications

Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here, we report Rh-catalyzed asymmetric Suzuki–Miyaura-type cross-coupling reactions between a racemic N-Boc-nortropane-derived allylic chloride and (hetero)aryl boronic esters. The reaction proceeds via an unexpected kinetic resolution, and the resolved enantiopure allyl chloride can undergo highly enantiospecific reactions with N-, O-, and S-containing nucleophiles. The method was applied in a highly stereoselective formal synthesis of YZJ-1139(1), a potential insomnia treatment that recently completed Phase II clinical trials. Our report represents an asymmetric catalytic method for the synthesis of YZJ-1139(1) and related compounds.

Feasibility Of The Transport Plus Intervention To Improve The Transitions Of Care For Patients Transported Home By Ambulance: A Non-Randomized Pilot Study, Kevin G Munjal, Sai Kaushik Yeturu, Hugh H Chapin, Nadir Tan, Diana Gregoriou, Daniela Garcia, Corita Grudzen, Ula Hwang, Barbara Morano, Hayley Neher, Ksenia Gorbenko, Glen Youngblood, Anjali Misra, Staley Dietrich, Cyndi Gonzalez, Giselle Appel, Erica Jacobs, Albert Siu, Lynne D Richardson

Student Papers, Posters & Projects

BACKGROUND: The growing population of patients over the age of 65 faces particular vulnerability following discharge after hospitalization or an emergency room visit. Specific areas of concern include a high risk for falls and poor comprehension of discharge instructions. Emergency medical technicians (EMTs), who frequently transport these patients home from the hospital, are uniquely positioned to aid in mitigating transition of care risks and are both trained and utilized to do so using the Transport PLUS intervention.

METHODS: Existing literature and focus groups of various stakeholders were utilized to develop two checklists: the fall safety assessment (FSA) and the discharge …

Counseling Active-Duty Female Service Members Who Have Experienced Sexual Assault: A Guide For Professional Counselors, Rebekah Cole, Rebecca Cowan, Taqueena Quintana

Journal of Social, Behavioral, and Health Sciences

Sexual assault is a prevailing problem for active duty women in the United States military. We explore the unique nature of military culture and explain the military’s dual pathway process for reporting sexual assault. In addition, we describe, in depth, evidence-based theoretical approaches applicable for counselors to use in their work with female service members who are survivors of sexual assault. Finally, we discuss sexual assault resources available to military clients and the steps counselors can take to engage in advocacy for and with this population.

Lipopolysaccharide-Induced Interferon Response Networks At Birth Are Predictive Of Severe Viral Lower Respiratory Infections In The First Year Of Life, James F. Read, Michael Serralha, Danny Mok, Barbara J. Holt, Mark Cruickshank, Yuliya V. Karpievitch, David I. Broadhurst, Peter D. Sly, Deborah H. Strickland, Stacey N. Reinke, Patrick G. Holt, Anthony Bosco

Research outputs 2022 to 2026

Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group. Employing a systems biology approach to analysis of multi-omic profiles generated from a high-risk cohort (n = 50), we found that the intensity of activation of an LPS-induced interferon gene network at birth was predictive of sLRI risk in infancy (AUC = 0.724). Connectivity patterns within this network were stronger among susceptible individuals, and a systems biology approach identified IRF1 as a putative master regulator of …

An Auto-Inhibited State Of Protein Kinase G And Implications For Selective Activation, Rajesh Sharma, Jeong Joo Kim, Liying Qin, Philipp Henning, Madoka Akimoto, Bryan Vanschouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R Mackenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim

Faculty, Staff and Students Publications

Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates biological functions as diverse as smooth muscle contraction, cardiac function, and axon guidance. Understanding how cGMP differentially triggers mammalian PKG isoforms could lead to new therapeutics that inhibit or activate PKGs, complementing drugs that target nitric oxide synthases and cyclic nucleotide phosphodiesterases in this signaling axis. Alternate splicing of PRKG1 transcripts confers distinct leucine zippers, linkers, and auto-inhibitory (AI) pseudo-substrate sequences to PKG Iα and Iβ that result in isoform-specific activation properties, but the mechanism of enzyme auto-inhibition and its alleviation …

Facilitators For Retaining Men Who Have Sex With Men In Pre-Exposure Prophylaxis Care In Real World Clinic Settings Within The United States, Brooke G Rogers, R R Patel, K Curoe, A Underwood, J Villalobos, Et Al.

