Medicine and Health Sciences Commons^™

Risk Factors For Reoperation Following Operative Fixation Of Distal Femur Fractures: A Report Of 73 Consecutive Cases, Aditya Desai, Victoria Oakes, John Pisquiy, Christopher Dodo, Ahmed A. Toreih, Wael Azzam, Amr Abdelgawad, Ahmed M. Thabet

Western Journal of Orthopaedics

Introduction: Various factors including patient demographics, fracture types, and fixation methods can affect the outcomes of distal femur fractures. This study aimed to analyze the risk factors for reoperation after operative fixation of these fractures. Methods: This was an institional review board (IRB) approved retrospective study of extra-articuilar, partial articular, and complete articular distal femur fractures treated with operative fixation at a Level I trauma center between 2008 and 2018. The study included a consecutive series of adult patients operatively treated for a distal femur fracture. The primary outcome was reoperation rate due to infection, non-union, or implant failure. Periprosthetic …

Case Report: Amyloid Deposits In The Flexor Tenosynovium Found During Primary Carpal Tunnel Releasetunnel Release, John B. Fuller, Kelly L. Scott, Moheb S. Moneim, Vann E. Schaffner, Natasha G. Dark, Deana M. Mercer

Western Journal of Orthopaedics

A 76-year-old female previously diagnosed with flexor tenosynovitis, presented to the clinic complaining of right wrist pain and numbness in her fingers. She was seen again after a rheumatologic workup, which was negative. It was noted that there was thenar atrophy when compared to the contralateral side. She was then scheduled for carpal tunnel release surgery. During surgery, a large area of synovitis was encountered. A radical synovectomy was performed and this tissue was sent for culture and pathology. The findings were most consistent with age-related amyloidosis. One week after surgery, the patient was contacted by telephone and reported that …

Comparison Of Biological Measurement And Physical Estimates Of Space Radiation In The International Space Station, Kayo Yoshida, Megumi Hada, Akane Kizu, Kohei Kitada, Kiyomi Eguchi-Kasai, Toshiaki Kokubo, Takeshi Teramura, Sachiko Yano, Hiromi Hashizum Suzuki, Hitomi Watanabe, Gen Kondoh, Aiko Nagamatsu, Premkumar Saganti, Francis A. Cucinotta, Takashi Morita

Integrated Health Sciences Faculty Research

Nowadays, ordinary people can travel in space, and the possibility of extended durations in an environment such as moon of the Earth and Mars with higher space radiation exposures compared to past missions, is increasing. Until now, the physical doses of space radiation have been measured, but measurement of direct biological effects has been hampered by its low dose and low dose-rate effect. To assess the biological effects of space radiation, we launched and kept frozen mouse embryonic stem (ES) cells in minus eighty degree Celsius freezer in ISS (MELFI) on the International Space Station (ISS) for a maximum of …

Regional Research-Practice-Policy Partnerships In Response To Climate-Related Disparities: Promoting Health Equity In The Pacific, Lawrence A. Palinkas, Meaghan O’Donnell, Susan Kemp, Jemaima Tiatia, Yvonette Duque, Michael Spencer, Rupa Basu, Kristine Idda Del Rosario, Kristin Diemer, Bonifacio Doma, David Forbes, Kari Gibson, Joshua Graff-Zivin, Bruce M. Harris, Nicola Hawley, Jill Johnston, Fay Lauraya, Nora Elizabeth F. Maniquiz, Jay Marlowe, Gordon C. Mccord, Imogen Nicholls, Smitha Rao, Angela Kim Saunders, Salvatore Sortino, Benjamin F. Springgate, David Takeuchi, Janette Ugsang, Vivien Villaverde

School of Medicine Faculty Publications

Although climate change poses a threat to health and well-being globally, a regional approach to addressing climate-related health equity may be more suitable, appropriate, and appealing to under-resourced communities and countries. In support of this argument, this commentary describes an approach by a network of researchers, practitioners, and policymakers dedicated to promoting climate-related health equity in Small Island Developing States and low- and middle-income countries in the Pacific. We identify three primary sets of needs related to developing a regional capacity to address physical and mental health disparities through research, training, and assistance in policy and practice implementation: (1) limited …

The Hearst Health Prize: The First Five Years, Alexa M. Waters, Alexis Skoufalos, Emily Frelick, Gregory Dorn, David B. Nash

Department of Family & Community Medicine Faculty Papers

The Hearst Health Prize is the first national annual award for excellence in population health. The prize was established "to discover, support, and showcase the work of an individual, group, organization, or institution that has successfully implemented a population health program or intervention that has made a measurable difference" in health outcomes. Now, 5 years since the award's inception, this article reflects on how submissions for the prize collectively mirror - and may even predict - changes within the field of population health. It examines how the most successful programs demonstrated genuine, measurable improvements in health outcomes and/or health behaviors. …

Spine Stereotactic Body Radiation Therapy (Sbrt): Using Biological Objectives In Treatment Planning A Comparative Plan Study, Joseph E. Pagano

Masters Projects

Introduction: The purpose of the study is intended to determine if gEUD optimization can be useful in the treatment planning for SBRT to the spine. The main goal was to study the dose effects when placing gEUD objectives on the targeted vertebral structure (Target gEUD) and spinal cord (Upper gEUD). Furthermore, to provide a better understanding of the utility of this tool.

Methods: Two planning techniques for SBRT spine treatments were compared retrospectively on 10 radiation therapy patients. The Varian Eclipse treatment planning system was utilized with the volumetric modulated arc therapy treatment technique. The planning techniques used different objectives …

Qualitative Interviews To Understand Health Care Providers’ Experiences Of Prescribing Licensed Peanut Oral Immunotherapy, Aikaterini Anagnostou, Claire Lawrence, Stephen A Tilles, Susan Laubach, Sarah M Donelson, Mohamed Yassine, Anna Nowak-Wegrzyn

Faculty, Staff and Students Publications

OBJECTIVE: This research sought to explore health care providers' (HCPs) experiences of delivering the first US Food and Drug Administration (FDA) and European Commission (EC) approved peanut oral immunotherapy (peanut OIT; Palforzia). Semi-structured qualitative interviews with HCPs who had initiated treatment with ≥ 3 patients in the first nine months following FDA approval sought to identify challenges faced and successful implementation strategies.

RESULTS: Eight allergists and three nurse practitioners from eight sites based in the United States participated. The HCPs included in this research were motivated to implement this novel treatment, however, entered the process with some reservations. HCPs described …

Structural Covariance Of The Ventral Visual Stream Predicts Posttraumatic Intrusion And Nightmare Symptoms: A Multivariate Data Fusion Analysis, Nathaniel G Harnett, Stacey L House, Et Al

2020-Current year OA Pubs

Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression. The present study used multimodal magnetic resonance imaging data (n = 278) collected two weeks after trauma exposure from the AURORA …

Audit And Feedback For Blood Glucose Point Of Care Testing, Faith A. Onwuka

Student Scholarly Projects

Practice Problem: Patient identification errors in point-of-care testing (POCT) is responsible for test results being missed or transferred to the wrong patient’s chart. A hospital in Los Angeles County experienced a 50% compliance rate in patient barcode scanning prior to blood glucose POCT which affected the delivery of care.

PICOT: The PICOT question that guided this project was: Among emergency room nursing staff (P), how does the implementation of audit and feedback (I), when compared to random observations (C) improve compliance of patient identification with barcode scanning before performing blood glucose check (O) within ten weeks (T)? Evidence: …

Intouch August 8, 2022, New York Medical College

InTouch

• White Coat Ceremony Caps Off Transition to Medical School Week for SOM Class of 2026
• Noted Biomedical Research Institute Joins Touro University and NYMC
• Jennifer Salcedo, M.D., M.P.H., M.P.P., FACOG, Named Designated Institutional Official
• Regina Williams Named Director of Human Resources
• SOM Student Senate Set to Tackle New Academic Year
• Chioma M. Okeoma, Ph.D., Has Risen Above Adversity to Excel in Her Field

Dosimetric Comparison Of Static Imrt And Vmat Apbi Treatment Planning In The Prone Position For Breast Conservation Therapy, Kelly A. Foucher