2020-Current year OA Pubs

BACKGROUND: Pre-exposure prophylaxis (PrEP) can significantly reduce HIV acquisition especially among communities with high HIV prevalence, including men who have sex with men (MSM). Much research has been finding suboptimal PrEP persistence; however, few studies examine factors that enhance PrEP persistence in real-world settings.

METHODS: We interviewed 33 patients who identified as MSM at three different PrEP clinics in three regions of the U.S. (Northeast, South, Midwest). Participants were eligible if they took PrEP and had been retained in care for a minimum of 6 months. Interviews explored social, structural, clinic-level and behavioral factors that influencing PrEP persistence.

RESULTS: Through …

Disease-Associated Mutations Within The Yeast Dnajb6 Homolog Sis1 Slow Conformer-Specific Substrate Processing And Can Be Corrected By The Modulation Of Nucleotide Exchange Factors, Ankan K Bhadra, Michael J Rau, Jil A Daw, James A J Fitzpatrick, Conrad C Weihl, Heather L True

2020-Current year OA Pubs

Molecular chaperones, or heat shock proteins (HSPs), protect against the toxic misfolding and aggregation of proteins. As such, mutations or deficiencies within the chaperone network can lead to disease. Dominant mutations within DNAJB6 (Hsp40)-an Hsp70 co-chaperone-lead to a protein aggregation-linked myopathy termed Limb-Girdle Muscular Dystrophy Type D1 (LGMDD1). Here, we used the yeast prion model client in conjunction with in vitro chaperone activity assays to gain mechanistic insights into the molecular basis of LGMDD1. Here, we show how mutations analogous to those found in LGMDD1 affect Sis1 (a functional homolog of human DNAJB6) function by altering the structure of client …

Concurrent Fnirs And Eeg For Brain Function Investigation: A Systematic, Methodology-Focused Review, Rihui Li, Dalin Yang, Feng Fang, Keum-Shik Hong, Allan L Reiss, Yingchun Zhang

2020-Current year OA Pubs

Electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) stand as state-of-the-art techniques for non-invasive functional neuroimaging. On a unimodal basis, EEG has poor spatial resolution while presenting high temporal resolution. In contrast, fNIRS offers better spatial resolution, though it is constrained by its poor temporal resolution. One important merit shared by the EEG and fNIRS is that both modalities have favorable portability and could be integrated into a compatible experimental setup, providing a compelling ground for the development of a multimodal fNIRS-EEG integration analysis approach. Despite a growing number of studies using concurrent fNIRS-EEG designs reported in recent years, the methodological …

Discovery And Validation Of Dominantly Inherited Alzheimer's Disease Mutations In Populations From Latin America, Leonel Tadao Takada, Bhagyashri D Burgute, Ellen Ziegemeier, Jennifer Petranek, Carlos Cruchaga, Maria Victoria Fernández, Eric Mcdade, Randall J Bateman, Celeste M Karch, Jorge J Llibre-Guerra, Et Al.

2020-Current year OA Pubs

BACKGROUND: In fewer than 1% of patients, AD is caused by autosomal dominant mutations in either the presenilin 1 (PSEN1), presenilin 2 (PSEN2), or amyloid precursor protein (APP) genes. The full extent of familial AD and frequency of these variants remains understudied in Latin American (LatAm) countries. Due to the rare nature of these variants, determining the pathogenicity of a novel variant in these genes can be challenging. Here, we use a systematic approach to assign the likelihood of pathogenicity in variants from densely affected families in Latin American populations.

METHODS: Clinical data was collected from LatAm families at risk …

Safety And Tolerability Of Carboplatin And Paclitaxel In Cancer Patients With Hiv (Amc-078), An Aids Malignancy Consortium (Amc) Study, Missak Haigentz, Page Moore, Milan Bimali, Timothy Cooley, Joseph Sparano, Michelle Rudek, Lee Ratner, David Henry, Juan Ramos, John Deeken, Paul Rubinstein, Elizabeth Chiao

2020-Current year OA Pubs

BACKGROUND: Persons living with human immunodeficiency virus are an underserved population for evidence-based cancer treatment. Paclitaxel and carboplatin (PCb) is an active regimen against a variety of solid tumors, including several seen in excess in patients with HIV infection. We performed a pilot trial to evaluate the safety of full-dose PCb in people living with human immunodeficiency virus and cancer.

METHODS: Eligible patients, stratified by concurrent antiretroviral therapy (ART) that included CYP3A4 inhibitors or not, received paclitaxel (175 mg/m2) in combination with carboplatin (target AUC 6) intravenously every 3 weeks for up to 6 cycles.

RESULTS: Sixteen evaluable patients received …

The Impact Of Ehealth Applications In Healthcare Intervention: A Systematic Review, Fadly Syah Arsad, Sharifah Saffinas Syed Soffian, Puteri Sofia Nadira Megat Kamaruddin, Nor Rumaizah Nordin, Mohd Hafiz Baharudin, Ummi Mirza Baharudin, Mohd Rohaizat Hassan, Azmawati Mohamed Nawi, Norfazilah Ahmad

Journal of Health Research

Background: Electronic health (eHealth) is the application of information communication technologies across all ranges of functions involved in the practice and delivery of health care. The rapid development of informatics and the Internet do not parallel eHealth interventions, and the knowledge gap needs to be explored. We aimed to identify and review the impact of eHealth applications (apps) on healthcare interventions.

Method: We used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) review protocol and formulated the research question based on PICO (Population or Problem, Interest, Context). The selected databases were Ovid, Web Of Science, PubMed, SAGE and …

Rethinking Tourism And Public Health Policies In International Travel Megahubs For The Post-Covid-19 Era, Jeconiah Louis Dreisbach, Sharon Mendoza-Dreisbach

Journal of Health Research

Background: This article rethinks current public health policies to transdisciplinarily reorient the countries’ tourism policies as a preparation to future pandemics. This adds to the public health discourse that West Asian international travel megahubs could be susceptible spaces to high risks of transnational viral transmissions.

Method: This is a letter to the editor.

Results: The United Arab Emirates, Turkey, and Qatar are the world’s leading international travel megahubs, with Saudi Arabia catching up following its efforts in establishing a new national airline to increase international passenger traffic. Collectively, they are connected to more than half of the world’s leading international …

The Covid-19 Pandemic In South Asia: A Comprehensive Review Of The Genomic Variations, Epidemiological Features, Diagnosis, Treatment And Preventive Schemes, Abdullah Al Noman, Jannatul Efte Ekra, Rima Islam Meem, Sujan Islam, Fariha Sharzana, Shofiqul Islam, Samiron Sana, Masnoon Kabir, Niaz Mahmud, Abdullah Al Mahedi, Taufique Joarder

Journal of Health Research

Background: The purpose of the study was to outline the genomic and epidemiological characteristics of COVID-19 in South Asian countries as well as the diagnosis, treatments, and prevention approaches undertaken by these countries to tackle the COVID-19 pandemic.

Methods: We searched electronic databases such as Google Scholar, PubMed, and Scopus as well as various national and international COVID-19 websites, WHO databases, and electronic media. 63 articles were included from databases and 34 articles from various other sources.