Masters Projects

Introduction

Prevalence of early-stage breast cancer is increasing with the aid of preventative screenings and early diagnosis. The standard of care is transforming from conventional approaches with long treatment regimens towards hypofractionation and tissue sparing techniques. Based on studies over the past ten years, there are reasons to consider a partial-breast, hypo fractionated treatment option in the supine position. In practice, aPBI is often produced using several static intensity modulated beams to control dose to the normal breast tissue and limit dose to the heart and lungs. Patients may also be treated in the prone treatment setup in order to …

Dose Comparison Of Automatic Feathering Algorithm Versus Traditional Techniques With The Introduction Of Setup Uncertainties, Caleb D. Mcgowan

Masters Projects

Introduction: Inter fractional setup uncertainties for patients receiving cervical radiation therapy treatments can cause a significant change in dose to the target structures resulting in under dosing or over dosing the patient. Varian has created an auto feathering algorithm for extended field radiotherapy to help smooth out the dose located at the junction between the two fields. This may reduce the percent change to the dose distribution when the setup uncertainties are introduced.

Methods: The study is a retrospective dosimetric analysis of 10 randomly selected female cervical cancer patients. Each patient had a plan created using the traditional technique of …

Plan Quality Comparison Between Cyberknife And Vmat Lung Sbrt After Modified Cyberknife Treatment Times., Lindsey Money

Masters Projects

Introduction

This retrospective study will aim compare Cyberknife SBRT and VMAT SBRT lung plans quality when the Cyberknife plans are replanned to have a comparable treatment time to the VMAT plans. Having data to show the difference in plan quality between the two treatment techniques could be a useful tool when deciding the best treatment option.

Methodology

Select ten SBRT lung patients who were all treated using the Cyberknife and plan a comparable VMAT treatment for each. Modify the original Cyberknife treatment plan so that the treatment time is similar to that of the corresponding VMAT plan. Then, evaluate and …

Oncogenic Collagen I Homotrimers From Cancer Cells Bind To Α3Β1 Integrin And Impact Tumor Microbiome And Immunity To Promote Pancreatic Cancer, Yang Chen, Sujuan Yang, Jena Tavormina, Desiree Tampe, Michael Zeisberg, Huamin Wang, Krishnan K Mahadevan, Chang-Jiun Wu, Hikaru Sugimoto, Chia-Chi Chang, Robert R Jenq, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts, pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 homotrimer results from epigenetic suppression of the Col1a2 gene and promotes oncogenic signaling, cancer cell proliferation, tumor organoid formation, and growth via α3β1 integrin on cancer cells, associated with tumor microbiome enriched in anaerobic Bacteroidales in hypoxic and immunosuppressive tumors. Deletion of Col1 homotrimers increases overall survival of mice with pancreatic ductal adenocarcinoma (PDAC), associated with reprograming of the tumor microbiome with increased microaerophilic Campylobacterales, which can be reversed with broad-spectrum antibiotics. Deletion of Col1 homotrimers enhances …

Analisis Hubungan Faktor Fisik Dan Psikososial Terhadap Keluhan Gangguan Otot Tulang Rangka Akibat Kerja Pada Guru Smk Negeri Di Kota Pekanbaru, Maria Yolanda Florensia, Baiduri Widanarko

National Journal of Occupational Health and Safety

Work-related musculoskeletal disorders (WMSDs) are one of the most common occupational health problems among workers, including teachers. High work demand and awkward posture are among the most common risk factors. In addition, individual characteristics are included as risk factors that can increase these complaints. Thus, the purpose of this research is to analyze the relationship between individual characteristics, physical and psychosocial risk factors against WMSDs on teachers at State Vocational High School. This research was conducted in April – July 2021 using various questionnaires like NMQ, QEC, and a combination of psychosocial questionnaires. A cross-sectional study design was used in …

Analisis Faktor Risiko Ergonomi Terhadap Keluhan Gangguan Muskuloskeletal Pada Pekerja Umkm Pengrajin Alas Kaki Di Kecamatan Ciomas, Dita Mayasari, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

Work activity on footwear Micro, Small, and Medium Enterprises (MSMEs) such as sitting work position, bending down, neck bend, long duration of work and uncertain can cause pain that lead to musculoskeletal disorder complaint. This research aim to analyze individual risk factors, occupational risk factors, work environment risk factors, and work equipment risk factors against musculoskeletal disorder complaint on footwear MSMEs workers in Ciomas district. This research using cross sectional study design. The result of the research showed that 84,7% of respondent have a musculoskeletal disorder complaint. On some risk factors researched, there was a significant relationship between individual risk …

Corpora Amylacea Are Associated With Tau Burden And Cognitive Status In Alzheimer's Disease, Connor M Wander, Tamy Harumy Moraes Tsujimoto, John F Ervin, Chanung Wang, Spencer M Maranto, Vanya Bhat, Julian D Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K Scott, David M Holtzman, Todd J Cohen

2020-Current year OA Pubs

Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular organelles, and other cellular debris. The structure, morphology, and suspected functions of CA in the brain imply disease relevance. Despite this, the link between CA and age-related neurodegenerative diseases, particularly Alzheimer's disease (AD), remains poorly defined. We performed a neuropathological analysis of mouse PAS granules and human CA and correlated these findings with AD progression. Increased PAS granule density was observed in symptomatic tau transgenic mice and APOE knock-in mice. Using a cohort of …

A Mouse Holder For Awake Functional Imaging In Unanesthetized Mice: Applications In 31p Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, And Resting-State Functional Magnetic Resonance Imaging, Lindsay C Fadel, Ivany V Patel, Jonathan Romero, I-Chih Tan, Shelli R Kesler, Vikram Rao, S A Amali S Subasinghe, Russell S Ray, Jason T Yustein, Matthew J Allen, Brian W Gibson, Justin J Verlinden, Stanley Fayn, Nicole Ruggiero, Caitlyn Ortiz, Elizabeth Hipskind, Aaron Feng, Chijindu Iheanacho, Alex Wang, Robia G Pautler

Faculty, Staff and Students Publications

Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies in awake, unanesthetized animals to obtain accurate results without the confounding physiological effects of anesthesia. Here, we describe a newly designed mouse holder that is interfaceable with existing MRI systems and enables awake in vivo mouse imaging. This holder significantly reduces head movement of the awake animal compared to previously designed holders and allows for the acquisition of improved anatomical images. In addition to applications in …

Identification Of Activity-Induced Egr3-Dependent Genes Reveals Genes Associated With Dna Damage Response And Schizophrenia, Ketan K Marballi, Khaled Alganem, Samuel J Brunwasser, Arhem Barkatullah, Kimberly T Meyers, Janet M Campbell, Annika B Ozols, Robert E Mccullumsmith, Amelia L Gallitano

2020-Current year OA Pubs

Bioinformatics and network studies have identified the immediate early gene transcription factor early growth response 3 (EGR3) as a master regulator of genes differentially expressed in the brains of patients with neuropsychiatric illnesses ranging from schizophrenia and bipolar disorder to Alzheimer's disease. However, few studies have identified and validated Egr3-dependent genes in the mammalian brain. We have previously shown that Egr3 is required for stress-responsive behavior, memory, and hippocampal long-term depression in mice. To identify Egr3-dependent genes that may regulate these processes, we conducted an expression microarray on hippocampi from wildtype (WT) and Egr3-/- mice following electroconvulsive seizure (ECS), a …

Clinical Decision Support For Intervention Reduction In Neonatal Patients: A Usability Assessment, Patrice Dolhonde Tremoulet

College of Science & Mathematics Departmental Research

Objective This study investigated how effectively simplified cognitive walkthroughs, performed independently by four nonclinical researchers, can be used to assess the usability of clinical decision support software. It also helped illuminate the types of usability issues in clinical decision support software tools that cognitive walkthroughs can identify. Method A human factors professor and three research assistants each conducted an independent cognitive walkthrough of a web-based demonstration version of T3, a physiologic monitoring system featuring a new clinical decision support software tool called MAnagement Application (MAP). They accessed the demo on personal computers in their homes and used it to walk …

Clinical Skills And A Quick Reference Guide For Critical Care, Kayla Mccarty

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Multifactorial Fall Prevention Program Development And Implementation Within An Assisted Living Facility, Makenzie King

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Effectiveness Of Support Groups For Stroke Patients, Wendy H. Rosario

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Occupational Therapy's Role In Home Health, Irving Noche