Results: Scientists observed genomic variations including common mutations in ORF1ab, ORF1a, ORF3a, and S genes, while several unique mutations exist in most isolates …

The Effect Of Positively Framed And Negatively Framed Messages On Televised Smoking Cessation Advertisement Success: A Systematic Review, Michelle H. James, Joanne E. Porter, Vaughan Reimers, Valerie Prokopiv

Journal of Health Research

Background: Smoking cessation campaigns aim to decrease the prevalence of smoking in the community. However, smoking cessation campaigns can be expensive to develop and implement, therefore is it essential that campaigns have high impact and broad reach to ensure the most efficient use of resources.

Method: A systematic review was conducted in October 2020 to assess the efficacy of positively framed and negatively framed messages used in televised smoking cessation advertisements. The search was restricted to quantitative primary research published between 2010-2020, yielding 4640 results. Study selection was performed using the PRISMA method. Population was inclusive of all ages and …

Situational Analysis Of The Extending National Health Insurance Coverage To Informal Sector In Indonesia: A Case Study Among Palms Sugar Farmers, Budi Aji, Siti Masfiah, Siti Harwanti, Nur Ulfah, Hoang Van Minh

Journal of Health Research

Background: To explore the situation of national health insurance coverage among informal workers and to identify the enrollment strategy for such workers.

Method: This is a qualitative research with a case study approach. Participants are eight palm sugar farmers and fifteen major and minor stakeholders of national health insurance in the district of Banyumas, Indonesia. This study includes semi-structured informant interview and open-ended questions. A thematic framework analysis is applied to guide the interpretation of the data. Data analysis is facilitated by using a qualitative data analysis software package MAXQDA 12.

Results: This study has highlighted several interesting issues regarding …

Predictors Of Intention To Stay As Perceived By Nurses Working At Community Hospitals, Ministry Of Public Health, Thailand, Rata Srisa-Art, Jintana Yunibhand, Chanokporn Jitpanya, Areewan Oumtanee

Journal of Health Research

Background: To understand how nurses perceive the intention to stay in the profession (ITSP) is a priority concern to combat the nursing shortage crisis. In Thailand, few studies have investigated and clarified ITSP in community hospitals (CHs). The purpose of this study is to examine and identify the predictors of ITSP at CHs functioning under the Ministry of Public Health, Thailand.

Method: A cross-sectional study was conducted in 47 CHs in 8 different provinces, utilizing multi-stage sampling. A total of 955 participants completed a set of e-questionnaires to measure personal factors, managerial characteristics (MCs), work characteristics (WCs), and the relationship …

Prevalence And Correlates Of Post-Traumatic Stress Disorders (Ptsd) Among The Military In A Low-Income Country, Shehu Usman Ibrahim, Mukadas Oyeniran Akindele, Ushotanefe Useh

Journal of Health Research

Background: This study investigated the prevalence and correlates of post-traumatic stress disorder (PTSD) and its risks among the military in a low-income country.

Method: All participants answered self-administered questionnaires that measured PTSD, combat exposure, musculoskeletal disorders (MSDs), perceived social support, and depression in addition to a socio-demographic form in this cross-sectional study. Chi-square test of independence and Fisher exact test were employed to compute PTSD prevalence and its difference among the services. Correlation and binary logistic regression were used to explore relationships and the impact of the predictor variables on PTSD.

Results: PTSD prevalence among participants on routine military duties …

Menstrual Irregularities, Hormonal Imbalance And Obesity In Adolescent Girls In Hyderabad, Sindh, Pakistan: An Observational Study, Meharunnissa Khaskheli, Ramsha Zafar Durrani, Shahla Baloch, Aneela Sheeba Baloch, Syed Ghulam Sarwar Shah

Journal of Health Research

Background: Obesity in young girls adversely affects reproductive health later in life and it is a serious public health issue. The objective was to study the association of obesity with menstrual irregularities and hormonal imbalance in teenage and adolescent girls.