Department of Occupational Therapy Entry-Level Capstone Projects

My capstone experience was completed at CORE Health Company in Riverside, California under a privately owned home health care (HHC) staffing company. CORE Health provide in-home Occupational therapy (OT) and physical therapy (PT) services for the adult and the older adult (ages 65 and over) population. Clients under private insurance, Medicare, hospice, or workers compensation can qualify to receive services. CORE Health proudly serves the Riverside and San Bernardino Counties. My site mentor for this capstone experience was Afshin Juybari, founder CEO of CORE Health and faculty mentor is Christina Kane, Ed. D., MS, OTR/L. I explored the Accreditation Council …

Clinical Practice Skills And The Development Of A Visual Perception Screening Tool For Inpatient Settings, Annie J. Mehl

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Reducing Caregiver Burden In Spinal Cord Injuries And Disorders (Sci/D), Heather Berto

Department of Occupational Therapy Entry-Level Capstone Projects

The following capstone project focused on the exploration of clinical and community-based resources that help reduce caregiver burden in the adult spinal cord injuries and disease (SCI/D) population. In order to best serve the chosen population, this capstone project aimed to help adults with SCI/D and their caregivers have access to resources that assist with handling adjustment, learning independent living skills, and navigating their relationship with one another, while ultimately taking into consideration their specific mental health needs.

An Evaluation Of Methods To Reduce Inframammary Surface Dose In Prone Breast Irradiation, Seth Alvarado

Doctoral Dissertations & Projects

In cases of breast radiation treatments via external beam radiation therapy, the incidence of radiation dermatitis has been reported. In prior studies, this acute radiation side-effect has been correlated with the immobilization devices in cases of prone breast irradiation. They attribute this to the bolus effect that occurs with the interaction of the incident photon beam at different projections causing an increase in measured surface dose. The type of radiation planning technique, and patient positioning during the undertaking of these techniques, have also shown to influence this bolus effect. This study focuses on these factors in treatment planning in order …

Psychometric Properties Of The Urdu Version Of The Eortc Qlq-H&N35 (European Organization For Research And Treatment Of Cancer Head And Neck Module) Quality Of Life Tool, Nida Zahid, Russell Seth Martins, Wajeeha Zahid, Iqbal Azam Syed, Mubasher Ikram, Aneesa Hassan, Shireen Shehzad Bhamani, Adnan Abdul Jabbar, Nargis Asad, Shabbir Akhtar, Moghira Iqbaluddin Siddiqui, Mohammad Sohail Awan, Khabir Ahmad

Department of Surgery Docs

Background: We translated and validated the Urdu version of the European Organization for Research and Treatment of Cancer Quality of Life (QoL) Questionnaire's Head and Neck (H&N) Cancer Module (EORTC QLQ-H&N35) and assessed its convergent and discriminant validity by examining correlations of QoL with depression, anxiety, and resilience.
Methods: We translated the EORTC QLQ-H&N35 according to EORTC instructions. Patients at a tertiary care hospital in Pakistan completed a survey consisting of Urdu versions of EORTC QLQ-C30 (core QoL tool), QLQ-H&N35, Hospital Anxiety and Depression Scale, and Wagnild and Young Resilience Scale (RS-14). Content validity, convergent validity, discriminant validity, and reliability …

An Evaluation Of Methods To Reduce Inframammary Surface Dose In Prone Breast Irradiation, Seth Alvarado

Masters Projects

In cases of breast radiation treatments via external beam radiation therapy, the incidence of radiation dermatitis has been reported. In prior studies, this acute radiation side-effect has been correlated with the immobilization devices in cases of prone breast irradiation. They attribute this to the bolus effect that occurs with the interaction of the incident photon beam at different projections causing an increase in measured surface dose. The type of radiation planning technique, and patient positioning during the undertaking of these techniques, have also shown to influence this bolus effect. This study focuses on these factors in treatment planning in order …

Adolescents With Depression Capstone Benchmark Project, Myeshia Salter

MSN Capstone Projects

This change project promotes the inclusion of adolescent involvement within the informed consenting process for recommended treatment plans for symptoms of depression. This project proposal will include the adolescent throughout the development of the treatment plan to promote compliance. The incorporation of this plan will encourage autonomy in the adolescent and aid with developing a plan that the adolescent agrees with. The current process does not include the adolescents' desires or opinions, which results in poor efficacy of the treatment plan, thus exacerbating the symptoms of depression.