Method: Participants comprised a convenience sample of 12-19 years old girls (N=83). The study was conducted in outpatient clinics at a university hospital. Data were collected through medical history by interview, physical examination and blood tests. Data were analysed using frequencies, descriptive statistics, Chi Squared tests of Independence and Binary Logistic Regression.

Results: The median age was 16 years (mean …

Health Risk Assessment From Organophosphate Insecticides Residues In Commonly Consumed Vegetables Of Local Markets, Northern Thailand, Warangkana Naksen, Surat Hongsibsong, Zhen-Lin Xu, Natthapol Kosashunhanan, Tanyaporn Kerdnoi, Tippawan Prapamontol, Vanvimol Patarasiriwong

Journal of Health Research

Background: Commonly consumed vegetables from local markets are considered at a higher risk for organophosphate insecticides (OPs) contamination. This study aimed to investigate the contamination of OP residues in commonly consumed vegetable samples from local markets in 5 provinces, i.e., Nan, Chiang Rai, Lamphun, Lampang, and Chiang Mai provinces located in Northern Thailand. A risk assessment of OPs among adult Thai population was also evaluated by calculating the estimated daily intake (EDI) and the acceptable daily intake (ADI).

Method: The multi cross-sectional studies were conducted in 5 provinces. Twelve vegetables were sampled from main local markets in every district of …

Improving Knowledge, Attitude, And Compliance Of Hand Hygiene Of Iranian Healthcare Workers: A Pilot Study Using Reminder Card, Zahra Chegini, Ifeoluwapo Kolawole, Prashant Singh, Farzaneh Alikhah, Yalda Rasti, Zahra Motazedi

Journal of Health Research

Background: Compliance rate of hand hygiene practice by healthcare workers has been observed to be universally low despite its importance, simplicity and cost-effectiveness in preventing the spread of infectious diseases in the healthcare settings. This study aimed to improve healthcare workers’ knowledge, attitudes, and compliance with hand hygiene by using reminder cards displayed by patients.

Method: This before-after interventional study was carried out in 2019 among healthcare workers of a hospital in Tabriz, Iran. The intervention was a ‘Reminder Card’ showed by patients to remind healthcare workers to clean their hands. Participants' knowledge and attitude about hand hygiene and …

How Area Health Management Leads To Improved Equity In Health: A Scoping Review, Methinee Intarates, Teerapon Dhippayom, Nilawan Upakdee, Vinai Leesmidt, Jain Weraphong, Mukdarut Bangpan

Journal of Health Research

Background: The scoping review of published studies aims to explore what practices and processes can improve equity (horizontal and vertical) in countries that adopted Area Health Management (AHM) utilizing the “Six Building Blocks Plus” (SBBP) concept.

Method: An electronic search was conducted from the inception to January 27, 2021, from 6 databases (Embase, Social Sciences, Web of Science, PubMed, CINAHL, and WHO) and the gray literature. The inclusion criteria were AH, SBBP, and equity. Data extraction was using a standardized data collection form.

Results: This scoping review includes 63 full-text studies. SBBP are identical in the horizontal and vertical equity. …

Factors That Influence Individual And Community Behavioural Change Regarding Environmental Health, Obadia Kyetuza Bishoge, Ademola Kabir Aremu, Dickson Dare Ajayi, Sayoki Godfrey Mfinanga

Journal of Health Research

Background: Increased environmental health problems have led to a rise in concern among individuals, as well as government and non-governmental organizations to tackle them. To achieve this, there is a need for behavioural change among individuals and the community on environmental health at local to international levels. The purpose of this paper is to critically explore the factors that influence personal and community behavioural change regarding environmental health.

Method: The study is a systematic review of the literature on the factors that influence personal behavioural change regarding environmental health based on the relevant studies published between 2005 and 2020. We …